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1. Full Text Benzyl Lsothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway
by Lai, Kuang-Chi and Huang, A.N.-Cheng and Hsu, Shu-Chun and Kuo, Chao-Lin and Yang, Jai-Sing and Wu, Shin-Hwar and Chung, Jing-Gung
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 03/2010, Volume 58, Issue 5, pp. 2935 - 2942
Migration | MMP2 | BITC | Human colon cancer ht29 cells | MMP9 | Invasion
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2. Full Text Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis
by Lee, Lennard Y.W and Woolley, Connor and Starkey, Thomas and Biswas, Sujata and Mirshahi, Tia and Bardella, Chiara and Segditsas, Stefania and Irshad, Shazia and Tomlinson, Ian
Clinical Cancer Research, ISSN 1078-0432, 01/2019, Volume 25, Issue 2, pp. 629 - 640
Purpose: The molecular events that determine intestinal cell differentiation are poorly understood and it is unclear whether it is primarily a passive event or... 
HUMAN COLON | TARGET | ACTIVATION | GENE | ONCOLOGY | ADENOCARCINOMA | RESISTANCE
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3. Full Text Influence of gender, age, shelf-life, and conservation method on the biomechanical behavior of colon tissue under dynamic solicitation
by Massalou, D and Masson, C and Afquir, S and Baqué, P and Arnoux, P.-J and Bège, T
Clinical Biomechanics, ISSN 0268-0033, 05/2019, Volume 65, pp. 34 - 40
Data from biomechanical tissue sample studies of the human digestive tract are highly variable. The aim of this study was to investigate 4 factors which could... 
Biomechanics | Colonic mechanical response | Human colon | Dynamic solicitation
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4. Full Text Addition of bevacizurnab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
by Kabbinavar, FF and Schulz, J and McCleod, M and Patel, T and Hamm, JT and Hecht, JR and Mass, R and Perrou, B and Nelson, B and Novotny, WF
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 06/2005, Volume 23, Issue 16, pp. 3697 - 3705
Purpose Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, increases survival when combined with irinotecan-based chemotherapy in... 
SOLID TUMORS | ANGIOGENESIS | ONCOLOGY | HUMAN COLON-CANCER | IN-VIVO | IRINOTECAN | MONOCLONAL-ANTIBODY | LIVER METASTASIS | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | PLUS FLUOROURACIL
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5. Full Text A big bang model of human colorectal tumor growth
by Sottoriva, Andrea and Kang, Haeyoun and Ma, Zhicheng and Graham, Trevor A and Salomon, Matthew P and Zhao, Junsong and Marjoram, Paul and Siegmund, Kimberly and Press, Michael F and Shibata, Darryl and Curtis, Christina
Nature Genetics, ISSN 1061-4036, 02/2015, Volume 47, Issue 3, pp. 209 - 216
What happens in early, still undetectable human malignancies is unknown because direct observations are impractical. Here we present and validate a 'Big Bang'... 
HUMAN COLON | STEM-CELLS | PASSENGER MUTATIONS | EVOLUTION | GENETIC INSTABILITY | CLONAL EXPANSION | INTRATUMOR HETEROGENEITY | METHYLATION PATTERNS | COPY NUMBER | GENETICS & HEREDITY | CANCER PROGRESSION | Models, Biological | Colorectal Neoplasms - genetics | Humans | Models, Genetic | Cell Growth Processes - genetics | Colorectal Neoplasms - pathology | Genetic Heterogeneity | Genetic aspects | Research | Gene mutations | Health aspects | Colorectal cancer | Genomes | Mutation | Cloning | Data bases | Tumors | Index Medicus
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6. Full Text p53 isoforms Delta 133p53 and p53 beta are endogenous regulators of replicative cellular senescence
by Fujita, K and Mondal, AM and Horikawa, I and Nguyen, GH and Kumamoto, K and Sohn, JJ and Bowman, ED and Mathe, EA and Schetter, AJ and Pine, SR and Ji, H and Vojtesek, B and Bourdon, JC and Lane, DP and Harris, CC
NATURE CELL BIOLOGY, ISSN 1465-7392, 09/2009, Volume 11, Issue 9, pp. 1135 - U208
The finite proliferative potential of normal human cells leads to replicative cellular senescence, which is a critical barrier to tumour progression in... 
APOPTOSIS | CELLS | DOWNSTREAM TARGET | MIR-34A | HUMAN-COLON | GENE | DNA-DAMAGE | ONCOGENE-INDUCED SENESCENCE | EXPRESSION | CANCER | CELL BIOLOGY
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7. Full Text The COX-2/PGE(2) pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment
by Greenhough, A and Smartt, HJM and Moore, AE and Roberts, HR and Williams, AC and Paraskeva, C and Kaidi, A
CARCINOGENESIS, ISSN 0143-3334, 03/2009, Volume 30, Issue 3, pp. 377 - 386
It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the abundance of its enzymatic product prostaglandin E-2 (PGE(2)) have key... 
SIZE-DEPENDENT INCREASE | ONCOLOGY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | EPIDERMAL-GROWTH-FACTOR | HUMAN COLON-CANCER | CYCLOOXYGENASE-2 EXPRESSION | FAMILIAL ADENOMATOUS POLYPOSIS | NF-KAPPA-B | INTESTINAL EPITHELIAL-CELLS | PROSTAGLANDIN E-2 | HUMAN COLORECTAL-CANCER
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8. Full Text The association between copy number aberration, DNA methylation and gene expression in tumor samples
by Sun, Wei and Bunn, Paul and Jin, Chong and Little, Paul and Zhabotynsky, Vasyl and Perou, Charles M and Hayes, David Neil and Chen, Mengjie and Lin, Dan-Yu
Nucleic Acids Research, ISSN 0305-1048, 04/2018, Volume 46, Issue 6, pp. 3009 - 3018
Abstract We systematically studied the association between somatic copy number aberration (SCNA), DNA methylation and gene expression using -omic data from The... 
HUMAN COLON | SITES | GENOMICS | CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | BREAST | Genomics
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9. Full Text Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2
by Tolhurst, Gwen and Heffron, Helen and Lam, Yu Shan and Parker, Helen E and Habib, Abdella M and Diakogiannaki, Eleftheria and Cameron, Jennifer and Grosse, Johannes and Reimann, Frank and Gribble, Fiona M
Diabetes, ISSN 0012-1797, 02/2012, Volume 61, Issue 2, pp. 364 - 371
Interest in how the gut microbiome can influence the metabolic state of the host has recently heightened. One postulated link is bacterial fermentation of... 
HUMAN COLON | PROPIONATE | GLP-1 | RAT | RESISTANT STARCH | ENDOCRINOLOGY & METABOLISM | GPR41 | FUNCTIONAL-CHARACTERIZATION | ACETATE | IDENTIFICATION | Physiological aspects | Cell receptors | Research | Peptides | Fatty acids | Index Medicus | Abridged Index Medicus | Signal Transduction
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10. Full Text Implications of epigenetic drift in colorectal neoplasia
by Luebeck, Georg E and Hazelton, William D and Curtius, Kit and Maden, Sean K and Yu, Ming and Carter, Kelly T and Burke, Wynn and Lampe, Paul D and Li, Christopher I and Ulrich, Cornelia M and Newcomb, Polly A and Westerhoff, Maria and Kaz, Andrew M and Luo, Yanxin and Inadomi, John M and Grady, William M
Cancer Research, ISSN 0008-5472, 02/2019, Volume 79, Issue 3, pp. 495 - 504
Many normal tissues undergo age-related drift in DNA methylation, providing a quantitative measure of tissue age. Here, we identify and validate 781 CpG... 
HUMAN COLON | METHYLATION | ONCOLOGY | LANDSCAPE | PATHWAY | PROLIFERATION | MUTATIONS | REVEAL | CANCER | PROGRESSION | LESIONS
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11. Full Text Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids
by Matano, Mami and Date, Shoichi and Shimokawa, Mariko and Takano, Ai and Fujii, Masayuki and Ohta, Yuki and Watanabe, Toshiaki and Kanai, Takanori and Sato, Toshiro
Nature Medicine, ISSN 1078-8956, 2015, Volume 21, Issue 3, pp. 256 - 262
Human colorectal tumors bear recurrent mutations in genes encoding proteins operative in the WNT, MAPK, TGF-beta, TP53 and PI3K pathways(1,2). Although these... 
HUMAN COLON | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | NICHE | CELL BIOLOGY | IN-VITRO | PATHWAY | EXPANSION | GENES | TUMORIGENESIS | EXPRESSION | Intestinal Mucosa | Adenoma - genetics | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Genes, APC | Phosphatidylinositol 3-Kinases - genetics | Genes, p53 | Animals | Class I Phosphatidylinositol 3-Kinases | Organoids | Smad4 Protein - genetics | Clustered Regularly Interspaced Short Palindromic Repeats | Adenocarcinoma - genetics | Mice | Mutation | Genes, ras | In Vitro Techniques | Models | Genetic aspects | Genetic engineering | Tissue engineering | Methods | Colorectal cancer | Small intestine | Tumors | Index Medicus
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12. Full Text NOD-scidIl2rgtm1Wjl and NOD-Rag1nullIl2rg tm1Wjl: A model for stromal cell-tumor cell interaction for human colon cancer
by Maykel, Justin and Liu, Jian Hua and Li, Hanchen and Shultz, Leonard D and Greiner, Dale L and Houghton, JeanMarie
Digestive Diseases and Sciences, ISSN 0163-2116, 2014, Volume 59, Issue 6, pp. 1169 - 1179
Human colon cancer | NRG | NSG | Immunodeficient mouse models | Tumor stroma
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13. Full Text Unstable genome and transcriptome dynamics during tumor metastasis contribute to therapeutic heterogeneity in colorectal cancers
by Cho, Sung-Yup and Chae, Jeesoo and Na, Deukchae and Kang, Wonyoung and Lee, Ahra and Min, Seoyeon and Kang, Jinjoo and Choi, Boram and Lee, Jieun and Sung, Chang Ohk and Chuang, Jeffrey H and Lee, Charles and Lee, Won-Suk and Park, Hansoo and Kim, Jong-Il
Clinical Cancer Research, ISSN 1078-0432, 2019, Volume 25, Issue 9, pp. 2821 - 2834
Purpose: Genomic and transcriptomic alterations during metastasis are considered to affect clinical outcome of colorectal cancers, but detailed clinical... 
HUMAN COLON | EVOLUTION | INSTABILITY | MODELS | ONCOLOGY | INTRATUMOR HETEROGENEITY | RESISTANCE | MUTATIONS | XENOGRAFTS
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14. Full Text Multi-omics Characterization of Interactionmediated Control of Human Protein Abundance levels
by Sousa, A and Goncalves, E and Mirauta, B and Ochoa, D and Stegle, O and Beltrao, P
MOLECULAR & CELLULAR PROTEOMICS, ISSN 1535-9476, 08/2019, Volume 18, pp. S114 - S125
Proteogenomic studies of cancer samples have shown that copy-number variation can be attenuated at the protein level for a large fraction of the proteome,... 
HUMAN COLON | RNA | PROTEOGENOMIC CHARACTERIZATION | STABILITY | GENE ORDER | BIOCHEMICAL RESEARCH METHODS | R PACKAGE | CANCER | EXPRESSION
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15. Full Text Myogenic effect of SP-1f and SP-1h two novel 3-adrenoceptor (3-AR) agonists in human colonic circular smooth muscle
by Maselli, Maria Antonietta and Trisolini, Piero and Ignazzi, Antonia and Notarnicola, Maria and Lorusso, Dionigi and Pezzolla, Francesco and Iacobazzi, Dominga and Scilimati, Antonio and Perrone, Maria Grazia
European Journal of Pharmacology, ISSN 0014-2999, 01/2014, Volume 723, Issue 1, pp. 62 - 66
The effect of two novel -adrenoceptor ( -AR) agonists SP-1f and SP-1h on human colon circular smooth muscle contractility and -AR mRNA expression have been... 
AR | Agonist | Human colon motility | Adrenoceptor
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16. Full Text Advantages of Fluorescence-Guided Laparoscopic Surgery of Pancreatic Cancer Labeled with Fluorescent Antie-Carcinoembryonic Antigen Antibodies in an Orthotopic Mouse Model
by Metildi, CA and Kaushal, S and Luiken, GA and Hoffman, RM and Bouvet, M
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, ISSN 1072-7515, 07/2014, Volume 219, Issue 1, pp. 132 - 141
BACKGROUND: Our laboratory has previously developed fluorescence-guided surgery of pancreatic and other cancers in orthotopic mouse models. Laparoscopic... 
SURVIVAL | SURGERY | NUDE-MICE | IMAGING-SYSTEM | CEA ANTIBODY | HUMAN COLON-CANCER | TUMOR | PATIENT | FUTURE | COMPLETE RESECTION
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17. Full Text Autonomous Multimodal Metabolomics Data Integration for Comprehensive Pathway Analysis and Systems Biology
by Huan, Tao and Palermo, Amelia and Ivanisevic, Julijana and Rinehart, Duane and Edler, David and Phommavongsay, Thiery and Benton, H. Paul and Guijas, Carlos and Domingo-Almenara, Xavier and Warth, Benedikt and Siuzdak, Gary
Analytical Chemistry, ISSN 0003-2700, 07/2018, Volume 90, Issue 14, pp. 8396 - 8403
Comprehensive metabolomic data can be achieved using multiple orthogonal separation and mass spectrometry (MS) analytical techniques. However, drawing... 
HUMAN COLON | CHEMISTRY, ANALYTICAL | METABOLITES | MASS-SPECTROMETRY DATA | OMICS DATA | COVERAGE | XCMS | Index Medicus
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18. Full Text Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
by Calon, Alexandre and Lonardo, Enza and Berenguer-Llergo, Antonio and Espinet, Elisa and Hernando-Momblona, Xavier and Iglesias, Mar and Sevillano, Marta and Palomo-Ponce, Sergio and Tauriello, Daniele V.F and Byrom, Daniel and Cortina, Carme and Morral, Clara and Barceló, Carles and Tosi, Sebastien and Riera, Antoni and Attolini, Camille Stephan-Otto and Rossell, David and Sancho, Elena and Batlle, Eduard
Nature Genetics, ISSN 1061-4036, 04/2015, Volume 47, Issue 4, pp. 320 - 329
Recent molecular classifications of colorectal cancer (CRC) based on global gene expression profiles have defined subtypes displaying resistance to therapy and... 
MOLECULAR SUBTYPES | GROWTH-FACTOR-BETA | TGF-BETA | METASTASIS | HUMAN-COLON | GENETICS & HEREDITY | STEM-CELL | RECEPTOR | TUMOR-GROWTH | TUMORIGENESIS | GENOME | Prognosis | Neoplasm Invasiveness | Stromal Cells - pathology | Colorectal Neoplasms - genetics | Humans | Stromal Cells - metabolism | Gene Expression Regulation, Neoplastic | Transcriptome | Colorectal Neoplasms - classification | Fibroblasts - pathology | Colorectal Neoplasms - diagnosis | HT29 Cells | Neoplasm Metastasis | Animals | Neoplastic Stem Cells - metabolism | Mice, Nude | Microarray Analysis | Neoplastic Stem Cells - pathology | Mice | Colorectal Neoplasms - pathology | Cluster Analysis | Fibroblasts - metabolism | Oncology, Experimental | Colorectal cancer | Genetic research | Development and progression | Genetic aspects | Research | Gene expression | Cancer | Datasets | Medical prognosis | Metastasis | Experiments | Cancer therapies | Patients | Tumors | Index Medicus
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19. Full Text Evaluation of bacteriophage therapy to control clostridium difficile and toxin production in an invitro human colon model system
by Meader, Emma and Mayer, Melinda J and Steverding, Dietmar and Carding, Simon R and Narbad, Arjan
Anaerobe, ISSN 1075-9964, 08/2013, Volume 22, pp. 25 - 30
Clostridium difficile is a leading cause of hospital-acquired diarrhoea and represents a major challenge for healthcare providers. Due to the decreasing... 
Toxin | Bacteriophage therapy | Clostridium difficile | Lysogeny | Human colon model
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20. Full Text Serine Threonine Kinase 17A Maintains the Epithelial State in Colorectal Cancer Cells
by Short, SP and Thompson, JJ and Bilotta, AJ and Chen, X and Revetta, FL and Washington, MK and Williams, CS
MOLECULAR CANCER RESEARCH, ISSN 1541-7786, 04/2019, Volume 17, Issue 4, pp. 882 - 894
Serine threonine kinase 17A (STK17A) is a ubiquitously expressed kinase originally identified as a regulator of apoptosis; however, whether it functionally... 
HUMAN COLON | APOPTOSIS | ACTIVATION | TGF-BETA | GENE | ONCOLOGY | STATISTICS | PROTEIN-KINASE | ADENOCARCINOMA | DEATH | BINDING | CELL BIOLOGY
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