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1. Full Text Antibacterial properties of human beta defensin-3 derivative: CHRG01
by Arora, A and Majhi, S and Mishra, A
Journal of Biosciences, ISSN 0250-5991, 9/2018, Volume 43, Issue 4, pp. 707 - 715
Antibiotic resistance in bacteria is a major health concern. Antimicrobial peptides (AMPs) are a class of peptides that are efficient in killing most microbes... 
Life Sciences | Biomedicine, general | Life Sciences, general | Microbiology | Zoology | Antimicrobial peptides | human β defensin-3 | pore-forming peptides | Plant Sciences | Cell Biology | peptide–lipid interaction | RESISTANT | HUMAN BETA-DEFENSIN-3 | MEMBRANE | BIOLOGY | peptide-lipid interaction | human beta defensin-3 | beta-Defensins - genetics | Antimicrobial Cationic Peptides - chemistry | Humans | Antimicrobial Cationic Peptides - pharmacology | Bacteria - drug effects | Amino Acid Sequence - genetics | beta-Defensins - chemistry | Microbial Sensitivity Tests | Protein Conformation, beta-Strand | X-Ray Diffraction | Anti-Bacterial Agents - chemistry | beta-Defensins - pharmacology | Anti-Bacterial Agents - pharmacology | Bacteria - pathogenicity | Circular Dichroism | Physiological aspects | Drug resistance in microorganisms | Genetic aspects | Research | Scanning electron microscopy | Membranes | Peptides | Outer membranes | Serine | Tertiary | Amino acids | Confocal microscopy | Electron microscopy | Small angle X ray scattering | Circular dichroism | Mode of action | Disease resistance | X-ray scattering | Antibiotics | Antibiotic resistance | Dichroism | Bacteria | Antibacterial activity | X ray scattering | Control resistance | Curvature | Pore formation
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2. Full Text The human beta-defensin-3, an antibacterial peptide with multiple biological functions
by Dhople, Vishnu and Krukemeyer, Amy and Ramamoorthy, Ayyalusamy
BBA - Biomembranes, ISSN 0005-2736, 2006, Volume 1758, Issue 9, pp. 1499 - 1512
A group of interesting molecules called defensins exhibit multiple functions but have been primarily recognized to possess a broad spectrum of antimicrobial... 
Antibacterial peptide | Innate and adaptive immunity | Membrane-disruption | Defensin | Structure | HβD-3 | HUMAN BETA-DEFENSINS | HELICAL ANTIMICROBIAL PEPTIDES | DISULFIDE BONDS | H beta D-3 | SOLID-STATE NMR | MAMMALIAN DEFENSINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | innate and adaptive immunity | LIPID-MEMBRANES | structure | IMMATURE DENDRITIC CELLS | antibacterial peptide | BIOPHYSICS | BACTERICIDAL ACTIVITY | defensin | HOST-DEFENSE | membrane-disruption | INNATE IMMUNITY | Peptides | Proteases | Antibacterial agents | Analysis
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3. Full Text Human beta-defensin-3 promotes wound heating in infected diabetic wounds
by Hirsch, T and Spielmann, M and Zuhaili, B and Fossum, M and Metzig, M and Koehler, T and Steinau, HU and Yao, F and Onderdonk, AB and Steinstraesser, L and Eriksson, E
JOURNAL OF GENE MEDICINE, ISSN 1099-498X, 03/2009, Volume 11, Issue 3, pp. 220 - 228
Background Infected wounds present a major complication in patients with diabetes. Staphylococcus aureus is the most common single isolate in diabetic wounds.... 
MEDICINE, RESEARCH & EXPERIMENTAL | HUMAN BETA-DEFENSINS | wound healing | gene transfer | HUMAN SKIN | MAST-CELLS | INNATE IMMUNE-RESPONSE | ANTIMICROBIAL PEPTIDES | bacterial infection | IN-VITRO | S. aureus | innate immunity | host defense peptides | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | HOST-DEFENSE | FOOT ULCERS | STAPHYLOCOCCUS-AUREUS | EXPRESSION
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4. Full Text pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37
by Mahmoud H. Abou Alaiwa and Leah R. Reznikov and Nicholas D. Gansemer and Kelsey A. Sheets and Alexander R. Horswill and David A. Stoltz and Joseph Zabner and Michael J. Welsh
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2014, Volume 111, Issue 52, pp. 18703 - 18708
The pulmonary airways are continuously exposed to bacteria. As a first line of defense against infection, the airway surface liquid (ASL) contains a complex... 
Antibacterials | Liquids | Lungs | Antimicrobials | Lung diseases | Luminescence | Cystic fibrosis | Bacteria | Synergism | Cathelicidin | Pseudomonas aeruginosa | Host defense | Staphylococcus aureus | DEFB1 GENE | cathelicidin | MULTIDISCIPLINARY SCIENCES | host defense | BREATH CONDENSATE | IN-VITRO | PEPTIDES | BACTERICIDAL ACTIVITY | ANTIBACTERIAL ACTIVITY | cystic fibrosis | CYSTIC-FIBROSIS PATIENTS | PRECURSOR LIPID II | STAPHYLOCOCCUS-AUREUS | INNATE IMMUNITY | Drug Synergism | beta-Defensins - agonists | Antimicrobial Cationic Peptides - agonists | Anti-Infective Agents - pharmacology | Humans | Pseudomonas aeruginosa - growth & development | Antimicrobial Cationic Peptides - pharmacology | beta-Defensins - pharmacology | Staphylococcus aureus - growth & development | Hydrogen-Ion Concentration | Biological Sciences
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5. Full Text Effects of genetically modified milk containing human beta-defensin-3 on gastrointestinal health of mice
by Chen, Xin and Yang, Yange and Shi, Zhaopeng and Gao, Ming-Qing and Zhang, Yong
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, p. e0159700
This study was performed to investigate the effects of genetically modified (GM) milk containing human beta-defensin-3 (HBD3) on mice by a 90-day feeding... 
ANIMALS | DIGESTION | IN-VITRO | FOOD ALLERGENS | SAFETY ASSESSMENT | STABILITY | MULTIDISCIPLINARY SCIENCES | CATTLE | RATS | RISK-ASSESSMENT | MEAT | beta-Defensins - genetics | Animals | Milk - metabolism | Consumer Product Safety | Humans | Food, Genetically Modified - adverse effects | Gastrointestinal Tract - drug effects | Mice | Digestion | Milk - adverse effects | Analysis | Gastrointestinal system | Genetically modified organisms | Physiological aspects | Chemical properties | Research | Health aspects | Milk | Veterinary colleges | Neurosciences | Disease | Laboratories | Microflora | Drug resistance | Veterinary medicine | Immunity | Proteins | E coli | Cattle | Intestine | Bacteria | Physiology | Intestinal microflora | Product safety | Genetic modification | Food | Digestibility | Nutrition | Gene transfer | Health | Gastric emptying | Antimicrobial agents | Gastrointestinal tract | Permeability | Risk analysis | Chemistry | Antibiotics | Breast milk
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6. Full Text Human beta-defensin-3 producing cells in septic implant loosening
by Levón, Jaakko and Al-Samadi, Ahmed and Mackiewicz, Zygmunt and Coer, Andrej and Trebse, Rihard and Waris, Eero and Konttinen, Yrjö T
Journal of Materials Science: Materials in Medicine, ISSN 0957-4530, 2/2015, Volume 26, Issue 2, pp. 1 - 10
Human β-defensin-3 (hBD-3) has been found in synovial fluid and later in periprosthetic tissues in septic joint implant loosening. The aim of the present study... 
Biomedical Engineering | Polymer Sciences | Regenerative Medicine/Tissue Engineering | Ceramics, Glass, Composites, Natural Methods | Material Science | Surfaces and Interfaces, Thin Films | Biomaterials | HUMAN BETA-DEFENSINS | DIAGNOSIS | MATERIALS SCIENCE, BIOMATERIALS | EPITHELIAL-CELLS | DENDRITIC CELLS | ENGINEERING, BIOMEDICAL | TOLL-LIKE RECEPTORS | INFECTION | ANTIMICROBIAL PEPTIDES | EXPRESSION | HIP | BIOFILM FORMATION | Heat shock proteins | Analysis | Robots | Resveratrol | Surgical outcomes | Prostheses | Body fluids | Biomedical materials | Joint replacement surgery | Human | Cellular | Fluid dynamics | Loosening | Fluid flow | Staining | Bacteria | Endothelial cells
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7. Full Text Membrane disruptive antimicrobial activities of human β-defensin-3 analogs
by Sudheendra, U.S and Dhople, Vishnu and Datta, Aritreyee and Kar, Rajiv K and Shelburne, Charles E and Bhunia, Anirban and Ramamoorthy, Ayyalusamy
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2015, Volume 91, pp. 91 - 99
Human beta defensin-3 (HβD-3) is a host-defense protein exhibiting antibacterial activity towards both Gram-negative and Gram-positive bacteria. There is... 
Fluorescence | Solid-state NMR | Dye leakage | HβD3 | Antimicrobial peptide | PARDAXIN | CHEMISTRY, MEDICINAL | MECHANISM | BETA-DEFENSINS | PERMEABILIZATION | INDUCTION | IDENTIFICATION | LIPID COMPOSITION | HUMAN-NEUTROPHILS | H beta D3 | EXPRESSION | ANTIBACTERIAL PEPTIDE | Fluoresceins - metabolism | Humans | Cell Membrane Permeability | Fluorescent Dyes - metabolism | Molecular Sequence Data | Structure-Activity Relationship | Cell Membrane - chemistry | Microbial Sensitivity Tests | Salmonella enterica - drug effects | Peptides - chemical synthesis | Biological Transport - drug effects | Cell Membrane - drug effects | Staphylococcus aureus - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | beta-Defensins - chemical synthesis | Protein Structure, Secondary | Membranes, Artificial | Models, Molecular | Salmonella enterica - growth & development | Phosphatidylcholines - chemistry | Salmonella enterica - metabolism | Static Electricity | Erythrocytes - drug effects | Peptides - pharmacology | Anti-Bacterial Agents - chemical synthesis | Phosphatidylglycerols - chemistry | Animals | Erythrocytes - metabolism | beta-Defensins - pharmacology | Sheep | Anti-Bacterial Agents - pharmacology | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Phosphatidylethanolamines - chemistry | solid state NMR | dye leakage | fluorescence
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8. Full Text Mouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3
by Kerstin Hinrichsen and Rainer Podschun and Sabine Schubert and Jens M. Schröder and Jürgen Harder and Ehrhardt Proksch
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 05/2008, Volume 52, Issue 5, pp. 1876 - 1879
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
INVASIVE BACTERIAL-INFECTION | RESISTANT | BETA-DEFENSIN EXPRESSION | PEPTIDES | KERATINOCYTES | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | SKIN | INDUCTION | IDENTIFICATION | PROTECTS | Amino Acid Sequence | beta-Defensins - genetics | Gene Expression - drug effects | Anti-Infective Agents - pharmacology | Humans | RNA, Messenger - genetics | Cells, Cultured | Molecular Sequence Data | Keratinocytes - cytology | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Microbial Sensitivity Tests | Sequence Homology, Amino Acid | Animals | Candida albicans - drug effects | Keratinocytes - drug effects | Keratinocytes - metabolism | beta-Defensins - pharmacology | Mice | Staphylococcus aureus - drug effects | Interferon-gamma - pharmacology | Transforming Growth Factor alpha - pharmacology | Susceptibility
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9. Full Text Safety assessment of genetically modified milk containing human beta-defensin-3 on rats by a 90-day feeding study
by Chen, Xin and Gao, Ming-Qing and Liang, Dong and Yin, Songna and Yao, Kezhen and Zhang, Yong
Food and Chemical Toxicology, ISSN 0278-6915, 02/2017, Volume 100, pp. 34 - 41
In recent years, transgenic technology has been widely applied in many fields. There is concern about the safety of genetically modified (GM) products with the... 
triglyceride | total bilirubin | Genetically modified milk | ALP | HBD3 | alanine aminotransferase | ALT | GLO | globulin | hematoxylin-eosin | total cholesterol | 90-Day feeding study | OECD | total protein | Organization for Economic Co-operation and Development | AIN93G diet | alkaline phosphatase | BUN | w/w | WHO | Food and Agriculture Organization | AST | World Health Organization | CAC | human beta-defensin-3 | T-CHOL | weight/weight | aspartate aminotransferase | Codex Alimentarius Commission | Growth purified diet for rodents recommended by the American Institute of Nutrition | Safety assessment | genetically modified | FAO | TBIL | ALB | albumin | urea nitrogen | SPRAGUE-DAWLEY RATS | METABOLIC SYNDROME | FOOD SCIENCE & TECHNOLOGY | MAIZE GRAIN | DISEASE | COWS | MASTITIS | TOXICOLOGY | HEALTH | EXPRESSION | MAMMARY-GLAND | RICE | Milk - chemistry | Risk Assessment | Animals, Genetically Modified | Consumer Product Safety | Humans | Body Weight - drug effects | Rats | Male | Rats, Sprague-Dawley | Organ Size - drug effects | Animals | Diet | Cattle | Food, Genetically Modified - toxicity | beta-Defensins - pharmacology | Female | Drug resistance in microorganisms | Safety and security measures | Agricultural biotechnology | Genetically modified organisms | Dairy cattle | Animal genetic engineering | Histochemistry | Index Medicus
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10. Full Text The Antimicrobial Peptide Human Beta-Defensin-3 Is Induced by Platelet-Released Growth Factors in Primary Keratinocytes
by Bayer, Andreas and Lammel, Justus and Tohidnezhad, Mersedeh and Lippross, Sebastian and Behrendt, Peter and Klüter, Tim and Pufe, Thomas and Cremer, Jochen and Jahr, Holger and Rademacher, Franziska and Gläser, Regine and Harder, Jürgen
Mediators of Inflammation, ISSN 0962-9351, 2017, Volume 2017, pp. 1 - 8
Platelet-released growth factors (PRGF) and its related clinically used formulations (e.g., Vivostat Platelet-Rich Fibrin (PRF (R))) contain a variety of... 
IN-VITRO | HUMAN SKIN | QUANTIFICATION | STAPHYLOCOCCUS-AUREUS | INDUCTION | DIFFERENTIATION | IMMUNOLOGY | IDENTIFICATION | BETA-DEFENSIN 3 | EXPRESSION | RICH PLASMA | CELL BIOLOGY | Platelet-derived growth factor | Peptides | Keratinocytes | Physiological research | Research | Gene expression | Health aspects | Cell culture | Antimicrobial activity | HBD-3 gene | Cell adhesion & migration | Lysates | Ultrasonic imaging | Epidermal growth factor | Immunology | Antimicrobial peptides | Growth factors | Wound healing | Cytokines | Epidermal growth factor receptors | Antimicrobial agents | Wounding | Fibrin | Hospitals | Biofilms | Skin | Diabetes | Platelets | Chemokines
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11. Full Text Infection of keratinocytes with trichophytum rubrum induces epidermal growth factor-dependent RNase 7 and human beta-defensin-3 expression
by Firat, Yasemin Helene and Simanski, Maren and Rademacher, Franziska and Schrod̈er, Lena and Brasch, Jochen and Harder, Jürgen
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e93941
Human keratinocytes are able to express various antimicrobial peptides (AMP) to protect the skin from exaggerated microbial colonization and infection.... 
DEFENSE | PATTERN-RECOGNITION RECEPTOR | MULTIDISCIPLINARY SCIENCES | DECTIN-2 | ANTIMICROBIAL PEPTIDES | SKIN | DERMATOPHYTES | Ribonucleases - genetics | beta-Defensins - genetics | ErbB Receptors - metabolism | Humans | Epidermal Growth Factor - metabolism | Interleukin-17 - pharmacology | Immunity, Innate | Keratinocytes - immunology | Trichophyton - physiology | Gene Expression Regulation - drug effects | Keratinocytes - drug effects | Keratinocytes - metabolism | Trichophyton - growth & development | Keratinocytes - microbiology | Interferon-gamma - pharmacology | Infectious skin diseases | Care and treatment | Epidermal growth factor | Analysis | Ribonuclease | Diagnosis | Gene expression | Health aspects | Risk factors | Ribonuclease A | Peptides | Blocking antibodies | Infections | Mycelia | Microorganisms | Ribonuclease T | Antimicrobial peptides | Inhibition | Cytokines | Epidermal growth factor receptors | Dermatology | Secretion | Germination | Keratinocytes | Antimicrobial agents | Pattern recognition | Defensins | γ-Interferon | Skin | Interferon | Ribonuclease 7 | Colonization | Conidia
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12. Full Text Molecular Insights into the Adsorption Mechanism of Human β‑Defensin‑3 on Bacterial Membranes
by Lee, Juho and Jung, Sang Won and Cho, Art E
Langmuir, ISSN 0743-7463, 02/2016, Volume 32, Issue 7, pp. 1782 - 1790
Human β-defensin-3 (hBD3) is an endogenous antimicrobial peptide that exhibits broad-spectrum antibacterial activity without eukaryotic cytotoxicity. In this... 
HUMAN BETA-DEFENSINS | HIGH-THROUGHPUT | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | CHEMISTRY, MULTIDISCIPLINARY | PEPTIDE | BUILDER | DYNAMICS | SURFACE | FORCE-FIELD | SIMULATIONS | CHARMM | LIPIDS | Amino Acid Sequence | Drug Resistance, Multiple - drug effects | Humans | Bacteria - drug effects | Molecular Sequence Data | Molecular Dynamics Simulation | beta-Defensins - chemistry | Cell Membrane - chemistry | Thermodynamics | Adsorption | Bacteria - cytology | Drug Design | beta-Defensins - pharmacology | Protein Conformation | Cell Membrane - drug effects | Index Medicus
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13. Full Text Thrombocytes are effectors of the innate immune system releasing human beta defensin-3
by Tohidnezhad, Mersedeh and Varoga, Deike and Podschun, Rainer and Wruck, Christoph Jan and Seekamp, Andreas and Brandenburg, Lars-Ove and Pufe, Thomas and Lippross, Sebastian
Injury, ISSN 0020-1383, 2010, Volume 42, Issue 7, pp. 682 - 686
Abstract Background Thrombocyte concentrate i.e. platelet-rich plasma (PRP) has become a popular adjunct for many surgical procedures. It is believed to... 
Orthopedics | Antimicrobial peptide (AMP) | Platelet-rich plasma (PRP) | Pseudarthrosis | Fracture healing | SURGERY | MANAGEMENT | REGENERATION | ANTIMICROBIAL PEPTIDES | GEL | OPEN FRACTURES | IN-VITRO | EMERGENCY MEDICINE | HUMAN BETA-DEFENSIN-3 | SHAFT FRACTURES | GROWTH-FACTORS | ORTHOPEDICS | EXPRESSION | CRITICAL CARE MEDICINE | Immunohistochemistry | Blood Platelets - immunology | Gram-Negative Bacteria | Humans | Platelet-Rich Plasma - physiology | Gram-Negative Bacterial Infections - immunology | Gram-Negative Bacterial Infections - therapy | Fractures, Open - therapy | Wounds and Injuries - therapy | Blood Platelets - metabolism | Orthopedic Procedures | Fracture Healing - physiology | beta-Defensins - metabolism | Cross infection | Fractures | Nosocomial infections | Universities and colleges | Peptides | Health aspects | Antimicrobial agents
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14. Full Text A 15-amino acid C-terminal peptide of beta-defensin-3 inhibits bone resorption by inhibiting the osteoclast differentiation and disrupting podosome belt formation
by Park, Ok-Jin and Kim, Jiseon and Ahn, Ki Bum and Lee, Jue Yeon and Park, Yoon-Jeong and Kum, Kee-Yeon and Yun, Cheol-Heui and Han, Seung Hyun
Journal of Molecular Medicine, ISSN 0946-2716, 12/2017, Volume 95, Issue 12, pp. 1315 - 1325
Human beta-defensin-3 (HBD3), which is secreted from cells in the skin, salivary gland, and bone marrow, exhibits antimicrobial and immunomodulatory... 
Human Genetics | Bone resorption | Biomedicine | Internal Medicine | Molecular Medicine | Human beta-defensin-3 | Osteoclast | Podosome belt formation | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | PROTEIN | DEFENSINS | ANTIMICROBIAL PEPTIDES | INDUCTION | ORGANIZATION | GENETICS & HEREDITY | LIPOPOLYSACCHARIDE | MICE | EXPRESSION | INNATE IMMUNITY | Aggregatibacter - chemistry | Osteoclasts - pathology | Mice, Inbred C57BL | NFATC Transcription Factors - metabolism | Bone Resorption - drug therapy | Proto-Oncogene Proteins c-fos - metabolism | Down-Regulation - drug effects | Osteoclasts - metabolism | beta-Defensins - chemistry | Lipopolysaccharides | Peptides - pharmacology | Podosomes - metabolism | RANK Ligand - pharmacology | Animals | Cell Differentiation - drug effects | Bone Resorption - pathology | Osteoclasts - drug effects | Peptides - therapeutic use | Podosomes - drug effects | Physiological aspects | Genetic aspects | Research | Osteoclasts (Biology) | Surgical implants | Antimicrobial activity | Destruction | Peptides | Amino acids | Antiinfectives and antibacterials | Bone growth | Biomedical materials | Antimicrobial peptides | Bone marrow | Cofilin | Biocompatibility | Inhibition | TRANCE protein | Bone loss | Immunomodulation | Implantation | Salivary gland | Antimicrobial agents | Pharmacology | Chemical compounds | Osteoclastogenesis | Acids | Vinculin | Osteoclasts | Skin | Bone | Disruption | Differentiation | Pits
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