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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2019, Volume 514, Issue 1, pp. 58 - 63
In different tissues hyperosmolarity induces cell differentiation. Nevertheless an exacerbated hyperosmolar stress alters the normal cellular development. The... 
TRPV-1 | EVT | Hyperosmolarity | Apoptosis
Journal Article
Ophthalmologe, ISSN 0941-293X, 05/2018, Volume 115, Issue 5, pp. 433 - 450
Journal Article
Journal Article
Canadian Journal of Ophthalmology, ISSN 0008-4182, 2018, Volume 54, Issue 2, pp. 176 - 179
Objective: To evaluate the effects of Behçet's syndrome (BS) on tear osmolarity and tear film function tests. Methods: Thirty patients with BS and 41 control... 
OCULAR SURFACE | CORNEAL | DIAGNOSIS | HYPEROSMOLARITY | OPHTHALMOLOGY | DRY | PREVALENCE | DISEASE-ACTIVITY
Journal Article
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 02/2019, Volume 60, Issue 2, pp. 748 - 760
PURPOSE. To test the hypothesis that high glucose and matrix metalloproteinases (MMPs) contribute to the diabetes-induced loss of platelet endothelial cell... 
PECAM-1 | APOPTOSIS | ACTIVATION | MMPs | DEFICIENCY | HYPEROSMOLARITY | INHIBITION | retina | endothelial | JUNCTIONS | OPHTHALMOLOGY | RETINOPATHY | COMPLICATIONS | TNF-ALPHA | diabetes | EXPRESSION | Retina | endothelial cells
Journal Article
by Wang, BW and Peng, LL and Ouyang, H and Wang, L and He, DL and Zhong, J and Xiao, YC and Deng, YQ and Li, M and Li, SQ and Yuan, J
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 07/2019, Volume 60, Issue 8, pp. 2836 - 2847
PURPOSE. To assess how DNA damage-inducible transcript 4 (DDIT4) and autophagic flux are altered in dry eye disease and reveal the underlying mechanisms... 
autophagic flux | autophagy | dry eye | SUPPRESSION | PATHOGENESIS | RESPONSES | HYPEROSMOLARITY | INHIBITION | DDIT4 | ROS | DISEASE | GENE-EXPRESSION | OPHTHALMOLOGY | RTP801 | RETINOPATHY | INFLAMMASOMES | oxidative stress
Journal Article
by Li, Y and Jin, R and Li, L and Yoon, HJ and Choi, JH and Park, JH and Liu, ZG and Li, W and Li, ZR and Yoon, KC
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 06/2019, Volume 60, Issue 7, pp. 2641 - 2649
PURPOSE. To investigate expression and role of nucleotide-binding oligomerization domain 2 (NOD2) in the ocular surface of experimental dry eye (EDE), which is... 
APOPTOSIS | ACTIVATION | KAPPA-B | dry eye | HYPEROSMOLARITY | NF-kappa B | nucleotide-binding oligomerization domain 2 (NOD2) | INFLAMMATION | DISEASE | UVEITIS | OPHTHALMOLOGY | INFLAMMASOMES | RECEPTORS | PROTEINS | RIP2
Journal Article
Journal Article
Giornale di Gerontologia, ISSN 0017-0305, 01/2015, Volume 63, pp. 140 - 145
Journal Article
BMJ Open, 03/2018, Volume 8, Issue 3, p. e020065
The objective of the current study was to explore the role of CHA DS -VASc score in predicting incidence of atrial fibrillation (AF) in patients with type 2... 
atrial fibrillation | hyperosmolar hyperglycemic state | diabetes mellitus | CHA2DS2-VASc score
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 01/2017, Volume 58, Issue 1, pp. 168 - 178
Journal Article
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 01/2017, Volume 58, Issue 1, pp. 168 - 178
PURPOSE. A population of corneal neurons in rats preferentially sense and monitor the hyperosmolar conditions of tears when the tears begin to evaporate during... 
FILM OSMOLARITY | rat | SENSITIVITY | dry eye disease | tear hyperosmolarity | ACCURACY | VARIABILITY | KERATOCONJUNCTIVITIS SICCA | TEMPERATURE | corneal nerve | DISEASE | PROGRESSIVELY INCREASED VARIATION | OPHTHALMOLOGY | eye blink | SEVERITY | DRY-EYE
Journal Article
Journal Francais d'Ophtalmologie, ISSN 0181-5512, 09/2016, Volume 39, Issue 7, pp. 641 - 651
Dry eye disease is a multifactorial disease affecting the lacrimal functional unit and which has a significant impact on the quality of life of patients. This... 
NFAT5 | Inflammation | Ocular surface | Dry eye disease | Hyperosmolarity
Journal Article
JAMA Ophthalmology, ISSN 2168-6165, 06/2015, Volume 133, Issue 6, pp. 662 - 667
IMPORTANCE Knowledge about the variability of measurements using the TearLab Osmolarity System is necessary when evaluating the clinical utility of readings.... 
SJOGRENS-SYNDROME | OPHTHALMOLOGY | TESTS | HYPEROSMOLARITY | FILM | CLASSIFICATION CRITERIA | Osmolar Concentration | Cross-Sectional Studies | Sjogren's Syndrome - diagnosis | Tears - chemistry | Humans | Middle Aged | Blepharitis - diagnosis | Adult | Female | Male | Aged | Sjogren's syndrome | Care and treatment | Inflammation | Risk factors | Eyelids | Index Medicus | Abridged Index Medicus
Journal Article
Experimental Eye Research, ISSN 0014-4835, 2006, Volume 82, Issue 4, pp. 588 - 596
Hyperosmolarity has been recognized to be a pro-inflammatory stress to the corneal epithelium. The cell signalling pathways linking hyperosmolar stress and... 
inflammatory cytokine | chemokine | cornea | JNK | epithelium | hyperosmolarity | MAPK | ERK | Chemokine | Cornea | Inflammatory cytokine | Epithelium | Hyperosmolarity | TRANSCRIPTION FACTORS | PATHWAYS | ACTIVATED PROTEIN-KINASE | SIGNAL-TRANSDUCTION | MESSENGER-RNA | OPHTHALMOLOGY | GROWTH-FACTOR | INFLAMMATORY CYTOKINES | NF-KAPPA-B | EXPRESSION | MMP-9
Journal Article