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PLoS Biology, ISSN 1544-9173, 04/2017, Volume 15, Issue 4, pp. e2001164 - e2001164
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2016, Volume 291, Issue 21, pp. 11083 - 11093
The AlkB repair enzymes, including Escherichia coli AlkB and two human homologues, ALKBH2 and ALKBH3, are iron(II)- and 2-oxoglutarate-dependent dioxygenases... 
PROTEIN | bacteria | RNA | OXIDATIVE DEMETHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CRYSTAL-STRUCTURES | DNA repair | enzyme structure | STRANDED-DNA | cancer therapy | chemical biology | enzyme inhibitor | DNA-protein interaction | STRUCTURAL BASIS | PROSTATE-CANCER | IN-VIVO | ALKYLATION DAMAGE | Humans | DNA Repair Enzymes - genetics | Crystallography, X-Ray | Mixed Function Oxygenases - metabolism | DNA Methylation | RNA Interference | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - antagonists & inhibitors | Enzyme Inhibitors - chemistry | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - metabolism | DNA Repair Enzymes - metabolism | DNA Repair Enzymes - antagonists & inhibitors | Escherichia coli Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Cell Line | Catalytic Domain | AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Models, Molecular | Escherichia coli Proteins - metabolism | Mixed Function Oxygenases - antagonists & inhibitors | Recombinant Proteins - genetics | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - genetics | AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase - genetics | Escherichia coli Proteins - genetics | AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase - metabolism | Anthraquinones - pharmacology | DNA Damage | Anthraquinones - chemistry | Mixed Function Oxygenases - genetics | Methyl Methanesulfonate - pharmacology | Index Medicus | DNA and Chromosomes
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 04/2017, Volume 35, Issue 10, pp. 1086 - 1095
Journal Article
Blood, ISSN 0006-4971, 04/2017, Volume 129, Issue 17, pp. 2420 - 2428
The endoplasmic reticulum kinase inositol-requiring enzyme 1 (IRE1) and its downstream target X-box-binding protein 1 (XBP1) drive B-cell differentiation... 
GERMINAL CENTER FORMATION | MULTIPLE-MYELOMA | B-CELL LYMPHOMA | UNFOLDED-PROTEIN RESPONSE | TRANSCRIPTION FACTOR XBP-1 | CERVICAL-CANCER | ENDOPLASMIC-RETICULUM STRESS | BIVALENT PROMOTERS | DIFFERENTIATION | HEMATOLOGY | METHYLTRANSFERASE EZH2 | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | RNA, Messenger - immunology | Endoribonucleases - genetics | Cell Proliferation | Epigenesis, Genetic | Germinal Center - immunology | Humans | Gene Expression Regulation, Neoplastic | X-Box Binding Protein 1 - antagonists & inhibitors | Endoribonucleases - antagonists & inhibitors | Mice, 129 Strain | Plasma Cells - pathology | Lymphoma, Large B-Cell, Diffuse - therapy | RNA, Messenger - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lymphoma, Large B-Cell, Diffuse - immunology | Cell Differentiation | B-Lymphocytes - pathology | Promoter Regions, Genetic | Enhancer of Zeste Homolog 2 Protein - genetics | X-Box Binding Protein 1 - immunology | Histones - immunology | Lymphoma, Large B-Cell, Diffuse - pathology | Signal Transduction | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Germinal Center - pathology | Indazoles - pharmacology | Xenograft Model Antitumor Assays | Leupeptins - pharmacology | Animals | B-Lymphocytes - immunology | Histones - genetics | Enhancer of Zeste Homolog 2 Protein - immunology | Cell Line, Tumor | Protein-Serine-Threonine Kinases - immunology | Mice | Lymphoma, Large B-Cell, Diffuse - genetics | X-Box Binding Protein 1 - genetics | Pyridones - pharmacology | Endoribonucleases - immunology | Plasma Cells - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Cancer, ISSN 0008-543X, 06/2015, Volume 121, Issue 11, pp. 1762 - 1771
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2015, Volume 59, Issue 5, pp. 831 - 839
DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects DNA polymerase errors during replication to maintain genomic integrity. In , the... 
COLON-CANCER | HELICASE INTERACTS | POLYMERASE-DELTA | STEM-CELLS | REPLICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETIC-RECOMBINATION | HOMOLOGOUS RECOMBINATION | MUTL-ALPHA | CHROMOSOMAL INSTABILITY | OVARIAN FAILURE | CELL BIOLOGY | Adaptor Proteins, Signal Transducing - chemistry | Chromatin - metabolism | MutL Protein Homolog 1 | Microsatellite Instability | Humans | Minichromosome Maintenance Proteins - metabolism | DNA Mismatch Repair - genetics | MutS Homolog 2 Protein - metabolism | DNA-Binding Proteins - metabolism | DNA Mismatch Repair - physiology | Base Sequence | Minichromosome Maintenance Proteins - genetics | MutS Homolog 3 Protein | Minichromosome Maintenance Proteins - deficiency | Nuclear Proteins - genetics | DNA Helicases - genetics | DNA Helicases - chemistry | Nuclear Proteins - metabolism | MutS Homolog 2 Protein - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | Gene Knockout Techniques | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | MutS Homolog 2 Protein - chemistry | DNA - genetics | DNA Helicases - metabolism | Adaptor Proteins, Signal Transducing - genetics | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Chromatin - genetics | Proteins | Excavating machinery | DNA replication | Escherichia coli | Genomics | DNA | Index Medicus | Life Sciences | Genetics
Journal Article
Journal Article
PLoS biology, 04/2017, Volume 15, Issue 4, p. e2001164
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2016, Volume 62, Issue 4, pp. 491 - 506
ULK1 and ULK2 are thought to be essential for initiating autophagy, and -deficient mice die perinatally of autophagy-related defects. Therefore, we used a... 
SEROTONIN TRANSPORTER | BIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXIT SITES | EXPORT | NEURONS | AUTOPHAGOSOME FORMATION | ULK1 | COMPONENT | HOMOLOG | PROTEINS | CELL BIOLOGY | Golgi Apparatus - enzymology | Protein-Serine-Threonine Kinases - deficiency | Fibroblasts - enzymology | Phosphorylation | Vesicular Transport Proteins - metabolism | Autophagy-Related Protein 7 - metabolism | Humans | Brain - enzymology | Caenorhabditis elegans Proteins - metabolism | Homeostasis | Male | Autophagy-Related Protein-1 Homolog - metabolism | Golgi Apparatus - pathology | Mice, 129 Strain | Autophagy | Endoplasmic Reticulum - pathology | Transfection | RNA Interference | Time Factors | HEK293 Cells | Female | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Endoplasmic Reticulum - enzymology | Caenorhabditis elegans - genetics | Mice, Inbred C57BL | Vesicular Transport Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Genotype | Nuclear Proteins - metabolism | Unfolded Protein Response | Autophagy-Related Protein 7 - genetics | Mice, Knockout | Protein Transport | Carrier Proteins - genetics | Phenotype | Animals | Autophagy-Related Protein-1 Homolog - deficiency | COP-Coated Vesicles - enzymology | Carrier Proteins - metabolism | Brain - pathology | Nerve Degeneration | Autophagy-Related Protein-1 Homolog - genetics | Caenorhabditis elegans - enzymology | Proteins | Neurons | Phosphoproteins | Cells | Index Medicus
Journal Article
Digestive Diseases and Sciences, ISSN 0163-2116, 10/2011, Volume 56, Issue 10, pp. 2992 - 3004
DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-frequency microsatellite instability (MSI-H), which are the hallmarks of... 
Biochemistry, general | Prognosis | Medicine & Public Health | O 6 -methylguanine-DNA methyltransferase ( MGMT ) gene | Hepatology | Gastroenterology | Promoter CpG island hypermethylation | Oncology | Human mutS homolog 2 ( hMSH2 ) gene | Human mutL homolog 1 ( hMLH1 ) gene | Transplant Surgery | Esophageal squamous cell carcinoma (ESCC) | Human mutS homolog 2 (hMSH2) gene | methylguanine-DNA methyltransferase (MGMT) gene | Human mutL homolog 1 (hMLH1) gene | HMSH2 | HYPERMETHYLATION | MICROSATELLITE INSTABILITY | MGMT PROMOTER METHYLATION | MISMATCH REPAIR | HMLH1 | COLORECTAL-CARCINOMA | O-6-methylguanine-DNA methyltransferase (MGMT) gene | PROTEIN EXPRESSION | SQUAMOUS-CELL CARCINOMA | GASTROENTEROLOGY & HEPATOLOGY | HIGH-INCIDENCE AREA | MutL Protein Homolog 1 | Predictive Value of Tests | Carcinoma, Squamous Cell - genetics | Humans | DNA Repair Enzymes - genetics | Male | DNA Repair - genetics | MutS Homolog 2 Protein - metabolism | Case-Control Studies | Carcinoma, Squamous Cell - diagnosis | Carcinoma, Squamous Cell - mortality | Tumor Suppressor Proteins - genetics | DNA Repair Enzymes - metabolism | Esophageal Neoplasms - mortality | Esophageal Neoplasms - diagnosis | Female | Nuclear Proteins - genetics | Tumor Suppressor Proteins - metabolism | DNA Modification Methylases - metabolism | Kaplan-Meier Estimate | Esophagus - metabolism | Nuclear Proteins - metabolism | DNA Methylation - genetics | MutS Homolog 2 Protein - genetics | DNA Modification Methylases - genetics | Esophageal Neoplasms - genetics | Adaptor Proteins, Signal Transducing - genetics | CpG Islands - genetics | DNA, Neoplasm - genetics | Adaptor Proteins, Signal Transducing - metabolism | Squamous cell carcinoma | Transferases | Oncology, Experimental | Research | Chemotherapy | Anopheles | DNA | Genetic research | Genetic aspects | Methylation | Esophageal cancer | Tumors | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article