X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (38) 38
humans (37) 37
hmth1 (29) 29
oxidative stress (29) 29
phosphoric monoester hydrolases - metabolism (19) 19
cancer (18) 18
dna repair enzymes - metabolism (17) 17
dna damage (16) 16
human mutt homolog (16) 16
mth1 (16) 16
female (14) 14
phosphoric monoester hydrolases - genetics (14) 14
hmth1 protein (13) 13
male (13) 13
mutagenic substrate (13) 13
dna repair (12) 12
animals (11) 11
dna repair enzymes - genetics (11) 11
messenger-rna (11) 11
toxicology (11) 11
deoxyguanosine - analogs & derivatives (9) 9
deoxyguanosine - metabolism (9) 9
dna (9) 9
middle aged (9) 9
nucleotide pool (9) 9
oxidative damage (9) 9
research (9) 9
analysis (8) 8
cell line (8) 8
expression (8) 8
genetics & heredity (8) 8
oncology (8) 8
8-oxoguanine (7) 7
base excision-repair (7) 7
biochemistry & molecular biology (7) 7
carcinogenesis (7) 7
cell line, tumor (7) 7
cells (7) 7
damage (7) 7
genetic aspects (7) 7
hmth1 messenger-rna (7) 7
mutation (7) 7
oxidative dna-damage (7) 7
aged (6) 6
enzymes (6) 6
escherichia-coli (6) 6
hogg1 (6) 6
protein (6) 6
proteins (6) 6
repair (6) 6
8-oxo-dg (5) 5
cell biology (5) 5
deoxyguanine nucleotides - metabolism (5) 5
dna-damage (5) 5
gene (5) 5
gene expression (5) 5
health aspects (5) 5
mice (5) 5
mutagenesis (5) 5
nucleic-acids (5) 5
nucleotides (5) 5
nucleotides - metabolism (5) 5
oxidative dna damage (5) 5
physiological aspects (5) 5
purine nucleoside triphosphatase (5) 5
stress (5) 5
5'-triphosphate pyrophosphohydrolase 8-oxo-dgtpase (4) 4
adult (4) 4
aged, 80 and over (4) 4
apoptosis (4) 4
article (4) 4
biotechnology & applied microbiology (4) 4
colorectal cancer (4) 4
dna glycosylases - genetics (4) 4
dna repair enzymes (4) 4
dna repair enzymes - antagonists & inhibitors (4) 4
dna repair enzymes - biosynthesis (4) 4
dna-synthesis (4) 4
free radicals (4) 4
guanine - analogs & derivatives (4) 4
guanine - metabolism (4) 4
human mth1 (4) 4
hydrolysis (4) 4
immunohistochemistry (4) 4
in-vivo (4) 4
inhibitors (4) 4
intracellular-localization (4) 4
lung cancer (4) 4
mammalian-cells (4) 4
medical and health sciences (4) 4
medicin och hälsovetenskap (4) 4
mitochondria (4) 4
neoplasms. tumors. oncology. including cancer and carcinogens (4) 4
overexpression (4) 4
oxidized forms (4) 4
phosphoric monoester hydrolases - antagonists & inhibitors (4) 4
phosphoric monoester hydrolases - biosynthesis (4) 4
reactive oxygen species - metabolism (4) 4
tumorigenesis (4) 4
tumors (4) 4
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 222 - 227
Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used... 
CELL LUNG-CANCER | RAS-TRANSFORMATION | OVEREXPRESSION | OXIDATIVE STRESS | HMTH1 | MESSENGER-RNA | GENE | MULTIDISCIPLINARY SCIENCES | HUMAN MUTT HOMOLOG | TUMORIGENESIS | SMALL-MOLECULE INHIBITION | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Pyridines - chemistry | Colonic Neoplasms - drug therapy | Humans | Substrate Specificity | DNA Breaks, Single-Stranded - drug effects | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Phosphoric Monoester Hydrolases - biosynthesis | DNA Repair Enzymes - metabolism | Female | Antineoplastic Agents - pharmacology | DNA Repair Enzymes - antagonists & inhibitors | Homeostasis - drug effects | Aminoquinolines - pharmacology | DNA Repair Enzymes - chemistry | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Pyrazoles - pharmacology | Crystallization | Models, Molecular | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Nucleotides - metabolism | Xenograft Model Antitumor Assays | Animals | Colonic Neoplasms - pathology | DNA Repair | DNA Repair Enzymes - biosynthesis | Proteomics | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Crizotinib | Enzymes | Colon cancer | Physiological aspects | Genetic aspects | Research | Nucleotides | Studies | Oxidative stress | Inhibitor drugs | Medical prognosis | Homeostasis | Mutation | Kinases | Experiments | Cancer | Index Medicus | Life Sciences | crizotinib | cancer | stereoselectivity | MTH1 | DNA repair | drug
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 56, pp. 95865 - 95879
Cancer cells are more addictive to MTH1 than normal cells because of their dysfunctional redox regulations. MTH1 plays an important role to maintain tumor cell... 
Natural inhibitors | Anti-tumor | Farnesyl phenolic compounds | MTH1 | Ganoderma sinense | LUCIDUM POLYSACCHARIDES | CELLS | HMTH1 | TRITERPENOIDS | natural inhibitors | CANCER | DAMAGE | CELL BIOLOGY | anti-tumor | REPAIR | POTENT | farnesyl phenolic compounds
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2006, Volume 41, Issue 4, pp. 620 - 626
Journal Article
BMC Cancer, ISSN 1471-2407, 04/2018, Volume 18, Issue 1, pp. 423 - 423
Background: Targeted therapies are based on exploiting cancer-cell-specific genetic features or phenotypic traits to selectively kill cancer cells while... 
Gemcitabine | MTH1 | Targeted therapy | Lung cancer | NUDT1 | Nucleotides | Combined therapy | Cisplatin | Genomic instability | Oxidative DNA damage | SURVIVAL | NUCLEOTIDE POOL | HMTH1 | REPLICATION STRESS | IN-VITRO | MESSENGER-RNA | ONCOLOGY | HOMOLOG 1 MTH1 | INHIBITORS | EXPRESSION | Oxidative stress | DNA damage | Analysis | Development and progression | Dosage and administration | Genetic aspects | Research | Drug therapy | Index Medicus
Journal Article
by Xu, J and Yang, Z.-Y and Chen, X and Liu, X
European Review for Medical and Pharmacological Sciences, ISSN 1128-3602, 2018, Volume 22, Issue 13, pp. 4363 - 4370
OBJECTIVE: To investigate the effect of hMTH1 (human mutT homologue 1) on inducing the metastasis and recurrence of parotid adenoma, which may provide a new... 
HMTH1 | DNA damage | Parotid adenoma | PATHWAYS | OXIDATIVE DAMAGE | RISK | HMTHI | CANCER | 8-OXOGUANINE | CARCINOGENESIS | MTH1 | POOL | PHARMACOLOGY & PHARMACY | SER326CYS POLYMORPHISM | CARCINOMA
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 62, pp. 105714 - 105726
Background: MutT-related proteins, including MTH1, MTH2, MTH3 and NUDT5, can effectively degrade 8-oxoGua-containing nucleotides. The MTH1 expression is... 
Oxidized nucleotides | Prognosis | Clinical relevance | MutT-related proteins | Colorectal cancer | HMTH1 PROTEIN | colorectal cancer | CELL NUCLEAR ANTIGEN | OXIDATIVE DAMAGE | HOMOLOG | DNA-SYNTHESIS | prognosis | clinical relevance | CELL BIOLOGY | MESSENGER-RNA | MTH1 | oxidized nucleotides | INHIBITORS | MUTAGENIC SUBSTRATE | EXPRESSION
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1541 - 17
The NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as mRNA processing. Although highly conserved throughout all organisms, their... 
HMTH1 PROTEIN | MOTIF 2 | OXIDATIVE STRESS | HUMAN MTH1 | MESSENGER-RNA | OXIDIZED FORMS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GENETIC INTERACTION | HUMAN MUTT HOMOLOG | PROTEIN HYDROLYZES | A549 Cells | Cell Line | Multigene Family | Pyrophosphatases - classification | Humans | Gene Expression Regulation, Neoplastic | Pyrophosphatases - genetics | Substrate Specificity | Gene Expression Profiling - methods | Phylogeny | Gene Regulatory Networks | Gene Expression Regulation, Enzymologic | Pyrophosphatases - metabolism | MCF-7 Cells | RNA Interference | Cell Line, Tumor | Hydrolase | Nucleotide sequence | mRNA processing | Redundancy | Homeostasis | Epistasis | Gene expression | Metabolism | Tissues | Substrates | Proteins | Cell cycle | Crystal structure | Cancer | Index Medicus | NUDT4 protein | phylogenetic tree | NUDT21 protein | Medical and Health Sciences | Nudix hydrolase | NUDT6 protein | functional genomics | DNA content | enzyme structure | enzyme activity | NUDT8 protein | protein | upregulation | cancer cell line | protein expression | algorithm | NUDT14 protein | colorectal cancer | cancer tissue | Medicinsk bioteknologi | gene silencing | melanoma | human cell | NUDT17 protein | biochemical composition | NUDT12 protein | Medical Biotechnology | NUDT10 protein | NUDT19 protein | metabolism | gene expression | unclassified drug | NUDT5 protein | sequence alignment | Medicin och hälsovetenskap | NUDT22 protein | tissue microarray | Article | NUDT1 protein | NUDT7 protein | NUDT20 protein | NUDT16 protein | gene interaction | immunohistochemistry | human | enzyme | cell survival | human tissue | cell cycle | NUDT13 protein | breast cancer | NUDT11 protein | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | homeostasis | A-549 cell line | controlled study | cancer | cell cycle regulation
Journal Article
Journal Article
OncoTargets and Therapy, ISSN 1178-6930, 12/2015, Volume 8, pp. 3649 - 3664
Inhibition of the nucleotide pool sanitizing enzyme MTH1 causes extensive oxidative DNA damages and apoptosis in cancer cells and hence may be used as an... 
Cell cycle arrest | 8-oxoG | MTH1 | Echinacoside | DNA damage | Apoptosis | HMTH1 | PROTEIN | INSTABILITY | NATURAL-PRODUCTS | DRUG DISCOVERY | apoptosis | MISMATCH REPAIR | cell cycle arrest | 8-OXOGUANINE | RIBONUCLEOTIDE | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA | EXPRESSION | Enzymes | Oxidative stress | Molecular targeted therapy | Care and treatment | Innovations | Hydrolases | Genetic aspects | Properties | Health aspects | Cancer
Journal Article
Lung Cancer, ISSN 0169-5002, 2017, Volume 109, pp. 52 - 57
Journal Article
Cancer Cell International, ISSN 1475-2867, 10/2017, Volume 17, Issue 1, pp. 92 - 92
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 11/2018, Volume 51, Issue 1, pp. 80 - 96
Journal Article