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hypoxia-inducible factor-1-alpha (2112) 2112
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Nature, ISSN 0028-0836, 06/2008, Volume 453, Issue 7196, pp. 807 - 811
The hypoxic response is an ancient stress response triggered by low ambient oxygen ( O-2) ( ref. 1) and controlled by hypoxia-inducible transcription factor- 1... 
OXYGEN | CELLS | HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA | CARCINOGENESIS | INHIBITION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | PREVENTION | IKK-BETA | EXPRESSION | CUTTING EDGE
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 07/2011, Volume 208, Issue 7, pp. 1367 - 1376
Upon antigen stimulation, the bioenergetic demands of T cells increase dramatically over the resting state. Although a role for the metabolic switch to... 
SIGNAL-TRANSDUCTION | EFFECTOR | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | IMMUNE-RESPONSES | INFLAMMATION | AKT-MTOR | RECEPTOR | IMMUNOLOGY | EXPRESSION | CUTTING EDGE
Journal Article
Cancer Research, ISSN 0008-5472, 01/2007, Volume 67, Issue 2, pp. 563 - 572
Adaptation to hypoxia is a critical step in tumor progression and is, in part, regulated by the transcription factor hypoxia-inducible factor-1 alpha (HIF-1... 
BREAST-CANCER | FACTOR 1-ALPHA | HIF-1 | OVEREXPRESSION | ONCOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | ANGIOGENIC SWITCH | HIF-1-ALPHA | EXPRESSION | CARCINOMA | TUMORS
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 03/2016, Volume 16, Issue 3, pp. 149 - 163
CD4(+) T cells differentiate and acquire distinct functions to combat specific pathogens but can also adapt their functions in response to changing... 
ROR-GAMMA-T | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | TRANSCRIPTION FACTOR FOXP3 | HELPER T | REGULATORY T | IMMUNOLOGY | CYTOKINE GENE-EXPRESSION | LYMPHOKINE ACTIVITIES | FUNCTIONAL-HETEROGENEITY | CUTTING EDGE | TH17 CELLS | CD4-Positive T-Lymphocytes - immunology | T-Lymphocyte Subsets - immunology | Immunotherapy - methods | Animals | Humans
Journal Article
Journal Article
Cancer research, ISSN 0008-5472, 05/2019, Volume 79, Issue 10, pp. 2564 - 2579
We hypothesized that candidate dependencies for which there are small molecules that are either approved or in advanced development for a nononcology... 
HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA | HIF PROLYL HYDROXYLASES | GENE | ONCOLOGY | ANEMIA | HIF-1-ALPHA | HYPOXIA | SUPPRESSION | ROXADUSTAT FG-4592 | EXPRESSION | HIF1-ALPHA
Journal Article
Transplantation Direct, ISSN 0041-1337, 07/2019, Volume 103, Issue 7, pp. e188 - e197
BACKGROUND.The development of liver transplantation (LT) is increasingly being limited by the unavailability of liver grafts. Unique regenerative capacity of... 
TARGET | SURGERY | SERINE | GENE | METABOLISM | HYPOXIA INDUCIBLE FACTOR-1-ALPHA | INJURY | MICE | IMMUNOLOGY | EXPRESSION | TRANSPLANTATION
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 06/2006, Volume 66, Issue 12, pp. 6264 - 6270
Overexpression of hypoxia-inducible factors (HIF), HIF-1 alpha and HIF-2 alpha, leads to the up-regulation of genes involved in proliferation, angiogenesis,... 
COLON-CANCER CELLS | FACTOR-2-ALPHA | HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA | FACTOR-1-ALPHA | ONCOLOGY | TRANSCRIPTION | TOPOISOMERASE-I | OSTEOBLAST-LIKE CELLS | INDUCTION | HIF-1-ALPHA | EXPRESSION
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2007, Volume 282, Issue 28, pp. 20534 - 20543
Tumors that form as a result of heightened mammalian target of rapamycin ( mTOR) signaling are highly vascularized. This process of angiogenesis is regulated... 
BINDING PARTNER | TRANSCRIPTIONAL ACTIVATION | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | PATHWAY | RHEB | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-PRODUCTS | TUBEROUS SCLEROSIS | IDENTIFICATION | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR
Journal Article
Kidney International, ISSN 0085-2538, 11/2018, Volume 94, Issue 5, pp. 849 - 851
Progressive cyst expansion in autosomal-dominant polycystic kidney disease has been shown to cause regional hypoxia in cystic and pericystic tissue. This... 
ACTIVATED CHLORIDE SECRETION | UROLOGY & NEPHROLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA
Journal Article
The Oncologist, ISSN 1083-7159, 11/2018, Volume 23, Issue 11, pp. 1269 - e125
经验获取 • 抗血管生成剂阿柏西普与热休克蛋白90抑制剂 ganetespib 联合使用与一些严重及意外的不良事件有关,并且试验给药计划不耐受。 • 这些研究都强调了在设计新型治疗组合方案时考虑交叉毒性的重要性。 摘要 背景。 虽然抑制血管生成是治疗癌症的有效策略,但血管生成治疗经常会造成获得性耐药。热休克蛋白... 
DESIGN | GROWTH-FACTOR TRAP | PROTEIN | ONCOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | SAFETY | COMBINATION | INHIBITOR | EXPRESSION | Clinical Trial Results
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 05/2013, Volume 48, Issue 5, pp. 531 - 539
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and has few effective therapies. It is characterized by anomalous... 
Hypoxia | Inflammation | Neutrophil | Protease | COPD | SMOKE-INDUCED EMPHYSEMA | hypoxia | BRONCHOALVEOLAR LAVAGE FLUID | BIOCHEMISTRY & MOLECULAR BIOLOGY | HAEMOPHILUS-INFLUENZAE | neutrophil | CELL BIOLOGY | protease | SYSTEMIC INFLAMMATION | inflammation | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | INDUCED SPUTUM | RESPIRATORY SYSTEM | AIRWAY BACTERIAL LOAD | APOPTOTIC CELLS | CIGARETTE-SMOKE | CATHEPSIN-G
Journal Article