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1. Full Text Genotyp-Phänotyp-Korrelation bei Zwillingsmädchen mit nichtklassischem adrenogenitalem Syndrom und 21-Hydroxylase-Defekt
by Dörr, Helmuth G and Oppelt, Patricia G
Gynäkologische Endokrinologie, ISSN 1610-2894, 05/2020, Volume 18, Issue 2, pp. 123 - 128
Hydroxylase
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2. Full Text Compromised Intestinal Lipid Absorption in Mice with a Liver-Specific Deficiency of Liver Receptor Homolog 1
by Chikage Mataki and Benjamin C. Magnier and Sander M. Houten and Jean-Sébastien Annicotte and Carmen Argmann and Charles Thomas and Henk Overmars and Wim Kulik and Daniel Metzger and Johan Auwerx and Kristina Schoonjans
Molecular and Cellular Biology, ISSN 0270-7306, 12/2007, Volume 27, Issue 23, pp. 8330 - 8339
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Liver Function Tests | Steroid 12-alpha-Hydroxylase - metabolism | Gene Targeting | Liver - pathology | Signal Transduction | Receptors, Cytoplasmic and Nuclear - deficiency | Bile Acids and Salts - metabolism | Hepatocytes - pathology | Lipid Metabolism | Organ Specificity | Gene Expression Regulation, Enzymologic | Cholesterol 7-alpha-Hydroxylase - genetics | Steroid 12-alpha-Hydroxylase - genetics | Animals | Biological Transport | Cholesterol 7-alpha-Hydroxylase - metabolism | Membrane Transport Proteins - metabolism | Mice | Feces | Intestinal Absorption - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Steroid 12-alpha-Hydroxylase | Liver | Biochemistry, Molecular Biology | Bile Acids and Salts | Receptors, Cytoplasmic and Nuclear | Intestinal Absorption | Life Sciences | Cholesterol 7-alpha-Hydroxylase | Hepatocytes | Membrane Transport Proteins | Molecular biology
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3. Full Text Development of monoclonal antibodies against human CYP11B1 and CYP11B2
by Gomez-Sanchez, Celso E and Qi, Xin and Velarde-Miranda, Carolina and Plonczynski, Maria W and Parker, C. Richard and Rainey, William and Satoh, Fumitoshi and Maekawa, Takashi and Nakamura, Yasuhiro and Sasano, Hironobu and Gomez-Sanchez, Elise P
Molecular and cellular endocrinology, ISSN 0303-7207, 03/2014, Volume 383, Issue 1-2, pp. 111 - 117
Monoclonal antibodies | Immunofluorescence | CYP11B2 | CYP11B1 | Adrenal cortex | 17α-Hydroxylase | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Antibodies, Monoclonal - biosynthesis | Humans | Steroid 11-beta-Hydroxylase - immunology | Molecular Sequence Data | Peptides - administration & dosage | Peptides - chemical synthesis | Zona Fasciculata - immunology | Steroid 17-alpha-Hydroxylase - immunology | Adult | Cytochrome P-450 CYP11B2 - metabolism | Infant, Newborn | Amino Acid Sequence | Zona Glomerulosa - ultrastructure | Peptides - immunology | Rats | Zona Glomerulosa - metabolism | Antibodies, Monoclonal - isolation & purification | Immunohistochemistry - methods | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Steroid 11-beta-Hydroxylase - metabolism | Cytochrome P-450 CYP11B2 - immunology | Zona Glomerulosa - immunology | Zona Fasciculata - metabolism | Mice | Steroid 17-alpha-Hydroxylase - metabolism | Zona Fasciculata - ultrastructure | Cytochrome P-450 | Index Medicus
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4. Full Text A steady state system for in vitro evaluation of steroidogenic pathway dynamics: Application for CYP11B1, CYP11B2 and CYP17 inhibitors
by Mangelis, Anastasios and Jühlen, Ramona and Dieterich, Peter and Peitzsch, Mirko and Lenders, Jacques W.M and Hahner, Stefanie and Schirbel, Andreas and Eisenhofer, Graeme
The Journal of steroid biochemistry and molecular biology, ISSN 0960-0760, 04/2019, Volume 188, pp. 38 - 47
Metabolic flux | CYP11B2 | LC–MS/MS | Aldosterone synthase inhibitors | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Line | Drug Evaluation, Preclinical - methods | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Humans | Enzyme Inhibitors - pharmacology | Enzyme Assays - methods | Steroid 11-beta-Hydroxylase - antagonists & inhibitors | Biosynthetic Pathways - drug effects | Steroid 11-beta-Hydroxylase - metabolism | Cytochrome P-450 CYP11B2 - antagonists & inhibitors | Steroids - metabolism | Steroid 17-alpha-Hydroxylase - metabolism | Steroids - analysis | Cytochrome P-450 CYP11B2 - metabolism | Dehydroepiandrosterone | Hormones, Sex | Corticosteroids | Enzyme kinetics | Mass spectrometry | Cytochrome P-450 | Corticosterone | Hydroxylase | Aldosterone synthase | Homology | Hydrocortisone | Aldosterone | Steroid 11β-hydroxylase | Perfusion | Computer applications | Steroidogenesis | Intracellular | Steroid hormones | Index Medicus
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5. Full Text Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract
by Blomberg Jensen, Martin and Nielsen, John E and Jørgensen, Anne and Rajpert-De Meyts, Ewa and Kristensen, David Møbjerg and Jørgensen, Niels and Skakkebaek, Niels E and Juul, Anders and Leffers, Henrik
Human reproduction (Oxford), ISSN 0268-1161, 5/2010, Volume 25, Issue 5, pp. 1303 - 1311
Testis | Reproduction | CYP | Hydroxylase | Vitamin D receptor | Life Sciences & Biomedicine | Obstetrics & Gynecology | Reproductive Biology | Science & Technology | Epididymis - metabolism | Immunohistochemistry | Steroid Hydroxylases - metabolism | Testis - metabolism | Seminal Vesicles - metabolism | Spermatogenesis | Humans | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics | Male | DNA Primers - genetics | Spermatozoa - metabolism | RNA, Messenger - metabolism | Prostate - metabolism | Tissue Distribution | Cytochrome P450 Family 2 | Base Sequence | Adult | Steroid Hydroxylases - genetics | Gene Expression | RNA, Messenger - genetics | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism | Rats | Vitamin D3 24-Hydroxylase | Genitalia, Male - metabolism | Receptors, Calcitriol - metabolism | Animals | Cholestanetriol 26-Monooxygenase - genetics | Cholestanetriol 26-Monooxygenase - metabolism | Vitamin D - metabolism | Mice | Index Medicus
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6. Full Text The phenylketonuria-associated substitution R68S converts phenylalanine hydroxylase to a constitutively active enzyme but reduces its stability
by Khan, Crystal A and Meisburger, Steve P and Ando, Nozomi and Fitzpatrick, Paul F
The Journal of biological chemistry, ISSN 0021-9258, 03/2019, Volume 294, Issue 12, pp. 4359 - 4367
protein structure | analytical ultracentrifugation | enzyme stability | phenylalanine hydroxylase | small-angle X-ray scattering (SAXS) | protein conformation | allosteric regulation | phenylketonuria | hydroxylase | enzyme kinetics | allostery | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Phenylalanine Hydroxylase - genetics | Allosteric Regulation | Electrophoresis, Polyacrylamide Gel | Enzyme Stability | Scattering, Small Angle | Spectrometry, Fluorescence | Ultracentrifugation | X-Ray Diffraction | Phenylketonurias - metabolism | Protein Conformation | Kinetics | Mutation | Phenylalanine Hydroxylase - chemistry | Phenylalanine Hydroxylase - metabolism | Index Medicus | Enzymology
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7. Full Text Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE -/- mice
by Hartman, Helen B and Gardell, Stephen J and Petucci, Chris J and Wang, Shuguang and Krueger, Julie A and Evans, Mark J
Journal of lipid research, ISSN 0022-2275, 06/2009, Volume 50, Issue 6, pp. 1090 - 1100
Cholesterol 7α-hydroxylase | Sterol 12 α-hydroxylase | Atherosclerosis | Small heterodimer partner | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Dyslipidemias - genetics | Apolipoproteins E - deficiency | Gene Expression - drug effects | Steroid 12-alpha-Hydroxylase - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - deficiency | Atherosclerosis - genetics | Male | Lipids - blood | Receptors, LDL - deficiency | Dyslipidemias - prevention & control | Female | Indoles - pharmacology | Receptors, LDL - genetics | Atherosclerosis - pathology | Mice, Inbred C57BL | Bile Acids and Salts - metabolism | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Atherosclerosis - metabolism | Mice, Knockout | Azepines - pharmacology | Cholesterol 7-alpha-Hydroxylase - genetics | Steroid 12-alpha-Hydroxylase - genetics | Animals | Apolipoproteins E - genetics | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Dyslipidemias - metabolism | Mice | Cholesterol 7-alpha-Hydroxylase - antagonists & inhibitors | Atherosclerosis - prevention & control | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | atherosclerosis | small heterodimer partner | sterol 12 α-hydroxylase | cholesterol 7α-hydroxylase
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8. Full Text Recent advances in developing inhibitors for hypoxia-inducible factor prolyl hydroxylases and their therapeutic implications
by Kim, So Yeon and Yang, Eun Gyeong
Molecules (Basel, Switzerland), ISSN 1420-3049, 11/2015, Volume 20, Issue 11, pp. 20551 - 20568
High-throughput screening (HTS) | Structure-based drug design (SBDD) | Prolyl hydroxylase (PHD) inhibitor | Hypoxia-inducible factor (HIF) | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Prolyl Hydroxylases - metabolism | Prolyl-Hydroxylase Inhibitors - pharmacology | Humans | Molecular Conformation | Ischemia - metabolism | Drug Discovery - methods | Structure-Activity Relationship | Enzyme Activation - drug effects | Hypoxia - metabolism | Prolyl-Hydroxylase Inhibitors - therapeutic use | Prolyl-Hydroxylase Inhibitors - chemistry | Anemia - metabolism | Inflammation - metabolism | Anemia - drug therapy | Animals | High-Throughput Screening Assays | Ischemia - drug therapy | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Inflammation - drug therapy | Prolyl Hydroxylases - chemistry | Protein Binding | Protein Interaction Domains and Motifs | Drug Evaluation, Preclinical | Index Medicus | structure-based drug design (SBDD) | prolyl hydroxylase (PHD) inhibitor | hypoxia-inducible factor (HIF) | high-throughput screening (HTS)
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9. Full Text Toward mechanistic models for genotype–phenotype correlations in phenylketonuria using protein stability calculations
by Scheller, Rasmus and Stein, Amelie and Nielsen, Sofie V and Marin, Frederikke I and Gerdes, Anne‐Marie and Marco, Miriam and Papaleo, Elena and Lindorff‐Larsen, Kresten and Hartmann‐Petersen, Rasmus
Human mutation, ISSN 1059-7794, 04/2019, Volume 40, Issue 4, pp. 444 - 457
proteasome | protein unfolding | PAH | genotype–phenotype | PKU | protein stability | protein degradation | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Phenylalanine Hydroxylase - genetics | Cell Line | Genetic Predisposition to Disease | Phenylketonurias - diagnosis | Phenylketonurias - genetics | Humans | Genetic Association Studies - methods | Models, Molecular | Genotype | Structure-Activity Relationship | Phenylalanine Hydroxylase - blood | Alleles | Protein Conformation | Enzyme Activation | Mutation | Proteasome Endopeptidase Complex - metabolism | Protein Stability | Phenylalanine Hydroxylase - chemistry | Proteins | Medical research | Phenylalanine | Proteolysis | Analysis | Denaturation | Medicine, Experimental | Genetic aspects | Hydroxylases | Sapropterin dihydrochloride | Cells | Phenylketonuria | Neurotoxicity | Phenotypes | Phenylalanine 4-monooxygenase | Tetrahydrobiopterin | Hydroxylase | Proteasomes | Localization | Genotypes | Proteasome inhibitors | Index Medicus
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10. Full Text Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy
by James, Nicholas D and de Bono, Johann S and Spears, Melissa R and Clarke, Noel W and Mason, Malcolm D and Dearnaley, David P and Ritchie, Alastair W.S and Amos, Claire L and Gilson, Clare and Jones, Rob J and Matheson, David and Millman, Robin and Attard, Gerhardt and Chowdhury, Simon and Cross, William R and Gillessen, Silke and Parker, Christopher C and Russell, J. Martin and Berthold, Dominik R and Brawley, Chris and Adab, Fawzi and Aung, San and Birtle, Alison J and Bowen, Jo and Brock, Susannah and Chakraborti, Prabir and Ferguson, Catherine and Gale, Joanna and Gray, Emma and Hingorani, Mohan and Hoskin, Peter J and Lester, Jason F and Malik, Zafar I and McKinna, Fiona and McPhail, Neil and Money-Kyrle, Julian and O’Sullivan, Joe and Parikh, Omi and Protheroe, Andrew and Robinson, Angus and Srihari, Narayanan N and Thomas, Carys and Wagstaff, John and Wylie, James and Zarkar, Anjali and Parmar, Mahesh K.B and Sydes, Matthew R and STAMPEDE Investigators
The New England journal of medicine, ISSN 0028-4793, 07/2017, Volume 377, Issue 4, pp. 338 - 351
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Prednisolone - adverse effects | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Prostatic Neoplasms - radiotherapy | Prednisolone - administration & dosage | Prostatic Neoplasms - surgery | Humans | Middle Aged | Abiraterone Acetate - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Prostate-Specific Antigen - blood | Prostatic Neoplasms - mortality | Abiraterone Acetate - administration & dosage | Neoplasm Metastasis - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Aged, 80 and over | Adult | Aged | Androgen Antagonists - administration & dosage | Androgen Antagonists - adverse effects | Prostatic Neoplasms - drug therapy | Androgen suppression therapy | Usage | Care and treatment | Prostate cancer | Prednisolone | Medical research | Prostate-specific antigen | Clinical trials | Endocrine therapy | Oncology | Metastasis | Radiation therapy | Cancer therapies | Metastases | Mens health | Androgens | Medical prognosis | Death | Prostate | Index Medicus | Abridged Index Medicus
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