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Molecular Oncology, ISSN 1574-7891, 05/2017, Volume 11, Issue 5, pp. 584 - 594
CD19 is expressed on normal and neoplastic B cells and is a promising target for immunotherapy. However, there is still an unmet need to further develop novel... 
CD19+ tumor | diphtheria toxin | immunotoxin | Pichia Pastoris | human CD19 | RECOMBINANT IMMUNOTOXIN | IL-2 FUSION TOXIN | ONCOLOGY | IMMUNOTHERAPY | IN-VIVO | B-CELL MALIGNANCIES | DT2219 | PICHIA-PASTORIS | LEUKEMIA | EXPRESSION | CD19(+) tumor | CD22 | Index Medicus
Journal Article
mAbs, ISSN 1942-0862, 01/2015, Volume 7, Issue 3, pp. 584 - 604
To harness the potent tumor-killing capacity of T cells for the treatment of CD19(+) malignancies, we constructed AFM11, a humanized tetravalent bispecific... 
Non-Hodgkin lymphoma | ALL | CD3 | T cells | Bispecific antibodies | NHL, non-Hodgkin lymphoma | CHO, Chinese hamster ovary | ACTIVATION | MWCO, molecular weight cut-off | FC-RECEPTORS | MONOCLONAL-ANTIBODY | PROLIFERATION | BBB, blood-brain barrier | WBA, whole body autoradiography | KD, dissociation constant | ECL, electrochemiluminescence | FACS, fluorescence-activated cell sorting | LYMPHOMA | CCS, cell culture supernatant | SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis | ANALYSIS TOOL | i.v., intravenous | ORR, overall response rate | PI, propidium iodide | TNF, tumor necrosis factor | VH, variable heavy | Vss, volume of distribution at steady state | PBS, phosphate buffered saline | FcRn, neonatal Fc receptor | Fab, fragment antigen-binding | ctrl., control | t(1/2), terminal elimination half-life | BITE ANTIBODY BLINATUMOMAB | IgG, immunoglobulin G | B-ALL, B-precursor acute lymphoblastic leukemia | NK, natural killer | E:T, effector:target | CLL, chronic lymphocytic leukemia | IL, interleukin | MALIGNANCIES | s.c., subcutaneous | His, histidine | FR, framework region | EC50, half maximal effective concentration | FCS, fetal calf serum | MEDICINE, RESEARCH & EXPERIMENTAL | CONSTRUCT | kd, dissociation rate constant | w/o, without | Fc, fragment crystallizable | LMF, low molecular weight forms | VL, variable light | HMF, high molecular weight forms | FcgR, Fc gamma receptor | F, fluorescence | SABC, standardized antibody binding capacity | SE-HPLC, size exclusion high-pressure liquid chromatography | CD, cluster of differentiation | CL, clearance | ACUTE LYMPHOBLASTIC-LEUKEMIA | SD, standard deviation | SEC, size exclusion chromatography | PBMC, peripheral blood mononuclear cell | scFv, single-chain variable fragment | IFN, interferon | MSD, MesoScale Discovery | BiTE, bispecific T cell engager | PHA, phytohemagglutinin | Fv, variable fragment | CAR, chimeric antigen receptor | HSA, human serum albumin | AUCtot, total area under the curve | PES, polyethersulfone | CNS, central nervous system | TandAb, tandem diabody | CDR, complementarity determining region | ka, association rate constant | DMSO, dimethyl sulfoxide | SPR, surface plasmon resonance | NOD/scid, nonobese diabetic/severe combined immunodeficiency | Cmax, maximal concentration | Cricetulus | Humans | Male | Neoplasms, Experimental - pathology | Antibodies, Neoplasm - pharmacology | Neoplasms, Experimental - immunology | HEK293 Cells | Antigens, CD19 - immunology | CHO Cells | Antibodies, Neoplasm - immunology | Cricetinae | Single-Chain Antibodies - pharmacology | Antibodies, Bispecific - pharmacology | Jurkat Cells | Mice, SCID | Antibodies, Bispecific - immunology | Xenograft Model Antitumor Assays | Animals | CD3 Complex - immunology | Antibodies, Bispecific - chemistry | Mice, Inbred NOD | Antibodies, Neoplasm - chemistry | Mice | Neoplasms, Experimental - drug therapy | Single-Chain Antibodies - chemistry | Single-Chain Antibodies - immunology
Journal Article
Journal Article
Cell, ISSN 0092-8674, 12/2017, Volume 171, Issue 7, pp. 1471 - 1471
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 13, pp. 5925 - 5930
Studies here respond to two long-standing questions: Are human "pre/pro-B" CD34⁺CD10⁻CD19⁺ and "common lymphoid progenitor (CLP)/early-B" CD34⁺CD10⁺CD19⁻... 
Phenotypes | B lymphocytes | Stem cells | Coculture techniques | Cell lines | Bone marrow | Cultured cells | Progenitor cells | Blood | Cells | B1 and B2 cells | Single-cell gene and protein expression profiles | Layered B-lymphocyte lineages | Umbilical cord blood | CD19, a pax5 reporter stepwise acquisition | PREFERENTIAL UTILIZATION | MULTIDISCIPLINARY SCIENCES | CORD BLOOD | CD19, a Pax5 reporter stepwise acquisition | layered B-lymphocyte lineages | ADULT | single-cell gene and protein expression profiles | IN-VITRO | GENE | HUMAN BONE-MARROW | umbilical cord blood | PRECURSORS | EXPRESSION | LYMPHOBLASTIC-LEUKEMIA | LIFE | Antigens, CD34 - metabolism | Cell Proliferation | Coculture Techniques | Humans | B-Lymphocyte Subsets - cytology | Precursor Cells, B-Lymphoid - immunology | Gene Expression Profiling | Lymphoid Progenitor Cells - immunology | Base Sequence | B-Lymphocyte Subsets - immunology | Infant, Newborn | Fetal Blood - immunology | Bone Marrow Cells - cytology | Lymphoid Progenitor Cells - cytology | Fetal Blood - cytology | Neprilysin - metabolism | DNA - genetics | Cell Differentiation - immunology | Models, Immunological | Animals | Gene Rearrangement, B-Lymphocyte, Heavy Chain | Leukemia, B-Cell - genetics | Lymphopoiesis - immunology | Precursor Cells, B-Lymphoid - cytology | Antigens, CD19 - metabolism | Mice | Leukemia, B-Cell - immunology | Stromal Cells - cytology | Biological Sciences
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 04/2018, Volume 141, Issue 4, pp. 1417 - 1426.e1
Allogeneic hematopoietic stem cell transplantation (HSCT) is used as a therapeutic approach for primary immunodeficiencies (PIDs). The best outcomes have been... 
hematopoietic stem cell transplantation | CD3+ T-cell receptor αβ+ cell depletion | haploidentical | mismatched unrelated | Primary immunodeficiency | cell depletion | CD3 | T-cell receptor αβ | Busulfan - analogs & derivatives | Immunologic Deficiency Syndromes - therapy | Humans | Antilymphocyte Serum - immunology | Child, Preschool | Hematopoietic Stem Cell Transplantation | Infant | Male | Receptors, Antigen, T-Cell, alpha-beta - immunology | Thiotepa - immunology | Vidarabine - analogs & derivatives | Graft vs Host Disease - immunology | CD3 Complex - immunology | Vidarabine - immunology | Female | Graft vs Host Disease - prevention & control | Retrospective Studies | Transplantation Conditioning - methods | Busulfan - immunology | Immunologic Deficiency Syndromes - immunology | Child | Alemtuzumab - immunology | Antigens, CD19 - immunology | Graft-versus-host reaction | Transplants & implants | Liver | Prophylaxis | Stem cell transplantation | Transplantation | Lymphocytes T | Infections | Treosulfan | Drug resistance | Grafting | Hematopoietic stem cells | T-cell receptor | Demographics | Lymphocytes | Children | Busulfan | Conditioning | Cytomegalovirus | Immunoglobulins | CD19 antigen | Neutrophils | Health risks | Immunodeficiency | Transplants | CD3 antigen | T cell receptors | Patients | Survival | Hemopoiesis | Graft rejection | Rejection | Fludarabine | Grafts | Depletion | Globulins | Thymocytes | Adenoviruses | Stem cells | Monoclonal antibodies | Histocompatibility antigen HLA | Methods | Viral infections
Journal Article
British Journal of Haematology, ISSN 0007-1048, 07/2017, Volume 178, Issue 2, pp. 308 - 318
Journal Article
Journal Article