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Polymer Chemistry, ISSN 1759-9954, 09/2017, Volume 8, Issue 34, pp. 4983 - 4987
We report nanoassemblies based on block copolymers of N-(2-hydroxypropyl) methacrylamide (HPMA) in which drug cleavage enhances the biological compatibility of... 
MACROMOLECULAR THERAPEUTICS | POLYMER SCIENCE | POLYMERIC NANOPARTICLES | DRUG-DELIVERY | IN-VIVO | DOXORUBICIN | VALPROIC ACID | MICELLES | INHIBITORS | RAFT POLYMERIZATION | HPMA COPOLYMERS
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 2008, Volume 132, Issue 3, pp. 193 - 199
-(2-hydroxypropyl) methacrylamide (HPMA) copolymer-RGDfK conjugates targeting the α β integrin have shown increased accumulation in solid tumors and promise... 
Tumor targeting | Renal targeting | Biodistribution | HPMA copolymer | RGD | MOLECULAR-WEIGHT | ANGIOGENESIS | IN-VIVO BIODISTRIBUTION | COPOLYMERS | CHEMISTRY, MULTIDISCIPLINARY | PEPTIDE | ALPHA(V)BETA | RADIONUCLIDE THERAPY | PHARMACOLOGY & PHARMACY | BINDING | Neoplasm Transplantation | Injections, Intravenous | Molecular Weight | Humans | Isothiocyanates - administration & dosage | Metabolic Clearance Rate | Pentetic Acid - administration & dosage | Pentetic Acid - analogs & derivatives | Acrylamides - pharmacokinetics | Integrin alphaVbeta3 - metabolism | Peptides, Cyclic - administration & dosage | Drug Carriers | Tissue Distribution | Kidney - metabolism | Kidney - diagnostic imaging | Carcinoma, Lewis Lung - diagnostic imaging | Female | Pentetic Acid - chemical synthesis | Binding, Competitive | Endothelial Cells - metabolism | Mice, Inbred C57BL | Isothiocyanates - blood | Carcinoma, Lewis Lung - metabolism | Pentetic Acid - pharmacokinetics | Chemistry, Pharmaceutical | Peptides, Cyclic - pharmacokinetics | Pentetic Acid - blood | Peptides, Cyclic - blood | Isothiocyanates - chemical synthesis | Animals | Acrylamides - administration & dosage | Peptides, Cyclic - chemical synthesis | Radionuclide Imaging | Cell Line, Tumor | Mice | Acrylamides - blood | Indium Radioisotopes | Acrylamides - chemical synthesis | Isothiocyanates - pharmacokinetics | Cyclohexane | Tumors | Index Medicus | HPMA Copolymer
Journal Article
Biomaterials, ISSN 0142-9612, 2014, Volume 35, Issue 24, pp. 6622 - 6635
Abstract Increasing the molecular weight of N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers by using micellar structures could result in more pronounced... 
Advanced Basic Science | Dentistry | pH-sensitive | Biodegradable | Cross-linked | β-sitosterol | HPMA copolymer conjugates | Polymeric micelles | PH-sensitive | CORE | DESIGN | MATERIALS SCIENCE, BIOMATERIALS | BLOCK-COPOLYMERS | beta-sitosterol | HPMA-BASED COPOLYMERS | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | DOXORUBICIN | BIODISTRIBUTION | IN-VITRO | PHASE-I | Doxorubicin - therapeutic use | Liver - pathology | Biocompatible Materials - chemistry | Humans | Fluorescein-5-isothiocyanate - metabolism | Alanine Transaminase - blood | Antineoplastic Agents - therapeutic use | Neoplasms - blood | Liver - drug effects | Micelles | Female | Sitosterols - chemistry | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Microscopy, Electron, Transmission | Tissue Distribution - drug effects | Cross-Linking Reagents - chemistry | Endocytosis - drug effects | Doxorubicin - pharmacokinetics | Acrylamides - chemistry | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Aspartate Aminotransferases - blood | Tumor Burden - drug effects | Cell Line, Tumor | Polymers - chemistry | Mice | Neoplasms - pathology | Acrylamides - chemical synthesis | Doxorubicin - pharmacology | Hydrogen-Ion Concentration | Drugs | Anthracyclines | Drug delivery systems | Sterols | Analysis | Permeability | Hydrogen-ion concentration | Tumors | Vehicles | Index Medicus
Journal Article
Macromolecular Bioscience, ISSN 1616-5187, 01/2018, Volume 18, Issue 1, pp. 1700209 - n/a
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 01/2014, Volume 174, Issue 1, pp. 81 - 87
Journal Article
Journal Article