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Clinical Science, ISSN 0143-5221, 02/2009, Volume 116, Issue 3, pp. 219 - 230
Healthy vascular function is primarily regulated by several factors including EDRF (endothelium-dependent relaxing factor), EDCF (endothelium-dependent... 
Macrovascular circulation | Microvascular circulation | Inflammation | Nitric oxide | Tumour Necrosis factor-α (TNF-α) | Reactive oxygen species (ROS) | RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | nitric oxide | IMPROVES ENDOTHELIAL FUNCTION | SUPEROXIDE-PRODUCTION | NITRIC-OXIDE SYNTHASE | microvascular circulation | reactive oxygen species (ROS) | macrovascular circulation | tumour necrosis factor-alpha (TNF-alpha) | TUMOR-NECROSIS-FACTOR | MESSENGER-RNA | inflammation | SMOOTH-MUSCLE-CELLS | CONGESTIVE-HEART-FAILURE | NF-KAPPA-B | MARROW PROGENITOR CELLS | Dietary Fats - adverse effects | Reactive Oxygen Species - metabolism | Humans | Endothelium, Vascular - physiopathology | Vascular Diseases - physiopathology | Animals | Tumor Necrosis Factor-alpha - physiology | Stem Cells - physiology | Exercise - physiology | Dietary Carbohydrates - adverse effects | Lipid Metabolism - physiology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Aging - metabolism | EET, epoxyeicosatrienoic acid | AMI, acute myocardial infarction | eNOS, endothelial NOS | DC, dendritic cell | RA, rheumatoid arthritis | IKK, IκB kinase | TNF, tumour necrosis factor | EPC, endothelial progenitor cell | iNOS, inducible NOS | RAGE, receptor for AGEs | Review | HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA | ICAM-1, intercellular adhesion molecule-1 | SCF, stem cell factor | XO, xanthine oxidase | R, ischaemia | cNOS, constitutive NOS | ZOF rat, Zucker Obese Fatty rat | ROS, reactive oxygen species | IκB, inhibitor of NF-κB | PGI2, prostacyclin | reperfusion | nNOS, neuronal NOS | NOS, NO synthase | IHD, ischaemic heart disease | O2•−, superoxide radical | NF-κB, nuclear factor κB | ONOO−, peroxynitrite | tumour necrosis factor-α (TNF-α) | HUVEC, human umbilical vein EC | VCAM-1, vascular cell adhesion molecule-1 | SK1, sphingosine kinase 1 | EDHF, endothelium-dependent hyperpolarizing factor | EC, endothelial cell | Sph1P, sphingosine-1-phosphate | IL, interleukin | t-PA, tissue plasminogen activator | ASS, argininosuccinate synthase | ACEI, angiotensin-converting enzyme inhibitor | CRP, C-reactive protein | AGE, advanced glycation end-product | HDL, high-density lipoprotein | TNFR, TNF receptor
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 05/2018, Volume 827, pp. 112 - 116
Protein kinase G (PKG) Iα mediates the cyclic guanosine monophosphate-mediated vasodilatory effects induced by NO. Endothelium-derived hyperpolarizing factors... 
Protein kinase G Iα | Endothelium-derived hyperpolarizing factors | S-nitrosothiols | Thioredoxin reductase | Soluble guanylyl cyclase | Protein kinase G I alpha | RAT | MOUSE AORTA | ANGIOTENSIN-II | CORONARY-ARTERIES | BRADYKININ-INDUCED RELAXATION | RECOGNITION SITES | PHARMACOLOGY & PHARMACY | EDHF | NITROSOCYSTEINE
Journal Article
Journal Article
Journal of Hypertension, ISSN 0263-6352, 03/2016, Volume 34, Issue 3, pp. 452 - 463
OBJECTIVES:The endothelium maintains vascular homeostasis through the release of endothelium-derived relaxing factors (EDRF) and endothelium-derived... 
developmental conditioning | maternal obesity | intermediate conductance calcium-activated potassium channels | endothelium derived hyperpolarizing factor | microvasculature | MICROVASCULAR DYSFUNCTION | SKELETAL-MUSCLE ARTERIOLES | DEPENDENT VASODILATION | POTASSIUM CHANNELS | CONDUCTED RESPONSES | CA2+-ACTIVATED K+ CHANNELS | OFFSPRING OBESITY | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | MYOENDOTHELIAL GAP-JUNCTIONS | GLYCATION END-PRODUCTS | Norepinephrine - pharmacology | Mesenteric Arteries - physiopathology | Male | Mesenteric Arteries - drug effects | Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism | RNA, Messenger - metabolism | Vasoconstriction - physiology | Arterioles - physiopathology | Diet, High-Fat | Female | Vasodilation - physiology | Biological Factors - metabolism | Real-Time Polymerase Chain Reaction | Hypertension | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Down-Regulation | Nitric Oxide | Prenatal Exposure Delayed Effects - physiopathology | Mesenteric Arteries - metabolism | Arterioles - drug effects | Nitric Oxide Synthase Type III - genetics | Vasoconstriction - drug effects | Prenatal Exposure Delayed Effects - metabolism | Small-Conductance Calcium-Activated Potassium Channels - metabolism | Pregnancy | Animals | Arterioles - metabolism | Diet | Mice | Vasodilation - drug effects | ORIGINAL PAPERS | Pathophysiological aspects
Journal Article
Circulation, ISSN 0009-7322, 05/2011, Volume 123, Issue 20, pp. 2244 - 2253
Background-We assessed the contribution of endothelium-derived hyperpolarizing factors to resting and agonist-stimulated vasodilator tone in health and... 
endothelium-derived vasoconstrictor factors | endothelium | nitric oxide | vasodilation | CARDIAC & CARDIOVASCULAR SYSTEMS | DEPENDENT VASODILATION | CA2+-ACTIVATED K+ CHANNELS | NITRIC-OXIDE ACTIVITY | ACTIVATED POTASSIUM CHANNELS | HYPERCHOLESTEROLEMIC PATIENTS | RADIAL ARTERY | TETRAETHYLAMMONIUM IONS | HUMAN CORONARY-CIRCULATION | PERIPHERAL VASCULAR DISEASE | ESSENTIAL-HYPERTENSION | HEMATOLOGY | EPOXYEICOSATRIENOIC ACIDS | Humans | Middle Aged | Potassium Channels - physiology | Endothelium, Vascular - drug effects | Male | Endothelium, Vascular - physiology | Enzyme Inhibitors - administration & dosage | Young Adult | Regional Blood Flow - drug effects | Forearm - blood supply | Adult | Female | Vasodilation - physiology | Cytochrome P-450 Enzyme System - physiology | Hypercholesterolemia - epidemiology | Potassium Channel Blockers - administration & dosage | Tetraethylammonium - administration & dosage | Biological Factors - physiology | Risk Factors | Nitric Oxide - physiology | omega-N-Methylarginine - administration & dosage | Acetylcholine - administration & dosage | Hypercholesterolemia - physiopathology | Vasodilation - drug effects | Bradykinin - administration & dosage | Regional Blood Flow - physiology | Plethysmography | Blood vessels | Influence | Research | Endothelium-derived relaxing factors | Dilatation | endothelium-derived factors | endothelial function | endothelium-derived hyperpolarizing factor
Journal Article
Journal Article
Journal Article
Clinical Interventions in Aging, ISSN 1176-9092, 01/2019, Volume 14, pp. 1579 - 1587
Background: Aging leads to structural and functional changes in the vasculature characterized by arterial endothelial dysfunction and stiffening of large... 
Hypertension | Medical research | Carbon dioxide | Cardiovascular disease | Smooth muscle | Endothelium | Proteins | Exercise | Coronary vessels | Nitric oxide | Aging | Physiology | Diabetes | Laboratory animals | Fitness training programs | Veins & arteries | endothelium | exercise | aging | endothelium-derived hyperpolarizing factor | TRPV4-KCa2.3 coupling
Journal Article