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PLoS biology, ISSN 1544-9173, 04/2017, Volume 15, Issue 4, p. e2001164
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 2017, Volume 35, Issue 10, pp. 1086 - 1095
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2016, Volume 291, Issue 21, pp. 11083 - 11093
The AlkB repair enzymes, including Escherichia coli AlkB and two human homologues, ALKBH2 and ALKBH3, are iron(II)- and 2-oxoglutarate-dependent dioxygenases... 
PROTEIN | bacteria | RNA | OXIDATIVE DEMETHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CRYSTAL-STRUCTURES | DNA repair | enzyme structure | STRANDED-DNA | cancer therapy | chemical biology | enzyme inhibitor | DNA-protein interaction | STRUCTURAL BASIS | PROSTATE-CANCER | IN-VIVO | ALKYLATION DAMAGE | Humans | DNA Repair Enzymes - genetics | Crystallography, X-Ray | Mixed Function Oxygenases - metabolism | DNA Methylation | RNA Interference | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - antagonists & inhibitors | Enzyme Inhibitors - chemistry | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - metabolism | DNA Repair Enzymes - metabolism | DNA Repair Enzymes - antagonists & inhibitors | Escherichia coli Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Cell Line | Catalytic Domain | AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Models, Molecular | Escherichia coli Proteins - metabolism | Mixed Function Oxygenases - antagonists & inhibitors | Recombinant Proteins - genetics | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - genetics | AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase - genetics | Escherichia coli Proteins - genetics | AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase - metabolism | Anthraquinones - pharmacology | DNA Damage | Anthraquinones - chemistry | Mixed Function Oxygenases - genetics | Methyl Methanesulfonate - pharmacology | DNA and Chromosomes
Journal Article
Chemistry, an Asian journal, ISSN 1861-4728, 10/2018, Volume 13, Issue 19, pp. 2854 - 2867
Dynamic combinatorial chemistry (DCC) is a powerful supramolecular approach for discovering ligands for biomolecules. To date, most, if not all, biologically... 
inhibitors | dynamic combinatorial chemistry | drug discovery | proteins | epigenetics | OXYGENASE INHIBITORS | HYDRAZONE FORMATION | PROTEIN STABILITY | OXIDATIVE DEMETHYLATION | HISTONE DEMETHYLASES | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | NUCLEOPHILIC CATALYSIS | BINDING INTERACTIONS | ZWITTERIONIC POLYMERS | Oxidoreductases, O-Demethylating - chemistry | Humans | Peptides - genetics | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - chemistry | Fluorometry - methods | Alpha-Ketoglutarate-Dependent Dioxygenase FTO - antagonists & inhibitors | Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics | AlkB Homolog 5, RNA Demethylase - genetics | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Protein Denaturation | Protein Engineering | Oxidoreductases, O-Demethylating - antagonists & inhibitors | AlkB Homolog 5, RNA Demethylase - chemistry | Molecular Structure | AlkB Homolog 5, RNA Demethylase - antagonists & inhibitors | Catalysis | Oxidoreductases, O-Demethylating - genetics | Combinatorial Chemistry Techniques - methods | Peptides - chemistry | Protein Structure, Secondary | Recombinant Fusion Proteins - chemistry | Alpha-Ketoglutarate-Dependent Dioxygenase FTO - chemistry | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - genetics | Hydrazones - chemistry | Recombinant Fusion Proteins - genetics | Ligands | Kinetics | Transition Temperature | Proteins | Combinatorial chemistry | Epigenetic inheritance | Drug discovery | Nucleic acids | Surface active agents
Journal Article
Familial Cancer, ISSN 1389-9600, 4/2018, Volume 17, Issue 2, pp. 225 - 228
Microsatellite instability, a well-established driver pathway in colorectal carcinogenesis, can develop in both sporadic and hereditary conditions via... 
Human Genetics | Biomedicine, general | Biomedicine | MLH1 methylation | MMR immunohistochemistry | Cancer Research | Microsatellite instability | Epidemiology | Double somatic mutation | Next generation sequencing | Lynch syndrome | ONCOLOGY | COLORECTAL-CANCER | GENETICS & HEREDITY | RISK | DEFICIENCY | Immunohistochemistry | Colonic Neoplasms - genetics | Adenocarcinoma - pathology | Humans | Gene Expression Regulation, Neoplastic | DNA-Binding Proteins - analysis | DNA Mismatch Repair - genetics | MutS Homolog 2 Protein - metabolism | DNA-Binding Proteins - metabolism | DNA Methylation | Mismatch Repair Endonuclease PMS2 - metabolism | Aged, 80 and over | Biomarkers, Tumor - metabolism | Germ-Line Mutation | Female | Adenocarcinoma - genetics | Biomarkers, Tumor - analysis | Mismatch Repair Endonuclease PMS2 - analysis | MutS Homolog 2 Protein - genetics | DNA-Binding Proteins - genetics | MutL Protein Homolog 1 - analysis | Phenotype | Colonic Neoplasms - pathology | MutL Protein Homolog 1 - genetics | Biomarkers, Tumor - genetics | MutL Protein Homolog 1 - metabolism | MutS Homolog 2 Protein - analysis | Mismatch Repair Endonuclease PMS2 - genetics | Proteins | Medical research | Colon cancer | Medicine, Experimental | Genetic aspects | Shiites | Methylation | Cancer | Adenocarcinoma | Phenotypes | MLH1 protein | MSH2 protein | Case reports | DNA repair | Carcinogenesis | MSH6 protein | MMR protein | Mismatch repair | Mutation | Solid tumors
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 567, Issue 7747, pp. 262 - 266
Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self DNA in the cytoplasm(1). Upon binding DNA, cGAS... 
SYNTHASE | CYCLIC GMP-AMP | MAVS | PROTEIN | ROLES | MULTIDISCIPLINARY SCIENCES | ADAPTER | SENSOR | Nucleotides, Cyclic - metabolism | Interferons - biosynthesis | Beclin-1 - deficiency | Vesicular Transport Proteins - metabolism | Humans | Endoplasmic Reticulum - metabolism | Autophagy-Related Protein 5 - genetics | Autophagy-Related Protein-1 Homolog - metabolism | DNA Viruses - metabolism | Interferons - immunology | Autophagy | DNA Viruses - genetics | Sea Anemones | Membrane Proteins - deficiency | HEK293 Cells | Membrane Proteins - metabolism | Nucleotidyltransferases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Phosphate-Binding Proteins | Signal Transduction | Membrane Proteins - genetics | DNA, Viral - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Autophagosomes - metabolism | Cytosol - virology | Protein Transport | Carrier Proteins - genetics | Animals | Autophagy-Related Protein-1 Homolog - deficiency | Carrier Proteins - metabolism | Monomeric GTP-Binding Proteins - metabolism | Autophagy-Related Protein 5 - deficiency | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Golgi Apparatus - metabolism | Mice | Beclin-1 - metabolism | Autophagy-Related Protein-1 Homolog - genetics | Nucleotides, Cyclic - immunology | Evolution, Molecular | Biological research | Autophagy (Cytology) | Enzymes | Physiological aspects | Interferon | Research | Cytoplasm | Biology, Experimental
Journal Article
Journal Article
Gynecologic oncology, ISSN 0090-8258, 2013, Volume 130, Issue 1, pp. 121 - 126
Abstract Objectives Lynch syndrome (LS) is a hereditary condition that increases the risk for endometrial and other cancers. Recognizing women at risk for LS... 
Hematology, Oncology and Palliative Medicine | Obstetrics and Gynecology | Immunohistochemistry | Genetic counseling | Microsatellite instability | Genetic testing | Endometrial cancer | Lynch syndrome | WOMEN | ONCOLOGY | NONPOLYPOSIS COLORECTAL-CANCER | CARCINOMA | OBSTETRICS & GYNECOLOGY | MutL Protein Homolog 1 | MutS Homolog 2 Protein - biosynthesis | Early Detection of Cancer - methods | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | DNA Repair Enzymes - genetics | Genetic Counseling | DNA-Binding Proteins - deficiency | Endometrial Neoplasms - genetics | Nuclear Proteins - biosynthesis | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Adenosine Triphosphatases - biosynthesis | MutS Homolog 2 Protein - deficiency | Nuclear Proteins - deficiency | Female | Mismatch Repair Endonuclease PMS2 | Nuclear Proteins - genetics | DNA Repair Enzymes - deficiency | Microsatellite Repeats | Adenosine Triphosphatases - deficiency | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | MutS Homolog 2 Protein - genetics | Academic Medical Centers | DNA-Binding Proteins - genetics | Endometrial Neoplasms - diagnosis | Adaptor Proteins, Signal Transducing - deficiency | DNA Repair Enzymes - biosynthesis | Adaptor Proteins, Signal Transducing - genetics | Endometrial Neoplasms - pathology | Adaptor Proteins, Signal Transducing - biosynthesis | Adenosine Triphosphatases - genetics | DNA-Binding Proteins - biosynthesis | Diagnosis | Medical centers | Cancer
Journal Article
Nature communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, p. 11384
Journal Article
Journal Article
Journal Article