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Cell Metabolism, ISSN 1550-4131, 2010, Volume 12, Issue 1, pp. 65 - 77
Obesity-induced inflammation is critical for the development of insulin resistance. Here, we show that genetic inactivation of PKCζ in vivo leads to a... 
HUMDISEASE
Journal Article
Cell Metabolism, ISSN 1550-4131, 12/2009, Volume 10, Issue 6, pp. 455 - 465
Long-term (72 hr) exposure of pancreatic islets to palmitate inhibited glucose-induced insulin secretion by >50% with first- and second-phase secretion being... 
HUMDISEASE
Journal Article
Neuron, ISSN 0896-6273, 06/2007, Volume 54, Issue 5, pp. 713 - 720
The apolipoprotein E (APOE) ε4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD). We conducted genome-wide surveys... 
HUMDISEASE | MOLNEURO
Journal Article
Cell, ISSN 0092-8674, 05/2008, Volume 133, Issue 4, pp. 727 - 741
p53 and p19ARF are tumor suppressors frequently mutated in human tumors. In a high-throughput screen in mice for mutations collaborating with either p53 or... 
SYSBIO | HUMDISEASE | SIGNALING | Resource
Journal Article
Cell metabolism, ISSN 1550-4131, 2010, Volume 11, Issue 3, pp. 194 - 205
Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme for triacylglycerol (TAG) hydrolysis in adipocytes. The precise mechanisms whereby ATGL is... 
HUMDISEASE
Journal Article
Cell metabolism, ISSN 1550-4131, 2009, Volume 10, Issue 1, pp. 13 - 26
Accumulation of unfolded protein within the endoplasmic reticulum (ER) attenuates mRNA translation through PERK-mediated phosphorylation of eukaryotic... 
HUMDISEASE
Journal Article
Cell metabolism, ISSN 1550-4131, 2007, Volume 5, Issue 5, pp. 331 - 344
WNK1 and WNK4 mutations have been reported to cause pseudohypoaldosteronism type II (PHAII), an autosomal-dominant disorder characterized by hyperkalemia and... 
HUMDISEASE
Journal Article
Cell, ISSN 0092-8674, 02/2010, Volume 140, Issue 4, pp. 477 - 490
Current models imply that the FERM domain protein Merlin, encoded by the tumor suppressor NF2, inhibits mitogenic signaling at or near the plasma membrane.... 
HUMDISEASE | SIGNALING
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2006, Volume 52, Issue 4, pp. 679 - 690
Zn2+ is thought to modulate neurotransmission by affecting currents mediated by ligand-gated ion channels and transmitter reuptake by Na+-dependent transporter... 
HUMDISEASE | MOLNEURO | SIGNALING
Journal Article
Cell metabolism, ISSN 1550-4131, 2007, Volume 6, Issue 2, pp. 137 - 143
Th1 cytokines promote monocyte differentiation into proatherogenic M1 macrophages, while Th2 cytokines lead to an “alternative” anti-inflammatory M2 macrophage... 
HUMDISEASE | DIFFERENTIATION | RECEPTORS | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | CELL BIOLOGY
Journal Article
Molecular cell, ISSN 1097-2765, 2009, Volume 34, Issue 3, pp. 271 - 284
The p16 tumor suppressor gene is a frequent target of epigenetic inactivation in human cancers, which is an early event in breast carcinogenesis. We describe... 
CELLCYCLE | DNA | HUMDISEASE
Journal Article
Cell Metabolism, ISSN 1550-4131, 03/2010, Volume 11, Issue 3, pp. 231 - 238
Bone remodeling is regulated by various neuronal inputs, including sympathetic tone, which is known to inhibit bone mass accrual. This aspect of sympathetic... 
HUMDISEASE
Journal Article
Neuron, ISSN 0896-6273, 2007, Volume 53, Issue 3, pp. 439 - 452
Hallucinogens, including mescaline, psilocybin, and lysergic acid diethylamide (LSD), profoundly affect perception, cognition, and mood. All known drugs of... 
HUMDISEASE | MOLNEURO | SIGNALING
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2008, Volume 59, Issue 1, pp. 43 - 55
As a disease-modifying approach for Alzheimer's disease (AD), clioquinol (CQ) targets β-amyloid (Aß) reactions with synaptic Zn and Cu yet promotes metal... 
CELLBIO | HUMDISEASE | MOLNEURO | PROTEIN | AMYLOID-BETA | IN-VIVO | DISEASE | TAU | PATHOLOGY | MODEL | NEUROSCIENCES | ZINC | OLIGOMERS | SYNAPTOPHYSIN
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2009, Volume 36, Issue 3, pp. 477 - 486
Activating B-Raf mutations that deregulate the MAPK pathway commonly occur in cancer. Whether additional proteins modulate the enzymatic activity of oncogenic... 
HUMDISEASE | SIGNALING
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2009, Volume 61, Issue 5, pp. 762 - 773
Migraine is a common disabling brain disorder. A subtype of migraine with aura (familial hemiplegic migraine type 1: FHM1) is caused by mutations in CaV2.1... 
SYSNEURO | HUMDISEASE | MOLNEURO | Brain | Neurosciences | Brain research | Neurons | Migraine | Headaches | Mutation
Journal Article
Cell metabolism, ISSN 1550-4131, 2007, Volume 5, Issue 6, pp. 426 - 437
Mice fed a high-fat, low-carbohydrate ketogenic diet (KD) exhibit marked changes in hepatic metabolism and energy homeostasis. Here, we identify liver-derived... 
HUMDISEASE | OVEREXPRESSION | ANGIOPOIETIN-LIKE PROTEIN-3 | CHOLESTEROL | SYNTHASE GENE | FATTY-ACID | LIVER | ENDOCRINOLOGY & METABOLISM | ANGPTL3 | ACTIVATED RECEPTOR-ALPHA | IDENTIFICATION | KETOGENIC DIET | CELL BIOLOGY
Journal Article
Cell metabolism, ISSN 1550-4131, 2009, Volume 10, Issue 3, pp. 189 - 198
Epigenetic modification through DNA methylation is implicated in metabolic disease. Using whole-genome promoter methylation analysis of skeletal muscle from... 
HUMDISEASE | DNA METHYLATION | METABOLISM | PHOSPHORYLATION | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MECHANISMS | INHERITANCE | PPARGC1A | HUMAN SKELETAL-MUSCLE | CYTOSINE METHYLATION | CELL BIOLOGY
Journal Article