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JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 04/2019, Volume 294, Issue 17, pp. 6843 - 6856
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 04/2017, Volume 19, Issue 4, pp. 822 - 835
Journal Article
EMBO MOLECULAR MEDICINE, ISSN 1757-4676, 12/2014, Volume 6, Issue 12, pp. 1525 - 1541
Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | colorectal cancer | PROTEIN | HUWE1 | C-MYC | IN-VITRO | RAS-DRIVEN TUMORIGENESIS | GENE | ubiquitination | MYC | MIZ1 | N-MYC | DIFFERENTIATION | EXPRESSION
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 12/2014, Volume 6, Issue 12, pp. 1525 - 1541
Journal Article
Cell Discovery, ISSN 2056-5968, 11/2016, Volume 2, Issue 1, p. 16040
In eukaryotes, many proteins function in multi-subunit complexes that require proper assembly. To maintain complex stoichiometry, cells use the endoplasmic... 
RNA-POLYMERASE-II | COMPLEX | unassembled soluble protein degradation (USPD) | CRYSTAL-STRUCTURE | QUALITY CONTROL DEGRADATION | HUWE1 | ER | ubiquitin | CELL BIOLOGY | protein quality control (PQC) | p97/Cdc48 | AAA-ATPASE | ENDOPLASMIC-RETICULUM | CYTOSOL | END RULE PATHWAY | REVEALS
Journal Article
Journal Article
CELLS, ISSN 2073-4409, 10/2018, Volume 7, Issue 10, p. 151
The HECT-type ubiquitin ligase HECT, UBA and WWE Domain Containing 1, (HUWE1) regulates key cancer-related pathways, including the Myc oncogene. It affects... 
ACTIVATION | PROTEIN | PROTEASOMAL DEGRADATION | endoreplication | JNK | DNA-DAMAGE | HUWE1 | HECT FAMILY | PROLIFERATION | CELL-CYCLE PROGRESSION | ubiquitin | HECT | CELL BIOLOGY | salivary gland | REPLICATION | dmP53 | MYC | TUMOR-SUPPRESSOR | dMyc
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 12/2014, Volume 6, Issue 12, pp. 1509 - 1511
MYC family oncoproteins (MYC, N‐MYC and L‐MYC) function as basic helix‐loop‐helix‐leucine zipper (bHLH‐Zip) transcription factors that are activated (i.e.,... 
Ubiquitin | Proteins | Transcription factors | Cell growth | Colorectal cancer | Stem cells | Cell cycle | Myc protein | Ubiquitin-protein ligase | Huwe1 protein | Leucine zipper proteins
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 12/2014, Volume 6, Issue 12, pp. 1525 - 1541
Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1... 
Ubiquitin | Cell culture | Laboratories | Tumor cells | Epithelial cells | Colorectal carcinoma | Colorectal cancer | Myc protein | Gene expression | Experiments | Carcinogenesis | Proteins | Gene silencing | Signal transduction | Molecular modelling | Colon cancer | Transcription activation | Stem cells | Xenografts | Tumorigenesis | Ubiquitin-protein ligase | Huwe1 protein
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 3755 - 18
Journal Article