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1. Full Text Increased interleukin-4, interleukin-5, and interferon-γ in airway CD4+ and CD8+ T cells in atopic asthma
by Cho, Sang-Heon and Stanciu, Luminita A and Holgate, Stephen T and Johnston, Sebastian L
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 02/2005, Volume 171, Issue 3, pp. 224 - 230
Increased Th2 cytokine production in asthma is widely accepted, but excess production by asthmatic human airway CD4(+) T cells has not been demonstrated, nor... 
Human | T lymphocytes | Flow cytometry | Sputum | Asthma | BRONCHIAL BIOPSIES | IFN-GAMMA | IL-5 MESSENGER-RNA | asthma | sputum | BRONCHOALVEOLAR LAVAGE | TUMOR-NECROSIS-FACTOR | CYTOKINE PRODUCTION | INDUCED SPUTUM | RESPIRATORY SYSTEM | IMMUNE REGULATION | flow cytometry | human | EXPRESSION | BLOOD | CRITICAL CARE MEDICINE | Sputum - cytology | Bronchial Hyperreactivity - immunology | Humans | Hypersensitivity, Immediate - blood | Bronchi - immunology | Eosinophils - immunology | Immunoglobulin E - blood | CD4-Positive T-Lymphocytes - immunology | Interleukin-5 - analysis | Ionophores - immunology | Sputum - immunology | T-Lymphocytes, Helper-Inducer - immunology | Asthma - blood | Asthma - immunology | Hypersensitivity, Immediate - immunology | Adult | Leukocyte Count | Asthma - classification | CD4 Lymphocyte Count | Ionomycin - immunology | Interleukin-4 - analysis | Interleukin-5 - blood | Interferon-gamma - analysis | Interleukin-4 - blood | Lymphocyte Count | Tetradecanoylphorbol Acetate - immunology | CD8-Positive T-Lymphocytes - immunology | Interferon-gamma - blood
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2. Full Text Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needs
by Varricchi, Gilda and Bagnasco, Diego and Borriello, Francesco and Heffler, Enrico and Canonica, Giorgio W
Current Opinion in Allergy and Clinical Immunology, ISSN 1528-4050, 04/2016, Volume 16, Issue 2, pp. 186 - 200
PURPOSE OF REVIEWHuman eosinophils were first identified and named by Paul Ehrlich in 1879 on the basis of the cellʼs granular uptake of eosin. Although... 
reslizumab | mepolizumab | eosinophils | asthma | benralizumab | chronic obstructive pulmonary disease | interleukin-5 | ALPHA MONOCLONAL-ANTIBODY | CHURG-STRAUSS-SYNDROME | MESSENGER-RNA EXPRESSION | MAST-CELLS | HUMAN BLOOD BASOPHILS | IMMUNOLOGY | COPD OVERLAP SYNDROME | OBSTRUCTIVE PULMONARY-DISEASE | ALLERGY | INDUCED ASTHMATIC RESPONSES | PLACEBO-CONTROLLED TRIAL | INFLAMMATORY BOWEL DISEASES | Eosinophils - drug effects | Granulomatosis with Polyangiitis - therapy | Humans | Receptors, Interleukin-5 - immunology | Antibodies, Monoclonal - therapeutic use | Clinical Trials as Topic | Eosinophils - immunology | Interleukin-5 - immunology | Pulmonary Disease, Chronic Obstructive - therapy | Animals | Signal Transduction - drug effects | Granulomatosis with Polyangiitis - immunology | Asthma - immunology | Adult | Asthma - therapy | Pulmonary Disease, Chronic Obstructive - immunology | Special
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3. Full Text Targeting interleukin-5 in refractory and relapsing churg-strauss syndrome
by Moosig, Frank and Gross, Wolfgang Ludwig and Herrmann, Kristina and Bremer, Jan Phillip and Hellmich, Bernhard
Annals of Internal Medicine, ISSN 0003-4819, 2011, Volume 155, Issue 5, pp. 341 - 343
MEDICINE, GENERAL & INTERNAL | MEPOLIZUMAB | Glucocorticoids - therapeutic use | Down-Regulation | Humans | Immunosuppressive Agents - therapeutic use | Antibodies, Monoclonal - therapeutic use | Methotrexate - therapeutic use | Remission Induction | Churg-Strauss Syndrome - drug therapy | Interleukin-5 - immunology | Antibodies, Monoclonal, Humanized | Churg-Strauss Syndrome - immunology | Drug Therapy, Combination | Immunologic Factors - therapeutic use
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4. Full Text Treatment for severe eosinophilic asthma—consistent effect of anti-interleukin-5 antibodies?
by Castro, Mario and Bacharier, Leonard B
Lancet, The, ISSN 0140-6736, 2016, Volume 388, Issue 10056, pp. 2059 - 2060
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0140-6736(16)31537-9 Byline: Mario Castro, Leonard B Bacharier Author... 
Internal Medicine | EXACERBATIONS | MEDICINE, GENERAL & INTERNAL | PLACEBO | COUNT | MEPOLIZUMAB | BLOOD | Interleukin-5 - immunology | Antibodies, Monoclonal, Humanized - therapeutic use | Anti-Asthmatic Agents - therapeutic use | Humans | Eosinophilia - drug therapy | Asthma - drug therapy | Eosinophils - immunology | Pulmonary Eosinophilia - drug therapy | Viral antibodies | Antibodies | Interleukins | Drug therapy | Asthma | Studies | Respiratory therapy | Immunoglobulins | Cytokines | Drug dosages
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5. Full Text Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial
by Straumann, A and Conus, S and Grzonka, P and Kita, H and Kephart, G and Bussmann, C and Beglinger, C and Smith, D A and Patel, J and Byrne, M and Simon, H-U
Gut, ISSN 0017-5749, 01/2010, Volume 59, Issue 1, pp. 21 - 30
Objective:Eosinophilic oesophagitis (EoO) is a clinicopathological condition defined by proton pump inhibitor-refractory oesophageal symptoms combined with... 
THERAPY | AIRWAY | FLUTICASONE PROPIONATE | ADULTS | HYPEREOSINOPHILIC SYNDROME | ASTHMA | IL-5 | CORTICOSTEROIDS | GASTROENTEROLOGY & HEPATOLOGY | ANTI-IL-5 TREATMENT | CHILDREN | Eosinophilia - blood | Esophagitis - blood | Humans | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Eosinophil-Derived Neurotoxin - metabolism | Esophagoscopy | Antibodies, Monoclonal, Humanized | Inflammation Mediators - metabolism | Esophagitis - drug therapy | Adult | Deglutition Disorders - etiology | Female | Eosinophils - pathology | Leukocyte Count | Deglutition Disorders - drug therapy | Eosinophilia - drug therapy | Double-Blind Method | Drug Administration Schedule | Treatment Outcome | Interleukin-5 - immunology | Esophagitis - complications | Esophagitis - immunology | Eosinophilia - immunology | Antibodies, Monoclonal - administration & dosage | Eosinophilia - complications | Esophagitis | Monoclonal antibodies | Care and treatment | Dosage and administration | Research | Eosinophilia | Studies | Immunoglobulins | Inflammation | Disease | Cytokines | Asthma
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6. Full Text Anti–interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes
by Garrett, Jennifer K and Jameson, Sean C and Thomson, Blythe and Collins, Margaret H and Wagoner, Lynne E and Freese, Debbie K and Beck, Lisa A and Boyce, Joshua A and Filipovich, Alexandra H and Villanueva, Joyce M and Sutton, Steven A and Assa'ad, Amal H and Rothenberg, Marc E
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 2004, Volume 113, Issue 1, pp. 115 - 119
Background: IL-5 is a cytokine critically involved in regulating several aspects of eosinophils including their production, activation, and tissue recruitment.... 
cytokine | IL-5 | hyper-eosinophilic | esophagitis | Eosinophils | humanized antibody | Esophagitis | Humanized antibody | Cytokine | Hypereosinophilic | Hypereosinophilic Syndrome - drug therapy | Glucocorticoids - therapeutic use | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Eosinophils - immunology | Interleukin-5 - immunology | Antibodies, Monoclonal, Humanized | Adolescent | Adult | Female | Leukocyte Count | Hypereosinophilic Syndrome - immunology | Drug Therapy, Combination | Gastroesophageal reflux | FDA approval | Disease | Pathogenesis | Patients | Asthma
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7. Full Text Targeting Interleukin-5 or Interleukin-5Rα: Safety Considerations
by Bagnasco, Diego and Ferrando, Matteo and Caminati, Marco and Bragantini, Alice and Puggioni, Francesca and Varricchi, Gilda and Passalacqua, Giovanni and Canonica, Giorgio Walter
Drug Safety, ISSN 0114-5916, 07/2017, Volume 40, Issue 7, pp. 559 - 570
Asthma is a highly prevalent chronic disease of the airways; approximately 10% of patients with asthma will experience a severe form of the disease. New... 
ALPHA MONOCLONAL-ANTIBODY | PLACEBO | MEPOLIZUMAB | RECEPTOR | BENRALIZUMAB | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | EOSINOPHILIC ASTHMA | ALLERGIC-ASTHMA | DOUBLE-BLIND | HYPEREOSINOPHILIC SYNDROME | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PERSONALIZED MEDICINE | Biomarkers | Interleukin-5 Receptor alpha Subunit - therapeutic use | Interleukin-5 - antagonists & inhibitors | Asthma - drug therapy | Humans | Drugs | Pathogenesis | Interleukin | Clinical trials | Drug development | Dermatitis | Churg-Strauss syndrome | Interleukin 5 | Atopic dermatitis | Chronic obstructive pulmonary disease | Safety | Chronic illnesses | Medical research | Cytokines | Therapeutic applications | Leukocytes (eosinophilic) | Lung diseases | Neutrophils | Esophagitis | Inflammation | Patients | Polyposis | Asthma | Obstructive lung disease | Eosinophils
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8. Full Text Anti-interleukin-5 therapy in severe asthma
by Garcia, Gilles and Taillé, Camille and Laveneziana, Pierantonio and Bourdin, Arnaud and Chanez, Pascal and Humbert, Marc
European Respiratory Review, ISSN 0905-9180, 10/2013, Volume 22, Issue 129, pp. 251 - 257
Asthma is a chronic inflammatory disorder of the airways that leads to acute symptoms, exacerbations and sometimes, for a small part of the asthmatic... 
Asthma - diagnosis | Severity of Illness Index | Asthma - physiopathology | Anti-Asthmatic Agents - therapeutic use | Interleukin-5 - metabolism | Humans | Treatment Outcome | Lung - physiopathology | Asthma - drug therapy | Disease Progression | Patient Selection | Phenotype | Animals | Interleukin-5 - antagonists & inhibitors | Lung - drug effects | Asthma - immunology | Anti-Inflammatory Agents - therapeutic use | Lung - immunology
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9. Full Text Interleukin-5
by Takatsu, Kiyoshi
Current Opinion in Immunology, ISSN 0952-7915, 1992, Volume 4, Issue 3, pp. 299 - 306
Interleukin-5 is a dimeric cytokine that controls the differentiation of B cells into antibody-secreting cells as well as inducing the growth of Ly-1(CD5) B... 
COLONY-STIMULATING FACTOR | CLONING | POSITIVE-B-CELLS | EOSINOPHILIA | RECEPTOR GENE FAMILY | IL-5 | IGA PRODUCTION | DIFFERENTIATION | IMMUNOLOGY | IDENTIFICATION | EXPRESSION | Interleukin-5 - chemistry | Signal Transduction - immunology | Receptors, Immunologic - chemistry | Animals | Humans | Receptors, Interleukin-5 | Receptors, Interleukin-3 - chemistry | Interleukin-5 - physiology | Interleukin-5 - genetics | Receptors, Interleukin | Receptors, Immunologic - metabolism | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - chemistry
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10. Full Text Eosinophil's Role Remains Uncertain as Anti-Interleukin-5 only Partially Depletes Numbers in Asthmatic Airway
by Flood-Page, Patrick T and Menzies-Gow, Andrew N and Kay, A. Barry and Robinson, Douglas S
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 01/2003, Volume 167, Issue 2, pp. 199 - 204
The role of eosinophils as effector cells in asthma pathogenesis has been questioned since an anti-interleukin (IL)-5 monoclonal antibody (mepolizumab), which... 
Anti-interleukin-5 | Asthma | Eosinophils | anti-interleukin-5 | MESSENGER-RNA EXPRESSION | MAST-CELLS | BONE-MARROW | eosinophils | asthma | MONOCLONAL-ANTIBODY | CYTOKINE GENE-EXPRESSION | BRONCHOALVEOLAR LAVAGE | RECEPTOR ALPHA-SUBUNIT | PREDNISOLONE TREATMENT | RESPIRATORY SYSTEM | MAJOR BASIC-PROTEIN | ATOPIC ASTHMA | CRITICAL CARE MEDICINE | Immunohistochemistry | Injections, Intravenous | Eosinophils - drug effects | Humans | Middle Aged | Male | Reference Values | Dose-Response Relationship, Drug | Antibodies, Monoclonal, Humanized | Sensitivity and Specificity | Asthma - immunology | Adult | Female | Leukocyte Count | Eosinophilia - drug therapy | Eosinophilia - physiopathology | Severity of Illness Index | Double-Blind Method | Drug Administration Schedule | Probability | Treatment Outcome | Asthma - drug therapy | Eosinophils - physiology | Antibodies, Monoclonal - administration & dosage | Bone Marrow - pathology | Adolescent | Respiratory Function Tests | Asthma - pathology
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11. Full Text Anti–Interleukin-5 Monoclonal Antibody to Treat Severe Eosinophilic Asthma
by Nair, Parameswaran
The New England Journal of Medicine, ISSN 0028-4793, 09/2014, Volume 371, Issue 13, pp. 1249 - 1251
Despite the availability of treatments such as glucocorticoids, leukotriene antagonists, long-acting bronchodilators, and a monoclonal antibody directed... 
EXACERBATIONS | MEDICINE, GENERAL & INTERNAL | MEPOLIZUMAB | SPUTUM | Glucocorticoids - administration & dosage | Antibodies, Monoclonal, Humanized - administration & dosage | Humans | Female | Male | Anti-Asthmatic Agents - administration & dosage | Asthma - drug therapy | Eosinophilia | Glucocorticoids | Cytokines | Leukocytes (eosinophilic) | Immunoglobulin E | Antagonists | Patients | Morbidity | Asthma | Quality of life | Studies | Interleukin 5 | Bronchodilators | Monoclonal antibodies | Respiratory tract diseases | Drug therapy | Drug dosages
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12. Full Text Interleukin-5 - Producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy
by Van Gool, Frédéric and Molofsky, Ari B and Morar, Malika M and Rosenzwajg, Michelle and Liang, Hong-Erh and Klatzmann, David and Locksley, Richard M and Bluestone, Jeffrey A
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 24, pp. 3572 - 3576
Interleukin (IL)-2 promotes regulatory T-cell development and function, and treatment with IL-2 is being tested as therapy for some autoimmune diseases.... 
RESPONSES | HOMEOSTASIS | IMMUNOTHERAPY | EXPANSION | DISEASE | LOW-DOSE INTERLEUKIN-2 | TYPE-2 IMMUNITY | IL-2 | HEMATOLOGY | Immunity, Innate - drug effects | Humans | Interleukin-2 - antagonists & inhibitors | Antibodies - pharmacology | Eosinophilia - pathology | Interleukin-5 - immunology | Lymphocytes - pathology | Animals | Interleukin-2 - immunology | Lymphocytes - immunology | Eosinophilia - immunology | Antibodies - immunology | Interleukin-2 - pharmacology | Cell Proliferation - drug effects | Mice | Eosinophilia - drug therapy | Immunobiology | Brief Report
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13. Full Text The GM–CSF/IL‐3/IL‐5 cytokine receptor family: from ligand recognition to initiation of signaling
by Broughton, Sophie E and Dhagat, Urmi and Hercus, Timothy R and Nero, Tracy L and Grimbaldeston, Michele A and Bonder, Claudine S and Lopez, Angel F and Parker, Michael W
Immunological Reviews, ISSN 0105-2896, 11/2012, Volume 250, Issue 1, pp. 277 - 302
Summary Granulocyte–macrophage colony‐stimulating factor (GM–CSF), interleukin‐3 (IL‐3), and IL‐5 are members of a discrete family of cytokines that regulates... 
cytokine | granulocyte–macrophage colony‐stimulating factor | interleukin‐3 | receptor signaling | crystal structures | interleukin‐5 | Crystal structures | interleukin-3 | granulocyte-macrophage colony-stimulating factor | interleukin-5 | COLLAGEN-INDUCED ARTHRITIS | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | COLONY-STIMULATING FACTOR | RECOMBINANT-HUMAN-ERYTHROPOIETIN | HIGH-AFFINITY BINDING | HUMAN INTERLEUKIN-5 RECEPTOR | IMMUNOLOGY | ENDOTHELIAL PROGENITOR CELLS | PULMONARY ALVEOLAR PROTEINOSIS | GM-CSF RECEPTOR | COMMON BETA-CHAIN | Inflammation - pathology | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Receptors, Interleukin-5 - chemistry | Humans | Crystallography, X-Ray | Receptors, Interleukin-3 - chemistry | Structure-Activity Relationship | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - chemistry | Leukemia, Myeloid - pathology | Inflammation - metabolism | Lymphocytes - immunology | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Interleukin-5 - chemistry | Lymphocytes - metabolism | Interleukin-3 - metabolism | Signal Transduction | Interleukin-3 - chemistry | Interleukin-5 - metabolism | Leukemia, Myeloid - immunology | Models, Molecular | Receptors, Interleukin-5 - immunology | Receptors, Interleukin-3 - metabolism | Inflammation - immunology | Interleukin-3 - immunology | Receptors, Interleukin-3 - immunology | Interleukin-5 - immunology | Lymphocytes - pathology | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Leukemia, Myeloid - metabolism | Protein Binding | Receptors, Interleukin-5 - metabolism | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - chemistry | Interleukins | Leukemia | Crystals | Macrophage colony stimulating factor | Structure | Cells | Membrane proteins
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