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Biochemical Pharmacology, ISSN 0006-2952, 11/2014, Volume 92, Issue 1, pp. 73 - 89
Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia associated with the metabolic syndrome and type 2 diabetes. In spite... 
Natural product | Nuclear receptor | Diabetes | Nutrition | PPAR gamma | NUCLEAR HORMONE RECEPTORS | INSULIN ACTION ENHANCER | NECROSIS-FACTOR-ALPHA | RANDOMIZED CONTROLLED-TRIAL | LIGAND-BINDING ACTIVITY | LOWERS BLOOD-PRESSURE | IMPROVES GLYCEMIC CONTROL | PHARMACOLOGY & PHARMACY | RETINOID-X-RECEPTOR | RED-CLOVER EXTRACT | NF-KAPPA-B | Biological Products - chemistry | Humans | PPAR gamma - agonists | Models, Molecular | Protein Binding | Biological Products - pharmacology | Molecular Structure | PPAR gamma - metabolism | Energy Metabolism - drug effects | DIO, diet-induced obesity | PPAR, peroxisome proliferator-activated receptor | TNF-α, tumor necrosis factor alpha | RXR, retinoid X receptor | CAP, c-Cbl-associated protein | DCM, dichloromethane | NF-κB, nuclear factor-kappaB | 9-(S)-HODE, (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid | AF-2, activation function-2 | Part of the Special Issue | MeOH, methanol | LDL, low-density lipoprotein | Cdk5, cyclin-dependent kinase 5 | DPP-4, dipeptidylpeptidase 4 | HUVEC, human umbilical vein endothelial cells | Glut4, glucose transporter type 4 | FDA, Food and Drug Administration | LBD, ligand-binding domain | EMA, European Medicines Agency | TCM, traditional Chinese medicine | PPRE, peroxisome proliferator response element | Metabolism 2014 – Alterations of metabolic pathways as therapeutic targets | PDB, protein data bank | SPPARMs, selective PPARγ modulators | HDL, high-density lipoprotein | MAPK, mitogen-activated protein kinase
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3738 - 3744
β-Defensin 3 (BD3) was identified as a ligand for the melanocortin receptors (MCRs) in 2007, although the pharmacology activity of BD3 has not been clearly... 
IN-VITRO | OBESITY | CHEMISTRY, MEDICINAL | MC1R | LIGANDS | MELANOCYTE-STIMULATING-HORMONE | AGOUTI | BLACK | COAT COLOR | SIMILARITY | DOMESTIC DOGS | β-defensin-1 | β-defensin-3 | endogenous agonist | MC4R | pigmentation | MC3R | innate immunity | Melanocortin receptors | feeding | anti-inflammatory | GPCR | obesity
Journal Article