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1. Full Text Chromosomal aberrations +1q21 and del(17p13) predict survival in patients with recurrent multiple myeloma treated with lenalidomide and dexamethasone
by Klein, Ulrike and Jauch, Anna and Hielscher, Thomas and Hillengass, Jens and Raab, Marc S and Seckinger, Anja and Hose, Dirk and Ho, Anthony D and Goldschmidt, Hartmut and Neben, Kai
Cancer, ISSN 0008-543X, 05/2011, Volume 117, Issue 10, pp. 2136 - 2144
BACKGROUND: In the era of novel agents such as lenalidomide and bortezomib, risk stratification by chromosomal abnormalities may enable a more rational... 
overall survival | multiple myeloma | lenalidomide | cytogenetics | RISK | DELETION | MOLECULAR CLASSIFICATION | WORKING GROUP | PROGNOSTIC-FACTOR | THERAPY | PLUS DEXAMETHASONE | ONCOLOGY | STEM-CELL TRANSPLANTATION | DOSE CHEMOTHERAPY | Chromosome Deletion | Recurrence | Translocation, Genetic | Dexamethasone - administration & dosage | Prognosis | Humans | Middle Aged | Male | Thalidomide - administration & dosage | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Chromosomes, Human, Pair 1 | Chromosomes, Human, Pair 17 | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Chromosome Aberrations | Aged, 80 and over | Adult | Chromosomes, Human, Pair 14 | Female | Aged | Care and treatment | Dexamethasone | Patient outcomes | Multiple myeloma | Human chromosome abnormalities | Dosage and administration | Research
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2. Full Text Connexin 50 gene on human chromosome 1q21 is associated with schizophrenia in matched case–control and family-based studies
by Ni, Xingqun and Valente, Jose and Azevedo, Maria H and Pato, Michelle T and Pato, Carlos N and Kennedy, James L
Journal of Medical Genetics, ISSN 0022-2593, 08/2007, Volume 44, Issue 8, pp. 532 - 536
Background: The gap junction subunit connexin permits direct intercellular exchange of ions and molecules including glutamate, and plays an important role in... 
CELLS | GAP-JUNCTIONS | DISEASE | GENETICS & HEREDITY | NEURONAL DIFFERENTIATION | CENTRAL-NERVOUS-SYSTEM | CHANNELS | RAT-BRAIN | LINKAGE | EXPRESSION | PEDIGREE | Gene Frequency | Humans | Connexins - genetics | European Continental Ancestry Group | Genotype | Male | Reference Values | Case-Control Studies | Linkage Disequilibrium | Polymorphism, Genetic | Chromosomes, Human, Pair 1 | Schizophrenia - genetics | Polymerase Chain Reaction | Family | Female | Polymorphism, Single Nucleotide | Eye Proteins - genetics | Human chromosome 21 | Hardy-Weinberg formula | Familial diseases | Schizophrenia | Development and progression | Genetic aspects | Research | Methods | Studies | Haplotypes | Confidence intervals | Brain research | Sample size | Genes | Whites | Chromosomes | Patients | connexin 50 | family study | schizophrenia | matched case–control study | Letter to JMG | connexin 40
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3. Full Text Evidence of an epigenetic origin for high-risk 1q21 copy number aberrations in multiple myeloma
by Sawyer, Jeffrey R and Tian, Erming and Heuck, Christoph J and Johann, Donald J and Epstein, Joshua and Swanson, Charles M and Lukacs, Janet L and Binz, Regina Lichti and Johnson, Marian and Sammartino, Gael and Zangari, Maurizio and Davies, Faith E and Van Rhee, Frits and Morgan, Gareth J and Barlogie, Bart
Blood, ISSN 0006-4971, 06/2015, Volume 125, Issue 24, pp. 3756 - 3759
Multiple myeloma is a B-cell malignancy stratified in part by cytogenetic abnormalities, including the high-risk copy number aberrations (CNAs) of 11q21 and... 
HUMAN-CHROMOSOMES | DNA METHYLATION | MECHANISM | 5-AZACYTIDINE | PROGNOSIS | GENETICS | JUMPING TRANSLOCATIONS | HEMATOLOGY | EXPRESSION | PERICENTROMERIC HETEROCHROMATIN | HYPOMETHYLATION | Translocation, Genetic | DNA Methylation | Epigenesis, Genetic | Humans | Chromosome Aberrations | Gene Dosage | Chromosomes, Human, Pair 1 - genetics | Multiple Myeloma - genetics | Lymphoid Neoplasia | Brief Report | 102
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4. Clinical and biological characteristics multiple myeloma with 1q21 amplification
by Zhong, Shizhen and Li, Chengwen and Yi, Shihua and Qiu, Lugui
Zhonghua yi xue za zhi, ISSN 0376-2491, 03/2016, Volume 96, Issue 8, p. 615
To study the clinical features of multiple myeloma (MM) patients with 1q21 amplification and the detection and biological characteristics of 1q21 copy number... 
Chromosomes, Human, Pair 1 | Humans | Chromosome Aberrations | Paraproteinemias | In Situ Hybridization, Fluorescence | DNA Copy Number Variations | Multiple Myeloma
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5. Effect of 1q21 amplification on bortezomib therapeutic response and prognosis of newly diagnosed multiple myeloma patients
by Liu, X L and Yang, P Y and Yu, X Y and Chen, J C and Liu, X L and Bai, J and Liu, Y M and He, H and Sun, J N and Fan, H Q and Zhang, C and Zhang, Y and Su, K J and Liu, C S and Tan, Y H and Gao, S J and Li, W and Jin, F Y
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, ISSN 0253-2727, 05/2018, Volume 39, Issue 5, p. 408
To investigate the effect of 1q21 amplification (1q) on the therapeutic response and prognosis of bortezomib(Btz) in the treatment of newly diagnosed multiple... 
Multiple Myeloma - drug therapy | Prognosis | Bortezomib - therapeutic use | Humans | Chromosome Aberrations | Retrospective Studies
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6. Abnormal Karyotypes Involving 1q21 and 12p13 and Their Clinical Significance
by Jia, Ru and Sun, Wan-Ling
Zhongguo shi yan xue ye xue za zhi, ISSN 1009-2137, 10/2015, Volume 23, Issue 5, p. 1527
Many hematological malignances involve recurrent chromosomal abnormalities, and the reciprocal translocation is one of them. However, there are a lot of... 
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Translocation, Genetic | Chromosomes, Human, Pair 1 | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Chromosomes, Human, Pair 12 | Child | Abnormal Karyotype | Multiple Myeloma - genetics | Leukemia, Myeloid, Acute - genetics
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7. 1q21 abnormality associated with multiple primary malignant tumor: two cases report and literatures review
by Zhang, Q Q and Tang, X W and Wang, A J and Xue, S L and Tian, X P and Wang, T J and Yin, J and Wu, D P
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, ISSN 0253-2727, 03/2017, Volume 38, Issue 3, p. 247
Chromosomes, Human, Pair 1 | Humans | Neoplasms, Multiple Primary | Neoplasms
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8. Prognostic factors in newly diagnosed multiple myeloma patients with 1q21 amplification/gain treated with bortezomib-based regimens followed by autologous hematopoietic stem cell transplantation
by Huang, W Y and Zou, D H and Liu, W and An, G and Xu, Y and Sui, W W and Deng, S H and Li, C W and Liu, H and Li, J and Qiu, L G
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, ISSN 0253-2727, 06/2018, Volume 39, Issue 6, p. 496
To explore the prognostic factors in newly diagnosed multiple myeloma (NDMM) patients with 1q21 amplification/gain treated with bortezomib-based regimens... 
Bortezomib | Prognosis | Humans | Middle Aged | Hematopoietic Stem Cell Transplantation | Male | Transplantation, Autologous | Treatment Outcome | Stem Cell Transplantation | Disease-Free Survival | Multiple Myeloma - therapy | Chromosomes, Human, Pair 1 | Chromosome Aberrations | Adult | Female | Retrospective Studies
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9. Full Text Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family
by Schäfer, Beat W and Wicki, Roland and Engelkamp, Dieter and Mattei, Marie-geneviève and Heizmann, Claus W
Genomics, ISSN 0888-7543, 1995, Volume 25, Issue 3, pp. 638 - 643
S100 proteins are low-molecular-weight calcium-binding proteins of the EF-hand superfamily and appear to be involved in the regulation of a number of cellular... 
Multigene Family | S100 Proteins - genetics | Chromosomes, Human, Pair 1 | Chromosomes, Artificial, Yeast | Base Sequence | Humans | Molecular Sequence Data | Terminology as Topic | Chromosome Mapping | DNA Primers
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10. Investigation of 1q21 amplification in patients with multiple myeloma using I-FISH and cIg-FISH
by Yang, Rui-fang and Li, Chun-ming and Qiu, Hai-rong and Lu, Hua and Wu, Han-xin and Xu, Jia-ren and Zhang, Peng and Li, Jian-yong and Chen, Li-juan
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, ISSN 1003-9406, 12/2011, Volume 28, Issue 6, p. 686
To investigate the prevlance of 1q21 amplification in patients with multiple myeloma (MM) and its correlation with the progression and prognosis of the... 
Prognosis | Syndecan-1 - metabolism | Multiple Myeloma - diagnosis | Humans | Middle Aged | Male | Multiple Myeloma - metabolism | Chromosomes, Human, Pair 1 | Gene Amplification | Adult | Female | Aged | Neoplasm Staging | In Situ Hybridization, Fluorescence - methods | Multiple Myeloma - genetics
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11. Full Text High-Resolution YAC Fragmentation Map of 1q21
by Lioumi, Maria and Olavesen, M.G and Nizetic, Dean and Ragoussis, Jiannis
Genomics, ISSN 0888-7543, 04/1998, Volume 49, Issue 2, pp. 200 - 208
Chromosomal band 1q21 contains a number of genes, constituting the Epidermal differentiation complex (EDC), most of which are involved in the process of... 
LINKAGE MAP | CALCIUM-BINDING PROTEINS | HUMAN GENOME | CELL-ENVELOPE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HUMAN-CHROMOSOME 1Q21 | CATHEPSIN-K | GENETICS & HEREDITY | GENE FAMILY | MOLECULAR-CLONING | EPIDERMAL DIFFERENTIATION COMPLEX | ENVELOPE PROTEINS | Gene Expression | Base Sequence | Chromosome Mapping - methods | DNA Fragmentation | Humans | Bacteriophage P1 - genetics | Cloning, Molecular - methods | DNA, Complementary - biosynthesis | Chromosomes, Human, Pair 1 - genetics | Chromosomes, Artificial, Yeast - genetics | Databases, Factual | Protein binding
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12. Update on the epidermal differentiation complex
by Henry, Julie and Toulza, Eve and Hsu, Chiung-Yueh and Pellerin, Laurence and Balica, Stefana and Hautier, Juliette Mazereeuw and Paul, Carle and Serre, Guy and Jonca, Nathalie and Simon, Michel
Frontiers in Bioscience, ISSN 1093-9946, 01/2012, Volume 17, Issue 4, pp. 1517 - 1532
On human chromosome 1q21, a 2-Mb region called the epidermal differentiation complex comprises many genes encoding structural and regulatory proteins that are... 
Psoriasis | Atopic dermatitis | Keratinocytes | Epidermis | Cornified cell envelopes | Filaggrin | Review | Differentiation | Atopic Dermatitis | Cornified Cell Envelopes | FUSED-TYPE PROTEIN | CORNIFIED CELL-ENVELOPE | HUMAN-CHROMOSOME 1Q21 | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSGLUTAMINASE CROSS-LINKING | FILAMENT-ASSOCIATED PROTEIN | SKIN BARRIER FUNCTION | PROLINE-RICH PROTEINS | CAUSE ICHTHYOSIS VULGARIS | CELL BIOLOGY | ATOPIC-DERMATITIS | HAIR-FOLLICLE | Sequence Homology, Amino Acid | Amino Acid Sequence | Humans | Cornified Envelope Proline-Rich Proteins - metabolism | Molecular Sequence Data | Cell Differentiation | Phylogeny | Cornified Envelope Proline-Rich Proteins - chemistry | Epidermis - cytology
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13. Refined mapping of the loss of heterozygosity on chromosome 1q21 in gastric carcinoma
by Liu, Teng-fei and Yin, Zhi-hua and Gan, Run-liang and Zhao, Qiang and Dong, Lin and Zhou, Jian-guo and Dong, Bi-hua
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, ISSN 1673-4254, 07/2008, Volume 28, Issue 7, p. 1229
To obtain allelic loss mapping and define the minimal lost region on chromosome 1q21 in gastric carcinomas, and explore role of 1q21 loss of heterozygosity... 
Stomach Neoplasms - genetics | Humans | Middle Aged | Female | Male | Adenocarcinoma - genetics | Chromosome Mapping | Lymphatic Metastasis | Chromosomes, Human, Pair 1 - genetics | Loss of Heterozygosity | Microsatellite Repeats
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14. Full Text Further evidence for linkage of autosomal dominant medullary cystic kidney disease (ADMCKD) on chromosome 1q21
by Turunen, J.A and Jarvela, I and Ala-Mello, S and Auranen, M
American Journal of Human Genetics, ISSN 0002-9297, 10/2001, Volume 69, Issue 4, p. 506
Human chromosome abnormalities | Genetic aspects | Genetic disorders | Research | Kidney diseases | Human genetics
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15. Full Text Physical Mapping of a Functional Cluster of Epidermal Differentiation Genes on Chromosome 1q21
by Volz, Armin and Korge, Bernhard P and Compton, John G and Ziegler, Andreas and Steinert, Peter M and Mischke, Dietmar
Genomics, ISSN 0888-7543, 10/1993, Volume 18, Issue 1, pp. 92 - 99
Genes of three protein families, which are in part specifically expressed in the course of terminal differentiation of human epidermis, have previously been... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | Multigene Family | S100 Proteins | Membrane Proteins - genetics | Humans | Peptides - genetics | S100 Calcium Binding Protein A6 | Molecular Sequence Data | DNA Primers | Restriction Mapping | Annexins - genetics | Cell Differentiation - genetics | Proline-Rich Protein Domains | Chromosomes, Human, Pair 1 | Base Sequence | Cell Cycle Proteins | Calcium-Binding Proteins - genetics | Epidermis - cytology | ETIOLOGY | BASIC BIOLOGICAL SCIENCES | SKIN DISEASES | ANIMAL TISSUES | CHROMOSOMES | HUMAN CHROMOSOME 1 | ORGANS | DISEASES | EPITHELIUM | GENETIC MAPPING | 550400 - Genetics | EPIDERMIS | CELL DIFFERENTIATION | MAPPING | SKIN | TISSUES | BODY | HUMAN CHROMOSOMES
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16. Full Text Six S100 Genes are Clustered on Human Chromosome 1q21: Identification of Two Genes Coding for the Two Previously Unreported Calcium-Binding Proteins S100D and S100E
by Dieter Engelkamp and Beat W. Schafer and M. Genevieve Mattei and Paul Erne and Claus W. Heizmann
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/1993, Volume 90, Issue 14, pp. 6547 - 6551
The human genome contains large regions that are highly structured. Sequence-related members of multigene families are often found in a clustered organization.... 
Proteins | Polymerase chain reaction | Complementary DNA | Epithelial cells | Exons | Genes | Genomics | DNA | Amino acids | Chromosomes | gene cluster | chromosome 1 | cancer | Calcium-binding proteins | Analysis | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | DNA SEQUENCING | ORGANIC COMPOUNDS | METASTASES | CHROMOSOMES | 550900 - Pathology | ALKALINE EARTH METALS | CHROMOSOMAL ABERRATIONS | ELEMENTS | DISEASES | STRUCTURAL CHEMICAL ANALYSIS | METALS | GENETIC MAPPING | 550400 - Genetics | GENES | CALCIUM | MAPPING | MUTATIONS | PROTEINS | HUMAN CHROMOSOMES
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17. Full Text On the role of the epidermal differentiation complex in ichthyosis vulgaris, atopic dermatitis and psoriasis
by Hoffjan, S and Stemmler, S
British Journal of Dermatology, ISSN 0007-0963, 09/2007, Volume 157, Issue 3, pp. 441 - 449
Summary Undisturbed epidermal differentiation is crucial for an intact skin barrier function. The epidermal differentiation complex (EDC) is a cluster of genes... 
atopic dermatitis | epidermal differentiation complex | ichthyosis | psoriasis | Epidermal differentiation complex | Psoriasis | Atopic dermatitis | Ichthyosis | HUMAN-CHROMOSOME 1Q21 | BARRIER FUNCTION | FLAKY TAIL | SUSCEPTIBILITY LOCI | OF-FUNCTION MUTATIONS | FUNCTION VARIANTS | PROLINE-RICH PROTEINS | CORNIFIED ENVELOPE | DERMATOLOGY | FILAGGRIN GENE PREDISPOSE | GRANULAR LAYER | Dermatitis, Atopic - genetics | Genetic Predisposition to Disease - genetics | Psoriasis - genetics | Pedigree | Humans | Intermediate Filament Proteins - genetics | Female | Male | Chromosomes, Human, Pair 1 - genetics | Ichthyosis Vulgaris - genetics | Mutation - genetics | Genetic Linkage
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18. Full Text Regulation of the Dynamic Chromatin Architecture of the Epidermal Differentiation Complex Is Mediated by a c-Jun/AP-1-Modulated Enhancer
by Oh, Inez Y and Albea, Danielle M and Goodwin, Zane A and Quiggle, Ashley M and Baker, Breeana P and Guggisberg, Ann M and Geahlen, Jessica H and Kroner, Grace M and de Guzman Strong, Cristina
Journal of Investigative Dermatology, ISSN 0022-202X, 09/2014, Volume 134, Issue 9, pp. 2371 - 2380
The epidermal differentiation complex (EDC) locus comprises a syntenic and linear cluster of genes whose concomitant expression is a hallmark feature of... 
ORGANIZATION | ATOPIC-DERMATITIS | ICHTHYOSIS VULGARIS | HUMAN-CHROMOSOME 1Q21 | SUSCEPTIBILITY LOCI | GENE-EXPRESSION | FILAGGRIN MUTATIONS | MECHANISMS | SKIN BARRIER FUNCTION | CORNIFIED ENVELOPE | DERMATOLOGY | Animals, Newborn | Multigene Family - genetics | Transcription Factor AP-1 - genetics | Humans | Gene Expression Regulation, Developmental - genetics | Mice, Transgenic | Mice, Inbred Strains | Transcription Factor AP-1 - metabolism | RNA - genetics | Pregnancy | Cell Differentiation - genetics | Animals | Epidermis - physiology | Chromatin - physiology | Epidermis - embryology | Female | Enhancer Elements, Genetic - genetics | Epidermis - cytology | Lac Operon
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19. Full Text Metastasis promoter S100A4 is a potentially valuable molecular target for cancer therapy
by Sherbet, G.V
Cancer Letters, ISSN 0304-3835, 2008, Volume 280, Issue 1, pp. 15 - 30
Abstract The growth, invasion and metastatic spread of cancer have been identified with the deregulation of cell proliferation, altered intercellular and... 
Hematology, Oncology and Palliative Medicine | Cell proliferation | Angiogenesis | S100A4 | Metastasis | Invasion | Apoptosis | Therapeutic targets | 18A2/MTS1 GENE-EXPRESSION | HUMAN-CHROMOSOME 1Q21 | E-CADHERIN EXPRESSION | MATRIX-METALLOPROTEINASE EXPRESSION | EPIDERMAL DIFFERENTIATION COMPLEX | SUPPRESSOR P53 PROTEIN | ONCOLOGY | B16 MURINE MELANOMA | EPITHELIAL TUMOR-CELLS | CALCIUM-BINDING PROTEIN | GLYCATION END-PRODUCTS | Neoplasms - metabolism | Cell Proliferation | S100 Proteins - antagonists & inhibitors | Signal Transduction | Neoplasm Invasiveness | S100 Calcium-Binding Protein A4 | Humans | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | Wnt Proteins - metabolism | Tissue Inhibitor of Metalloproteinases - metabolism | Neoplasms - drug therapy | Neoplasm Metastasis | Models, Biological | Cytoskeleton - metabolism | Cell Differentiation | S100 Proteins - physiology | Antimitotic agents | Care and treatment | Analysis | Antineoplastic agents | Health aspects | Cancer | Hands | Enzymes | Transcription factors | Motility | Genes | Cell division | Cell adhesion & migration | Proteins | Cell growth | Rodents | Cell cycle | Binding sites | Crystal structure
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20. Full Text Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function
by Wolf, Ronald and Wolf, Ronald and Ruzicka, Thomas and Ruzicka, Thomas and Yuspa, Stuart H and Yuspa, Stuart H
Amino Acids, ISSN 0939-4451, 10/2011, Volume 41, Issue 4, pp. 789 - 796
S100A7 (psoriasin) and S100A15 (koebnerisin) were first identified in inflamed psoriatic skin. They are of major interest because of their putative functional... 
Biochemistry, general | Psoriasin | Koebnerisin | Paralogs | Neurobiology | Innate immunity | Inflammation | RAGE | Life Sciences | Analytical Chemistry | Life Sciences, general | Calcium-binding protein | Biochemical Engineering | Proteomics | S100 | Evolution | Cancer | HUMAN-CHROMOSOME 1Q21 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PSORIASIN S100A7 | SUBCELLULAR-LOCALIZATION | EPIDERMAL DIFFERENTIATION COMPLEX | CORNIFIED ENVELOPE | BREAST-CANCER | ATOPIC-DERMATITIS | MOLECULAR-CLONING | PROTEIN PSORIASIN | GLYCATION END-PRODUCTS | Neoplasms - metabolism | S100 Calcium Binding Protein A7 | Amino Acid Sequence | Epithelial Cells - metabolism | Humans | Molecular Sequence Data | Epithelial Cells - pathology | S100 Proteins - metabolism | S100 Proteins - chemistry | Sequence Homology, Amino Acid | Inflammation - metabolism | S100 Proteins - genetics | Chromosomes, Human, Pair 1 | Human | Reproduction | Control | Genes | Homeostasis | Amino acids | Homology
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