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Molecular Cell, ISSN 1097-2765, 10/2009, Volume 36, Issue 1, pp. 15 - 27
The multifunctional, stress-inducible molecular chaperone HSP70 has important roles in aiding protein folding and maintaining protein homeostasis. HSP70... 
PROTEINS | CHEMBIO | CELLCYCLE | CANCER-CELLS | HSP70 | CHAPERONE-MEDIATED AUTOPHAGY | NEGATIVE REGULATION | LYSOSOMAL MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEAT-SHOCK RESPONSE | APAF-1 APOPTOSOME | P53 PROTEINS | P62 | CELL-DEATH | CELL BIOLOGY | HSP70 Heat-Shock Proteins - antagonists & inhibitors | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | NF-kappa B - metabolism | Cathepsin L - metabolism | Autophagy - drug effects | DNA-Binding Proteins - metabolism | Caspases - metabolism | Lysosomes - metabolism | Protein Binding - drug effects | Lymphoma - pathology | Protein Interaction Domains and Motifs | Cell Death - drug effects | Lysosomes - drug effects | Cell Survival - drug effects | HSP40 Heat-Shock Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | HSP70 Heat-Shock Proteins - genetics | Mice, Transgenic | Mice, Inbred Strains | Sulfonamides - pharmacology | Apoptotic Protease-Activating Factor 1 - metabolism | HSP70 Heat-Shock Proteins - metabolism | Transcription Factors - metabolism | Animals | Sulfonamides - therapeutic use | Lymphoma - prevention & control | Sulfonamides - metabolism | Cell Line, Tumor | Mice | Adaptor Proteins, Signal Transducing - metabolism | Protein Multimerization - drug effects | Protein Binding - physiology | Proteins | Heat shock proteins | Analysis | Tumors | Index Medicus
Journal Article
Journal Article
Gastroenterology, ISSN 0016-5085, 03/2018, Volume 154, Issue 4, pp. 1066 - 1079.e5
Cholangiocarcinomas (CCA) are resistant to chemotherapy, so new therapeutic agents are needed. We performed a screen to identify small-molecule compounds that... 
Organoid | Bile Duct Cancer | DNAJB5 | AUY922 | BILIARY-TRACT CANCER | INTRAHEPATIC CHOLANGIOCARCINOMA | ADVANCED SOLID TUMORS | PANCREATIC-CANCER | ACQUIRED-RESISTANCE | I DOSE-ESCALATION | TYROSINE KINASE INHIBITORS | HSP90 INHIBITORS | PROSTATE-CANCER | GASTROENTEROLOGY & HEPATOLOGY | MICRORNA EXPRESSION | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - metabolism | Cholangiocarcinoma - metabolism | Dose-Response Relationship, Drug | Transfection | Organoids | Time Factors | Antineoplastic Agents - pharmacology | HSP90 Heat-Shock Proteins - genetics | Bile Duct Neoplasms - genetics | Tumor Cells, Cultured | Nuclear Proteins - genetics | Bile Duct Neoplasms - drug therapy | Cell Survival - drug effects | HSP40 Heat-Shock Proteins - metabolism | Bile Duct Neoplasms - metabolism | HSP40 Heat-Shock Proteins - genetics | Isocitrate Dehydrogenase - genetics | Transcription Factors - genetics | Mice, SCID | Xenograft Model Antitumor Assays | Cholangiocarcinoma - pathology | Drug Resistance, Neoplasm - genetics | Animals | Cholangiocarcinoma - drug therapy | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | Cholangiocarcinoma - genetics | HSP90 Heat-Shock Proteins - metabolism | Mice, Inbred NOD | MicroRNAs - genetics | Bile Duct Neoplasms - pathology | Mutation | Index Medicus | Abridged Index Medicus | FFPE, formalin-fixed paraffin-embedded | FGFR, fibroblast growth factor receptor | WT, wild type | PDO, patient-derived organoid | GI, growth inhibition | miRNA, microRNA | HTS, high-throughput screen | DMSO, dimethyl sulfoxide | HSP, heat shock protein | iCCA, intrahepatic cholantiocarcinoma | CCA, cholangiocarcinoma
Journal Article
Scientific Reports, ISSN 2045-2322, 01/2016, Volume 6, Issue 1, pp. 19063 - 19063
Journal Article
Diabetes, ISSN 0012-1797, 11/2012, Volume 61, Issue 11, pp. 2823 - 2832
It is unknown whether adipokines derived from adipose tissues modulate endoplasmic reticulum (ER) stress induced in obesity. Here, we show that visceral... 
ACTIVATION | INSULIN-RESISTANCE | PROSTATE-CANCER CELLS | ENDOCRINOLOGY & METABOLISM | GRP78 | ALPHA-MACROGLOBULIN | RECEPTOR | SERUM | MICE | ENDOPLASMIC-RETICULUM STRESS | ADIPOSE-TISSUE | Up-Regulation | Humans | Heat-Shock Proteins - antagonists & inhibitors | Hepatocytes - pathology | Male | Neoplasm Proteins - antagonists & inhibitors | Hepatocytes - metabolism | Neoplasm Proteins - metabolism | Serpins - chemistry | Recombinant Proteins - isolation & purification | Heat-Shock Proteins - genetics | Adipokines - genetics | Serpins - isolation & purification | Adipokines - chemistry | Cell Membrane - metabolism | Neoplasm Proteins - genetics | Recombinant Proteins - metabolism | HSP40 Heat-Shock Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Serpins - genetics | HSP40 Heat-Shock Proteins - genetics | Serpins - metabolism | Signal Transduction | Heat-Shock Proteins - metabolism | Rats | Mice, Transgenic | Adipokines - metabolism | HSP40 Heat-Shock Proteins - antagonists & inhibitors | Intra-Abdominal Fat - metabolism | Mice, Knockout | Obesity - metabolism | Obesity - pathology | Protein Transport | Animals | Endoplasmic Reticulum Stress | Cell Line, Tumor | Ligands | Mice | Adipokines - isolation & purification | Physiological aspects | Obesity | Research | Protease inhibitors | Endoplasmic reticulum | Analysis | Index Medicus | Abridged Index Medicus | Obesity Studies
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2006, Volume 24, Issue 2, pp. 213 - 225
High threshold for stress-induced activation of the heat shock transcription factor, Hsf1, may contribute to vulnerability of motor neurons to disease and... 
Hsp90 | Hsp70 | PDTC | Heat shock transcription factor 1 | Heat shock proteins | Amyotrophic lateral sclerosis | 17-AAG | Motor neuron | Geldanamycin | Radicicol | Hsp40 | CANCER H460 CELLS | MOTOR-NEURONS | MOLECULAR CHAPERONES | STRESS-RESPONSE | FACTOR-I | amyotrophic lateral sclerosis | radicicol | NEUROSCIENCES | ANDROGEN RECEPTOR PROTEIN | CU/ZN-SUPEROXIDE-DISMUTASE | NONSMALL CELL LUNG | motor neuron | geldanamycin | NEURONAL CELLS | heat shock proteins | TRANSCRIPTION FACTOR | heat shock transcription factor 1 | Gene Expression Regulation, Enzymologic - drug effects | Amyotrophic Lateral Sclerosis - physiopathology | HSP70 Heat-Shock Proteins - antagonists & inhibitors | Humans | Superoxide Dismutase - antagonists & inhibitors | Heat-Shock Proteins - antagonists & inhibitors | Motor Neurons - pathology | Heat Shock Transcription Factors | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Heat-Shock Proteins - genetics | Superoxide Dismutase - toxicity | Neuroprotective Agents - pharmacology | Thiocarbamates - pharmacology | Transfection | Cytoprotection - drug effects | Macrolides - pharmacology | HSP90 Heat-Shock Proteins - genetics | Motor Neurons - drug effects | HSP40 Heat-Shock Proteins - metabolism | Neuroprotective Agents - chemistry | Amyotrophic Lateral Sclerosis - genetics | Heat-Shock Proteins - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Up-Regulation - genetics | HSP40 Heat-Shock Proteins - antagonists & inhibitors | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Lactams, Macrocyclic - pharmacology | HSP70 Heat-Shock Proteins - metabolism | Benzoquinones - pharmacology | Motor Neurons - metabolism | Up-Regulation - drug effects | Animals | Gene Expression Regulation, Enzymologic - genetics | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Amyotrophic Lateral Sclerosis - metabolism | HSP90 Heat-Shock Proteins - metabolism | Cytoprotection - genetics | Mice | Genetic Vectors | Proteins | Genetic aspects | Neurons | Analysis | Index Medicus
Journal Article
Journal of Biomolecular Screening, ISSN 1087-0571, 12/2010, Volume 15, Issue 10, pp. 1211 - 1219
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2017, Volume 292, Issue 28, pp. 11792 - 11803
DNAJB12 (JB12) is an endoplasmic reticulum (ER)-associated Hsp40 family protein that recruits Hsp70 to the ER surface to coordinate the function of... 
COMPLEX | HSP70 | UBIQUITIN LIGASE | endoplasmic reticulum-associated protein degradation (ERAD) | post-transcriptional regulation | BIOCHEMISTRY & MOLECULAR BIOLOGY | endoplasmic reticulum stress (ER stress) | ER-ASSOCIATED DEGRADATION | QUALITY-CONTROL | proteostasis | Hsp40 | UNFOLDED PROTEIN RESPONSE | PATHWAY | protein quality control | 70-kilodalton heat shock protein (Hsp70) | MEMBRANE-PROTEINS | INHIBITOR | CFTR | RNA Interference - drug effects | Apoptosis - drug effects | Humans | Cercopithecus aethiops | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Proteolysis - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Carcinoma, Hepatocellular - drug therapy | Proteasome Endopeptidase Complex - drug effects | HEK293 Cells | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | HSP40 Heat-Shock Proteins - metabolism | Endoplasmic Reticulum Stress - drug effects | HSP40 Heat-Shock Proteins - genetics | Liver Neoplasms - drug therapy | HSP40 Heat-Shock Proteins - antagonists & inhibitors | Recombinant Fusion Proteins - chemistry | Receptors, Autocrine Motility Factor - metabolism | Animals | Protein Stability - drug effects | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Thiazoles - pharmacology | Mutation | Proteasome Endopeptidase Complex - metabolism | COS Cells | Amino Acid Substitution | Carcinoma, Hepatocellular - metabolism | Index Medicus | Protein Synthesis and Degradation | endoplasmic reticulum–associated protein degradation (ERAD)
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 2068 - 11
Acetaminophen (APAP) is the active component of many medications used to treat pain and fever worldwide. Its overuse provokes liver injury and it is the second... 
ELECTRON-TRANSPORT CHAIN | RESPIRATORY-CHAIN | PROTEIN | SUPERCOMPLEXES | COMPLEX-I | RESPIRASOME | HEPATECTOMY | MULTIDISCIPLINARY SCIENCES | ARCHITECTURE | ENERGY-METABOLISM | REPRESSOR | Liver - pathology | Molecular Chaperones - metabolism | Uncoupling Agents - pharmacology | Mitochondria, Liver - metabolism | Humans | Middle Aged | Male | Mitochondrial Proteins - genetics | Electron Transport Complex I - metabolism | Uncoupling Agents - therapeutic use | Young Adult | Rotenone - therapeutic use | Mitochondrial Proteins - metabolism | Rotenone - pharmacology | Drug Overdose - etiology | Adult | Female | Drug Overdose - complications | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Disease Models, Animal | HSP40 Heat-Shock Proteins - metabolism | Acetaminophen - toxicity | Mice, Inbred C57BL | Mitochondrial Proteins - antagonists & inhibitors | Molecular Chaperones - genetics | HSP40 Heat-Shock Proteins - antagonists & inhibitors | Gene Knockout Techniques | Molecular Chaperones - antagonists & inhibitors | Animals | Hepatocytes | Adolescent | Chemical and Drug Induced Liver Injury - drug therapy | Liver - cytology | Mice | Primary Cell Culture | RNA, Small Interfering - metabolism | Reactive oxygen species | Liver diseases | Toxicity | Liver | Acetylcysteine | Fever | Mitochondria | Injury prevention | Pain | Analgesics | Acetaminophen | Biocompatibility | Overdose | Index Medicus
Journal Article
Annals of Surgical Oncology, ISSN 1068-9265, 7/2012, Volume 19, Issue S3, pp. 421 - 429
Previous study indicated that PS-341 induces cell death via JNK pathway in vitro in glioma. However, suppressing proteasome complex by PS-341 may induce... 
Oncology | Medicine & Public Health | Surgical Oncology | Surgery | MULTIPLE-MYELOMA | SURGERY | GLIOBLASTOMA | ONCOLOGY | PROTEASOME INHIBITION | INDUCED APOPTOSIS | N-TERMINAL KINASE | IN-VIVO | BORTEZOMIB | PS-341 | CANCER | ADJUVANT TEMOZOLOMIDE | HSP70 Heat-Shock Proteins - antagonists & inhibitors | Apoptosis - drug effects | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Gene Knockdown Techniques | Heat Shock Transcription Factors | Transcription Factors - drug effects | Brain - metabolism | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | HSP70 Heat-Shock Proteins - drug effects | Pyrrolidinones - pharmacology | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | JNK Mitogen-Activated Protein Kinases - drug effects | HSP40 Heat-Shock Proteins - metabolism | Bortezomib | DNA-Binding Proteins - drug effects | HSP40 Heat-Shock Proteins - antagonists & inhibitors | HSP40 Heat-Shock Proteins - drug effects | Hot Temperature | Transcription Factors - genetics | DNA-Binding Proteins - genetics | HSP70 Heat-Shock Proteins - metabolism | Transcription Factors - metabolism | Up-Regulation - drug effects | Cell Line, Tumor | Benzhydryl Compounds - pharmacology | RNA, Small Interfering | Pyrazines - pharmacology | Boronic Acids - pharmacology | Index Medicus
Journal Article