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11/2010
The role of hypocretin neurons in modulating somatic motoneuron excitability and hence muscle tone is poorly understood. We investigated whether hypocretin... 
Hypocretin | 0317
Dissertation
Neuropsychopharmacology, ISSN 0893-133X, 09/2012, Volume 37, Issue 10, pp. 2210 - 2221
Growing evidence indicates that an increase of orexin (or hypocretin) signaling is involved in the pathophysiology of major depression, but little is known... 
hypothalamic-pituitary-adrenal axis | orexin/hypocretin | depression | antidepressant | dual orexin/hypocretin receptor antagonist | hippocampal neurogenesis | ADULT HIPPOCAMPUS | PSYCHIATRY | CHRONIC MILD STRESS | CELL-PROLIFERATION | OREXIN/HYPOCRETIN NEURONS | REWARD-SEEKING | MAJOR DEPRESSION | CEREBROSPINAL-FLUID | NEUROSCIENCES | PHARMACOLOGY & PHARMACY | ANIMAL-MODEL | RAT-BRAIN | Cell Proliferation | Neuropeptides - physiology | Depression - drug therapy | Acetamides - therapeutic use | Behavior, Animal - drug effects | Fluoxetine - therapeutic use | Disease Models, Animal | Neuropeptides - analysis | Hypothalamo-Hypophyseal System - drug effects | Microtubule-Associated Proteins - analysis | Orexins | Pituitary-Adrenal System - drug effects | Receptors, Neuropeptide - antagonists & inhibitors | Orexin Receptors | Antidepressive Agents - therapeutic use | Animals | Ki-67 Antigen - analysis | Neurogenesis - physiology | Bromodeoxyuridine - analysis | Receptors, G-Protein-Coupled - antagonists & inhibitors | Biomarkers | Isoquinolines - therapeutic use | Mice | Mice, Inbred BALB C | Intracellular Signaling Peptides and Proteins - physiology | Cell proliferation | Neonates | Animal models | Dexamethasone | Fluoxetine | Bromodeoxyuridine | Depression | Hypothalamic-pituitary-adrenal axis | Neurogenesis | Stress | Antidepressants | Feedback | Orexin receptors | Doublecortin protein | Hippocampus | animal models | dual orexin | hypocretin receptor antagonist | neuropeptides | unipolar | psychopharmacology | hypocretin | bipolar | orexin | Original
Journal Article
Sleep, ISSN 0161-8105, 10/2018, Volume 41, Issue 10
Study Objectives: The present study investigated the function of Hypocretin (Hcrt or Orexin/OX) receptor antagonists in sleep modulation and memory function... 
fiber photometry | memory | orexin/hypocretin receptor antagonist | EEG spectral analysis | optogenetics | sleep pattern | SUVOREXANT | SLEEP-DEPRIVATION | NEUROSCIENCES | DISCOVERY | CLINICAL NEUROLOGY | HYPOCRETIN OREXIN | NARCOLEPSY | ZOLPIDEM | ESZOPICLONE | NEURONS | orexin/ hypocretin receptor antagonist | REM-SLEEP
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 07/2012, Volume 37, Issue 8, pp. 1911 - 1922
Journal Article
Brain Research, ISSN 0006-8993, 2018
The orexin system includes the neuropeptides orexin A and B and the cognate receptors of orexin-1 (OX1) and -2 (OX2) and has been indicated in a number of... 
Antagonist | Addiction | Selective | Hypocretin | Orexin
Journal Article
Neuropharmacology, ISSN 0028-3908, 08/2019, Volume 154, pp. 68 - 78
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2017, Volume 114, Issue 27, pp. E5464 - E5473
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 06/2013, Volume 110, Issue 24, pp. E2229 - E2238
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2018, Volume 38, Issue 6, pp. 1588 - 1599
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 11/2018, Volume 104, Issue 5, pp. 1022 - 1029
The orexin system regulates sleep and arousal and is targeted by ACT‐541468, a new dual orexin receptor antagonist (DORA). Healthy male subjects received a... 
SYSTEM | DRUG | SUVOREXANT | INSOMNIA | SLEEP | OREXIN/HYPOCRETIN | SAFETY | HYPOCRETIN | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | ALMOREXANT
Journal Article
BRAIN RESEARCH, ISSN 0006-8993, 05/2011, Volume 1391, pp. 54 - 59
A role for orexin A in mediating the primary and conditioned reinforcing effects of alcohol has been established. It is unclear however whether the... 
SYSTEM | Self-administration | Ethanol | Sucrose | INDUCED REINSTATEMENT | HYPOCRETIN | SB-334867 | NEUROSCIENCES | Orexin/Hypocretin | PEPTIDES | Motivation | NEURONS | SEEKING | SCHEDULES
Journal Article