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Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2012, Volume 20, Issue 22, pp. 6598 - 6612
Journal Article
Pancreas, ISSN 0885-3177, 09/2014, Volume 43, Issue 8, pp. 1223 - 1231
Journal Article
Journal Article
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 06/2016, Volume 110-111, pp. 80 - 91
A series of fatty chain conjugates of exenatide were designed and synthesized. showed favorable long-acting glucose-lowering effect in diabetic mice and... 
Protracted antidiabetic effects | Ex-4 | Cysteine modified | Fatty chain | SOLID-PHASE SYNTHESIS | PLASMA STABILITY | RECEPTOR | ACID-CONJUGATED EXENDIN-4 | ZUCKER RATS | GLUCAGON-LIKE PEPTIDE-1 | BIOLOGICAL-ACTIVITY | PHARMACOLOGY & PHARMACY | BETA-CELL | MICE | DERIVATIVES | Diabetes Mellitus, Experimental - drug therapy | Obesity - drug therapy | Streptozocin | Humans | Peptides - pharmacokinetics | Diabetes Mellitus, Experimental - genetics | Diet, High-Fat - adverse effects | Half-Life | Male | Obesity - genetics | Glucagon-Like Peptide-1 Receptor - genetics | Glycated Hemoglobin A - antagonists & inhibitors | Glucagon-Like Peptide-1 Receptor - metabolism | Insulin-Secreting Cells - metabolism | Peptides - chemical synthesis | Drug Design | HEK293 Cells | Obesity - etiology | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Amino Acid Sequence | Glucose Tolerance Test | Hypoglycemic Agents - pharmacokinetics | Fatty Acids - chemistry | Cell Survival | Gene Expression Regulation | Rats | Mice, Inbred Strains | Glycated Hemoglobin A - biosynthesis | Rats, Sprague-Dawley | Hypoglycemic Agents - pharmacology | Obesity - metabolism | Peptides - pharmacology | Venoms - chemical synthesis | Animals | Fluorenes - chemistry | Insulin-Secreting Cells - drug effects | Hypoglycemic Agents - chemical synthesis | Cell Line, Tumor | Mice | Venoms - pharmacology | Insulin-Secreting Cells - pathology | Glucagon-Like Peptide-1 Receptor - agonists | Venoms - pharmacokinetics | Hypoglycemic agents | Type 2 diabetes | Diabetics | Peptides | Body weight | Low density lipoproteins | Albumin | Glycosylated hemoglobin | Glucose | Glucose tolerance tests | Reducing diets | Polyols | Dextrose | Cystine | Analysis | Drug discovery | Mass spectrometry | High performance liquid chromatography
Journal Article
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