X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (130) 130
biochemistry & molecular biology (123) 123
microbiology (110) 110
molecular sequence data (89) 89
escherichia-coli (66) 66
models, molecular (62) 62
archaeal proteins - metabolism (61) 61
haloarcula-marismortui (59) 59
proteins (56) 56
amino acid sequence (54) 54
bacteria (49) 49
haloarcula marismortui - metabolism (49) 49
research (47) 47
crystal-structure (45) 45
haloarcula marismortui - genetics (44) 44
archaea (40) 40
archaeal proteins - genetics (39) 39
base sequence (39) 39
ribosomes - chemistry (39) 39
analysis (38) 38
enzymes (38) 38
phylogeny (37) 37
physiological aspects (37) 37
archaeal proteins - chemistry (36) 36
binding sites (36) 36
ribosomes - metabolism (34) 34
haloarcula - genetics (32) 32
haloarcula - metabolism (32) 32
nucleic acid conformation (32) 32
crystallography, x-ray (31) 31
haloarcula marismortui (29) 29
hydrogen-ion concentration (29) 29
biotechnology & applied microbiology (28) 28
rna (28) 28
protein conformation (27) 27
biotechnology (26) 26
genetic aspects (26) 26
research article (26) 26
angstrom resolution (25) 25
biophysics (25) 25
haloarcula marismortui - chemistry (25) 25
haloarcula marismortui - enzymology (24) 24
kinetics (24) 24
multidisciplinary sciences (24) 24
purification (24) 24
identification (23) 23
haloarcula - enzymology (22) 22
life sciences (22) 22
temperature (22) 22
gene expression (21) 21
haloarcula-hispanica (21) 21
haloferax-volcanii (21) 21
halophilic archaea (21) 21
protein binding (21) 21
enzyme stability (20) 20
genes (20) 20
sequence analysis, dna (20) 20
escherichia coli - genetics (19) 19
haloarcula (19) 19
protein (19) 19
recombinant proteins - genetics (19) 19
ribosomal proteins - metabolism (19) 19
sequence homology, amino acid (19) 19
substrate specificity (19) 19
antibiotics (18) 18
cloning, molecular (18) 18
dead-sea (18) 18
halophilic archaeon (18) 18
recombinant proteins - metabolism (18) 18
ribosomal proteins - chemistry (18) 18
ribosomes (18) 18
salinity (18) 18
sequence (18) 18
rna, ribosomal, 23s - chemistry (17) 17
rna, ribosomal, 23s - metabolism (17) 17
catalysis (16) 16
chemical properties (16) 16
gene (16) 16
protein structure, tertiary (16) 16
recombinant proteins - chemistry (16) 16
rna, ribosomal, 16s - genetics (16) 16
sequence alignment (16) 16
space life sciences (16) 16
transfer-rna (16) 16
bacterial proteins - metabolism (15) 15
biochemistry (15) 15
escherichia coli (15) 15
genome sequence (15) 15
metabolism (15) 15
mutation (15) 15
rna, archaeal - chemistry (15) 15
archaebacterium (14) 14
article (14) 14
bacteriorhodopsin (14) 14
biology (14) 14
cell biology (14) 14
escherichia coli - metabolism (14) 14
genomics (14) 14
halobacteria (14) 14
malate dehydrogenase - metabolism (14) 14
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17152 - 17157
Differences between the structures of bacterial, archaeal, and eukaryotic ribosomes account for the selective action of antibiotics. Even minor variations in... 
Ketolides | Antibiotics | Macrolides | Drug interactions | Ribosomes | Bacteria | Nucleotides | Electron density | Genetic mutation | Binding sites | Ribosome structure | Chloramphenicol | Telithromycin | Erythromycin | Clindamycin | PROTEIN | BACTERIAL RIBOSOME | RNA GENE | MULTIDISCIPLINARY SCIENCES | telithromycin | RESISTANCE MUTATIONS | CONFERRING RESISTANCE | erythromycin | DOMAIN-II | BINDING-SITE | chloramphenicol | MACROLIDE ANTIBIOTICS | ribosome structure | clindamycin | PLEUROMUTILINS | Haloarcula marismortui - genetics | Haloarcula marismortui - metabolism | Chloramphenicol - chemistry | Erythromycin - metabolism | Molecular Sequence Data | Ribosomes - metabolism | Deinococcus - metabolism | Deinococcus - genetics | Haloarcula marismortui - chemistry | X-Ray Diffraction | Anti-Bacterial Agents - chemistry | Base Sequence | Escherichia coli - metabolism | Ketolides - metabolism | Deinococcus - chemistry | Molecular Structure | Clindamycin - chemistry | Peptidyl Transferases - metabolism | Clindamycin - metabolism | Peptidyl Transferases - chemistry | Ribosomes - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli - chemistry | RNA, Ribosomal, 23S - chemistry | Erythromycin - chemistry | Escherichia coli - genetics | Ketolides - chemistry | RNA, Ribosomal, 23S - metabolism | Chloramphenicol - metabolism | Escherichia coli | Crystals | Genetic aspects | Research | Properties | Structure | Observations | Peptidyl transferases | Drugs | lincosamides | Pathogens | rRNA | rRNA 23S | Data processing | Ribosomal subunits | Ionizing radiation | Peptidyltransferase | Crystal structure | Tunnels | Biological Sciences
Journal Article
Science, ISSN 0036-8075, 8/2000, Volume 289, Issue 5481, pp. 920 - 930
Using the atomic structures of the large ribosomal subunit from Haloarcula marismortui and its complexes with two substrate analogs, we establish that the... 
Phosphates | Molecules | RNA | Active sites | Hydrogen bonds | Ribosomes | Chemical bases | Atoms | Research Articles | Transfer RNA | Tunnels | LOCATION | RIBOZYME | PROTEIN | RECOGNITION | MULTIDISCIPLINARY SCIENCES | COLI RIBOSOME | A-SITE | TRANSFER-RNA | TRANSLATION | MICROSCOPY | SUBUNIT | Ribosomal Proteins - chemistry | Haloarcula marismortui - metabolism | Haloarcula marismortui - ultrastructure | RNA, Archaeal - chemistry | RNA, Catalytic - metabolism | Archaeal Proteins - chemistry | Phosphates - chemistry | Molecular Sequence Data | Ribosomes - metabolism | Ribosomal Proteins - metabolism | Haloarcula marismortui - chemistry | Peptide Biosynthesis | Peptides - metabolism | Base Sequence | RNA, Transfer, Amino Acyl - metabolism | Catalysis | Nucleic Acid Conformation | RNA, Catalytic - chemistry | Binding Sites | Peptidyl Transferases - antagonists & inhibitors | Archaeal Proteins - metabolism | Peptidyl Transferases - metabolism | RNA, Transfer - metabolism | Peptidyl Transferases - chemistry | Puromycin - metabolism | Crystallization | Ribosomes - chemistry | Models, Molecular | RNA, Ribosomal, 23S - chemistry | Oligonucleotides - metabolism | Phosphates - metabolism | Base Pairing | Hydrogen Bonding | RNA, Archaeal - metabolism | Protein Conformation | RNA, Ribosomal, 23S - metabolism | Evolution, Molecular | Hydrogen-Ion Concentration | Proteins | Synthesis | Peptides | Biochemistry | Research | Structure | Bacteria | Chemistry | Ribonucleic acid--RNA | Ribonucleic acid | L4 protein | L22 protein | L39e protein
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17158 - 17163
The increasing prevalence of antibiotic-resistant pathogens reinforces the need for structures of antibiotic-ribosome complexes that are accurate enough to... 
Molecules | Antibiotics | Macrolides | Drug interactions | Ribosomes | Drug design | Biochemistry | Potassium | Functional groups | Lactones | Structure-based drug design | Crystal structure | structure-based drug design | DESIGN | RNA | MULTIDISCIPLINARY SCIENCES | KETOLIDES | MITOCHONDRIAL-DNA | NUCLEOTIDE | CHLORAMPHENICOL ACETYLTRANSFERASE | PEPTIDYL TRANSFERASE CENTER | crystal structure | RESISTANCE | BINDING-SITE | MACROLIDE ANTIBIOTICS | Haloarcula marismortui - genetics | Haloarcula marismortui - metabolism | Chloramphenicol - chemistry | Azithromycin - metabolism | Bacterial Proteins - chemistry | Erythromycin - metabolism | Ribosomes - metabolism | Thermus thermophilus - metabolism | Deinococcus - metabolism | Deinococcus - genetics | Haloarcula marismortui - chemistry | Thermus thermophilus - genetics | Anti-Bacterial Agents - chemistry | Ketolides - metabolism | Deinococcus - chemistry | Molecular Structure | Binding Sites | Thermus thermophilus - chemistry | Azithromycin - chemistry | Ribosomes - chemistry | Anti-Bacterial Agents - metabolism | Erythromycin - chemistry | Ketolides - chemistry | Bacterial Proteins - metabolism | Chloramphenicol - metabolism | Crystals | Chemical properties | Research | Properties | Bacterial genetics | Structure | Observations | Antibacterial agents | Pathogens | lactones | Azithromycin | Macrolide antibiotics | Chloramphenicol | Telithromycin | Models | Erythromycin | Conformation | ANTIBIOTICS | CHLORAMPHENICOL | ESCHERICHIA COLI | LACTONES | SPECIFICITY | ERYTHROMYCIN | ELECTRON DENSITY | RIBOSOMES | 60 APPLIED LIFE SCIENCES | PATHOGENS | Biological Sciences
Journal Article
Science, ISSN 0036-8075, 9/2006, Volume 313, Issue 5795, pp. 1935 - 1942
Journal Article
Journal Article