X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
human-leukocyte elastase (876) 876
humans (579) 579
biochemistry & molecular biology (336) 336
animals (293) 293
chemistry, organic (233) 233
cathepsin-g (212) 212
chemistry, medicinal (199) 199
index medicus (153) 153
kinetics (146) 146
porcine pancreatic elastase (142) 142
male (133) 133
inhibitors (130) 130
pharmacology & pharmacy (125) 125
leukocyte elastase - antagonists & inhibitors (123) 123
human neutrophil elastase (121) 121
amino acid sequence (119) 119
molecular sequence data (115) 115
pancreatic elastase - antagonists & inhibitors (115) 115
structure-activity relationship (113) 113
serine proteases (112) 112
elastase (109) 109
derivatives (103) 103
human leukocyte elastase (100) 100
leukocyte elastase (100) 100
leukocyte elastase - metabolism (97) 97
serine proteinase inhibitors - pharmacology (92) 92
female (91) 91
neutrophil elastase (89) 89
pancreatic elastase - metabolism (87) 87
chemistry, multidisciplinary (84) 84
models, molecular (84) 84
neutrophils - enzymology (81) 81
proteases (81) 81
substrate specificity (77) 77
design (76) 76
molecular structure (76) 76
middle aged (75) 75
binding sites (74) 74
cell biology (73) 73
serine proteinase inhibitors - chemistry (72) 72
mechanism (70) 70
hydrolysis (68) 68
cathepsin g (66) 66
drug design (65) 65
aged (64) 64
chymotrypsin (61) 61
research (61) 61
adult (60) 60
crystal-structure (60) 60
emphysema (60) 60
human-leukocyte (60) 60
serine endopeptidases - metabolism (59) 59
swine (58) 58
inflammation (57) 57
inhibition (57) 57
mechanism-based inhibitors (56) 56
enzyme inhibitors - pharmacology (55) 55
enzymes (55) 55
rats (54) 54
alpha-1-proteinase inhibitor (53) 53
alpha-chymotrypsin (53) 53
chemistry (51) 51
biophysics (50) 50
inhibitor (50) 50
mice (50) 50
protein binding (50) 50
respiratory system (50) 50
degradation (49) 49
analysis (48) 48
protease inhibitors (46) 46
cattle (43) 43
immunology (43) 43
neutrophils (42) 42
peptides (42) 42
serine endopeptidases (40) 40
cystic-fibrosis (39) 39
nonpeptidic inhibitors (39) 39
protease inhibitors - pharmacology (39) 39
complex (38) 38
enzyme inhibitors - chemistry (38) 38
protease (38) 38
pancreatic elastase - chemistry (37) 37
serine proteinase inhibitors - chemical synthesis (37) 37
protein conformation (36) 36
proteins (36) 36
specificity (36) 36
pancreatic elastase - blood (35) 35
substrate (35) 35
binding (34) 34
cathepsins - antagonists & inhibitors (34) 34
crystallography, x-ray (34) 34
benzoxazinones (33) 33
catalysis (33) 33
obstructive pulmonary-disease (33) 33
dose-response relationship, drug (32) 32
serine endopeptidases - chemistry (32) 32
acid (31) 31
activation (31) 31
enzyme (31) 31
in vitro techniques (31) 31
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
IMMUNITY, ISSN 1074-7613, 06/2015, Volume 42, Issue 6, pp. 1075 - 1086
Breaching endothelial cells (ECs) is a decisive step in the migration of leukocytes from the vascular lumen to the extravascular tissue, but fundamental... 
ADHESION | MOLECULE | VENULAR WALLS | INFLAMMATION | AMMATORY ARTHRITIS | HUMAN-LEUKOCYTE ELASTASE | ACUTE LUNG INJURY | VASCULAR-PERMEABILITY | IMMUNOLOGY | INHIBITOR | RESPIRATORY-DISTRESS-SYNDROME
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, p. 6722
An imbalance between neutrophil-derived proteases and extracellular inhibitors is widely regarded as an important pathogenic mechanism for lung injury. Despite... 
PROTEINASE-INHIBITORS | CHYMOTRYPSIN | EVOLUTION | DISEASES | SERINE PROTEASES | ALPHA-PROTEINASE INHIBITOR | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | EMPHYSEMA | HUMAN-LEUKOCYTE ELASTASE | ALPHA-1-ANTITRYPSIN DEFICIENCY | Leukocyte Elastase - metabolism | Small Molecule Libraries - pharmacology | Peptides - antagonists & inhibitors | Humans | Molecular Sequence Data | Leukocyte Elastase - antagonists & inhibitors | Peptides - administration & dosage | Pulmonary Emphysema - chemically induced | Lung - enzymology | Leukocyte Elastase - administration & dosage | Peptides - metabolism | Proteolysis | HEK293 Cells | Female | Neutrophils - pathology | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Gene Expression | Lung - pathology | Macrophages - pathology | Neutrophils - enzymology | Peptides - chemistry | Mice, Inbred C57BL | Neutrophils - drug effects | Pulmonary Emphysema - pathology | Recombinant Proteins - chemistry | Pulmonary Emphysema - drug therapy | Recombinant Proteins - administration & dosage | Sequence Homology, Amino Acid | Proteinase Inhibitory Proteins, Secretory - pharmacology | Animals | Leukocyte Elastase - chemistry | Lung - drug effects | alpha 1-Antitrypsin - pharmacology | Macrophages - drug effects | Mice | Cytokines - biosynthesis | Pulmonary Emphysema - enzymology
Journal Article
Journal Article
MOLECULAR & CELLULAR PROTEOMICS, ISSN 1535-9476, 08/2017, Volume 16, Issue 8, pp. 1507 - 1527
Journal Article