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International Journal of Pediatric Otorhinolaryngology, ISSN 0165-5876, 2016, Volume 92, pp. 61 - 66
Abstract Objective Cisplatin is commonly used to treat solid tumors. However, permanent hearing loss is a major side effect of cisplatin chemotherapy and often... 
Otolaryngology | Pediatrics | Peanut sprout | Cell death | Cisplatin | Ototoxicity | Apoptosis | RESVERATROL | CELLS | ACTIVATION | PROTECTION | MECHANISMS | TOXICITY | ANTIOXIDANT | OTORHINOLARYNGOLOGY | PEDIATRICS | STRESS | EXPRESSION | Up-Regulation | Catalase - drug effects | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Plant Extracts - pharmacology | Heme Oxygenase-1 - drug effects | NAD(P)H Dehydrogenase (Quinone) - genetics | Antineoplastic Agents - toxicity | Heme Oxygenase-1 - genetics | Poly(ADP-ribose) Polymerases - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | Cisplatin - toxicity | Oxidation-Reduction - drug effects | Caspases - drug effects | Glutathione Peroxidase - drug effects | Real-Time Polymerase Chain Reaction | Cell Line | Cell Survival - drug effects | Catalase - genetics | Membrane Proteins - genetics | NF-E2-Related Factor 2 - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Blotting, Western | Glutamate-Cysteine Ligase - drug effects | Glutathione Peroxidase - genetics | Seedlings | Hair Cells, Auditory - drug effects | Poly(ADP-ribose) Polymerases - metabolism | Animals | NAD(P)H Dehydrogenase (Quinone) - drug effects | NF-E2-Related Factor 2 - metabolism | Proto-Oncogene Proteins c-bcl-2 - drug effects | Membrane Proteins - drug effects | Glutamate-Cysteine Ligase - genetics | Mice | In Vitro Techniques | Arachis | Labyrinth Supporting Cells - drug effects | Antioxidants | Medical colleges | Chemotherapy | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 27, pp. 10984 - 10989
Aminoglycosides are potent antibacterials, but therapy is compromised by substantial toxicity causing, in particular, irreversible hearing loss. Aminoglycoside... 
Deafness | Antibacterials | Antibiotics | Protein synthesis | Hair cells | Drug interactions | Ribosomes | Glycosides | Aminoglycosides | Inhibitory concentration 50 | Misreading | Antibiotic | Translation | Mycobacteria | antibiotic | SITE | TRANSLOCATION | ANTIBIOTICS | RNA | MULTIDISCIPLINARY SCIENCES | 30S RIBOSOMAL-SUBUNIT | TOXICITY | mycobacteria | INDUCED HEARING-LOSS | HAIR-CELLS | misreading | translation | RESISTANCE | deafness | SELECTIVITY | Humans | Nebramycin - toxicity | Bacteria - drug effects | Protein Biosynthesis - physiology | Ribosomes - metabolism | Gentamicins - toxicity | Drug Design | HEK293 Cells | Anti-Bacterial Agents - toxicity | Binding Sites - drug effects | Organ Culture Techniques | Rabbits | Guinea Pigs | Nebramycin - chemistry | Bacterial Infections - drug therapy | Ribosomes - chemistry | Deafness - physiopathology | Mitochondria - metabolism | Mitochondria - drug effects | Pseudomonas aeruginosa - drug effects | Nebramycin - analogs & derivatives | Mycobacterium - drug effects | Hair Cells, Auditory - drug effects | Animals | Reticulocytes - cytology | Aminoglycosides - toxicity | Ribosomes - drug effects | Protein Biosynthesis - drug effects | Mice | Mutagenesis - physiology | Staphylococcus aureus - drug effects | Deafness - chemically induced | Physiological aspects | Development and progression | Health aspects | Hearing loss | Biological Sciences
Journal Article
Developmental Biology, ISSN 0012-1606, 09/2012, Volume 369, Issue 1, pp. 101 - 114
Embryonic development is controlled by a small set of signal transduction pathways, with vastly different phenotypic outcomes depending on the time and place... 
Development | Calvarial mesenchyme | Mouse model | Ror2 | Hair follicles | Wnt5a | PLANAR CELL POLARITY | CONVERGENT EXTENSION | DEVELOPMENTAL BIOLOGY | BETA | XENOPUS | PATHWAY | GENE-EXPRESSION | BONE | PROTEINS | RECEPTOR TYROSINE KINASE | Embryo, Mammalian - drug effects | Meninges - embryology | Skin - metabolism | Wnt-5a Protein | Wnt Proteins - metabolism | Embryo, Mammalian - metabolism | Bone and Bones - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Wnt Proteins - genetics | Female | Models, Animal | Hair Follicle - embryology | Repressor Proteins - metabolism | Skin - embryology | Calcification, Physiologic - genetics | Calcification, Physiologic - drug effects | Receptor Tyrosine Kinase-like Orphan Receptors - metabolism | Osteogenesis - drug effects | Tetracycline - pharmacology | Embryonic Development - genetics | Gene Expression Regulation, Developmental - drug effects | Mice, Transgenic | Meninges - drug effects | beta Catenin - metabolism | Hair Follicle - drug effects | Pregnancy | Hair Follicle - cytology | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Receptor Tyrosine Kinase-like Orphan Receptors - genetics | Mice | Bone and Bones - abnormalities | Bone and Bones - embryology | Embryonic Development - drug effects | Skin - drug effects | development | hair follicles | calvarial mesenchyme | mouse model
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 50, pp. 82074 - 82084
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 34, pp. 14348 - 14353
Nuclear-associated oscillations in calcium act as a secondary messenger in the symbiotic signaling pathway of legumes. These are decoded by a nuclear-localized... 
Legumes | Nuclear pore | Calcium | Hair cells | Cell nucleus | Adenosine triphosphatases | Plant roots | Nuclear membrane | Root hairs | Plant cells | NODULATION | LOTUS-JAPONICUS | PLANT-CELL NUCLEI | MEDICAGO-TRUNCATULA | CA2+ SPIKING | FUNGAL | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | ARBUSCULAR MYCORRHIZA | TRUNCATULA ROOT HAIRS | SARCOPLASMIC-RETICULUM | Gene Silencing - drug effects | Cytosol - drug effects | Nuclear Envelope - ultrastructure | Symbiosis - physiology | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Protein Transport - drug effects | Plant Epidermis - metabolism | Plant Roots - ultrastructure | Plant Roots - drug effects | Endoplasmic Reticulum - drug effects | Plant Epidermis - cytology | Medicago truncatula - ultrastructure | Plant Proteins - metabolism | Symbiosis - drug effects | Medicago truncatula - enzymology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Plant Roots - cytology | Plant Epidermis - drug effects | Medicago truncatula - metabolism | Diffusion - drug effects | Nuclear Envelope - metabolism | Nuclear Envelope - drug effects | Ion Channels - metabolism | Medicago truncatula - cytology | Calcium Signaling - drug effects | Models, Biological | Lipopolysaccharides - pharmacology | Cytosol - metabolism | Beans | Calcium channels | Calcium, Dietary | Nuclear membranes | Physiological aspects | Research | Mimosaceae | Biological Sciences
Journal Article
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2008, Volume 58, Issue 4, pp. 545 - 570
Chemotherapeutic agents give rise to numerous well described adverse effects that may affect the skin, hair, mucous membranes, or nails. The mucocutaneous... 
Dermatology | CELL LUNG-CANCER | CHRONIC MYELOGENOUS LEUKEMIA | GROWTH-FACTOR RECEPTOR | PEGYLATED LIPOSOMAL DOXORUBICIN | PHASE-II TRIAL | RADIATION-RECALL DERMATITIS | CHRONIC LYMPHOCYTIC-LEUKEMIA | TYROSINE-KINASE INHIBITOR | CHRONIC MYELOID-LEUKEMIA | HAND-FOOT SYNDROME | DERMATOLOGY | Erlotinib Hydrochloride | Niacinamide - analogs & derivatives | Drug Eruptions - pathology | Humans | Antibodies, Monoclonal - adverse effects | Phenylurea Compounds | Protein Kinase Inhibitors - adverse effects | Benzenesulfonates - adverse effects | Antibodies, Monoclonal, Humanized | Pyridines - adverse effects | Fusion Proteins, bcr-abl | Antineoplastic Agents - adverse effects | Nail Diseases - chemically induced | Drug-Related Side Effects and Adverse Reactions | Hair Diseases - chemically induced | Pyrroles - adverse effects | Mucous Membrane - drug effects | Cetuximab | Taxoids - adverse effects | Platinum Compounds - adverse effects | Drug Eruptions - etiology | Skin Diseases - chemically induced | Imatinib Mesylate | Piperazines - adverse effects | Antimetabolites - adverse effects | Indoles - adverse effects | Signal Transduction - drug effects | Pyrimidines - adverse effects | Quinazolines - adverse effects | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Benzamides | Proteasome Inhibitors | Skin - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors | Chemotherapy | Platelet-derived growth factor | Formulae, receipts, prescriptions | Dermatologic agents | Lung cancer, Non-small cell | Cancer | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e34152
Background: Alopecia is the common hair loss problem that can affect many people. However, current therapies for treatment of alopecia are limited by low... 
STEM-CELLS | HISTONE DEACETYLASE INHIBITION | PATHWAY | FOLLICLE DEVELOPMENT | BIOLOGY | NEURONAL DIFFERENTIATION | NEURAL PROGENITOR CELLS | BETA-CATENIN | BIPOLAR DISORDER | WNT | EXPRESSION | Minoxidil - pharmacology | Humans | Alkaline Phosphatase - metabolism | Glycogen Synthase Kinase 3 beta | Male | Wnt Proteins - metabolism | Valproic Acid - pharmacology | Dermis - drug effects | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Dermis - enzymology | Hair Follicle - physiology | Dermis - metabolism | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cells, Cultured | Enzyme Activation - drug effects | Glycogen Synthase Kinase 3 - metabolism | Regeneration - physiology | beta Catenin - metabolism | Mice, Inbred C3H | Keratin-15 - metabolism | Alopecia - metabolism | Hair Follicle - drug effects | Up-Regulation - drug effects | Regeneration - drug effects | Animals | MAP Kinase Signaling System - drug effects | Wnt Signaling Pathway - drug effects | Signal Transduction - drug effects | Cell Differentiation - drug effects | Alopecia - drug therapy | Hair Follicle - metabolism | Hair Follicle - growth & development | Mice | Intermediate Filament Proteins - metabolism | Divalproex | Phosphatases | Valproic acid | Minoxidil | Alkaline phosphatase | Biotechnology | Animal models | Wnt protein | Lithium chloride | Leukemia | Filaggrin | Kinases | Phosphatase | Butyric acid | Proteins | β-catenin | Fibroblasts | Life sciences | Hair | Research & development--R&D | Wounds | Gene expression | Regeneration | Side effects | Alopecia | Acids | Stem cells | Skin | In vivo methods and tests | Lithium chlorides | Topical application | Hair loss | In vitro methods and tests | Cancer | Research & development | R&D
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2015, Volume 112, Issue 31, pp. 9781 - 9786
Journal Article
Plant Physiology, ISSN 0032-0889, 8/2012, Volume 159, Issue 4, pp. 1571 - 1581
A number of phosphate (Pi) starvation- or mycorrhiza-regulated Pi transporters belonging to the Pht1 family have been functionally characterized in several... 
Phosphates | Yeasts | Leaves | Plant roots | Phosphate transport proteins | Root hairs | Plants | Transgenic plants | ENVIRONMENTAL STRESS AND ADAPTATION TO STRESS | Rice | Seedlings | RESPONSES | HOMEOSTASIS | ARBUSCULAR MYCORRHIZAL SYMBIOSIS | GENE | BARLEY | KINETIC-PROPERTIES | PLANTS | ARABIDOPSIS | SACCHAROMYCES-CEREVISIAE | PHT1 FAMILY | PLANT SCIENCES | Protons | Oryza - metabolism | Saccharomyces cerevisiae - genetics | Phosphate Transport Proteins - metabolism | Molecular Sequence Data | Saccharomyces cerevisiae - drug effects | Cell Membrane - physiology | Genetic Complementation Test | Gene Knockdown Techniques | Plant Roots - drug effects | Oryza - growth & development | Oryza - genetics | Plants, Genetically Modified | Biological Transport - drug effects | Plant Leaves - drug effects | Plant Proteins - metabolism | Phosphate Transport Proteins - genetics | Phosphates - pharmacology | Plant Roots - growth & development | Cell Membrane - drug effects | Membrane Potentials - drug effects | Plant Roots - metabolism | Plant Roots - cytology | Oryza - drug effects | Mutation - genetics | Up-Regulation - drug effects | Plant Proteins - genetics | Gene Expression Regulation, Plant - drug effects | Phenotype | Phosphates - metabolism | Plant Leaves - metabolism | Plant Shoots - metabolism | Biological transport | Plant genetics | Physiological aspects | Genetic aspects | Research
Journal Article