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hmbpp (23) 23
biochemistry & molecular biology (16) 16
cell biology (14) 14
index medicus (14) 14
biophysics (13) 13
isoprenoid biosynthesis (12) 12
phosphoantigen (11) 11
methyl (10) 10
enzymes (9) 9
physiological aspects (9) 9
erythritol - analogs & derivatives (8) 8
erythritol - metabolism (8) 8
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mep (8) 8
non-mevalonate pathway (8) 8
dimethylallyl diphosphate (7) 7
methylerythritol phosphate-pathway (7) 7
tuberculosis (7) 7
bacterial proteins - metabolism (6) 6
dmapp (6) 6
ipp (6) 6
isopentenyl diphosphate (6) 6
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terpenes - metabolism (6) 6
bacterial proteins - genetics (5) 5
dmapp, dimethylallyl diphosphate (5) 5
erythritol-4-phosphate (5) 5
escherichia coli - metabolism (5) 5
gcpe (5) 5
ipp, isopentenyl diphosphate (5) 5
oxidoreductases - metabolism (5) 5
phosphates (5) 5
sugar phosphates - metabolism (5) 5
-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (4) 4
analysis (4) 4
animals (4) 4
biosynthesis (4) 4
crystallography, x-ray (4) 4
drug design (4) 4
enzyme (4) 4
enzymes - chemistry (4) 4
erythritol 4-phosphate (4) 4
escherichia coli - enzymology (4) 4
ferredoxins - metabolism (4) 4
immunology (4) 4
iron-sulfur proteins - metabolism (4) 4
ispg (4) 4
lymphocytes (4) 4
lytb (4) 4
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organophosphorus compounds - metabolism (4) 4
recombinant proteins - chemistry (4) 4
recombinant proteins - metabolism (4) 4
t cell receptor (4) 4
x-ray structure (4) 4
-4-hydroxy-3-methylbut-2-enyl diphosphate (3) 3
1-deoxy (3) 3
2-c-methyl-d-erythritol 4-phosphate pathway (3) 3
4-hydroxy-3-methyl-but-2-enyl diphosphate (3) 3
4-hydroxy-3-methylbut-2-enyl diphosphate (3) 3
4fe-4s cluster (3) 3
4fe-4s protein (3) 3
article (3) 3
bacterial proteins - chemistry (3) 3
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catalytic domain (3) 3
cloning, molecular (3) 3
diphosphate synthase gcpe (3) 3
electrophoresis, polyacrylamide gel (3) 3
erythritol (3) 3
erythritol 2,4-cyclodiphosphate (3) 3
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γδ t cells (3) 3
1-deoxy-d-xylulose 5-phosphate reductoisomerase (2) 2
1-hydroxy-2-methyl-but-2-enyl-4-diphosphate (2) 2
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Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 6/2017, Volume 198, Issue 12, pp. 4753 - 4763
Dominant Vγ2Vδ2 T-cell subset recognizes phosphoantigen, and exist only in humans and nonhuman primates. Despite the discovery of γδ T cells for >30 years, a... 
γδ T cells | Macaques | tuberculosis | HMBPP | phosphoantigen
Journal Article
FEBS Letters, ISSN 0014-5793, 2006, Volume 580, Issue 6, pp. 1547 - 1552
In the methylerythritol phosphate pathway for isoprenoid biosynthesis, the GcpE/IspG enzyme catalyzes the conversion of 2- -methyl- -erythritol... 
GcpE | IspG | Ferredoxin | Photosynthesis | Isoprenoid biosynthesis | GcpE, IspG | HMBPP | IPP | MEcDP | erythritol 4-phosphate | HMBPP synthase | isopentenyl diphosphate | LytB, IspH | HMBPP reductase | MEP | DMAPP | methyl | erythritol 2,4-cyclodiphosphate | dimethylallyl diphosphate | 4-hydroxy-3-methylbut-2-enyl diphosphate | isoprenoid biosynthesis | METHYLERYTHRITOL PHOSPHATE-PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE PATHWAY | HAIRY ROOT CULTURES | ESCHERICHIA-COLI | (E)-4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE | CELL BIOLOGY | ferredoxin | BIOPHYSICS | photosynthesis | ISOPENTENYL DIPHOSPHATE | MYCORRHIZAL ROOTS | MEVALONATE-INDEPENDENT PATHWAY | NONMEVALONATE PATHWAY | Electron Transport | Arabidopsis - enzymology | Escherichia coli - enzymology | Erythritol - analogs & derivatives | Oxidation-Reduction | Ferredoxins - metabolism | Alkyl and Aryl Transferases - metabolism | Spinacia oleracea - metabolism | Thylakoids - radiation effects | Thylakoids - metabolism | Arabidopsis Proteins - isolation & purification | Arabidopsis Proteins - metabolism | Thylakoids - enzymology | Terpenes - metabolism | Light | Spinacia oleracea - radiation effects | Erythritol - metabolism | Spinacia oleracea - enzymology | Arabidopsis thaliana | Phosphates | Enzymes | Pyridine | Phytochemistry | Physiological aspects | Catalysis
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2019, Volume 116, Issue 13, pp. 6371 - 6378
Tuberculosis (TB) remains a leading killer among infectious diseases, and a better TB vaccine is urgently needed. The critical components and mechanisms of... 
MYCOBACTERIUM-TUBERCULOSIS | LISTERIA-MONOCYTOGENES | PULMONARY | MULTIDISCIPLINARY SCIENCES | tuberculosis | HMBPP | gamma delta T cells | BCG | PREVENTION | CD8(+) T | phosphoantigen | vaccine | HIV-INFECTION | IMMUNE-RESPONSES | RHESUS MACAQUES
Journal Article
CHEMISTRY-A EUROPEAN JOURNAL, ISSN 0947-6539, 09/2017, Volume 23, Issue 49, pp. 11945 - 11954
V gamma 9V delta 2 T cells play an important role in the cross talk of the innate and adaptive immune system. For their activation by phosphoantigens (PAgs),... 
B30.2 domain | STIMULATION | BTN3A1 | RECOGNITION | ANALOGS | PYROPHOSPHATE | BIOSYNTHESIS | HMBPP | photoaffinity label | PHOSPHORYLATED ANTIGENS | CHEMISTRY, MULTIDISCIPLINARY | phosphoantigen
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2013, Volume 587, Issue 17, pp. 2806 - 2817
The methylerythritol phosphate (MEP) pathway of ( ) has become an attractive target for anti-malarial drug discovery. This study describes a kinetic model of... 
Drug target | Kinetic model | Malaria | Metabolic control analysis | Methylerythritol phosphate (MEP) | xylulose 5-phosphate synthase | flux control coefficient | HMBPP | IPP | SBML | erythritol synthase | MECPPS | BLAST | Isopentenyl pyrophosphate | FCC | butenyl 4-diphosphate synthase | basic local alignment search tool | erythritol kinase | MECPP | CDPME | GAP | erythritol 2,4-cyclodiphosphate synthase | MEP | DMAPP | xylulose 5-phosphate | DXP | DXS | methylerythritol phosphate | DXR | glyceraldehyde 3-phosphate | 4-(cytidine 5′-diphospho)-2 | PDB | concentration control coefficient | xylulose 5-phosphate reductoisomerase | protein data bank | methyl | 2-phospho-4-(cytidine 5′-diphospho)-2 | BLAST-P | dimethylallyl diphosphate | CCC | butenyl 4-diphosphate reductase | PYR | PSI-BLAST | HMBPPR | pyruvate | HMBPPS | system biology markup language | CDPMEP | protein BLAST | CDPMES | butenyl 4-diphosphate | erythritol 2,4-cyclodiphosphate | position-specific iterated BLAST | CDPMEK | 1-hydroxy-2-methyl-2- | erythritol | 1-deoxy | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | NON-MEVALONATE PATHWAY | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE | CELL BIOLOGY | STEADY-STATE TREATMENT | SUBSTRATE-BINDING | BIOPHYSICS | BIOSYNTHESIS | PLANTS | SYSTEMS BIOLOGY | Enzymes - chemistry | Oxidoreductases - antagonists & inhibitors | Plasmodium falciparum - enzymology | Erythritol - analogs & derivatives | Models, Chemical | Phosphotransferases (Alcohol Group Acceptor) - chemistry | Oxidoreductases - chemistry | Terpenes - metabolism | Computer Simulation | Enzyme Inhibitors - chemistry | Plasmodium falciparum - metabolism | Protozoan Proteins - chemistry | Erythritol - metabolism | Phosphorus-Oxygen Lyases - chemistry | Transferases - antagonists & inhibitors | Escherichia coli Proteins - antagonists & inhibitors | Aldose-Ketose Isomerases - chemistry | Escherichia coli - enzymology | Transferases - chemistry | Biosynthetic Pathways | Multienzyme Complexes - antagonists & inhibitors | Multienzyme Complexes - chemistry | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Algorithms | Models, Biological | Kinetics | Aldose-Ketose Isomerases - antagonists & inhibitors | Escherichia coli Proteins - chemistry | Phosphorus-Oxygen Lyases - antagonists & inhibitors | Phosphates | Plasmodium falciparum | Enzymes | Metabolites | Analysis | Phytochemistry | Physiological aspects | Models | Sugars | Monosaccharides
Journal Article
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 09/2017, Volume 23, Issue 49, pp. 11945 - 11954
Vγ9Vδ2 T cells play an important role in the cross talk of the innate and adaptive immune system. For their activation by phosphoantigens (PAgs), both cell... 
B30.2 domain | BTN3A1 | HMBPP | photoaffinity label | phosphoantigen
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 07/2018, Volume 9
V gamma 9V delta 2(+) lymphocytes are among the first T-cells to develop in the human fetus and are the predominant peripheral blood gamma delta T-cell... 
RECOGNITION | V gamma 9V delta 2(+) T-cell | HMBPP | NONPEPTIDE ANTIGENS | CORD BLOOD | INNATE | T-cell receptor repertoire | IMMUNOLOGY | gamma/delta T-cell | phosphoantigen | TRANSPLANTATION | FETAL-DEVELOPMENT | RESPONSES | ONTOGENY | PULMONARY TUBERCULOSIS | LYMPHOCYTES
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 07/2018, Volume 9, p. 1501
Vγ9Vδ2 lymphocytes are among the first T-cells to develop in the human fetus and are the predominant peripheral blood γδ T-cell population in most adults.... 
Phosphoantigen | T-cell receptor repertoire | Gamma/delta T-cell | T-cell | Vγ9Vδ2 | HMBPP | Vγ9Vδ2+ T-cell | gamma/delta T-cell | phosphoantigen
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2019, Volume 116, Issue 13, pp. 6371 - 6378
Tuberculosis (TB) remains a leading killer among infectious diseases, and a better TB vaccine is urgently needed. The critical components and mechanisms of... 
Phosphoantigen | γδ T cells | Vaccine | Tuberculosis | HMBPP | T-Lymphocyte Subsets - immunology | Macaca mulatta - immunology | Male | Interferon-gamma - metabolism | Listeria monocytogenes - immunology | Mycobacterium tuberculosis - drug effects | Organophosphates | Female | Bacterial Proteins - immunology | Tuberculosis Vaccines - immunology | Immunologic Memory - immunology | Disease Models, Animal | Tuberculosis - pathology | Tuberculosis Vaccines - pharmacology | Immunization | Lung - pathology | Peptide Termination Factors - genetics | Membrane Proteins - genetics | Bacterial Proteins - genetics | Peptide Termination Factors - immunology | Membrane Proteins - immunology | Receptors, Antigen, T-Cell, gamma-delta - immunology | Tuberculosis - immunology | Vaccines, Attenuated - immunology | Animals | Lymphocyte Activation - drug effects | Tuberculosis - prevention & control | Listeria monocytogenes - genetics | CD8-Positive T-Lymphocytes - immunology | Lung - immunology | Immunological memory | Memory cells | CD8 antigen | Vaccination | Organs | Effector cells | Listeria monocytogenes | Infections | Lymphocytes T | Vaccines | Critical components | CD4 antigen | Respiratory tract | Infectious diseases | Lungs | Lymphocytes | γ-Interferon | Primates | Perforin | Containment | Biological Sciences | vaccine | PNAS Plus | tuberculosis | phosphoantigen
Journal Article
Cellular and Molecular Immunology, ISSN 1672-7681, 01/2013, Volume 10, Issue 1, pp. 58 - 64
Journal Article