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NATURE BIOTECHNOLOGY, ISSN 1087-0156, 06/2014, Volume 32, Issue 6, pp. 577 - 577
Genome editing by Cas9, which cleaves double-stranded DNA at a sequence programmed by a short single-guide RNA (sgRNA), can result in off-target DNA... 
CRISPR | IMMUNITY | RNA | NICKASES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HUMAN-CELLS | TARGET DNA | DNA-CLEAVAGE | PROTEINS | ZINC-FINGER NUCLEASES | REVEALS
Journal Article
Nature Biotechnology, ISSN 1087-0156, 01/2016, Volume 34, Issue 8, pp. 807 - 808
Journal Article
NATURE, ISSN 0028-0836, 03/2017, Volume 543, Issue 7646, pp. 573 - 573
Cell proliferation and survival require the faithful maintenance and propagation of genetic information, which are threatened by the ubiquitous sources of DNA... 
POLYMERASE-KAPPA | N-6-METHYLADENOSINE | LOCALIZATION | REPAIR | N6-METHYLADENOSINE | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | MOUSE | TRANSCRIPTION | POL-KAPPA | NUCLEAR-RNA
Journal Article
NATURE REVIEWS GENETICS, ISSN 1471-0056, 04/2012, Volume 13, Issue 4, pp. 271 - 282
MicroRNAs (miRNAs) have emerged as key gene regulators in diverse biological pathways. These small non-coding RNAs bind to target sequences in mRNAs, typically... 
MESSENGER-RNAS | POSTTRANSCRIPTIONAL REGULATION | CAENORHABDITIS-ELEGANS | TRANSLATIONAL REPRESSION | WIDE IDENTIFICATION | HUMAN-CELLS | GENETICS & HEREDITY | MIRNA TARGETS | BINDING PROTEIN HUR | SYSTEMATIC IDENTIFICATION | C. ELEGANS
Journal Article
Journal of Toxicology and Environmental Health, Part A, ISSN 1528-7394, 04/2019, Volume 82, Issue 7, pp. 473 - 482
Triclosan has been used in a large number of consumer products and concerns have been raised over regarding potential genotoxicity. However, the genotoxicity... 
genotoxicity | risk assessment | Triclosan | cytotoxicity | human cells
Journal Article
Nature Biotechnology, ISSN 1087-0156, 10/2016, Volume 34, Issue 10, pp. 1014 - 1015
Journal Article
Cell Reports, ISSN 2211-1247, 07/2013, Volume 4, Issue 1, pp. 220 - 228
Here, we present a simple and highly efficient method for generating and detecting mutations of any gene in through the use of the CRISPR/Cas9 system... 
IMMUNITY | REPAIR | GENE | HUMAN-CELLS | HOMOLOGOUS RECOMBINATION | IDENTIFICATION | CLEAVAGE | ZINC-FINGER NUCLEASES | GENOME | PROKARYOTES | CELL BIOLOGY | Index Medicus
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 05/2015, Volume 125, Issue 5, pp. 1998 - 2006
Current strategies to alter disease-associated epigenetic modifications target ubiquitously expressed epigenetic regulators. This approach does not allow... 
MEDICINE, RESEARCH & EXPERIMENTAL | DESIGN | DNA METHYLATION | GENE | HUMAN-CELLS | P16(INK4A) | PROTEINS
Journal Article
NATURE REVIEWS CANCER, ISSN 1474-175X, 12/2008, Volume 8, Issue 12, pp. 957 - 967
Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing gamma H2AX) is a sensitive marker for DNA double-strand breaks... 
GENOMIC INSTABILITY | HISTONE H2AX PHOSPHORYLATION | ONCOLOGY | HUMAN-CELLS | DOUBLE-STRAND BREAKS | ATM ACTIVATION | IONIZING-RADIATION | DNA-DAMAGE-RESPONSE | TOPOISOMERASE-I INHIBITORS | ATAXIA-TELANGIECTASIA | NUCLEOTIDE EXCISION-REPAIR
Journal Article
NATURE PLANTS, ISSN 2055-026X, 03/2017, Volume 3, Issue 3
Clustered regularly interspaced short palindromic repeats (CRISPR)-Cpf1 has emerged as an effective genome editing tool in animals. Here we compare the... 
SPECIFICITIES | HUMAN-CELLS | DNA | CPF1 | MICE | TARGETED MUTAGENESIS | NUCLEASES | PLANT SCIENCES
Journal Article
by Xie, KB and Yang, YN
MOLECULAR PLANT, ISSN 1674-2052, 11/2013, Volume 6, Issue 6, pp. 1975 - 1983
Targeted gene mutation was successfully achieved in rice using the CRISPRCas9 system. Experimental analyses of mutation efficiency and off-target effect as... 
genome editing | IMMUNITY | BACTERIA | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | gene targeting | CAS SYSTEMS | ZINC-FINGER NUCLEASES | DNA-BINDING SPECIFICITY | PLANT SCIENCES | EFFECTORS | ENDONUCLEASE | CRISPRCas
Journal Article
Nature, ISSN 0028-0836, 06/2018, Volume 558, Issue 7711, pp. 620 - 623
G-protein-coupled receptors (GPCRs) form the largest family of receptors encoded by the human genome (around 800 genes). They transduce signals by coupling to... 
Index Medicus
Journal Article
Nature Reviews Genetics, ISSN 1471-0056, 03/2010, Volume 11, Issue 3, pp. 191 - 203
Methylation of cytosine bases in DNA provides a layer of epigenetic control in many eukaryotes that has important implications for normal biology and disease.... 
BREAST-CANCER | DATABASE METHDB | CPG-ISLAND METHYLATION | MEDIATED CYTOSINE CONVERSION | POLYMERASE-CHAIN-REACTION | UTILITY PROGRAM | BISULFITE-TREATED DNA | HUMAN-CELLS | COLORECTAL-CANCER | GENETICS & HEREDITY | MASS-SPECTROMETRY | Physiological aspects | Epigenetic inheritance | Research | DNA damage
Journal Article