1993, 16
Book
Book
Genes and Development, ISSN 0890-9369, 04/2014, Volume 28, Issue 7, pp. 749 - 764
The Drosophila protein brain tumor (Brat) forms a complex with Pumilio (Pum) and Nanos (Nos) to repress hunchback (hb) mRNA translation at the posterior pole...
Hunchback | TRIM-NHL | Translational repression | BRAT | Gene regulation | RNA binding | STEM-CELLS | PROTEIN | TUMOR | SELF-RENEWAL | DEVELOPMENTAL BIOLOGY | translational repression | PUMILIO | CELL BIOLOGY | BETA-PROPELLER | gene regulation | hunchback | NANOS | GENETICS & HEREDITY | MICROSCALE THERMOPHORESIS | EXPRESSION | DROSOPHILA EMBRYOS | Molecular Sequence Data | Phylogeny | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Drosophila melanogaster - genetics | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Gene Expression Regulation, Developmental | Base Sequence | Binding Sites | Insect Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Insect Proteins - genetics | Models, Molecular | Drosophila melanogaster - classification | Drosophila Proteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Sequence Alignment | Animals | Insect Proteins - chemistry | Drosophila Proteins - genetics | Mutation | RNA-Binding Proteins - metabolism | Messenger RNA | Research | Genetic translation | Binding sites (Biochemistry) | Research Paper
Hunchback | TRIM-NHL | Translational repression | BRAT | Gene regulation | RNA binding | STEM-CELLS | PROTEIN | TUMOR | SELF-RENEWAL | DEVELOPMENTAL BIOLOGY | translational repression | PUMILIO | CELL BIOLOGY | BETA-PROPELLER | gene regulation | hunchback | NANOS | GENETICS & HEREDITY | MICROSCALE THERMOPHORESIS | EXPRESSION | DROSOPHILA EMBRYOS | Molecular Sequence Data | Phylogeny | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Drosophila melanogaster - genetics | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Gene Expression Regulation, Developmental | Base Sequence | Binding Sites | Insect Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Insect Proteins - genetics | Models, Molecular | Drosophila melanogaster - classification | Drosophila Proteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Sequence Alignment | Animals | Insect Proteins - chemistry | Drosophila Proteins - genetics | Mutation | RNA-Binding Proteins - metabolism | Messenger RNA | Research | Genetic translation | Binding sites (Biochemistry) | Research Paper
Journal Article
Cell, ISSN 0092-8674, 08/2013, Volume 154, Issue 4, pp. 789 - 800
Early embryonic patterning events are strikingly precise, a fact that appears incompatible with the stochastic gene expression observed across phyla. Using...
FINGER PROTEIN | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | SEGMENTATION | ZYGOTIC GENOME | NOISE | SACCHAROMYCES-CEREVISIAE | POSITIONAL INFORMATION | DROSOPHILA EMBRYO | HUNCHBACK | CELL BIOLOGY | Drosophila melanogaster - embryology | Embryo, Nonmammalian - metabolism | Cytoplasm - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Transcription Factors - metabolism | Animals | Cell Nucleus - metabolism | Cell Nucleus - genetics | Stochastic Processes | Gene Expression Regulation, Developmental | Transcription, Genetic | Drosophila Proteins - genetics | Genetic aspects | Genetic transcription | RNA | Genes
FINGER PROTEIN | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | SEGMENTATION | ZYGOTIC GENOME | NOISE | SACCHAROMYCES-CEREVISIAE | POSITIONAL INFORMATION | DROSOPHILA EMBRYO | HUNCHBACK | CELL BIOLOGY | Drosophila melanogaster - embryology | Embryo, Nonmammalian - metabolism | Cytoplasm - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Transcription Factors - metabolism | Animals | Cell Nucleus - metabolism | Cell Nucleus - genetics | Stochastic Processes | Gene Expression Regulation, Developmental | Transcription, Genetic | Drosophila Proteins - genetics | Genetic aspects | Genetic transcription | RNA | Genes
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 06/2013, Volume 33, Issue 23, pp. 9644 - 9654
The ability to regulate intrinsic membrane excitability, to maintain consistency of action potential firing, is critical for stable neural circuit activity....
GERMLINE STEM-CELLS | NERVOUS-SYSTEM | INTRINSIC EXCITABILITY | DENDRITE MORPHOGENESIS | GATED SODIUM-CHANNELS | AXON INITIAL SEGMENT | LONG-TERM POTENTIATION | NEURONAL EXCITABILITY | NEUROSCIENCES | RNA-BINDING PROTEIN | HUNCHBACK MESSENGER-RNA
GERMLINE STEM-CELLS | NERVOUS-SYSTEM | INTRINSIC EXCITABILITY | DENDRITE MORPHOGENESIS | GATED SODIUM-CHANNELS | AXON INITIAL SEGMENT | LONG-TERM POTENTIATION | NEURONAL EXCITABILITY | NEUROSCIENCES | RNA-BINDING PROTEIN | HUNCHBACK MESSENGER-RNA
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 10/2015, Volume 43, Issue 5, pp. 801 - 806
Pumilio is an RNA-binding protein originally identified in Drosophila, with a Puf domain made up of eight Puf repeats, three helix bundles arranged in a...
Hunchback | Ribonucleic acid (RNA) recognition | Pumilio | Ribonucleic acid (RNA)-binding protein | Puf domain | ribonucleic acid (RNA)-binding protein | HOMOLOGY DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ribonucleic acid (RNA) recognition | PUF PROTEINS | GERMLINE STEM-CELLS | BRAIN-TUMOR | GREEN FLUORESCENT PROTEIN | hunchback | BINDING | DROSOPHILA EMBRYOS | HUNCHBACK MESSENGER-RNA | MOLECULAR-MECHANISMS | LIVING CELLS | RNA-Binding Proteins - genetics | Humans | RNA-Binding Proteins - chemistry | Models, Molecular | RNA - chemistry | Amino Acid Motifs | Animals | Hydrogen Bonding | Protein Engineering | Protein Conformation | Protein Interaction Domains and Motifs | Mutation | Nucleic Acid Conformation | Binding Sites | RNA-Binding Proteins - metabolism | RNA - metabolism
Hunchback | Ribonucleic acid (RNA) recognition | Pumilio | Ribonucleic acid (RNA)-binding protein | Puf domain | ribonucleic acid (RNA)-binding protein | HOMOLOGY DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ribonucleic acid (RNA) recognition | PUF PROTEINS | GERMLINE STEM-CELLS | BRAIN-TUMOR | GREEN FLUORESCENT PROTEIN | hunchback | BINDING | DROSOPHILA EMBRYOS | HUNCHBACK MESSENGER-RNA | MOLECULAR-MECHANISMS | LIVING CELLS | RNA-Binding Proteins - genetics | Humans | RNA-Binding Proteins - chemistry | Models, Molecular | RNA - chemistry | Amino Acid Motifs | Animals | Hydrogen Bonding | Protein Engineering | Protein Conformation | Protein Interaction Domains and Motifs | Mutation | Nucleic Acid Conformation | Binding Sites | RNA-Binding Proteins - metabolism | RNA - metabolism
Journal Article
Current Biology, ISSN 0960-9822, 11/2013, Volume 23, Issue 21, pp. 2140 - 2145
Spatiotemporal patterns of gene expression are fundamental to every developmental program. The resulting domains have been mainly characterized by their levels...
LOCALIZATION | BOUNDARIES | MESSENGER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GENE-EXPRESSION | MORPHOGEN | TIME | POSITIONAL INFORMATION | HUNCHBACK | PRECISION | CELL BIOLOGY | Drosophila melanogaster - embryology | Embryo, Nonmammalian - metabolism | Embryo, Nonmammalian - embryology | In Situ Hybridization, Fluorescence | Drosophila Proteins - metabolism | Animals, Genetically Modified - metabolism | Drosophila melanogaster - genetics | DNA-Directed DNA Polymerase - genetics | Drosophila melanogaster - metabolism | Microscopy, Confocal | Animals | Animals, Genetically Modified - embryology | Animals, Genetically Modified - genetics | Gene Expression Regulation, Developmental | Body Patterning | DNA-Directed DNA Polymerase - metabolism | Drosophila Proteins - genetics | Embryonic development | Genetic transcription | RNA | Drosophila
LOCALIZATION | BOUNDARIES | MESSENGER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GENE-EXPRESSION | MORPHOGEN | TIME | POSITIONAL INFORMATION | HUNCHBACK | PRECISION | CELL BIOLOGY | Drosophila melanogaster - embryology | Embryo, Nonmammalian - metabolism | Embryo, Nonmammalian - embryology | In Situ Hybridization, Fluorescence | Drosophila Proteins - metabolism | Animals, Genetically Modified - metabolism | Drosophila melanogaster - genetics | DNA-Directed DNA Polymerase - genetics | Drosophila melanogaster - metabolism | Microscopy, Confocal | Animals | Animals, Genetically Modified - embryology | Animals, Genetically Modified - genetics | Gene Expression Regulation, Developmental | Body Patterning | DNA-Directed DNA Polymerase - metabolism | Drosophila Proteins - genetics | Embryonic development | Genetic transcription | RNA | Drosophila
Journal Article
DEVELOPMENT, ISSN 0950-1991, 04/2019, Volume 146, Issue 7, p. dev175570
The generation of neuronal diversity is essential for circuit formation and behavior. Morphological differences in sequentially born neurons could be due to...
Hunchback | Dendrite morphology | Temporal transcription factors | Motor neuron | DEVELOPMENTAL BIOLOGY | SPECIFICATION | GUIDANCE | CEREBRAL-CORTEX | Motor circuits | IDENTITY | Larval locomotion | NEUROBLAST COMPETENCE | CORTICAL-NEURONS | Neural circuits | PROGENITOR COMPETENCE | SPECIFY | MAINTAIN | Heterochronic | GRADIENTS | Temporal identity
Hunchback | Dendrite morphology | Temporal transcription factors | Motor neuron | DEVELOPMENTAL BIOLOGY | SPECIFICATION | GUIDANCE | CEREBRAL-CORTEX | Motor circuits | IDENTITY | Larval locomotion | NEUROBLAST COMPETENCE | CORTICAL-NEURONS | Neural circuits | PROGENITOR COMPETENCE | SPECIFY | MAINTAIN | Heterochronic | GRADIENTS | Temporal identity
Journal Article
Developmental Biology, ISSN 0012-1606, 08/2019, Volume 452, Issue 1, pp. 34 - 42
Specification of the primordial germ cells (PGCs) is essential for sexually reproducing animals. Although the mechanisms of PGC specification are diverse...
Delta/notch | Beta-catenin | Germ line | Nanos | FoxY | Sea urchin | Wnt | ChIP | DEVELOPMENTAL BIOLOGY | SPECIFICATION | DROSOPHILA | TRANSLATIONAL CONTROL | SEA-URCHIN | CELL LINEAGE | SMALL MICROMERES | SEQUENCE | ACCUMULATION | HUNCHBACK MESSENGER-RNA | Genetic aspects | Genetic transcription | Analysis | Cells | Protein binding
Delta/notch | Beta-catenin | Germ line | Nanos | FoxY | Sea urchin | Wnt | ChIP | DEVELOPMENTAL BIOLOGY | SPECIFICATION | DROSOPHILA | TRANSLATIONAL CONTROL | SEA-URCHIN | CELL LINEAGE | SMALL MICROMERES | SEQUENCE | ACCUMULATION | HUNCHBACK MESSENGER-RNA | Genetic aspects | Genetic transcription | Analysis | Cells | Protein binding
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 33, pp. 13570 - 13575
Segmentation of the Drosophila embryo begins with the establishment of spatially restricted gap gene-expression patterns in response to broad gradients of...
Transcription factors | Drosophila | Genes | Genomics | Blastoderm | Repression | Transgenes | Gene expression | Embryos | Binding sites | Development | Robustness | Cis-regulation | TRANSCRIPTION FACTORS | SYSTEM | development | ACTIVATION | BODY PATTERN | MULTIDISCIPLINARY SCIENCES | cis-regulation | robustness | REPRESSOR GRADIENTS | BLASTODERM | TRANSGENESIS | MORPHOGEN | MELANOGASTER | HUNCHBACK | Drosophila melanogaster - embryology | Animals | Body Patterning | Embryo, Nonmammalian | Embryonic Induction | Enhancer Elements, Genetic - physiology | GTPase-Activating Proteins - genetics | Transcription Factors - genetics | Drosophila melanogaster - genetics | Gene Expression Regulation, Developmental - physiology | Physiological aspects | Embryonic development | Genetic aspects | Research | Biological Sciences
Transcription factors | Drosophila | Genes | Genomics | Blastoderm | Repression | Transgenes | Gene expression | Embryos | Binding sites | Development | Robustness | Cis-regulation | TRANSCRIPTION FACTORS | SYSTEM | development | ACTIVATION | BODY PATTERN | MULTIDISCIPLINARY SCIENCES | cis-regulation | robustness | REPRESSOR GRADIENTS | BLASTODERM | TRANSGENESIS | MORPHOGEN | MELANOGASTER | HUNCHBACK | Drosophila melanogaster - embryology | Animals | Body Patterning | Embryo, Nonmammalian | Embryonic Induction | Enhancer Elements, Genetic - physiology | GTPase-Activating Proteins - genetics | Transcription Factors - genetics | Drosophila melanogaster - genetics | Gene Expression Regulation, Developmental - physiology | Physiological aspects | Embryonic development | Genetic aspects | Research | Biological Sciences
Journal Article
Frontiers in Physiology, ISSN 1664-042X, 01/2019, Volume 9
The pea aphid, Acyrthosiphon pisum, is an important agricultural pest and biological model organism, and RNA interference (RNAi) is an important tool for...
RNA interference | double-stranded RNA | pre-exposure | hunchback | aphids
RNA interference | double-stranded RNA | pre-exposure | hunchback | aphids
Journal Article
Nature, ISSN 0028-0836, 12/2003, Volume 426, Issue 6968, pp. 849 - 853
Gradients of regulatory factors are essential for establishing precise patterns of gene expression during development; however, it is not clear how patterning...
KRUPPEL | EMBRYO | GENE | PAIR-RULE STRIPES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MORPHOGEN | ACTIVATORS | BINDING-SITES | EXPRESSION | HUNCHBACK | Drosophila melanogaster - embryology | Homeodomain Proteins - metabolism | RNA, Messenger - genetics | Repressor Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Drosophila melanogaster - genetics | Homeodomain Proteins - genetics | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Transcription Factors - metabolism | Animals | Gene Expression Regulation, Developmental | Body Patterning | Enhancer Elements, Genetic - genetics | Response Elements - genetics | Drosophila Proteins - genetics | Repressor Proteins - metabolism | Biochemistry | Deoxyribonucleic acid | DNA | Genes | even-skipped (eve) gene | Knirps (Kni) gene | Hunchback (Hb) gene
KRUPPEL | EMBRYO | GENE | PAIR-RULE STRIPES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MORPHOGEN | ACTIVATORS | BINDING-SITES | EXPRESSION | HUNCHBACK | Drosophila melanogaster - embryology | Homeodomain Proteins - metabolism | RNA, Messenger - genetics | Repressor Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Drosophila melanogaster - genetics | Homeodomain Proteins - genetics | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Transcription Factors - metabolism | Animals | Gene Expression Regulation, Developmental | Body Patterning | Enhancer Elements, Genetic - genetics | Response Elements - genetics | Drosophila Proteins - genetics | Repressor Proteins - metabolism | Biochemistry | Deoxyribonucleic acid | DNA | Genes | even-skipped (eve) gene | Knirps (Kni) gene | Hunchback (Hb) gene
Journal Article
Developmental Biology, ISSN 0012-1606, 10/2012, Volume 370, Issue 2, pp. 165 - 172
In embryonic development, the Bicoid (Bcd) protein establishes positional information of downstream developmental genes like ( ), which has a strong anterior...
Hunchback | Bicoid | Hill coefficient | Cooperative binding | Drosophila melanogaster | Self-regulation | DNA-BINDING | ACTIVATION | PROTEIN | SEGMENTATION GENE HUNCHBACK | MECHANISM | ANTERIOR | GAP GENES | DEVELOPMENTAL BIOLOGY | DIFFERENTIAL REGULATION | GRADIENT | EXPRESSION DATA | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Transcription Factors - metabolism | Drosophila melanogaster - embryology | Animals | Homeodomain Proteins - metabolism | Body Patterning | Embryo, Nonmammalian - metabolism | Trans-Activators - metabolism | Drosophila Proteins - metabolism | Genes, Developmental | Embryonic development | Analysis | Drosophila | self-regulation | hunchback | cooperative binding
Hunchback | Bicoid | Hill coefficient | Cooperative binding | Drosophila melanogaster | Self-regulation | DNA-BINDING | ACTIVATION | PROTEIN | SEGMENTATION GENE HUNCHBACK | MECHANISM | ANTERIOR | GAP GENES | DEVELOPMENTAL BIOLOGY | DIFFERENTIAL REGULATION | GRADIENT | EXPRESSION DATA | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Transcription Factors - metabolism | Drosophila melanogaster - embryology | Animals | Homeodomain Proteins - metabolism | Body Patterning | Embryo, Nonmammalian - metabolism | Trans-Activators - metabolism | Drosophila Proteins - metabolism | Genes, Developmental | Embryonic development | Analysis | Drosophila | self-regulation | hunchback | cooperative binding
Journal Article
Cell, ISSN 0092-8674, 01/2013, Volume 152, Issue 1-2, pp. 97 - 108
Stem and/or progenitor cells often generate distinct cell types in a stereotyped birth order and over time lose competence to specify earlier-born fates by...
TEMPORAL IDENTITY | TRANSCRIPTION FACTORS | NEUROBLAST COMPETENCE | DISTAL-ANTENNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR LAMINA INTERACTIONS | DNA-BINDING PROTEINS | CENTRAL-NERVOUS-SYSTEM | CELL-FATE DETERMINATION | CEREBRAL-CORTEX | HUNCHBACK | CELL BIOLOGY | Drosophila - cytology | Nuclear Proteins - metabolism | Drosophila Proteins - metabolism | Neural Stem Cells - cytology | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Animals | Gene Expression Regulation, Developmental | Drosophila - embryology | Neurons - metabolism | Drosophila - metabolism | Genome, Insect | Neural Stem Cells - metabolism | Drosophila - genetics | Neurosciences | Genetic transcription | Genes | Drosophila | Genomics
TEMPORAL IDENTITY | TRANSCRIPTION FACTORS | NEUROBLAST COMPETENCE | DISTAL-ANTENNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR LAMINA INTERACTIONS | DNA-BINDING PROTEINS | CENTRAL-NERVOUS-SYSTEM | CELL-FATE DETERMINATION | CEREBRAL-CORTEX | HUNCHBACK | CELL BIOLOGY | Drosophila - cytology | Nuclear Proteins - metabolism | Drosophila Proteins - metabolism | Neural Stem Cells - cytology | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Animals | Gene Expression Regulation, Developmental | Drosophila - embryology | Neurons - metabolism | Drosophila - metabolism | Genome, Insect | Neural Stem Cells - metabolism | Drosophila - genetics | Neurosciences | Genetic transcription | Genes | Drosophila | Genomics
Journal Article
Neuron, ISSN 0896-6273, 2009, Volume 61, Issue 1, pp. 57 - 70
Prolonged stimulation leads to specific and stable changes in an animal's behavior. In interneurons, this plasticity requires spatial and temporal control of...
CELLBIO | RNA | MOLNEURO | PUF PROTEIN | CAENORHABDITIS-ELEGANS | MEMORY | GERM-LINE | C-ELEGANS | POLY(A) POLYMERASE | SYNAPTIC PLASTICITY | PROTEIN-SYNTHESIS | NEUROSCIENCES | DROSOPHILA | HUNCHBACK MESSENGER-RNA
CELLBIO | RNA | MOLNEURO | PUF PROTEIN | CAENORHABDITIS-ELEGANS | MEMORY | GERM-LINE | C-ELEGANS | POLY(A) POLYMERASE | SYNAPTIC PLASTICITY | PROTEIN-SYNTHESIS | NEUROSCIENCES | DROSOPHILA | HUNCHBACK MESSENGER-RNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2008, Volume 105, Issue 34, pp. 12265 - 12270
In the simplest view of transcriptional regulation, the expression of a gene is turned on or off by changes in the concentration of a transcription factor...
Input output | Information retrieval noise | Statistical variance | Genes | Drosophila | Government regulation | Signal noise | Data transmission | Gene expression | Embryos | Gene regulatory networks | Information theory | BICOID PROTEIN | gene regulatory networks | MULTIDISCIPLINARY SCIENCES | NOISE | information theory | EXPRESSION | GRADIENT | HUNCHBACK | Drosophila Proteins | Animals | Information Theory | Homeodomain Proteins | Gene Expression Regulation | Transcription, Genetic | Transcription Factors | Gene Regulatory Networks | DNA-Binding Proteins | Drosophila - genetics | Research | Genetic transcription | Genetic regulation | Biological Sciences
Input output | Information retrieval noise | Statistical variance | Genes | Drosophila | Government regulation | Signal noise | Data transmission | Gene expression | Embryos | Gene regulatory networks | Information theory | BICOID PROTEIN | gene regulatory networks | MULTIDISCIPLINARY SCIENCES | NOISE | information theory | EXPRESSION | GRADIENT | HUNCHBACK | Drosophila Proteins | Animals | Information Theory | Homeodomain Proteins | Gene Expression Regulation | Transcription, Genetic | Transcription Factors | Gene Regulatory Networks | DNA-Binding Proteins | Drosophila - genetics | Research | Genetic transcription | Genetic regulation | Biological Sciences
Journal Article