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Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 28, pp. 24638 - 24648
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 06/2003, Volume 107, Issue 22, pp. 2829 - 2836
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2015, Volume 25, Issue 20, pp. 4370 - 4381
.... However, despite intensive drug discovery efforts, even five decades later, no neutrophil elastase inhibitors are available for a disease-modifying treatment of (cardio... 
Medicinal chemistry | Elastase inhibitors | Induced fit | Heterocyclic chemistry | PAH | Biological activity | Protease–antiprotease balance | COPD | BE bronchiectasis | PAH pulmonary arterial hypertension | SIRS systemic inflammatory response syndrome | DMPK drug metabolism and pharmacokinetics | NCF non-cystic fibrosis | HNE human neutrophil elastase | SMOL small molecule | PH pulmonary hypertension | AATD alpha-1 antitrypsin deficiency | ARDS acute respiratory distress syndrome | Abbreviations AAT alpha-1 antitrypsin (alpha-1 proteinase inhibitor α-1 PI) | CF cystic fibrosis | COPD chronic obstructive pulmonary disease | NE neutrophil elastase | NSCLC non-small cell lung carcinoma | ALI acute lung injury | CHEMISTRY, MEDICINAL | SPUTUM | AZD9668 | CHEMISTRY, ORGANIC | ACUTE LUNG INJURY | Protease-antiprotease balance | NONOXIDATIVE MECHANISM | LEUKOCYTE ELASTASE | ORAL INHIBITOR | CATHEPSIN-G | QUANTUM PROTEOLYSIS | GENE-THERAPY | ELAFIN | Lung Diseases - metabolism | Cardiovascular Diseases - metabolism | Cardiovascular Diseases - drug therapy | Humans | Proteinase Inhibitory Proteins, Secretory - metabolism | Proteinase Inhibitory Proteins, Secretory - chemistry | Lung Diseases - drug therapy | Proteinase Inhibitory Proteins, Secretory - therapeutic use | Medical tests | Care and treatment | Lung diseases
Journal Article
The Journal of pathology, ISSN 1096-9896, 2019, Volume 248, Issue 1, pp. 88 - 102
.... In this context, pharmacological targeting of neutrophil elastase (NE) has shown promising anti... 
elastase | venular basement membrane | ischemia/reperfusion injury | neutrophil | MIGRATION | TRANSMIGRATION | MICE DEMONSTRATE | HUMAN-LEUKOCYTE ELASTASE | reperfusion injury | PATHOLOGY | ischemia | ISCHEMIA-REPERFUSION INJURY | ADHESION | ONCOLOGY | IN-VIVO | HOST-DEFENSE | JAM-A | INHIBITOR | Venules - physiopathology | Venules - pathology | Kidney - blood supply | Kidney - pathology | Male | Venules - enzymology | Basement Membrane - pathology | Myocardial Reperfusion Injury - enzymology | Neutrophil Infiltration - physiology | Myocardial Reperfusion Injury - pathology | Gene Deletion | Vascular Remodeling - physiology | Transendothelial and Transepithelial Migration - physiology | Basement Membrane - enzymology | Leukocyte Elastase - deficiency | Disease Models, Animal | Neutrophils - enzymology | Reperfusion Injury - pathology | Reperfusion Injury - enzymology | Mice, Inbred C57BL | Neutrophils - physiology | Leukocyte Elastase - genetics | Myocardial Reperfusion Injury - physiopathology | Mice, Knockout | Basement Membrane - physiopathology | Microscopy, Confocal | Leukocyte Elastase - physiology | Animals | Reperfusion Injury - physiopathology | Myocardial infarction | Animal models | Leukocyte migration | Confocal microscopy | Activation | Gene deletion | Macrophages | Remodeling | Impact analysis | Proteins | Cell activation | Reperfusion | Ischemia | Intestine | Animal tissues | Elastase | Matrix protein | Injuries | Cerebral infarction | Stroke | Diapedesis | Kidneys | Free radicals | Therapeutic applications | Neutrophils | Muscles | Leukocytes (neutrophilic) | Pharmacology | Inflammation | Entrapment | Monocytes | Microscopy | Infarction | Mice | Infiltration | Index Medicus
Journal Article