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Cancer Research, ISSN 0008-5472, 02/2010, Volume 70, Issue 4, pp. 1469 - 1478
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 141, Issue 1, pp. 279 - 291.e5
Background & Aims Some cancer cells have activities that are similar to those of stem cells from normal tissues, and cell dedifferentiation correlates with... 
Gastroenterology and Hepatology | Gene Regulation | Tumor Development | Systems Biology | Colon Cancer | A33 ANTIGEN | TRANSCRIPTION FACTOR SNAIL | E-CADHERIN | NECK-CANCER | TUMOR-INITIATING CELLS | EPITHELIAL-MESENCHYMAL TRANSITION | HUMAN COLON-CANCER | PROSTATE-CANCER | GENE-EXPRESSION | GASTROENTEROLOGY & HEPATOLOGY | PROGRESSION | Interleukin-8 - genetics | Oligonucleotide Array Sequence Analysis | Neoplastic Stem Cells - drug effects | Colorectal Neoplasms - genetics | Humans | Middle Aged | Radiation Tolerance | Drug Resistance, Neoplasm | Epithelial-Mesenchymal Transition - drug effects | Fetal Proteins - metabolism | Antigens, CD - metabolism | Neoplastic Stem Cells - metabolism | Time Factors | Colorectal Neoplasms - drug therapy | Hyaluronan Receptors - metabolism | Aged, 80 and over | Neoplastic Stem Cells - pathology | Antimetabolites, Antineoplastic - pharmacology | Interleukin-8 - metabolism | Signal Transduction - radiation effects | Binding Sites | Carcinoma - drug therapy | Colorectal Neoplasms - immunology | Signal Transduction - drug effects | Mice, Nude | Carcinoma - genetics | Fluorouracil - pharmacology | Mice | Interleukin-8 - immunology | Dose-Response Relationship, Radiation | Gene Expression Regulation, Neoplastic | Neoplastic Stem Cells - immunology | Dose-Response Relationship, Drug | Transfection | Adult | Cell Adhesion Molecules, Neuronal - metabolism | Tumor Cells, Cultured | Carcinoma - pathology | Spheroids, Cellular | Snail Family Transcription Factors | Colorectal Neoplasms - metabolism | Neoplastic Stem Cells - radiation effects | Carcinoma - immunology | Gene Expression Profiling - methods | Transcription Factors - genetics | E-Box Elements | Antibodies - pharmacology | HT29 Cells | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Aged | Cell Proliferation - drug effects | Carcinoma - metabolism | Colorectal Neoplasms - pathology | Antigen-antibody reactions | Developmental biology | Antibodies | Development and progression | Viral antibodies | Anopheles | Colon cancer | Epidermal growth factor | Interleukins | Stem cells | Genetic research | Fibroblast growth factors | Universities and colleges | Tumors
Journal Article
by Hu, Y.-B and Yan, C and Mu, L and Mi, Y.L and Zhao, H and Hu, H and Li, X.-L and Tao, D.-D and Wu, Y.-Q and Gong, J.-P and Qin, J.-C
Oncogene, ISSN 0950-9232, 03/2019, Volume 38, Issue 11, pp. 1951 - 1965
Cancer stem cells (CSCs) are inherently resistant to chemotherapy, and CSCs in chemotherapy-failed recurrent tumors are enriched; however, the cellular origin... 
POPULATION | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENVIRONMENT | SELF-RENEWAL | BETA-CATENIN | FIBROBLASTS | CELL BIOLOGY | HETEROGENEITY | ONCOLOGY | EQUILIBRIUM | GENETICS & HEREDITY | EXPRESSION | PROGRESSION | Exosomes - drug effects | Exosomes - metabolism | Fibroblasts - physiology | Neoplastic Stem Cells - drug effects | Humans | Wnt Signaling Pathway - physiology | Exosomes - pathology | Colorectal Neoplasms - drug therapy | Neoplastic Stem Cells - pathology | Female | Antineoplastic Agents - pharmacology | Colorectal Neoplasms - metabolism | Neoplastic Stem Cells - physiology | Cell Dedifferentiation - drug effects | Cells, Cultured | Fibroblasts - pathology | Mice, SCID | HT29 Cells | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Oxaliplatin - pharmacology | Animals | Wnt Signaling Pathway - drug effects | Paracrine Communication - drug effects | Mice, Inbred NOD | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Mice | Pyridines - pharmacology | Colorectal Neoplasms - pathology | Pyrazines - pharmacology | Cell Dedifferentiation - genetics | Drug Resistance, Neoplasm - drug effects | Chemotherapy | Usage | Care and treatment | Cancer cells | Colorectal cancer | Cellular signal transduction | Research | Drug resistance | Cell differentiation | Cancer | Wnt protein | Colorectal carcinoma | Stem cells | Chemoresistance | Fibroblasts | Cell interactions | Exosomes | Tumors | Cell biology | Cancer therapeutic resistance | Cancer stem cells | Cancer microenvironment
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2016, Volume 22, Issue 6, pp. 624 - 631
Cetuximab is a monoclonal antibody that is effective in the treatment of metastatic colorectal cancer (mCRC). Cetuximab blocks epidermal growth factor receptor... 
MEDICINE, RESEARCH & EXPERIMENTAL | 1ST-LINE TREATMENT | PLUS IRINOTECAN | EFFICACY | BIOCHEMISTRY & MOLECULAR BIOLOGY | METASTATIC COLORECTAL-CANCER | CELL BIOLOGY | CALRETICULIN EXPOSURE | COLON-CANCER | BRAF MUTATION | POOLED ANALYSIS | ENDOPLASMIC-RETICULUM | KRAS | Leucovorin - administration & dosage | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Dendritic Cells - immunology | Humans | Cell Death - immunology | X-Box Binding Protein 1 - drug effects | Endoplasmic Reticulum Stress - immunology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Fluorouracil - administration & dosage | Calreticulin - drug effects | Calreticulin - metabolism | Camptothecin - administration & dosage | Dendritic Cells - drug effects | Indoles - pharmacology | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Camptothecin - analogs & derivatives | Disease Models, Animal | Phagocytosis - drug effects | X-Box Binding Protein 1 - immunology | Endoplasmic Reticulum Stress - drug effects | Antibodies, Monoclonal - pharmacology | HCT116 Cells | Phagocytosis - immunology | Cetuximab - pharmacology | Sulfonamides - pharmacology | Unfolded Protein Response | HT29 Cells | Animals | Colorectal Neoplasms - immunology | Proto-Oncogene Proteins B-raf - genetics | X-Box Binding Protein 1 - metabolism | Cell Line, Tumor | Mice | Pyridones - pharmacology | Physiological aspects | Genetic aspects | Immune response | Research | Drug therapy | Colorectal cancer | Care and treatment | Usage | Chemotherapy | Epidermal growth factor | Cell death | Analysis | Endoplasmic reticulum | Cancer | Monoclonal antibodies | Apoptosis | Immune system
Journal Article
Cancer Research, ISSN 0008-5472, 12/2011, Volume 71, Issue 23, pp. 7226 - 7237
Journal Article
Cancer Cell, ISSN 1535-6108, 12/2015, Volume 28, Issue 6, pp. 815 - 829
Hierarchical organization of tissues relies on stem cells, which either self-renew or produce committed progenitors predestined for lineage differentiation.... 
β-catenin | cancer stem cells | MYC | retinoids | Retinoids | Cancer stem cells | INTESTINAL EPITHELIUM | HOMEOSTASIS | RETINOIC ACID | PROTEIN | ONCOLOGY | PATHWAY | GENE-EXPRESSION | RECEPTOR | PROLIFERATION | BETA-CATENIN | CELL BIOLOGY | Intestinal Mucosa - metabolism | Cell Proliferation | Neoplastic Stem Cells - drug effects | Colorectal Neoplasms - genetics | Homeodomain Proteins - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Phosphoproteins - metabolism | Neoplasm Metastasis | Transfection | Neoplastic Stem Cells - metabolism | RNA Interference | Time Factors | Cell Transformation, Neoplastic - genetics | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Neoplastic Stem Cells - pathology | Female | Antineoplastic Agents - pharmacology | Cell Differentiation | Tumor Cells, Cultured | Colorectal Neoplasms - metabolism | Caco-2 Cells | Tissue Culture Techniques | HCT116 Cells | Mice, Inbred C57BL | Mice, Transgenic | Phosphoproteins - genetics | Cell Transformation, Neoplastic - metabolism | Homeodomain Proteins - genetics | HT29 Cells | Feedback, Physiological | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Aged | Cell Transformation, Neoplastic - pathology | Colorectal Neoplasms - pathology | Retinoids - pharmacology | Intestinal Mucosa - pathology | Development and progression | Developmental biology | Colorectal cancer | Stem cells | Prevention | Resveratrol | Transplantation | Metastasis | Cancer
Journal Article
International Journal of Cancer, ISSN 0020-7136, 04/2012, Volume 130, Issue 7, pp. 1577 - 1589
Journal Article
Journal Article
Journal Article