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Osteoarthritis and Cartilage, ISSN 1063-4584, 2015, Volume 23, Issue 12, pp. 2288 - 2296
Summary Objective Hypoxia-inducible factor-2α (HIF-2α) transcriptionally upregulates Nampt in articular chondrocytes. NAMPT, which exhibits nicotinamide... 
Rheumatology | NAD+ biosynthesis | Hypoxia-inducible factor (HIF) | Sirtuin | Osteoarthritis | Chondrocytes | NAD | biosynthesis | APOPTOSIS | RHEUMATOLOGY | SIRTUINS | NAD(+) biosynthesis | SIRT1 | CARTILAGE | NUCLEUS PULPOSUS CELLS | METABOLISM | BIOLOGY | GROWTH | STRESS | ORTHOPEDICS | EXPRESSION | Sirtuin 1 - metabolism | Up-Regulation | Arthritis, Experimental - genetics | Immunoprecipitation | Matrix Metalloproteinase 12 - genetics | RNA, Messenger - metabolism | Sirtuin 1 - genetics | Arthritis, Experimental - metabolism | Sirtuin 2 - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Nicotinamide Phosphoribosyltransferase - metabolism | Cartilage, Articular - metabolism | Sirtuins - genetics | Cytokines - genetics | Chondrocytes - metabolism | NAD - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Cytokines - metabolism | Matrix Metalloproteinase 13 - genetics | Matrix Metalloproteinase 3 - metabolism | Matrix Metalloproteinase 12 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Matrix Metalloproteinase 13 - metabolism | Sirtuin 2 - genetics | Nicotinamide Phosphoribosyltransferase - genetics | Animals | Osteoarthritis, Knee - genetics | Mice | Matrix Metalloproteinase 3 - genetics | Sirtuins - metabolism | Osteoarthritis, Knee - metabolism
Journal Article
Journal Article
Journal Article
Kidney International, ISSN 0085-2538, 2014, Volume 85, Issue 2, pp. 276 - 288
Although the protective effect of lipopolysaccharide (LPS) pretreatment on renal ischemia/reperfusion injury is known, a link to hypoxia-inducible factors... 
ischemia/reperfusion | kidney | nitric oxide | HIF-2α | LPS | HIF-2 alpha | RELAXING FACTOR | ACUTE-PHASE RESPONSE | SMOOTH-MUSCLE | HIF-2-ALPHA | ENDOTHELIAL-CELLS | ENDOTOXIN TOLERANCE | UROLOGY & NEPHROLOGY | TNF-ALPHA | GENE ACTIVATION | HIF-1-ALPHA EXPRESSION | Kidney - blood supply | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Human Umbilical Vein Endothelial Cells - immunology | Male | NF-kappa B - metabolism | Acute Kidney Injury - genetics | Microcirculation - drug effects | Kidney - metabolism | Transfection | Basic Helix-Loop-Helix Transcription Factors - metabolism | RNA Interference | Time Factors | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Bone Marrow Transplantation | Renal Circulation - drug effects | Nitric Oxide Donors - pharmacology | Nitric Oxide Synthase Type III - metabolism | Reperfusion Injury - genetics | Reperfusion Injury - metabolism | Basic Helix-Loop-Helix Transcription Factors - deficiency | Cytoprotection | Disease Models, Animal | Basic Helix-Loop-Helix Transcription Factors - genetics | Human Umbilical Vein Endothelial Cells - drug effects | Kidney - drug effects | Signal Transduction | Endothelial Cells - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Cells, Cultured | Enzyme Inhibitors - pharmacology | Acute Kidney Injury - physiopathology | Acute Kidney Injury - prevention & control | Mice, Knockout | Nitric Oxide Synthase Type III - antagonists & inhibitors | Endothelial Cells - immunology | Animals | Reperfusion Injury - prevention & control | Warm Ischemia | Lipopolysaccharides - pharmacology | Reperfusion Injury - physiopathology | Mice | Acute Kidney Injury - metabolism | Nitric Oxide - metabolism | Endothelial Cells - drug effects | Nitric Oxide Synthase Type II - metabolism
Journal Article
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 05/2007, Volume 14, Issue 5, pp. 420 - 426
Hypoxia stimulates erythropoiesis, the major iron-utilization pathway. We report the discovery of a conserved, functional iron-responsive element (IRE) in the... 
TRANSLATIONAL REGULATION | ERYTHROPOIETIN | HOMEOSTASIS | MOLECULAR CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-REGULATION | FERRITIN MESSENGER-RNA | RESPONSIVE ELEMENTS | CELL BIOLOGY | BIOPHYSICS | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | TRANSCRIPTION FACTOR | BINDING
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, ISSN 0193-1857, 08/2019, Volume 317, Issue 2, pp. G98 - G107
Hypoxia is a notable feature of inflammatory bowel disease and chronic induction of hypoxia-inducible factor (HIF)-1 alpha and HIF-2 alpha (endothelial PAS... 
hypoxia | ACTIVATION | PHYSIOLOGY | colitis | PROTECTION | RNA | hypoxia-inducible factor-2 alpha | INFLAMMATORY-BOWEL-DISEASE | COLORECTAL-CANCER | INCREASE | BIOLOGY | GASTROENTEROLOGY & HEPATOLOGY | INNATE IMMUNITY | Index Medicus
Journal Article
CIRCULATION, ISSN 0009-7322, 01/2019, Volume 139, Issue 4, pp. 502 - 517
Background: Hypoxia-inducible factors (HIFs), especially HIF-1 and HIF-2, are key mediators of the adaptive response to hypoxic stress and play essential roles... 
CELLS | endothelial cells | CARDIAC & CARDIOVASCULAR SYSTEMS | PULMONARY-HYPERTENSION | ANGIOGENESIS | TIE2 | Notch | RECEPTOR | ANGIOPOIETIN-1 | angiopoietin | DEFICIENCY | lung | HIF-2 | hypoxia inducible factors | DISEASE | PERIPHERAL VASCULAR DISEASE | MICE | GROWTH-FACTOR | Hypoxia | Research | Health aspects | Analysis | Airway (Medicine) | Endothelium
Journal Article
Journal Article
Bone, ISSN 8756-3282, 01/2020, Volume 130, p. 115123
Oestrogen and hypoxia inducible factor-2α (HIF2α) are key regulators in the pathogenesis of osteoarthritis (OA). However, the cellular interaction between... 
Hypoxia-inducible factor-2α (HIF2α) | Osteoarthritis (OA) | Oestrogen (E2) | Temporomandibular joint (TMJ) | CELLS | Hypoxia-inducible factor-2 alpha (HIF2 alpha) | PROLIFERATION | RECEPTOR-ALPHA | ORGAN | HIF-2-ALPHA | TEMPOROMANDIBULAR-JOINT | ENDOCRINOLOGY & METABOLISM | DEGRADATION | EXPRESSION | Oestrogen (E-2)
Journal Article
Gut, ISSN 0017-5749, 09/2017, Volume 66, Issue 9, pp. 1542 - 1554
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2011, Volume 187, Issue 4, pp. 1970 - 1976
Macrophage secretion of vascular endothelial growth factor (VEGF) in response to the hypoxic tumor microenvironment contributes to tumor growth, angiogenesis,... 
CELLS | MELANOMA | HIF-2-ALPHA | VEGF | HIF-1-ALPHA | IMMUNOLOGY | EXPRESSION | CANCER | PROGRESSION | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Lung Neoplasms - metabolism | Neoplasm Proteins - immunology | Lung Neoplasms - pathology | Vascular Endothelial Growth Factor A - metabolism | Neoplasm Proteins - metabolism | Vascular Endothelial Growth Factor A - genetics | Oxygen - metabolism | Neovascularization, Pathologic - pathology | Neoplasm Metastasis | Basic Helix-Loop-Helix Transcription Factors - metabolism | Lung Neoplasms - secondary | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Melanoma - genetics | Vascular Endothelial Growth Factor Receptor-1 - immunology | Neovascularization, Pathologic - immunology | Neoplasm Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Macrophages - immunology | Vascular Endothelial Growth Factor Receptor-1 - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - immunology | Lung Neoplasms - genetics | Melanoma - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Macrophages - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Gene Expression Regulation, Neoplastic - immunology | Vascular Endothelial Growth Factor A - immunology | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Oxygen - immunology | Melanoma - pathology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | Lung Neoplasms - immunology | Macrophages - metabolism | Animals | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Melanoma - immunology | Oxygen Consumption - genetics | Cell Line, Tumor | Basic Helix-Loop-Helix Transcription Factors - immunology | Neovascularization, Pathologic - genetics | Oxygen Consumption - immunology | Mice | Neovascularization, Pathologic - metabolism
Journal Article