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PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 6, pp. e39679 - e39679
The target of rapamycin (TOR) is a high molecular weight protein kinase that regulates many processes in cells in response to mitogens and variations in... 
CELLS | TRANSCRIPTIONAL ACTIVATION | DNA-BINDING | PHOSPHOPROTEOMIC ANALYSIS | FACTOR-1 | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | KINASE | AUTOPHAGY | BINDING PROTEIN | THERMOTOLERANCE | Phosphotransferases - metabolism | Phosphorylation | Protein Biosynthesis | Transcription Factors - chemistry | TOR Serine-Threonine Kinases - metabolism | Humans | Stress, Physiological | Heat-Shock Proteins - biosynthesis | Molecular Sequence Data | Substrate Specificity | Promoter Regions, Genetic - genetics | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Heat-Shock Proteins - genetics | Peptides - metabolism | Transcription, Genetic | Amino Acid Sequence | Peptides - chemistry | Heat-Shock Proteins - metabolism | Gene Expression Regulation | Gene Silencing | HSP70 Heat-Shock Proteins - genetics | Phosphoserine - metabolism | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Heat-Shock Response | HeLa Cells | RNA | Genes | Heat shock proteins | Protein biosynthesis | Amino acids | Genetic transcription | Protein kinases | Mitogens | Cell culture | Tissue culture | Proteins | Signal transduction | Life sciences | Sodium arsenite | Stress response | Chemical synthesis | Deoxyribonucleic acid--DNA | Stresses | Medical research | RNA-mediated interference | Rapamycin | Hsp70 protein | Gene expression | Heat | Ribonucleic acids | Sodium | Protein synthesis | Adapter proteins | Hyperthermia | TOR protein | Shock | Hsp90 protein | Serine | Gene regulation | Oncology | Activation | Kinases | Autophagy | Molecular weight | Heat shock factors | Reduction | Transcription activation | HSF1 protein | Alanine | Fever | Proteasome inhibitors | Stress | Protein kinase | Plasmids | Nutrient availability | Protein expression | Arsenite | Heat shock | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Molecular Genetics and Genomics, ISSN 1617-4615, 12/2011, Volume 286, Issue 5, pp. 321 - 332
Journal Article
Journal Article
Journal Article
Journal Article
Gastroenterology, ISSN 0016-5085, 03/2018, Volume 154, Issue 4, pp. 1066 - 1079.e5
Cholangiocarcinomas (CCA) are resistant to chemotherapy, so new therapeutic agents are needed. We performed a screen to identify small-molecule compounds that... 
Organoid | Bile Duct Cancer | DNAJB5 | AUY922 | BILIARY-TRACT CANCER | INTRAHEPATIC CHOLANGIOCARCINOMA | ADVANCED SOLID TUMORS | PANCREATIC-CANCER | ACQUIRED-RESISTANCE | I DOSE-ESCALATION | TYROSINE KINASE INHIBITORS | HSP90 INHIBITORS | PROSTATE-CANCER | GASTROENTEROLOGY & HEPATOLOGY | MICRORNA EXPRESSION | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - metabolism | Cholangiocarcinoma - metabolism | Dose-Response Relationship, Drug | Transfection | Organoids | Time Factors | Antineoplastic Agents - pharmacology | HSP90 Heat-Shock Proteins - genetics | Bile Duct Neoplasms - genetics | Tumor Cells, Cultured | Nuclear Proteins - genetics | Bile Duct Neoplasms - drug therapy | Cell Survival - drug effects | HSP40 Heat-Shock Proteins - metabolism | Bile Duct Neoplasms - metabolism | HSP40 Heat-Shock Proteins - genetics | Isocitrate Dehydrogenase - genetics | Transcription Factors - genetics | Mice, SCID | Xenograft Model Antitumor Assays | Cholangiocarcinoma - pathology | Drug Resistance, Neoplasm - genetics | Animals | Cholangiocarcinoma - drug therapy | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | Cholangiocarcinoma - genetics | HSP90 Heat-Shock Proteins - metabolism | Mice, Inbred NOD | MicroRNAs - genetics | Bile Duct Neoplasms - pathology | Mutation | Index Medicus | Abridged Index Medicus | FFPE, formalin-fixed paraffin-embedded | FGFR, fibroblast growth factor receptor | WT, wild type | PDO, patient-derived organoid | GI, growth inhibition | miRNA, microRNA | HTS, high-throughput screen | DMSO, dimethyl sulfoxide | HSP, heat shock protein | iCCA, intrahepatic cholantiocarcinoma | CCA, cholangiocarcinoma
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2010, Volume 285, Issue 49, pp. 37964 - 37975
Using a pharmacological inhibitor of Hsp90 in cultured malarial parasite, we have previously implicated Plasmodium falciparum Hsp90 (PfHsp90) as a drug target... 
CELLS | HSP90 MOLECULAR CHAPERONE | ATPASE ACTIVITY | INHIBITION | HEAT-SHOCK-PROTEIN-90 | PLASMODIUM-FALCIPARUM | HUMAN ERYTHROCYTES | GELDANAMYCIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | EXPRESSION | Malaria, Falciparum - enzymology | Plasmodium falciparum - enzymology | Malaria, Falciparum - genetics | Protozoan Proteins - antagonists & inhibitors | Trypanosoma - genetics | Humans | Plasmodium berghei - genetics | Trypanosomiasis - enzymology | Protozoan Proteins - genetics | Protozoan Proteins - metabolism | Plasmodium berghei - enzymology | Plasmodium falciparum - genetics | HSP90 Heat-Shock Proteins - genetics | Trypanosoma - enzymology | Disease Models, Animal | Protein Structure, Tertiary | Malaria, Falciparum - drug therapy | Trypanosomiasis - genetics | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - metabolism | Lactams, Macrocyclic - pharmacology | Antiprotozoal Agents - pharmacology | Benzoquinones - pharmacology | Trypanosomiasis - drug therapy | Adenosine Triphosphatases - antagonists & inhibitors | Acetylation - drug effects | Animals | HSP90 Heat-Shock Proteins - antagonists & inhibitors | HSP90 Heat-Shock Proteins - metabolism | Adenosine Triphosphatases - genetics | Mice | Index Medicus | Hsp90 | Trypanosoma evansi | Molecular Bases of Disease | Plasmodium falciparum | Parasitology | Post-translational Modification | Protozoan | Geldanamycin | Preclinical Study | Protein-Drug Interactions | Heat Shock Protein
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 10/2015, Volume 54, Issue 10, pp. 1147 - 1158
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2011, Volume 108, Issue 45, pp. 18378 - 18383
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2014, Volume 289, Issue 9, pp. 6110 - 6119
Journal Article
Eukaryotic Cell, ISSN 1535-9778, 11/2012, Volume 11, Issue 11, pp. 1324 - 1332
Journal Article
Journal Article