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Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 222 - 227
Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used... 
CELL LUNG-CANCER | RAS-TRANSFORMATION | OVEREXPRESSION | OXIDATIVE STRESS | HMTH1 | MESSENGER-RNA | GENE | MULTIDISCIPLINARY SCIENCES | HUMAN MUTT HOMOLOG | TUMORIGENESIS | SMALL-MOLECULE INHIBITION | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Pyridines - chemistry | Colonic Neoplasms - drug therapy | Humans | Substrate Specificity | DNA Breaks, Single-Stranded - drug effects | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Phosphoric Monoester Hydrolases - biosynthesis | DNA Repair Enzymes - metabolism | Female | Antineoplastic Agents - pharmacology | DNA Repair Enzymes - antagonists & inhibitors | Homeostasis - drug effects | Aminoquinolines - pharmacology | DNA Repair Enzymes - chemistry | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Pyrazoles - pharmacology | Crystallization | Models, Molecular | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Nucleotides - metabolism | Xenograft Model Antitumor Assays | Animals | Colonic Neoplasms - pathology | DNA Repair | DNA Repair Enzymes - biosynthesis | Proteomics | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Crizotinib | Enzymes | Colon cancer | Physiological aspects | Genetic aspects | Research | Nucleotides | Studies | Oxidative stress | Inhibitor drugs | Medical prognosis | Homeostasis | Mutation | Kinases | Experiments | Cancer | Life Sciences | crizotinib | cancer | stereoselectivity | MTH1 | DNA repair | drug
Journal Article
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 11/2018, Volume 51, Issue 1, pp. 80 - 96
Background/Aims: Chronic hepatitis B virus (HBV) infection markedly increases the risk of development of hepatocellular carcinoma (HCC). Among the seven viral... 
Original Paper | 8-oxo-7 | Hbv X protein | MTH2 (NUDT15) | MTH1 (NUDT1) | 8-dihydro-2.-deoxyguanosine | HMTH1 PROTEIN | PHYSIOLOGY | 5'-TRIPHOSPHATE PYROPHOSPHOHYDROLASE 8-OXO-DGTPASE | OXIDATIVE DNA-DAMAGE | LIVER-DISEASE | HUMAN MUTT HOMOLOG | HEPATOCELLULAR-CARCINOMA | HUMAN MTH1 | MESSENGER-RNA | OXIDIZED FORMS | 8-dihydro-2?-deoxyguanosine | MUTAGENIC SUBSTRATE | Hepatitis B - metabolism | Reactive Oxygen Species - metabolism | Hepatitis B virus - pathogenicity | Humans | DNA Repair Enzymes - genetics | Hepatitis B - virology | Pyrophosphatases - genetics | Male | Hepatocytes - metabolism | DNA Methylation | Hepatocytes - cytology | DNA Repair Enzymes - metabolism | Trans-Activators - genetics | Hepatitis B, Chronic - pathology | Deoxyguanosine - analogs & derivatives | Hepatitis B, Chronic - metabolism | DNA Damage - drug effects | Hydrogen Peroxide - toxicity | Promoter Regions, Genetic | Phosphoric Monoester Hydrolases - genetics | Mice, Inbred C57BL | Hepatitis B - pathology | Mice, Transgenic | Pyrophosphatases - metabolism | Animals | Cell Line, Tumor | Deoxyguanosine - metabolism | Trans-Activators - metabolism | Mice | Hepatitis B virus - metabolism | Phosphoric Monoester Hydrolases - metabolism | Proteins | Enzymes | Hepatitis | Oxidative stress | E coli | Epigenetics | Oxidation | Mitochondrial DNA | Deoxyribonucleic acid--DNA | Cancer | Index Medicus | 8-dihydro-2ʹ-deoxyguanosine
Journal Article
by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
by Berglund, U. Warpman and Warpman Berglund, U and Sanjiv, K and Sanjiv, K and Gad, H and Gad, H and Kalderén, C and Kalderén, C and Koolmeister, T and Koolmeister, T and Pham, T and Pham, T and Gokturk, C and Gokturk, C and Jafari, R and Jafari, R and Maddalo, G and Maddalo, G and Seashore-Ludlow, B and Seashore-Ludlow, B and Chernobrovkin, A and Chernobrovkin, A and Manoilov, A and Manoilov, A and Pateras, I.S and Pateras, I.S and Rasti, A and Rasti, A and Jemth, A-S and Jemth, A.-S and Almlöf, I and Almlöf, I and Loseva, O and Loseva, O and Visnes, T and Visnes, T and Einarsdottir, B.O and Einarsdottir, B.O and Gaugaz, F.Z and Gaugaz, F.Z and Saleh, A and Saleh, A and Platzack, B and Platzack, B and Wallner, O.A and Wallner, O.A and Vallin, K S A and Vallin, K.S.A and Henriksson, M and Henriksson, M and Wakchaure, P and Wakchaure, P and Borhade, S and Borhade, S and Herr, P and Herr, P and Kallberg, Y and Kallberg, Y and Baranczewski, P and Baranczewski, P and Homan, E.J and Homan, E.J and Wiita, E and Wiita, E and Nagpal, V and Nagpal, V and Meijer, T and Meijer, T and Schipper, N and Schipper, N and Rudd, S.G and Rudd, S.G and Bräutigam, L and Bräutigam, L and Lindqvist, A and Lindqvist, A and Filppula, A and Filppula, A and Lee, T.-C and Lee, T-C and Artursson, P and Artursson, P and Nilsson, J.A and Nilsson, J.A and Gorgoulis, V.G and Gorgoulis, V.G and Lehtiö, J and Lehtiö, J and Zubarev, R.A and Zubarev, R.A and Scobie, M and Scobie, M and Helleday, T and Helleday, Thomas and SP Process Development
Annals of oncology : official journal of the European Society for Medical Oncology, ISSN 0923-7534, 2016, Volume 27, Issue 12, pp. 2275 - 2283
Journal Article
FEBS Letters, ISSN 0014-5793, 08/2011, Volume 585, Issue 16, pp. 2617 - 2621
Journal Article
American Journal of Translational Research, ISSN 1943-8141, 2016, Volume 8, Issue 6, pp. 2803 - 2811
Malignant glioma is the most common primary tumor of the central nervous system. Chemotherapy and radiotherapy are the most common therapeutic approaches in... 
Stemness | Reactive oxygen species | GBM | MTH1 | Viability | CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | NUCLEOTIDE POOL | PROTEIN | GLIOMA | stemness | DNA-DAMAGE | REPAIR PATHWAYS | HUMAN MUTT HOMOLOG | viability | 8-OXOGUANINE | ONCOLOGY | OXIDIZED FORMS | reactive oxygen species | ROS
Journal Article