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PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 6, p. e39679
The target of rapamycin (TOR) is a high molecular weight protein kinase that regulates many processes in cells in response to mitogens and variations in... 
CELLS | TRANSCRIPTIONAL ACTIVATION | DNA-BINDING | PHOSPHOPROTEOMIC ANALYSIS | FACTOR-1 | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | KINASE | AUTOPHAGY | BINDING PROTEIN | THERMOTOLERANCE | Phosphotransferases - metabolism | Phosphorylation | Protein Biosynthesis | Transcription Factors - chemistry | TOR Serine-Threonine Kinases - metabolism | Humans | Stress, Physiological | Heat-Shock Proteins - biosynthesis | Molecular Sequence Data | Substrate Specificity | Promoter Regions, Genetic - genetics | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Heat-Shock Proteins - genetics | Peptides - metabolism | Transcription, Genetic | Amino Acid Sequence | Peptides - chemistry | Heat-Shock Proteins - metabolism | Gene Expression Regulation | Gene Silencing | HSP70 Heat-Shock Proteins - genetics | Phosphoserine - metabolism | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Heat-Shock Response | HeLa Cells | RNA | Genes | Heat shock proteins | Protein biosynthesis | Amino acids | Genetic transcription | Protein kinases | Mitogens | Cell culture | Tissue culture | Proteins | Signal transduction | Life sciences | Sodium arsenite | Stress response | Chemical synthesis | Deoxyribonucleic acid--DNA | Stresses | Medical research | RNA-mediated interference | Rapamycin | Hsp70 protein | Gene expression | Heat | Sodium | Protein synthesis | Adapter proteins | Hyperthermia | TOR protein | Hsp90 protein | Serine | Gene regulation | Oncology | Activation | Kinases | Autophagy | Molecular weight | Heat shock factors | Reduction | Transcription activation | HSF1 protein | Alanine | Ribonucleic acid--RNA | Fever | Proteasome inhibitors | Stress | Protein kinase | Plasmids | Nutrient availability | Protein expression | Arsenite | Heat shock | Apoptosis | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, p. e0141786
The two cytosolic/nuclear isoforms of the molecular chaperone HSP90, stress-inducible HSP90 alpha and constitutively expressed HSP90 beta, fold, assemble and... 
ACTIVATION | COMPLEX | MECHANISM | GELDANAMYCIN | MULTIDISCIPLINARY SCIENCES | KINASE | HSF1 | ATP BINDING | HEAT-SHOCK | CHAPERONE | REVEALS | Humans | Receptor, ErbB-2 - metabolism | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Protein Isoforms - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Protein Isoforms - chemistry | Adenosine Triphosphate - metabolism | HEK293 Cells | HSP90 Heat-Shock Proteins - chemistry | HSP90 Heat-Shock Proteins - genetics | Binding Sites | Kelch-Like ECH-Associated Protein 1 | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Lactams, Macrocyclic - pharmacology | Benzoquinones - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | HSP90 Heat-Shock Proteins - antagonists & inhibitors | HSP90 Heat-Shock Proteins - metabolism | Protein Binding | Protein Conformation | Protein Kinase Inhibitors - pharmacology | Mutation | Protein Isoforms - antagonists & inhibitors | GTP-Binding Proteins - metabolism | Protein Isoforms - genetics | Ubiquitin | Heat shock proteins | DNA binding proteins | Ligases | Protein binding | Medical research | Hsp90 protein | Transcription factors | Life assessment | Oncology | Genomes | Geldanamycin | Kinases | Clients | ErbB-2 protein | Mutants | Proteins | Inhibitors | Isoforms | Hypoxia | HSF1 protein | ATP | Binding sites | Cancer
Journal Article
Journal Article
The FEBS Journal, ISSN 1742-464X, 06/2017, Volume 284, Issue 11, pp. 1606 - 1627
Living organisms are endowed with the capability to tackle various forms of cellular stress due to the presence of molecular chaperone machinery complexes that... 
HSF1 inhibitor | HSF1 activator | cytoprotection | hormesis | sulfhydryl reactivity | phytochemical | DNA-BINDING DOMAIN | TRANSCRIPTION FACTOR HSF1 | CELLULAR STRESS-RESPONSE | MOLECULAR CHAPERONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | INTERACTING PROTEIN 1-LIKE | FACTOR-I | DIFFERENTIAL REGULATION | INDUCED UP-REGULATION | Mammals - genetics | Phosphorylation | Transcription Factors - chemistry | Phylogeny | Heat Shock Transcription Factors | DNA-Binding Proteins - agonists | Adaptation, Physiological - genetics | Mammals - physiology | Transcription, Genetic | Acetylation | Stress, Physiological - physiology | DNA-Binding Proteins - physiology | Transcription Factors - physiology | DNA-Binding Proteins - antagonists & inhibitors | Stress, Physiological - genetics | Gene Expression Regulation | Adaptation, Physiological - physiology | Models, Molecular | Transcription Factors - antagonists & inhibitors | Hot Temperature | DNA-Binding Proteins - chemistry | Protein Folding | Animals | Sumoylation | Protein Conformation | Protein Processing, Post-Translational | Proteasome Endopeptidase Complex - metabolism | Transcription Factors - agonists | Heat shock proteins | Physiological aspects | Chromatin | Molecular structure | Genes | Cytology | Homeostasis | Agglomeration | Heat shock factors | Machinery and equipment | Degradation | Proteins | SUMO protein | Elevation | Control | Protein folding | Post-translation | HSF1 protein | Repair | Stresses | Translation | Macromolecules | Maintenance | Mammals | Metabolism | Stress | Heat | Inhibitors | Structural damage | Proteasomes | Cellular structure | Heat shock | Structure-function relationships
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 01/2017, Volume 16, Issue 1, pp. 156 - 168
Malignant gliomas exhibit a high intrinsic resistance against stimuli triggering apoptotic cell death. HSF1 acts as transcription factor upstream of HSP70 and... 
CANCER-CELLS | SURVIVAL | BCL-2 | GLIOBLASTOMA | ONCOLOGY | BAG3 PROTEIN | HEAT-SHOCK | AUTOPHAGY | RADIOTHERAPY | TUMOR-GROWTH | ADJUVANT TEMOZOLOMIDE | RNA, Small Interfering - genetics | Apoptosis - drug effects | Humans | NF-kappa B - metabolism | Biomarkers, Tumor | Gene Knockdown Techniques | Glioma - metabolism | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Glioma - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Molecular Mimicry | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Glioma - pathology | Apoptosis Regulatory Proteins - genetics | Inhibitor of Apoptosis Proteins - metabolism | Gene Expression | Sulfonamides - pharmacology | Cell Adhesion | Piperazines - pharmacology | Apoptosis Regulatory Proteins - metabolism | HSP70 Heat-Shock Proteins - metabolism | Transcription Factors - metabolism | Gossypol - pharmacology | Animals | Signal Transduction - drug effects | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Gossypol - analogs & derivatives | Protein Binding | Mice | Adaptor Proteins, Signal Transducing - metabolism | bcl-X Protein - metabolism | Drug Resistance, Neoplasm - drug effects | Sensitizing | Phosphorylation | Cell survival | Bcl-2 protein | Brain tumors | Mortality | Glioblastoma | Interference | Caspase | Hsp70 protein | Mcl-1 protein | Proteins | Mitochondria | Detachment | Inhibitors | Cell death | Glioma cells | Anoikis | Combined treatment | Focal adhesion kinase | HSF1 protein | Three dimensional models | Cancer | Apoptosis
Journal Article
PLoS Genetics, ISSN 1553-7390, 07/2017, Volume 13, Issue 7, pp. e1006849 - e1006849
The unfolded protein response (UPR) in the endoplasmic reticulum (ER) and the cytoplasmic heat stress response are two major stress response systems necessary... 
UNFOLDED-PROTEIN RESPONSE | ALZHEIMERS-DISEASE | ER STRESS | HEAT-SHOCK RESPONSE | MOUSE MODEL | GENETICS & HEREDITY | PAIRED HELICAL FILAMENTS | ENDOPLASMIC-RETICULUM STRESS | ALPHA-SYNUCLEIN | HUNTINGTONS-DISEASE | NEURODEGENERATIVE DISEASES | Neurons - pathology | Transcription Factor CHOP - genetics | Phosphorylation | Tauopathies - genetics | Humans | Tauopathies - pathology | tau Proteins - metabolism | Endoplasmic Reticulum Stress - genetics | Alzheimer Disease - pathology | Heat Shock Transcription Factors | Heat-Shock Proteins - genetics | tau Proteins - genetics | Proteolysis | Neurons - metabolism | Autophagy - genetics | Transcription Factor CHOP - biosynthesis | Protein Aggregation, Pathological - genetics | Unfolded Protein Response - genetics | Gene Expression Regulation | Rats | Transcription Factors - biosynthesis | Hippocampus - pathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Heat-Shock Response - genetics | Mice, Knockout | Hippocampus - metabolism | Tauopathies - metabolism | Animals | Alzheimer Disease - metabolism | Mice | Alzheimer Disease - genetics | DNA-Binding Proteins - biosynthesis | Genetic aspects | Neural circuitry | Protein folding | Health aspects | Tau proteins | Advertising executives | Brain | Neurons | Heat shock proteins | Stress (Physiology) | Alzheimer's disease | Target marketing | Huntingtons disease | Neurosciences | Animal models | Toxicity | Pathogenesis | Crosstalk | Cognitive ability | Neurobiology | Homeostasis | Homology | Agglomeration | Activation | Biochemistry | CCAAT/enhancer-binding protein | Kinases | Heat shock factors | Degradation | Proteins | Neurodegeneration | Heat stress | Stress response | HSF1 protein | Inducers | Departments | Neurodegenerative diseases | Hsp70 protein | Pharmacology | Pathology | Tau protein | Aberration | Alzheimers disease | Endoplasmic reticulum | Phagocytosis | Apoptosis | Heat shock | Dementia | Index Medicus
Journal Article
Journal Article