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Molecular Cancer Therapeutics, ISSN 1535-7163, 05/2017, Volume 16, Issue 5, pp. 793 - 804
Journal Article
Oncogene, ISSN 0950-9232, 10/2014, Volume 33, Issue 40, pp. 4867 - 4876
Journal Article
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2015, Volume 52, pp. 109 - 119
Abstract Background Pancreatic cancer (PC) is an aggressive malignancy characterised by chemoresistance. HSP90 is important for stabilisation of proteins, cell... 
Hematology, Oncology and Palliative Medicine | Ganetespib | Chemotherapy | Survival | Pancreatic cancer | CELLS | APOPTOSIS | STAT3 | TUMOR | TRANSDUCER | CHAPERONE | K-RAS | ONCOLOGY | RESISTANCE | GROWTH-FACTOR | EXPRESSION | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Molecular Targeted Therapy | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Transfection | RNA Interference | Time Factors | Janus Kinase 2 - metabolism | Female | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Pancreatic Neoplasms - pathology | Janus Kinase 2 - genetics | Pancreatic Neoplasms - enzymology | Pancreatic Neoplasms - genetics | Drug Synergism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Mice, Nude | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Cell Proliferation - drug effects | Proteins | Heat shock proteins | Mutual fund industry | Cancer | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2014, Volume 20, Issue 2, pp. 413 - 424
Journal Article
Journal Article
Investigational New Drugs, ISSN 0167-6997, 8/2014, Volume 32, Issue 4, pp. 577 - 586
The integration of targeted agents to standard cytotoxic regimens has improved outcomes for patients with colorectal cancer (CRC) over recent years; however... 
Ganetespib | Medicine & Public Health | HSP90 inhibition | Colorectal cancer | Oncology | Pharmacology/Toxicology | Combination therapy | TUMOR-CELLS | RADIATION | NVP-AUY922 | CELL LUNG-CANCER | POTENT ANTITUMOR-ACTIVITY | TARGETED INHIBITION | ONCOLOGY | SHOCK-PROTEIN 90 | GELDANAMYCIN | IN-VIVO | 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN | PHARMACOLOGY & PHARMACY | Apoptosis - drug effects | Capecitabine | Humans | Colorectal Neoplasms - radiotherapy | Deoxycytidine - pharmacology | Colorectal Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Radiation, Ionizing | DNA Damage - drug effects | Cell Survival - drug effects | DNA Repair - drug effects | Fluorouracil - analogs & derivatives | HCT116 Cells | Radiation-Sensitizing Agents - pharmacology | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Chemotherapy, Adjuvant - methods | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Mice, Nude | Cell Line, Tumor | Fluorouracil - pharmacology | Mice | Cell Cycle - drug effects | Deoxycytidine - analogs & derivatives | Complications and side effects | Heat shock proteins | Physiological aspects | Monoclonal antibodies | Dosage and administration | Research | Drug therapy | Inhibitor drugs | Statistical analysis | Patients | Cancer therapies | Index Medicus | Preclinical Studies
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e56134 - e56134
Heat shock protein 90 (HSP90) is involved in the regulation of diverse biological processes such as cell signaling, proliferation and survival, and has been... 
CANCER-CELLS | SIGNAL-TRANSDUCTION | BRAF INHIBITION | METASTATIC MELANOMA | HSP90 INHIBITOR | IN-VITRO | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | CELL-CYCLE ARREST | KINASE CASCADE | B-RAF | Receptor, IGF Type 1 - metabolism | Apoptosis - drug effects | Humans | Immunoblotting | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Melanoma - genetics | Inhibitory Concentration 50 | Membrane Proteins - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Skin Neoplasms - pathology | Cell Survival - drug effects | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Melanoma - pathology | Down-Regulation - drug effects | Skin Neoplasms - metabolism | Proto-Oncogene Proteins c-akt | Triazoles - pharmacology | GTP Phosphohydrolases - metabolism | Cell Cycle Checkpoints - drug effects | GTP Phosphohydrolases - genetics | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - genetics | Skin Neoplasms - genetics | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Cell Proliferation - drug effects | Mutation | Care and treatment | Gene mutations | Melanoma | Heat shock proteins | B cells | Health aspects | Phosphotransferases | Cancer | Biotechnology | Hsp90 protein | Phosphorylation | Target recognition | Raf protein | AKT protein | Insulin-like growth factors | Metastasis | Kinases | Cancer therapies | Skin cancer | Cyclin-dependent kinase | Cell cycle | Inhibition | Women | Cell survival | Epidermal growth factor receptors | Cyclin-dependent kinases | Extracellular signal-regulated kinase | Biological activity | Cyclins | Signaling | Cyclin-dependent kinase inhibitor p21 | Inhibitors | Lymphocytes B | Cell lines | Response rates | Cyclin-dependent kinase inhibitor p27 | Regulation | Apoptosis | Heat shock | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, pp. e18552 - e18552
Journal Article
Cancer Research, ISSN 0008-5472, 12/2013, Volume 73, Issue 23, pp. 7022 - 7033
Journal Article
International Journal of Oncology, ISSN 1019-6439, 1/2013, Volume 42, Issue 1, pp. 35 - 43
Journal Article