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FASEB Journal, ISSN 0892-6638, 11/2018, Volume 32, Issue 11, pp. 5927 - 5936
Asthma affects ∼300 million people worldwide. Despite multiple treatment options, asthma treatment remains unsatisfactory in a subset of patients. Airway... 
Cellular signaling | Airway hyperresponsiveness | Integrins
Journal Article
11/2012
Airway hyperresponsiveness (AHR) is a cardinal feature of asthma that is aggravated by environmental air pollution (EAP). Splenocyte tyrosine kinase Syk has... 
Syk | 0564 | asthma | pollution | airways hyperresponsiveness | 0768
Dissertation
Journal of Asthma, ISSN 0277-0903, 12/2018, Volume 55, Issue 12, pp. 1278 - 1285
Objective: There is no standard definition of asthma for epidemiological purposes; most surveys use symptoms and bronchial hyperresponsiveness. Few studies... 
specificity | indirect challenges | sensitivity | mannitol | Airway hyperresponsiveness | STATEMENT | BRONCHIAL HYPERRESPONSIVENESS | TESTS AIRWAY HYPERRESPONSIVENESS | ADULTS | SYMPTOMS | DRY POWDER | DEFINITIONS | PERCEPTION | ALLERGY | RESPIRATORY SYSTEM | EUROPEAN-COMMUNITY | VALIDITY
Journal Article
Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 02/2016, Volume 137, Issue 2, pp. 390 - 399
Background Although ambient air pollution has been linked to reduced lung function in healthy children, longitudinal analyses of pollution effects in asthmatic... 
airway hyperresponsiveness | lung function | ambient air pollution | Asthma | inhaled corticosteroids
Journal Article
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 08/2012, Volume 130, Issue 2, pp. 556 - 557
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 11/2018, Volume 32, Issue 11, pp. 5927 - 5936
Asthma affects approximate to 300 million people worldwide. Despite multiple treatment options, asthma treatment remains unsatisfactory in a subset of... 
airway hyperresponsiveness | CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | TUMOR-SUPPRESSOR PTEN | HYPERRESPONSIVENESS | CELL BIOLOGY | integrins | TISSUE DISTRIBUTION | GROWTH | BIOLOGY | cellular signaling | RHO | ASTHMA | MFGE8
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 06/2013, Volume 14, Issue 6, pp. 536 - 542
The initiation of type 2 immune responses by the epithelial cell-derived cytokines IL-25, IL-33 and TSLP has been an area of extensive research in the past... 
ADAPTIVE IMMUNITY | ALTERNATIVELY ACTIVATED MACROPHAGES | EFFECTOR T-CELLS | DENDRITIC CELLS | TRANSCRIPTION FACTOR GATA3 | MAST-CELLS | TYPE-2 IMMUNITY | AIRWAY HYPERRESPONSIVENESS | IMMUNOLOGY | LUNG INFLAMMATION | THYMIC STROMAL LYMPHOPOIETIN
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 08/2008, Volume 9, Issue 8, pp. 873 - 879
Interleukin 23 (IL-23) is integral to the pathogenesis of chronic inflammation. The resolution of acute inflammation is an active process mediated by specific... 
RESPONSES | IN-VIVO | IL-17 | GENE-EXPRESSION | ASTHMA | MICE | MEDIATORS | IMMUNOLOGY | IL-23 | HYPERRESPONSIVENESS | T-CELLS
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 07/2018, Volume 142, Issue 1, pp. 207 - 218.e6
Airway hyperresponsiveness is a major feature of asthma attributed predominantly to an extrinsic immune/inflammatory response increasing airway smooth muscle... 
airway smooth muscle | airway hyperresponsiveness | asthma | sarcoplasmic reticulum Ca2+ transport ATPase 2b | ORMDL3 | sarcoplasmic reticulum Ca | transport ATPase 2b | CELLS | RESPONSIVENESS | CALCIUM OSCILLATIONS | SENSITIVITY | IMMUNOLOGY | SERCA | HYPERRESPONSIVENESS | HYPERTROPHY | ALLERGY | ALLERGIC-ASTHMA | EXPRESSION | BRONCHIAL-ASTHMA
Journal Article
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 07/2010, Volume 10, Issue 7, pp. 467 - 478
gamma delta T cells have several innate cell-like features that allow their early activation following recognition of conserved stress-induced ligands. Here we... 
DENDRITIC-CELLS | INTESTINAL INFLAMMATION | COLLAGEN-INDUCED ARTHRITIS | IFN-GAMMA | ALPHA-BETA | IN-VIVO | PULMONARY TUBERCULOSIS | AIRWAY HYPERRESPONSIVENESS | IMMUNOLOGY | INTRAEPITHELIAL LYMPHOCYTES | CUTTING EDGE
Journal Article
Journal of Asthma, ISSN 0277-0903, 01/2018, Volume 55, Issue 12, pp. 1 - 5
Objectives: Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR). A bronchial provocation test (BPT) is used to test for... 
body plethysmography | physiology | airway hyperresponsiveness | asthma diagnosis | Bronchial provocation test | airway resistance | RESPONSIVENESS | ALLERGY | RESPIRATORY SYSTEM | INHALATION | METHACHOLINE | HYPERRESPONSIVENESS
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 08/2015, Volume 7, Issue 301
Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct molecular mechanisms. In a cross-sectional study of asthmatics of... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | INTERLEUKIN-17 | EXACERBATIONS | NECROSIS-FACTOR-ALPHA | AIRWAY HYPERRESPONSIVENESS | IL-13 | IDENTIFICATION | EXPRESSION | CLUSTER-ANALYSIS | THYMIC STROMAL LYMPHOPOIETIN | CELL BIOLOGY
Journal Article
11/2013
Spleen tyrosine kinase (Syk) plays a critical role in regulation of immune and inflammatory responses. This thesis investigated the role of Syk in the... 
Murine Model | Allergic Airway Inflammation | 0680 | Airway Hyperresponsiveness | 0714 | House Dust Mite
Dissertation
Medicine & Science in Sports & Exercise, ISSN 0195-9131, 08/2019, Volume 51, Issue 8, pp. 1582 - 1590
Journal Article
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, ISSN 1073-449X, 04/2015, Volume 191, Issue 8, pp. 884 - 893
Rationale: Airway smooth muscle (ASM) plays a key role in airway hyperresponsiveness (AHR) but it is unclear whether its contractility is intrinsically changed... 
STRAINS | airway hyperresponsiveness | RESPONSIVENESS | smooth muscle | REACTIVITY | asthma | MECHANICAL-PROPERTIES | HYPERRESPONSIVENESS | BETA-ADRENOCEPTOR AGONISTS | DEEP INSPIRATION | AIRWAY | FATAL ASTHMA | shortening velocity | RESPIRATORY SYSTEM | airway smooth muscle mechanics | CRITICAL CARE MEDICINE
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 06/2019, Volume 852, pp. 25 - 33
The effects of candesartan and irbesartan, antagonists of the type I angiotensin II receptor, were investigated on allergic asthma. The antigen-induced... 
Angiotensin II receptor | Irbesartan | Candesartan | Degranulation | Anti-asthmatic | Anti-allergic | Mast cell | VITRO | ACTIVATION | BRONCHIAL HYPERRESPONSIVENESS | VIVO | INFLAMMATION | PPAR-GAMMA | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | AIRWAY HYPERRESPONSIVENESS | METHACHOLINE | EXPRESSION | Antigens | Analysis | Pharmacy | Angiotensin | Albumin | Drugstores | Asthma
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 12/2017, Volume 57, Issue 6, pp. 674 - 682
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 3, pp. 769 - 780
Background Inflammation and oxidative stress play critical roles in patients with chronic obstructive pulmonary disease (COPD). Mitochondrial oxidative stress... 
Allergy and Immunology | airway hyperresponsiveness | antioxidant | proliferation | MitoQ | inflammation | mitochondria | airway smooth muscle | Ozone | oxidative stress | chronic obstructive pulmonary disease | ASTHMA FEATURES | CELLS | IMMUNITY | MECHANISMS | IMMUNOLOGY | BETA | MURINE MODEL | ALLERGY | ALLERGIC-ASTHMA | ENERGY-METABOLISM | COPD | Respiratory System - pathology | Reactive Oxygen Species - metabolism | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - pathology | Bronchial Hyperreactivity - genetics | Ubiquinone - pharmacology | Muscle, Smooth - drug effects | Smoking - physiopathology | Organophosphorus Compounds - pharmacology | Myocytes, Smooth Muscle - drug effects | Pneumonia - genetics | Pulmonary Disease, Chronic Obstructive - genetics | Bronchial Hyperreactivity - chemically induced | Signal Transduction | Mitochondria - pathology | Smoking - metabolism | Bronchial Hyperreactivity - pathology | Reactive Oxygen Species - antagonists & inhibitors | Electron Transport Chain Complex Proteins - metabolism | Pulmonary Disease, Chronic Obstructive - chemically induced | Respiratory System - drug effects | Airway Remodeling - genetics | Mice | Oxidative Stress - drug effects | Bronchial Hyperreactivity - drug therapy | Myocytes, Smooth Muscle - pathology | Pneumonia - pathology | Membrane Potential, Mitochondrial - drug effects | Pneumonia - chemically induced | Adult | Female | Pulmonary Disease, Chronic Obstructive - metabolism | Myocytes, Smooth Muscle - metabolism | Ubiquinone - analogs & derivatives | Gene Expression Regulation | Hydrogen Peroxide - pharmacology | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Muscle, Smooth - metabolism | Animals | Pneumonia - drug therapy | Respiratory System - metabolism | Aged | Muscle, Smooth - pathology | Oxidative stress | Care and treatment | Lung diseases, Obstructive | Inflammation | Pharmaceutical industry | Biomedical research | Disease | Laboratories | Mortality | Colleges & universities | Smooth muscle | Mitochondrial DNA | Metabolism | Defects | Antioxidants | Mitochondria | Hospitals | Biopsy | Chronic obstructive pulmonary disease | Apoptosis | Smoking | Index Medicus | Abridged Index Medicus | NO, Nitric oxide | ΔΨm, Mitochondrial membrane potential | ASM, Airway smooth muscle | NAC, N-acetylcysteine | RL, Lung resistance | BAL, Bronchoalveolar lavage | OCR, Oxygen consumption rate | dTPP, Decyltriphenylphosphonium bromide | AHR, Airway hyperresponsiveness | logPC100, Concentration of acetylcholine that increased lung resistance by 100 | GOLD, Global Initiative for Chronic Obstructive Lung Disease | ATP, Adenosine triphosphate | KC, Keratinocyte-derived cytokine | JC-1, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide | COPD, Chronic obstructive pulmonary disease | ROS, Reactive oxygen species | Mechanisms of Allergy and Clinical Immunology
Journal Article
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