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Cancer Cell, ISSN 1535-6108, 11/2015, Volume 28, Issue 5, pp. 557 - 568
Histone H3K36 trimethylation (H3K36me3) is frequently lost in multiple cancer types, identifying it as an important therapeutic target. Here we identify a... 
WEE1 inhibitor | KDM4A | SETD2 | DNA replication | RRM2 | histone modification | synthetic lethality | CDK | ChIP | H3.3K36M | H3K36me3 | AZD1775 | epigenetic target | iPOND | ATR inhibitor | CHK1 inhibitor | cancer | Synthetic lethality | IPOND | Histone modification | Epigenetic target | Cancer | EPIGENETIC REGULATORS | METHYLTRANSFERASE SETD2 | REPAIR | THERAPEUTIC STRATEGY | ONCOLOGY | GENOME INTEGRITY | S-PHASE | STRAND DNA BREAKS | HOMOLOGOUS RECOMBINATION | REPLICATION INITIATION | RENAL-CELL CARCINOMA | CELL BIOLOGY | Neoplasms - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Cell Survival - genetics | Molecular Sequence Data | Nucleotides - genetics | Neoplasms - prevention & control | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | Neoplasms - genetics | RNA Interference | Base Sequence | Cell Cycle Proteins - genetics | Lysine - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Ribonucleoside Diphosphate Reductase - metabolism | Nuclear Proteins - genetics | Pyrazoles - pharmacology | Amino Acid Sequence | Cell Survival - drug effects | Histone-Lysine N-Methyltransferase - genetics | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Ribonucleoside Diphosphate Reductase - genetics | Pyrimidines - pharmacology | Nucleotides - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Sequence Homology, Nucleic Acid | Blotting, Western | Sequence Homology, Amino Acid | Xenograft Model Antitumor Assays | Lysine - genetics | Animals | Histones - genetics | Histone-Lysine N-Methyltransferase - metabolism | Methylation - drug effects | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice, Inbred BALB C | Histones - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Medical colleges | Starvation | Hospitals | Epigenetic inheritance | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2011, Volume 17, Issue 17, pp. 5638 - 5648
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 11/2017, Volume 23, Issue 22, pp. 6993 - 7005
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 16, pp. 4540 - 4544
Wee1 is a protein kinase that regulates the G2 checkpoint and prevents entry into mitosis in response to DNA damage. Cyclindependent kinases (CDK) are a family... 
DNA-DAMAGING AGENTS | IN-VITRO | INHIBITOR AZD1775 | THERAPY | ONCOLOGY | P53-DEFICIENT TUMOR-CELLS | OVARIAN-CANCER | G CHECKPOINT | S-PHASE CHECKPOINT | MK-1775 | CYCLE | Neoplasms - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Antineoplastic Combined Chemotherapy Protocols - adverse effects | CDC2 Protein Kinase - metabolism | Carboplatin - adverse effects | Cell Cycle Proteins - antagonists & inhibitors | G2 Phase Cell Cycle Checkpoints - drug effects | Phosphorylation - drug effects | Pyrazoles - adverse effects | Pyrimidines - administration & dosage | Cell Cycle Proteins - metabolism | Carboplatin - administration & dosage | Nuclear Proteins - metabolism | Clinical Trials as Topic | Neoplasms - drug therapy | Pyrazoles - administration & dosage | Animals | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Models, Biological | Nuclear Proteins - antagonists & inhibitors | Pyrimidines - adverse effects | Drug Screening Assays, Antitumor | Protein-Tyrosine Kinases - antagonists & inhibitors | Cdc2 protein | Schedules | Phosphorylation | Mitosis | p53 Protein | DNA damage | Serine | Kinases | Damage prevention | DNA repair | Anticancer properties | Proteins | Cyclin B | Cell cycle | Inhibition | Deoxyribonucleic acid--DNA | Threonine | CHK1 protein | Cyclin-dependent kinases | Poly(ADP-ribose) polymerase | Side effects | Protein kinase | Carboplatin | Antitumor activity | Tumors | Cancer | Index Medicus
Journal Article
BMC Cancer, ISSN 1471-2407, 2011, Volume 11, Issue 1, pp. 156 - 156
Journal Article
Cancer Research, ISSN 0008-5472, 09/2017, Volume 77, Issue 17, pp. 4663 - 4672
G(1)-S checkpoint loss contributes to carcinogenesis and increases reliance upon the G(2)-M checkpoint for adaptation to stress and DNA repair, making... 
TARGET | INACTIVATION | VULNERABILITIES | IN-VITRO | PROTEIN | ONCOLOGY | SENSITIVITY | TUMOR-SUPPRESSOR | STRESS | LKB1 | EXPRESSION | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Cell Cycle Proteins - antagonists & inhibitors | Female | Phosphorylation - drug effects | Tumor Cells, Cultured | Drug Evaluation, Preclinical | Pyrazoles - pharmacology | Carcinoma, Non-Small-Cell Lung - pathology | Cell Survival - drug effects | Carcinoma, Non-Small-Cell Lung - metabolism | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Pyrimidines - pharmacology | Mutation - genetics | Animals | Cell Cycle Checkpoints - drug effects | Nuclear Proteins - antagonists & inhibitors | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Protein-Tyrosine Kinases - antagonists & inhibitors | Phosphorylation | Animal models | Toxicity | p53 Protein | Lung | Lung cancer | DNA damage | Radiation | Clinical trials | Cytotoxicity | Carcinogenesis | DNA repair | K-Ras protein | LKB1 protein | Carcinogens | Deoxyribonucleic acid--DNA | Medical research | Threonine | Data processing | Cisplatin | Molecular modelling | Inhibitors | Immune checkpoint | Cell lines | Tumor suppressor genes | Protein-serine/threonine kinase | Genetic engineering | Mutation | Viability | Radiation damage | Cancer | Apoptosis | Index Medicus
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 10/2015, Volume 33, Issue 30, pp. 3409 - 3415
Journal Article
Journal Article
Cell Cycle, ISSN 1538-4101, 07/2012, Volume 11, Issue 13, pp. 2507 - 2517
Targeting Chk1 protein kinase can enhance the antitumor effects of radio- and chemotherapy. Recent evidence disclosed a role of Chk1 in unperturbed cell... 
targeted therapy | WEE1 | Chk1 | in vivo antitumor activity | synthetic lethality | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | In vivo antitumor activity | Wee1 | Synthetic lethality | Targeted therapy | CHECKPOINT KINASE 1 | PHOSPHORYLATION | PROTEIN-KINASE | DNA-DAMAGE | G CHECKPOINT | CANCER-THERAPY | CELL BIOLOGY | GENOME INTEGRITY | CELL-CYCLE | ATR | Protein Kinases - metabolism | Protein Kinases - genetics | Pyrazoles - therapeutic use | Apoptosis - drug effects | DNA Replication - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | Protein Kinases - chemistry | Transplantation, Heterologous | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | RNA Interference | Cell Cycle Proteins - genetics | Female | Drug Therapy, Combination | Nuclear Proteins - genetics | Ovarian Neoplasms - drug therapy | Pyrazoles - pharmacology | Benzodiazepinones - pharmacology | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | Drug Synergism | Animals | Mitosis - drug effects | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Checkpoint Kinase 1 | Mice | Protein Kinase Inhibitors - pharmacology | Benzodiazepinones - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 18, Issue 3, pp. 244 - 257
Journal Article