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Journal of Biological Chemistry, ISSN 0021-9258, 11/2003, Volume 278, Issue 45, pp. 44966 - 44974
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2013, Volume 288, Issue 29, pp. 21197 - 21207
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2013, Volume 451, Issue 3, pp. 427 - 437
The compound BAY 11-7082 inhibits I kappa B alpha [inhibitor of NF-kappa B (nuclear factor kappa B)alpha] phosphorylation in cells and has been used to... 
Linear ubiquitin assembly complex (LUBAC) | Myeloid differentiation factor 88 (MyD88) | Nuclear factor κB (NF-κB) | Lymphoma | Ubiquitin conjugating 13 (Ubc13) | Proteasome | nuclear factor kappa B (NF-kappa B) | proteasome | ACTIVATION | CELL LYMPHOMA-CELLS | LINEAR POLYUBIQUITIN CHAINS | linear ubiquitin assembly complex (LUBAC) | BIOCHEMISTRY & MOLECULAR BIOLOGY | lymphoma | KINASE | IKK | myeloid differentiation factor 88 (MyD88) | CROSS-TALK | IN-VIVO | CONJUGATING ENZYMES | NF-KAPPA-B | NEMO | ubiquitin conjugating 13 (Ubc13) | Nitriles - pharmacology | Humans | Receptors, Interleukin-1 - genetics | Ubiquitin - metabolism | Molecular Sequence Data | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | I-kappa B Proteins - metabolism | Sulfones - pharmacology | Proteasome Endopeptidase Complex - drug effects | Ubiquitination - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Myeloid Differentiation Factor 88 - antagonists & inhibitors | Amino Acid Sequence | NF-KappaB Inhibitor alpha | Ubiquitin - antagonists & inhibitors | NF-kappa B p50 Subunit - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Myeloid Differentiation Factor 88 - genetics | Ubiquitin-Conjugating Enzymes - genetics | Macrophages - cytology | Interleukin-1 - pharmacology | Receptors, Interleukin-1 - metabolism | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Mice | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Conjugating Enzymes - antagonists & inhibitors | Myeloid Differentiation Factor 88 - metabolism | Index Medicus | TRAF, tumour-necrosis-factor-receptor-associated factor | HRMS, high-resolution mass spectra | K48-pUb, Lys48-linked polyubiquitin | UBE, ubiquitin-activating enzyme | IKK, IκB kinase | NEMO, NF-κB essential modifier | HEK, human embryonic kidney | TBK1, tumour-necrosis-factor-receptor-associated factor-associated NF-κB activator-binding kinase 1 | JNK, c-Jun N-terminal kinase | HOIP, haem-oxidized IRP2 ligase-1-interacting protein | LUBAC, linear ubiquitin assembly complex | ERK, extracellular-signal-regulated kinase | HTLV-1, human T-cell lymphotropic virus 1 | K63-pUb, Lys63-linked polyubiquitin | IRAK, IL-receptor-associated kinase | pUb, polyubiquitin | IκB, inhibitor of NF-κB | MALDI–TOF, matrix-assisted laser-desorption ionization–time-of-flight | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | MyD88, myeloid differentiation factor 88 | DLBCL, diffuse large B-cell lymphoma | GFP, green fluorescent protein | NF-κB, nuclear factor κB | MS, tandem MS | Ubc, ubiquitin conjugating | TAK1, transforming growth factor β-activated kinase 1 | DAPI, 4′,6-diamidino-2-phenylindole | IL-1R, IL-1 receptor | DMEM, Dulbecco’s modified Eagle’s medium | HIF1α, hypoxia-inducible factor 1α | IL, interleukin | NEDD8, neural-precursor-cell-expressed developmentally down-regulated 8 | RBR, RING-between-RING, TAB, TAK1-binding protein | LPS, lipopolysaccharide | nuclear factor κB (NF-κB) | MAPK, mitogen-activated protein kinase | PAMP, pathogen-associated molecular pattern
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 52, pp. 43543 - 43556
Endorepellin, the angiostatic C-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits angiogenesis by simultaneously binding to the alpha 2... 
CANCER GROWTH | COLON CARCINOMA-CELLS | DOMAIN-III | ANGIOSTATIC ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PERLECAN PROTEIN CORE | VEGF RECEPTOR-2 | HEPARAN-SULFATE PROTEOGLYCAN | BASEMENT-MEMBRANE PROTEOGLYCANS | TUMOR-GROWTH | ALPHA-2-BETA-1 INTEGRIN | Protein Kinase C - genetics | MAP Kinase Signaling System - physiology | Human Umbilical Vein Endothelial Cells - metabolism | TOR Serine-Threonine Kinases - metabolism | Active Transport, Cell Nucleus - physiology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Proto-Oncogene Proteins c-akt - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | Cell Nucleus - metabolism | MAP Kinase Kinase 4 - metabolism | TOR Serine-Threonine Kinases - genetics | Heparan Sulfate Proteoglycans - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Protein Kinase C - metabolism | Swine | Human Umbilical Vein Endothelial Cells - cytology | Proto-Oncogene Proteins c-akt - metabolism | Peptide Fragments - genetics | Protein-Serine-Threonine Kinases - metabolism | Peptide Fragments - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | NFATC Transcription Factors - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Neovascularization, Physiologic - physiology | Transcription, Genetic - physiology | Animals | Cell Nucleus - genetics | Heparan Sulfate Proteoglycans - metabolism | MAP Kinase Kinase 4 - genetics | NFATC Transcription Factors - genetics | Index Medicus | Proteoglycan | Angiogenesis | Vascular Endothelial Growth Factor (VEGF) | AP1 | VEGF Receptor 2 | Vascular Biology | Calcineurin | Perlecan | Glycobiology and Extracellular Matrices | Endothelial Cell | NFAT1
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 10/2011, Volume 15, Issue 7, pp. 1789 - 1797
Journal Article
Hypertension, ISSN 0194-911X, 03/2016, Volume 67, Issue 3, pp. 597 - 605
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, pp. 19857 - 19857
Through both gain-and loss-of-TTF-1 expression strategies, we show that TTF-1 positively regulates vascular endothelial growth factor (VEGF) and that the VEGF... 
SURVIVAL | MORPHOGENESIS | EPITHELIAL-CELLS | GM-CSF | VEGF | MULTIDISCIPLINARY SCIENCES | LUNG ADENOCARCINOMA | GENE-EXPRESSION | NKX2-1 | CANCER | ENDOTHELIAL GROWTH-FACTOR | Exosomes - metabolism | Angiogenic Proteins - genetics | Neovascularization, Physiologic - drug effects | Thyroid Nuclear Factor 1 | TOR Serine-Threonine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Culture Media, Conditioned - pharmacology | Lung Neoplasms - pathology | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor Receptor-2 - immunology | Vascular Endothelial Growth Factor A - genetics | Cell Hypoxia | Transcription Factors - secretion | Nuclear Proteins - secretion | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Cytokines - genetics | Real-Time Polymerase Chain Reaction | Lung Neoplasms - blood supply | A549 Cells | Promoter Regions, Genetic | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Cell Survival | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Indoles - toxicity | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Vascular Endothelial Growth Factor A - analysis | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Blotting, Western | Antibodies - pharmacology | Transcription Factors - metabolism | Up-Regulation - drug effects | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Pyrroles - toxicity | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Angiogenic Proteins - metabolism | RNA, Small Interfering - metabolism | TOR protein | Statistical analysis | Granulocyte-macrophage colony-stimulating factor | Lung | Lung cancer | Media | Rapamycin | Secretome | Exosomes | Macrophages | Angiogenesis | Hypoxia | Colony-stimulating factor | Vascular endothelial growth factor | Thyroid transcription factor 1 | Thyroid | Index Medicus
Journal Article
Cellular Signalling, ISSN 0898-6568, 05/2014, Volume 26, Issue 5, pp. 1030 - 1039
Sorafenib, the first-line systemic drug for advanced hepatocellular carcinoma (HCC), has demonstrated limited benefits with very low response rates. Thus it is... 
Hepatocellular carcinoma | Hypoxia | Hypoxia-inducible factor-2 α | Epidermal growth factor receptor-α | Sorafenib | Transforming growth factor-α | Hypoxia-inducible factor-2 alpha | DOXORUBICIN | Transforming growth factor-alpha | CANCER | EGFR | HYPOXIA-INDUCIBLE FACTORS | CELL BIOLOGY | GROWTH-FACTOR RECEPTOR | OVEREXPRESSION | ANTISENSE HIF-1-ALPHA | IN-VIVO | Epidermal growth factor receptor-alpha | TUMORIGENESIS | EXPRESSION | Niacinamide - analogs & derivatives | Receptor, Epidermal Growth Factor - genetics | Humans | Gene Expression Regulation, Neoplastic | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Transforming Growth Factor alpha - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Transforming Growth Factor alpha - antagonists & inhibitors | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Transforming Growth Factor alpha - genetics | Up-Regulation - drug effects | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Quinazolines - pharmacology | Carcinoma, Hepatocellular - metabolism | Index Medicus | Cellular | Inhibitors | Effectiveness | Pathways | Activation | Growth factors | Apoptosis | Tumors
Journal Article