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Clinical Cancer Research, ISSN 1078-0432, 11/2018, Volume 24, Issue 22, pp. 5496 - 5498
Targeting BRAF in BRAF-mutant melanoma is highly effective, but most patients develop resistance. HSP90 has been implicated and identified as a therapeutic... 
ONCOLOGY | HSP90
Journal Article
The FEBS Journal, ISSN 1742-464X, 08/2017, Volume 284, Issue 15, pp. 2378 - 2395
The molecular chaperone heat shock protein 90 (Hsp90α) regulates cell proteostasis and mitigates the harmful effects of endogenous and exogenous stressors on... 
Hsp90α | double‐strand break | 17 | DNA | AAG | damage response | ATM | NBN | ionizing radiation | H2AX | DNA damage response | 17-AAG | DNA double-strand break | CANCER-CELLS | DEPENDENT PHOSPHORYLATION | GENOTOXIC STRESS | MRE11 COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | Hsp90 alpha | HISTONE H2AX | HEAT-SHOCK-PROTEIN | HSP90 INHIBITORS | DAMAGE RESPONSE | CELL-CYCLE | IONIZING-RADIATION | Nijmegen Breakage Syndrome - pathology | Ataxia Telangiectasia Mutated Proteins - metabolism | Checkpoint Kinase 2 - chemistry | Humans | Checkpoint Kinase 1 - chemistry | DNA Breaks, Double-Stranded | Cell Cycle Proteins - chemistry | Checkpoint Kinase 2 - metabolism | Proteasome Endopeptidase Complex - drug effects | Ubiquitination - drug effects | Protein Processing, Post-Translational - drug effects | RNA Interference | Gene Deletion | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Cell Cycle Proteins - genetics | HSP90 Heat-Shock Proteins - chemistry | Phosphorylation - drug effects | Nuclear Proteins - genetics | DNA Repair - drug effects | Ataxia Telangiectasia Mutated Proteins - chemistry | Nijmegen Breakage Syndrome - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Nuclear Proteins - metabolism | Lactams, Macrocyclic - pharmacology | Nuclear Proteins - chemistry | Nijmegen Breakage Syndrome - genetics | Benzoquinones - pharmacology | Checkpoint Kinase 1 - metabolism | Point Mutation | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Models, Biological | Protein Stability - drug effects | HSP90 Heat-Shock Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins - genetics | Cell Line, Transformed | Protein Multimerization - drug effects | Amino Acid Substitution | Biotechnology | Hsp90 protein | Phosphorylation | DNA damage | Irradiated | Kinases | DNA repair | Degradation | Proteins | Ionizing radiation | MRE11 protein | Fibroblasts | Ataxia | Inhibition | Localization | Repair | Deoxyribonucleic acid--DNA | CHK2 protein | BRCA1 protein | Alpha rays | Lymphoblastoid cell lines | Heat shock proteins | I.R. radiation | Breast cancer | Clients | Damage localization | DNA-dependent protein kinase | Ataxia telangiectasia | Ataxia telangiectasia mutated protein | Control stability | Iridium | Position (location) | Radiation damage | Adenosine triphosphatase | Heat shock | Index Medicus
Journal Article
Malaria Journal, ISSN 1475-2875, 07/2017, Volume 16, Issue 1, pp. 292 - 292
Journal Article
06/2012
Drug resistance is one of the major impediments to control Plasmodium falciparum malaria worldwide. Heat shock protein 90 (Hsp90) is an essential component of... 
hsp90 | 0718 | malaria
Dissertation
Journal of Biological Chemistry, ISSN 0021-9258, 12/2010, Volume 285, Issue 49, pp. 37964 - 37975
Using a pharmacological inhibitor of Hsp90 in cultured malarial parasite, we have previously implicated Plasmodium falciparum Hsp90 (PfHsp90) as a drug target... 
CELLS | HSP90 MOLECULAR CHAPERONE | ATPASE ACTIVITY | INHIBITION | HEAT-SHOCK-PROTEIN-90 | PLASMODIUM-FALCIPARUM | HUMAN ERYTHROCYTES | GELDANAMYCIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | EXPRESSION | Malaria, Falciparum - enzymology | Plasmodium falciparum - enzymology | Malaria, Falciparum - genetics | Protozoan Proteins - antagonists & inhibitors | Trypanosoma - genetics | Humans | Plasmodium berghei - genetics | Trypanosomiasis - enzymology | Protozoan Proteins - genetics | Protozoan Proteins - metabolism | Plasmodium berghei - enzymology | Plasmodium falciparum - genetics | HSP90 Heat-Shock Proteins - genetics | Trypanosoma - enzymology | Disease Models, Animal | Protein Structure, Tertiary | Malaria, Falciparum - drug therapy | Trypanosomiasis - genetics | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - metabolism | Lactams, Macrocyclic - pharmacology | Antiprotozoal Agents - pharmacology | Benzoquinones - pharmacology | Trypanosomiasis - drug therapy | Adenosine Triphosphatases - antagonists & inhibitors | Acetylation - drug effects | Animals | HSP90 Heat-Shock Proteins - antagonists & inhibitors | HSP90 Heat-Shock Proteins - metabolism | Adenosine Triphosphatases - genetics | Mice | Index Medicus | Hsp90 | Trypanosoma evansi | Molecular Bases of Disease | Plasmodium falciparum | Parasitology | Post-translational Modification | Protozoan | Geldanamycin | Preclinical Study | Protein-Drug Interactions | Heat Shock Protein
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2017, Volume 23, Issue 20, pp. 6215 - 6226
Purpose: HSP90, a highly conserved molecular chaperone that regulates the function of several oncogenic client proteins, is altered in glioblastoma. However,... 
STEM-CELLS | IN-VITRO | GLIOBLASTOMA | COMPLEX | ONCOLOGY | STRAND-BREAK REPAIR | 17-AAG | AT13387 | PROTEIN 90 INHIBITOR | PHASE-I | EXPRESSION | Ribosomal Protein S6 Kinases - metabolism | Benzamides - pharmacokinetics | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Glioma - metabolism | Receptor, Epidermal Growth Factor - metabolism | Neoplastic Stem Cells - metabolism | Dacarbazine - pharmacology | Glioma - pathology | Dacarbazine - analogs & derivatives | Dacarbazine - pharmacokinetics | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | HSP90 Heat-Shock Proteins - genetics | Drug Therapy, Combination | Isoindoles - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Gene Expression | Glioma - mortality | Isoindoles - pharmacokinetics | Survival Rate | Zebrafish | Blood-Brain Barrier - metabolism | Protein Transport | Drug Synergism | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Cell Proliferation - drug effects | Mice | Glioma - drug therapy | Brain | Biotechnology | Hsp90 protein | Animal models | Toxicity | Brain tumors | Glioblastoma | Clinical trials | AKT protein | Proteins | Angiogenesis | Biological effects | Blood-brain barrier | Glioma cells | Xenografts | Medical research | Cell survival | Effectiveness | Epidermal growth factor receptors | Pharmacology | Chemical compounds | Survival | Signaling | Inhibitors | Experimental design | Cell lines | Temozolomide | Pharmacokinetics | Cell migration | Cancer | Index Medicus | temozolomide | HSP90 | onalespib | malignant glioma | HSP90 inhibitors
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2012, Volume 287, Issue 45, pp. 37732 - 37744
Prostate cancer (PCa) is the most frequently diagnosed malignancy in men, and the second highest contributor of male cancer related lethality. Disease... 
CELLS | HEPATOCELLULAR-CARCINOMA | EXTRACELLULAR HSP90 | ACTIVATION | RECEPTOR-RELATED PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | TRANSCRIPTION FACTOR SNAIL | GENE-EXPRESSION | BONE METASTASIS | UP-REGULATION | Prostatic Neoplasms - metabolism | Humans | Gene Expression Regulation, Neoplastic | Male | Antibodies, Blocking - pharmacology | Epithelial-Mesenchymal Transition - genetics | Low Density Lipoprotein Receptor-Related Protein-1 - genetics | Cell Movement - genetics | Protease Inhibitors - pharmacology | Matrix Metalloproteinase 9 - metabolism | Prostatic Neoplasms - genetics | HSP90 Heat-Shock Proteins - immunology | RNA Interference | Matrix Metalloproteinase 9 - genetics | HEK293 Cells | HSP90 Heat-Shock Proteins - genetics | Prostatic Neoplasms - pathology | Matrix Metalloproteinase 2 - metabolism | Dipeptides - pharmacology | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Disease Progression | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Antibodies, Blocking - immunology | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Index Medicus | Hsp90 | Extracellular Hsp90 | Cell Motility | Epithelial to Mesenchymal Transition | Prostate Cancer | Matrix Metalloproteinase (MMP) | Prostate | Cell Biology | ERK
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 09/2015, Volume 21, Issue 39, pp. 13598 - 13608
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4532 - 13
Journal Article