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1. Full Text Targeting interleukin-5 in refractory and relapsing churg-strauss syndrome
by Moosig, Frank and Gross, Wolfgang Ludwig and Herrmann, Kristina and Bremer, Jan Phillip and Hellmich, Bernhard
Annals of internal medicine, ISSN 0003-4819, 2011, Volume 155, Issue 5, pp. 341 - 343
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Glucocorticoids - therapeutic use | Down-Regulation | Humans | Immunosuppressive Agents - therapeutic use | Antibodies, Monoclonal - therapeutic use | Methotrexate - therapeutic use | Remission Induction | Churg-Strauss Syndrome - drug therapy | Interleukin-5 - immunology | Antibodies, Monoclonal, Humanized | Churg-Strauss Syndrome - immunology | Drug Therapy, Combination | Immunologic Factors - therapeutic use | Index Medicus | Abridged Index Medicus
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2. Full Text Increased interleukin-4, interleukin-5, and interferon-γ in airway CD4+ and CD8+ T cells in atopic asthma
by Cho, Sang-Heon and Stanciu, Luminita A and Holgate, Stephen T and Johnston, Sebastian L
American journal of respiratory and critical care medicine, ISSN 1073-449X, 02/2005, Volume 171, Issue 3, pp. 224 - 230
Human | T lymphocytes | Flow cytometry | Sputum | Asthma | Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Transfusions. Complications. Transfusion reactions. Cell and gene therapy | Biological and medical sciences | Intensive care medicine | Medical sciences | Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis | Emergency and intensive respiratory care | Sputum - cytology | Bronchial Hyperreactivity - immunology | Humans | Hypersensitivity, Immediate - blood | Bronchi - immunology | Eosinophils - immunology | Immunoglobulin E - blood | CD4-Positive T-Lymphocytes - immunology | Interleukin-5 - analysis | Ionophores - immunology | Sputum - immunology | T-Lymphocytes, Helper-Inducer - immunology | Asthma - blood | Asthma - immunology | Hypersensitivity, Immediate - immunology | Adult | Leukocyte Count | Asthma - classification | CD4 Lymphocyte Count | Ionomycin - immunology | Interleukin-4 - analysis | Interleukin-5 - blood | Interferon-gamma - analysis | Interleukin-4 - blood | Lymphocyte Count | Tetradecanoylphorbol Acetate - immunology | CD8-Positive T-Lymphocytes - immunology | Interferon-gamma - blood | Index Medicus | Abridged Index Medicus
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3. Full Text Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial
by Straumann, A and Conus, S and Grzonka, P and Kita, H and Kephart, G and Bussmann, C and Beglinger, C and Smith, D A and Patel, J and Byrne, M and Simon, H-U
Gut, ISSN 0017-5749, 01/2010, Volume 59, Issue 1, pp. 21 - 30
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Eosinophilia - blood | Esophagitis - blood | Humans | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Eosinophil-Derived Neurotoxin - metabolism | Esophagoscopy | Antibodies, Monoclonal, Humanized | Inflammation Mediators - metabolism | Esophagitis - drug therapy | Adult | Deglutition Disorders - etiology | Female | Eosinophils - pathology | Leukocyte Count | Deglutition Disorders - drug therapy | Eosinophilia - drug therapy | Double-Blind Method | Drug Administration Schedule | Treatment Outcome | Interleukin-5 - immunology | Esophagitis - complications | Esophagitis - immunology | Eosinophilia - immunology | Antibodies, Monoclonal - administration & dosage | Eosinophilia - complications | Esophagitis | Monoclonal antibodies | Care and treatment | Dosage and administration | Research | Eosinophilia | Studies | Immunoglobulins | Inflammation | Disease | Cytokines | Asthma | Index Medicus | Abridged Index Medicus
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4. Full Text Treatment for severe eosinophilic asthma—consistent effect of anti-interleukin-5 antibodies?
by Castro, Mario and Bacharier, Leonard B
The Lancet (British edition), ISSN 0140-6736, 2016, Volume 388, Issue 10056, pp. 2059 - 2060
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Interleukin-5 - immunology | Antibodies, Monoclonal, Humanized - therapeutic use | Anti-Asthmatic Agents - therapeutic use | Humans | Eosinophilia - drug therapy | Asthma - drug therapy | Eosinophils - immunology | Pulmonary Eosinophilia - drug therapy | Viral antibodies | Antibodies | Interleukins | Drug therapy | Asthma | Studies | Respiratory therapy | Immunoglobulins | Cytokines | Drug dosages | Index Medicus | Abridged Index Medicus
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5. Full Text Anti–interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes
by Garrett, Jennifer K and Jameson, Sean C and Thomson, Blythe and Collins, Margaret H and Wagoner, Lynne E and Freese, Debbie K and Beck, Lisa A and Boyce, Joshua A and Filipovich, Alexandra H and Villanueva, Joyce M and Sutton, Steven A and Assa'ad, Amal H and Rothenberg, Marc E
Journal of allergy and clinical immunology, ISSN 0091-6749, 2004, Volume 113, Issue 1, pp. 115 - 119
cytokine | IL-5 | hyper-eosinophilic | esophagitis | Eosinophils | humanized antibody | Esophagitis | Humanized antibody | Cytokine | Hypereosinophilic | Hematologic and hematopoietic diseases | Other diseases. Hematologic involvement in other diseases | Biological and medical sciences | Medical sciences | Hypereosinophilic Syndrome - drug therapy | Glucocorticoids - therapeutic use | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Eosinophils - immunology | Interleukin-5 - immunology | Antibodies, Monoclonal, Humanized | Adolescent | Adult | Female | Leukocyte Count | Hypereosinophilic Syndrome - immunology | Drug Therapy, Combination | Gastroesophageal reflux | FDA approval | Disease | Pathogenesis | Patients | Asthma | Index Medicus | Abridged Index Medicus
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6. Full Text Targeting Interleukin-5 or Interleukin-5Rα: Safety Considerations
by Bagnasco, Diego and Ferrando, Matteo and Caminati, Marco and Bragantini, Alice and Puggioni, Francesca and Varricchi, Gilda and Passalacqua, Giovanni and Canonica, Giorgio Walter
Drug safety, ISSN 0114-5916, 07/2017, Volume 40, Issue 7, pp. 559 - 570
Pharmacology & Pharmacy | Public, Environmental & Occupational Health | Toxicology | Life Sciences & Biomedicine | Science & Technology | Biomarkers | Interleukin-5 Receptor alpha Subunit - therapeutic use | Interleukin-5 - antagonists & inhibitors | Asthma - drug therapy | Humans | Drugs | Pathogenesis | Interleukin | Clinical trials | Drug development | Dermatitis | Churg-Strauss syndrome | Interleukin 5 | Atopic dermatitis | Chronic obstructive pulmonary disease | Safety | Chronic illnesses | Medical research | Cytokines | Therapeutic applications | Leukocytes (eosinophilic) | Lung diseases | Neutrophils | Esophagitis | Inflammation | Patients | Polyposis | Asthma | Obstructive lung disease | Eosinophils
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7. Full Text Interleukin‐5 induces apoptotic defects in CD4+ T cells of patients with allergic rhinitis
by Luo, Xiang‐Qian and Ma, Fei and Wang, Shuai and Zhao, Mei‐Zhen and Shao, Jian‐Bo and Geng, Xiao‐Rui and Liu, Jiang‐Qi and Mo, Li‐Hua and Guan, Li and Liu, Zhi‐Gang and Liu, Da‐Bo and Yang, Ping‐Chang
Journal of leukocyte biology, ISSN 0741-5400, 04/2019, Volume 105, Issue 4, pp. 719 - 727
nasal mucosa | allergy | apoptosis | immunity | lymphocyte | Immunology | Life Sciences & Biomedicine | Hematology | Science & Technology | Cell Biology | Fas Ligand Protein - metabolism | Rhinitis, Allergic - genetics | Interleukin-5 - metabolism | Rhinitis, Allergic - immunology | Humans | RNA, Messenger - genetics | Male | Rhinitis, Allergic - blood | RNA, Messenger - metabolism | Interleukin-5 - blood | CD4-Positive T-Lymphocytes - immunology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Muscle Proteins - metabolism | Adult | Female | Transcription, Genetic | Fas Ligand Protein - genetics | Apoptosis | Rhinitis, Allergic - pathology | Index Medicus
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8. Full Text Anti-interleukin-5 therapy in severe asthma
by Garcia, Gilles and Taillé, Camille and Laveneziana, Pierantonio and Bourdin, Arnaud and Chanez, Pascal and Humbert, Marc
European respiratory review, ISSN 0905-9180, 10/2013, Volume 22, Issue 129, pp. 251 - 257
Asthma - diagnosis | Severity of Illness Index | Asthma - physiopathology | Anti-Asthmatic Agents - therapeutic use | Interleukin-5 - metabolism | Humans | Treatment Outcome | Lung - physiopathology | Asthma - drug therapy | Disease Progression | Patient Selection | Phenotype | Animals | Interleukin-5 - antagonists & inhibitors | Lung - drug effects | Asthma - immunology | Anti-Inflammatory Agents - therapeutic use | Lung - immunology | Index Medicus
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9. Full Text Eosinophil's Role Remains Uncertain as Anti-Interleukin-5 only Partially Depletes Numbers in Asthmatic Airway
by Flood-Page, Patrick T and Menzies-Gow, Andrew N and Kay, A. Barry and Robinson, Douglas S
American journal of respiratory and critical care medicine, ISSN 1073-449X, 01/2003, Volume 167, Issue 2, pp. 199 - 204
Anti-interleukin-5 | Asthma | Eosinophils | Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | Medical sciences | Respiratory system | Immunomodulators | Pharmacology. Drug treatments | Immunohistochemistry | Injections, Intravenous | Eosinophils - drug effects | Humans | Middle Aged | Male | Reference Values | Dose-Response Relationship, Drug | Antibodies, Monoclonal, Humanized | Sensitivity and Specificity | Asthma - immunology | Adult | Female | Leukocyte Count | Eosinophilia - drug therapy | Eosinophilia - physiopathology | Severity of Illness Index | Double-Blind Method | Drug Administration Schedule | Probability | Treatment Outcome | Asthma - drug therapy | Eosinophils - physiology | Antibodies, Monoclonal - administration & dosage | Bone Marrow - pathology | Adolescent | Respiratory Function Tests | Asthma - pathology | Index Medicus | Abridged Index Medicus
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10. Full Text Elevated Sputum Interleukin-5 and Submucosal Eosinophilia in Obese Individuals with Severe Asthma
by Desai, Dhananjay and Newby, Christopher and Symon, Fiona A and Haldar, Pranabashis and Shah, Sachil and Gupta, Sumit and Bafadhel, Mona and Singapuri, Amisha and Siddiqui, Salman and Woods, Joanne and Herath, Athula and Anderson, Ian K and Bradding, Peter and Green, Ruth and Kulkarni, Nita and Pavord, Ian and Marshall, Richard P and Sousa, Ana R and May, Richard D and Wardlaw, Andrew J and Brightling, Chris E
American journal of respiratory and critical care medicine, ISSN 1073-449X, 09/2013, Volume 188, Issue 6, pp. 657 - 663
Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Hematologic and hematopoietic diseases | Other diseases. Hematologic involvement in other diseases | Obesity | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Biological and medical sciences | Metabolic diseases | Intensive care medicine | Medical sciences | Chronic obstructive pulmonary disease, asthma | Pneumology | Biomarkers - metabolism | Body Mass Index | Severity of Illness Index | Eosinophilia - metabolism | Asthma - metabolism | Eosinophils - metabolism | Interleukin-5 - metabolism | Obesity - complications | Obesity - immunology | Humans | Middle Aged | Male | Eosinophils - immunology | Sputum - metabolism | Obesity - metabolism | Interleukin-5 - immunology | Sputum - immunology | Eosinophilia - immunology | Asthma - complications | Respiratory Mucosa - immunology | Asthma - immunology | Female | Eosinophilia - complications | Respiratory Mucosa - metabolism | Index Medicus | Abridged Index Medicus | asthma | cytokines | phenotypes | eosinophil | obesity
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11. Full Text Interleukin-5 - Producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy
by Van Gool, Frédéric and Molofsky, Ari B and Morar, Malika M and Rosenzwajg, Michelle and Liang, Hong-Erh and Klatzmann, David and Locksley, Richard M and Bluestone, Jeffrey A
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 24, pp. 3572 - 3576
Life Sciences & Biomedicine | Hematology | Science & Technology | Immunity, Innate - drug effects | Humans | Interleukin-2 - antagonists & inhibitors | Antibodies - pharmacology | Eosinophilia - pathology | Interleukin-5 - immunology | Lymphocytes - pathology | Animals | Interleukin-2 - immunology | Lymphocytes - immunology | Eosinophilia - immunology | Antibodies - immunology | Interleukin-2 - pharmacology | Cell Proliferation - drug effects | Mice | Eosinophilia - drug therapy | Index Medicus | Abridged Index Medicus | Immunobiology | Brief Report
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12. Full Text Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial
by FitzGerald, J Mark, Dr and Bleecker, Eugene R, Prof and Nair, Parameswaran, Prof and Korn, Stephanie, MD and Ohta, Ken, MD and Lommatzsch, Marek, Prof and Ferguson, Gary T, MD and Busse, William W, Prof and Barker, Peter, PhD and Sproule, Stephanie, MMath and Gilmartin, Geoffrey, MD and Werkström, Viktoria, MD and Aurivillius, Magnus, MD and Goldman, Mitchell, MD and CALIMA study investigators
The Lancet (British edition), ISSN 0140-6736, 2016, Volume 388, Issue 10056, pp. 2128 - 2141
Internal Medicine | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Anti-Asthmatic Agents - therapeutic use | Humans | Middle Aged | Administration, Inhalation | Male | Adrenal Cortex Hormones - therapeutic use | Asthma - drug therapy | Disease Progression | Dose-Response Relationship, Drug | Forced Expiratory Volume | Asthma - complications | Injections, Subcutaneous | Adult | Female | Aged | Drug Therapy, Combination | Receptors, Interleukin-5 - antagonists & inhibitors | Child | Pulmonary Eosinophilia - blood | Index Medicus | Abridged Index Medicus
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