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Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2013, Volume 63, pp. 758 - 764
Journal Article
Scientific Reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, pp. 9054 - 9054
Aberrant cholesterol homeostasis and biosynthesis has been observed in different tumour types. This paper investigates the role of the post-squalenic enzyme of... 
COLON-CANCER | ANTIANGIOGENIC THERAPY | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | PANCREATIC-CANCER | 2,3-OXIDOSQUALENELANOSTEROL CYCLASE | RO 48-8071 | ANTIFUNGAL DRUG ITRACONAZOLE | GROWTH-FACTOR | INHIBITORS | HYPOXIA | Neoplasms - metabolism | Apoptosis - drug effects | Colonic Neoplasms - drug therapy | Humans | Benzophenones - pharmacology | Male | Phosphatidylinositol 3-Kinases - metabolism | Colonic Neoplasms - metabolism | Neoplasm Metastasis | Fluorouracil - administration & dosage | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | HCT116 Cells | Cell Adhesion - drug effects | Benzophenones - administration & dosage | Neoplasms - drug therapy | Intramolecular Transferases - metabolism | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Neovascularization, Pathologic - drug therapy | Colonic Neoplasms - pathology | Intramolecular Transferases - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Mice | Neovascularization, Pathologic - metabolism | Cholesterol - biosynthesis | Neoplasms - pathology | Adenocarcinoma | Enzymes | Phosphorylation | Animal models | Leukocyte migration | 5-Fluorouracil | Homeostasis | AKT protein | Biosynthesis | Metastasis | Cholesterol | Cell adhesion & migration | 1-Phosphatidylinositol 3-kinase | Metastases | Angiogenesis | Pancreatic carcinoma | Rodents | Cell adhesion | Colon | Pancreas | Cell migration | Cancer | Tumors | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2012, Volume 55, Issue 11, pp. 4990 - 5002
Ten oxidosqualene c-yclase inhibitors with high efficacy as cholesterol-lowering agents and of different chemical structure classes were evaluated as potential... 
GLIOMA-CELLS | LOVASTATIN | CHEMISTRY, MEDICINAL | LANOSTEROL CYCLASE | LIPID-METABOLISM | HUMAN GLIOBLASTOMA CELLS | IN-VIVO | DOWN-REGULATION | RO 48-8071 | STATINS | CHOLESTEROL-BIOSYNTHESIS | Alkynes - chemical synthesis | Antineoplastic Agents - chemical synthesis | Cyclohexanes - pharmacology | Humans | Anticholesteremic Agents - chemistry | Structure-Activity Relationship | Carbamates - chemistry | Neovascularization, Pathologic - pathology | Brain - blood supply | Alkynes - pharmacology | Cyclohexanes - chemistry | Antineoplastic Agents - pharmacology | Microsomes, Liver - enzymology | Angiogenesis Inhibitors - chemical synthesis | Heptanoic Acids - pharmacology | Carbamates - pharmacology | Anticholesteremic Agents - chemical synthesis | Cricetinae | Angiogenesis Inhibitors - pharmacology | Alkynes - chemistry | Antineoplastic Agents - chemistry | Cyclohexanes - chemical synthesis | Drug Synergism | Atorvastatin Calcium | Carbamates - chemical synthesis | Pyrroles - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Endothelial Cells - cytology | Intramolecular Transferases - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Anticholesteremic Agents - pharmacology | Angiogenesis Inhibitors - chemistry | Drug Screening Assays, Antitumor | Endothelial Cells - drug effects | Index Medicus
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2003, Volume 46, Issue 20, pp. 4240 - 4243
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 7/2014, Volume 146, Issue 1, pp. 51 - 62
Journal Article