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Cellular Signalling, ISSN 0898-6568, 07/2019, Volume 59, pp. 96 - 109
The healthy vascular endothelium constantly releases autacoids which cause an increase of intracellular cyclic nucleotides to tame platelets from inappropriate... 
Epinephrine | α | adrenoceptor | Human platelets | Nitric oxide | Cyclic nucleotide | Prostacyclin
Journal Article
BLOOD, ISSN 0006-4971, 10/2006, Volume 108, Issue 7, pp. 2244 - 2247
The capacity of clopidogrel to inhibit ADP-induced platelet aggregation shows wide intersubject variability. To determine whether frequent functional variants... 
VARIABILITY | PERCUTANEOUS CORONARY INTERVENTION | ANTIAGGREGATING ACTIVITY | PRETREATMENT | METABOLISM | ACUTE MYOCARDIAL-INFARCTION | HUMAN PLATELETS | DRUG-RESISTANCE | HEMATOLOGY | ASPIRIN | VASP PHOSPHORYLATION
Journal Article
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, ISSN 1079-5642, 08/2012, Volume 32, Issue 8, pp. 1777 - 1783
Deep vein thrombosis (DVT) is a major health problem that requires improved prophylaxis and treatment. Inflammatory conditions such as infection, cancer, and... 
neutrophil extracellular traps | HUMAN-PLATELETS | RISK-FACTORS | mouse model | VENOUS THROMBOSIS | MITOCHONDRIAL-DNA | VON-WILLEBRAND-FACTOR | LEUKOCYTE ELASTASE | deep vein thrombosis | CANCER-PATIENTS | inflammation | PULMONARY-EMBOLISM | ENDOTHELIAL-CELLS | thrombolytic therapy | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | deoxyribonuclease | INNATE IMMUNITY
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 10/2018, Volume 83, Issue 19, pp. 12297 - 12304
A convenient method to synthesize A-type proanthocyanidin analogues from flavylium salts and pi-nucleophiles has been developed. It was found that the... 
CINNAMTANNIN B-1 | CELLS | PROCYANIDINS | CHEMISTRY, ORGANIC | HUMAN PLATELETS | STEREOSELECTIVE-SYNTHESIS | BAY WOOD
Journal Article
Cellular Signalling, ISSN 0898-6568, 07/2019, Volume 59, pp. 96 - 109
The healthy vascular endothelium constantly releases autacoids which cause an increase of intracellular cyclic nucleotides to tame platelets from inappropriate... 
Epinephrine | Cyclic nucleotide | α2A adrenoceptor | Prostacyclin | Human platelets | Nitric oxide
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 10/2011, Volume 112, Issue 10, pp. 2794 - 2802
Journal Article
CURRENT BIOLOGY, ISSN 0960-9822, 09/2006, Volume 16, Issue 18, pp. 1796 - 1806
Background: Integrin receptors, composed of transmembrane alpha and beta subunits, are essential for the development and functioning of multicellular animals.... 
CYTOPLASMIC DOMAIN | ALPHA(IIB)BETA | PROTEIN-KINASE-C | HUMAN-PLATELETS | LIGAND-BINDING | RAP1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | AFFINITY MODULATION | PLAQUE PROTEIN | TALIN BINDING | MEDIATES RAP1-INDUCED ADHESION
Journal Article
BLOOD, ISSN 0006-4971, 07/2013, Volume 122, Issue 4, pp. 608 - 617
Endogenous protective pathways mitigate the overshooting of inflammation after sterile or infectious injury. Here we report that formyl peptide receptor 2... 
MUCOSAL INJURY | PRIMED NEUTROPHILS | RESOLUTION | ANNEXIN-1 | HUMAN PLATELETS | MICE | RENAL ISCHEMIA/REPERFUSION INJURY | LIPID MEDIATORS | ISCHEMIA-REPERFUSION | HEMATOLOGY | ACUTE-INFLAMMATION
Journal Article
Nature Genetics, ISSN 1061-4036, 05/2013, Volume 45, Issue 5, pp. 531 - 536
Journal Article
Blood, ISSN 0006-4971, 02/2008, Volume 111, Issue 4, pp. 1749 - 1750
Journal Article
Pharmacopsychiatry, ISSN 0176-3679, 11/2009, Volume 42, Issue 6, pp. 270 - 276
Abstract INTRODUCTION: The neurotrophin brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are a central part of the molecular concepts on... 
Original Paper | DEPRESSED-PATIENTS | PSYCHIATRY | ANTIDEPRESSANT TREATMENT | HUMAN PLATELETS | PHARMACOLOGY & PHARMACY | BLOOD-BRAIN | LEARNED HELPLESSNESS | NGF | DIFFERENTIAL REGULATION | FACTOR BDNF | EXPRESSION | NERVE GROWTH-FACTOR
Journal Article
BLOOD, ISSN 0006-4971, 03/2003, Volume 101, Issue 6, pp. 2285 - 2293
Human platelets are anucleate blood cells that retain cytoplasmic mRNA and maintain functionally intact protein translational capabilities. We have adapted... 
PROTEIN | TURNOVER | MESSENGER-RNA | CLONING | MOUSE | ACTIVATED HUMAN PLATELETS | RETICULATED PLATELETS | HEMATOLOGY | CANCER | PEPTIDE | TRANSLATIONAL CONTROL
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 05/2019, Volume 39, Issue 5, pp. 956 - 964
OBJECTIVE—ACT017 is a novel, first in class, therapeutic antibody to platelet GPVI (glycoprotein VI) with potent and selective antiplatelet effects. This... 
ACTIVATION | COLLAGEN | pharmacodynamics | HUMAN PLATELETS | FUTURE | immunoglobulin Fab fragment | FIBRIN | platelet membrane glycoprotein | platelet aggregation inhibitors | safety | pharmacokinetics | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ISCHEMIC-STROKE
Journal Article
JOURNAL OF CELL SCIENCE, ISSN 0021-9533, 05/2019, Volume 132, Issue 10
Stromal interaction molecule 1 (STIM1) is one of the key elements for the activation of store-operated Ca2+ entry (SOCE). Hence, identification of the relevant... 
KINASE | Orai1 | PROTEIN-TYROSINE PHOSPHORYLATION | HUMAN PLATELETS | CELL BIOLOGY | ERK1/2 | OPERATED CALCIUM-ENTRY | STIM1 | CHANNEL | Tyrosine phosphorylation | STORE | SARAF | MEDIATED CA2+ ENTRY | ASSOCIATION | I-CRAC | Y-316
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 10/2016, Volume 6
4-aminopyridine is commonly used to stimulate neurotransmitter release resulting from sustained plasma membrane depolarization and Ca2+-influx from the... 
TRANSMITTER RELEASE | HUMAN-PLATELETS | MULTIDISCIPLINARY SCIENCES | SYNAPTOSOMES | GLUTAMATE TRANSPORTER | NEURONS | RECEPTOR | ISCHEMIA | RETICULUM | MODULATION
Journal Article
Langmuir, ISSN 0743-7463, 01/2011, Volume 27, Issue 2, pp. 697 - 704
We present the first direct comparison of scanning ion conductance microscopy (SICM) with atomic force microscopy (AFM) for cell imaging. By imaging the same... 
MATERIALS SCIENCE, MULTIDISCIPLINARY | MEMBRANES | CHEMISTRY, PHYSICAL | HUMAN PLATELETS | MECHANICAL-PROPERTIES | CHEMISTRY, MULTIDISCIPLINARY | ELASTICITY | IN-VITRO | ENDOTHELIAL-CELLS | SURFACE | DYNAMICS | SOFT SAMPLES | LIVING CELLS | Microscopy, Atomic Force | Fibroblasts - cytology | Lung - cytology | Humans | Microscopy, Scanning Probe | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7
Fever is a common response to inflammation and infection. The mechanism involves prostaglandin E-2 (PGE(2))-EP3 receptor signaling in the hypothalamus, which... 
FEBRILE RESPONSE | CYTOSOLIC PHOSPHOLIPASE A | HUMAN-PLATELETS | MULTIDISCIPLINARY SCIENCES | LIPOPOLYSACCHARIDE | HYDROLYSIS | LIPASE | MICE | RECEPTORS | SUPPRESSION | BRAIN ENDOTHELIAL-CELLS
Journal Article
PLOS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10
In platelets, group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) has been implicated as a key regulator in the hydrolysis of platelet membrane... 
STIMULATED HUMAN PLATELETS | LIPID-METABOLISM | INHIBITION | AGAMMA | 12-LIPOXYGENASE | MULTIDISCIPLINARY SCIENCES | HYDROLYSIS | RELEASE | RECEPTORS | ARACHIDONATE
Journal Article
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