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Antiviral Research, ISSN 0166-3542, 10/2019, Volume 170, pp. 104568 - 104568
Hepatitis B virus (HBV) infection remains a global health problem, causing nearly one million deaths annually. Forkhead box O (FoxO) transcription factors play... 
ERK signaling | FoxO4 | Core promoter | HBV | HNF4α | Index Medicus
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 6/2016, Volume 63, Issue 6, pp. 1860 - 1874
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease that ranges from simple steatosis to non-alcoholic steatohepatitis (NASH). So far, the... 
lipogenesis and HNF4α | lipolysis | Carboxylesterase 2 | steatosis
Journal Article
The EMBO Journal, ISSN 0261-4189, 10/2007, Volume 26, Issue 21, pp. 4445 - 4456
The transcriptional modulator Cited2 is induced by various biological stimuli including hypoxia, cytokines, growth factors, lipopolysaccharide (LPS) and flow... 
liver development | HNF4α | coactivator | Cited2 | Coactivator | Liver development
Journal Article
ACS Applied Materials and Interfaces, ISSN 1944-8244, 06/2019, Volume 11, Issue 22, pp. 19808 - 19818
Hepatocellular carcinoma (HCC) is one of the most prevalent and deadly malignancies characterized by high rate of recurrence. Tumor recurrence is often... 
gene delivery | mesoporous silica nanoparticles | HNF4α | differentiation therapy | hepatocellular carcinoma | Huh7 | CD133
Journal Article
Gene, ISSN 0378-1119, 03/2018, Volume 647, pp. 174 - 180
The rabbitfish was the first marine teleost demonstrated to have the ability of biosynthesizing long-chain polyunsaturated fatty acids (LC-PUFA) from C PUFA... 
LC-PUFA biosynthesis | Transcriptional regulation mechanism | HNF4α | NF-1 | Fatty acyl desaturase | Rabbitfish Siganus canaliculatus | Marine teleost | Index Medicus
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 04/2019, Volume 18, Issue 4, pp. 1582 - 1594
Environmental pollution contributes to fatty liver disease pathogenesis. Polychlorinated biphenyl (PCB) exposures have been associated with liver enzyme... 
steatohepatitis | liver | TASH | HNF4α | Aroclor 1260 | metabolism | polychlorinated biphenyl | EGFR | ACTIVATION | PHOSPHORYLATION | BIOCHEMICAL RESEARCH METHODS | NONALCOHOLIC STEATOHEPATITIS | HNF4 alpha | GROWTH-FACTOR RECEPTOR | DISRUPTING CHEMICALS | GLUTATHIONE | DISEASE | GENE-EXPRESSION
Journal Article
Developmental Cell, ISSN 1534-5807, 2009, Volume 16, Issue 4, pp. 588 - 599
Journal Article
Genes & Immunity, ISSN 1466-4879, 10/2012, Volume 13, Issue 7, pp. 556 - 565
Journal Article
by Zheng, BN and Ding, CH and Chen, SJ and Zhu, KK and Shao, JW and Feng, JF and Xu, WP and Cai, LY and Zhu, CP and Duan, WH and Ding, J and Zhang, X and Luo, C and Xie, WF
THERANOSTICS, ISSN 1838-7640, 2019, Volume 9, Issue 9, pp. 2606 - 2617
Background: Liver cancer stem cells (LCSCs) are responsible for the initiation, progression and chemoresistance of liver cancer. However, no agent targeting... 
MEDICINE, RESEARCH & EXPERIMENTAL | PRMT5 | SELECTIVE INHIBITOR | METHYLATION | POTENT | PROTEIN | cancer stem cells | HNF4 alpha | hepatocellular carcinoma | ARGININE METHYLTRANSFERASE 5
Journal Article
Cell Reports, ISSN 2211-1247, 03/2019, Volume 26, Issue 10, pp. 2549 - 2557.e3
Hepatocyte nuclear factor 4α (HNF4α) is a dimeric transcription factor that controls as much as 60% of all liver genes. However, how it achieves such broad... 
nuclear receptors | differential gene expression | isoform heterodimers | transcription | inflammation | HNF4α | HNF4A | immunity | isoform homodimers | NR2A1 | ACID | HNF4 | COLORECTAL-CANCER | TRANSCRIPTION | RECEPTOR | NUCLEAR FACTOR 4-ALPHA | PROMOTER | IDENTIFICATION | SPLICE VARIANTS | EXPRESSION | CELL BIOLOGY
Journal Article
Journal of Cell Science, ISSN 0021-9533, 07/2018, Volume 131, Issue 13, pp. jcs214734 - jcs214734
HNF4 alpha is a key nuclear receptor for regulating gene expression in the gut. Although both P1 and P2 isoform classes of HNF4 alpha are expressed in colonic... 
β-catenin | P1 and P2 isoforms | HNF4α | Colorectal cancer | Transcriptome | beta-catenin | HUMAN COLON | STEM-CELLS | TRANSCRIPTION | HNF4 alpha | INTESTINAL EPITHELIAL-CELLS | CELL BIOLOGY | HUMAN GENOME | RNA-SEQ | LIVER | GENE-EXPRESSION | DIFFERENTIATION | HEPATOCYTE NUCLEAR FACTOR-4-ALPHA | Cell survival | Colorectal carcinoma | Gene expression | Metabolism | Epithelium | Isoforms | Shutdowns | Tumorigenesis | Colon | Inhibition | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 10, pp. 7345 - 7356
Hepatocyte nuclear factor 4 alpha (HNF4 alpha) regulates genes involved in lipid and bile acid synthesis, gluconeogenesis, amino acid metabolism, and blood... 
FIBROSIS | HORMONE RECEPTOR SUPERFAMILY | HEPATOCELLULAR-CARCINOMA | LIVER-REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROSTATE-CANCER | MOUSE | BONE MORPHOGENETIC PROTEIN-7 | GENE-EXPRESSION | HNF4-ALPHA | TRANSCRIPTION FACTOR | Hepatomegaly - pathology | Fatty Liver - pathology | Bone Morphogenetic Protein 7 - genetics | Hepatocytes - pathology | Hepatocytes - metabolism | Phosphoproteins - metabolism | Tumor Suppressor Protein p53 - genetics | Organ Specificity - genetics | Carcinoma, Hepatocellular - genetics | Trans-Activators - genetics | Liver Neoplasms - pathology | Cell Differentiation | Disease Models, Animal | Fatty Liver - genetics | Hepatocyte Nuclear Factor 4 - metabolism | Fatty Liver - metabolism | Liver Neoplasms - genetics | Membrane Proteins - genetics | Tumor Suppressor Protein p53 - metabolism | Hepatocyte Nuclear Factor 4 - genetics | Hepatomegaly - genetics | Phosphoproteins - genetics | Mice, Knockout | Membrane Proteins - biosynthesis | Animals | Cell Cycle | Bone Morphogenetic Protein 7 - metabolism | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Trans-Activators - metabolism | Hepatomegaly - metabolism | Mice | Carcinoma, Hepatocellular - metabolism | Index Medicus | Gene Regulation | Cell Proliferation | General Transcription Factors | Gene Knockout | Hepatocyte | HNF4α
Journal Article