European Journal of Pharmacology, ISSN 0014-2999, 08/2015, Volume 761, p. 217
Cardiovascular effects of a highly selective prostaglandin E.sub.2 type 4 (EP.sub.4) receptor agonist ONO-AE1-329 were assessed with the halothane-anesthetized...
Halothane
Halothane
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 10/2014, Volume 740, p. 263
Journal Article
Tetrahedron: Asymmetry, ISSN 0957-4166, 02/2012, Volume 23, Issue 3-4, p. 201
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2019, Volume 58, Issue 36, pp. 12308 - 12308
Halothane, a commonly used anesthetic can simultaneously function as a hydrogen‐bond and a halogen‐bond donor in the solid state and in solution, as shown by...
halogen bond | cryocrystallography | halothane | anesthetics | hydrogen bond
halogen bond | cryocrystallography | halothane | anesthetics | hydrogen bond
Journal Article
Journal of Anaesthesiology Clinical Pharmacology, ISSN 0970-9185, 07/2018, Volume 34, Issue 3, p. 421
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 03/2015, Volume 171, p. 169
A practical and convenient synthesis of (E)-[beta]-(trifluoromethyl)styrenes has been achieved by the reaction of halothane (HCFC-123B1) and hydrazones in the...
Chlorofluorocarbons | Halothane | Styrene | Ethylenediamines
Chlorofluorocarbons | Halothane | Styrene | Ethylenediamines
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 05/2014, Volume 1838, Issue 5, pp. 1389 - 1395
The α7 nicotinic acetylcholine receptor (nAChR), assembled as homomeric pentameric ligand-gated ion channels, is one of the most abundant nAChR subtypes in the...
General anesthetics | NMR | Ketamine | α7 nAChR structure | Protein dynamics | Halothane | Protein Structure, Tertiary | Xenopus | Anesthetics - chemistry | alpha7 Nicotinic Acetylcholine Receptor - chemistry | Humans | Ketamine - chemistry | Models, Molecular | Halothane - chemistry | Cell Membrane - chemistry | Thermodynamics | Animals | Halothane - metabolism | Membrane Proteins - chemistry | Nuclear Magnetic Resonance, Biomolecular - methods | Anesthetics - metabolism | Protein Binding | Protein Conformation | Cell Membrane - metabolism | Ketamine - metabolism | Membrane Proteins - metabolism | alpha7 Nicotinic Acetylcholine Receptor - metabolism | Binding Sites
General anesthetics | NMR | Ketamine | α7 nAChR structure | Protein dynamics | Halothane | Protein Structure, Tertiary | Xenopus | Anesthetics - chemistry | alpha7 Nicotinic Acetylcholine Receptor - chemistry | Humans | Ketamine - chemistry | Models, Molecular | Halothane - chemistry | Cell Membrane - chemistry | Thermodynamics | Animals | Halothane - metabolism | Membrane Proteins - chemistry | Nuclear Magnetic Resonance, Biomolecular - methods | Anesthetics - metabolism | Protein Binding | Protein Conformation | Cell Membrane - metabolism | Ketamine - metabolism | Membrane Proteins - metabolism | alpha7 Nicotinic Acetylcholine Receptor - metabolism | Binding Sites
Journal Article
Cerebral blood flow velocity changes under nitrous oxide halothane anesthesia in patients with frontotemporal gliomas: A comparison of the normal and abnormal cerebral hemispheres, 01/2004
Background: Regional differences in vascular response to anesthetic agents in brain areas with and without tumors have not been investigated till now. The...
Neurology | ni04019 Cerebral blood flow, Brain tumors, Transcranial doppler, Halothane, Nitrous oxide, Gliomas
Neurology | ni04019 Cerebral blood flow, Brain tumors, Transcranial doppler, Halothane, Nitrous oxide, Gliomas
Journal
Biophysical Journal, ISSN 0006-3495, 09/2010, Volume 99, Issue 6, pp. 1801 - 1809
Cys-loop receptors are molecular targets of general anesthetics, but the knowledge of anesthetic binding to these proteins remains limited. Here we investigate...
TRYPTOPHAN FLUORESCENCE | MOLECULAR-DYNAMICS | GABA(A) RECEPTOR | BIOPHYSICS | STRUCTURAL BASIS | SERUM-ALBUMIN | AMINO-ACIDS | 4-ALPHA-HELIX BUNDLE | HIGH-RESOLUTION | NICOTINIC ACETYLCHOLINE-RECEPTOR | AGONIST BINDING | Bacterial Proteins - chemistry | Cyanobacteria - metabolism | Substrate Specificity | Anesthetics - pharmacology | Protein Subunits - metabolism | Extracellular Space - metabolism | Thiopental - chemistry | Thiopental - metabolism | Volatilization | Anesthetics - metabolism | Cell Membrane - metabolism | Ligand-Gated Ion Channels - metabolism | Binding Sites | Halothane - pharmacology | Protein Structure, Tertiary | Bacterial Proteins - antagonists & inhibitors | Ligand-Gated Ion Channels - antagonists & inhibitors | Reproducibility of Results | Anesthetics - chemistry | Ligand-Gated Ion Channels - chemistry | Spectrometry, Fluorescence | Halothane - chemistry | Protein Structure, Quaternary - drug effects | Molecular Dynamics Simulation | Thiopental - pharmacology | Cyanobacteria - cytology | Halothane - metabolism | Protein Binding | Bacterial Proteins - metabolism | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Protein Multimerization - drug effects | Proteins | Medical colleges | Analysis | Halothane | Crystals | Fluorescence | Tryptophan | Chemical properties | Structure | Protein binding | Binding | Computer simulation | Molecular dynamics | Bacteria | Anesthetics | Channels | Quenching
TRYPTOPHAN FLUORESCENCE | MOLECULAR-DYNAMICS | GABA(A) RECEPTOR | BIOPHYSICS | STRUCTURAL BASIS | SERUM-ALBUMIN | AMINO-ACIDS | 4-ALPHA-HELIX BUNDLE | HIGH-RESOLUTION | NICOTINIC ACETYLCHOLINE-RECEPTOR | AGONIST BINDING | Bacterial Proteins - chemistry | Cyanobacteria - metabolism | Substrate Specificity | Anesthetics - pharmacology | Protein Subunits - metabolism | Extracellular Space - metabolism | Thiopental - chemistry | Thiopental - metabolism | Volatilization | Anesthetics - metabolism | Cell Membrane - metabolism | Ligand-Gated Ion Channels - metabolism | Binding Sites | Halothane - pharmacology | Protein Structure, Tertiary | Bacterial Proteins - antagonists & inhibitors | Ligand-Gated Ion Channels - antagonists & inhibitors | Reproducibility of Results | Anesthetics - chemistry | Ligand-Gated Ion Channels - chemistry | Spectrometry, Fluorescence | Halothane - chemistry | Protein Structure, Quaternary - drug effects | Molecular Dynamics Simulation | Thiopental - pharmacology | Cyanobacteria - cytology | Halothane - metabolism | Protein Binding | Bacterial Proteins - metabolism | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Protein Multimerization - drug effects | Proteins | Medical colleges | Analysis | Halothane | Crystals | Fluorescence | Tryptophan | Chemical properties | Structure | Protein binding | Binding | Computer simulation | Molecular dynamics | Bacteria | Anesthetics | Channels | Quenching
Journal Article
11.
Genetics of anesthetic response: autosomal mutations that render Drosophila resistant to halothane
Pharmacology Biochemistry and Behavior, ISSN 0091-3057, 12/2000, Volume 67, Issue 4, pp. 749 - 757
Molecular mechanisms of anesthetic action are poorly understood. Genetic approaches to investigate mechanisms of anesthesia, although sparse and rather new,...
halothane
halothane
Journal Article
Neuroscience, ISSN 0306-4522, 2017, Volume 356, pp. 182 - 192
Highlights • The background activity of CN cells was significantly suppressed under halothane. • The number of visually active responsive neurons in the CN was...
Neurology | caudate nucleus | halothane anesthetized cats | visual stimulation | behaving cats | neuron classification | MEDIALIS-SUPRAGENICULATE NUCLEUS | RAT NEOSTRIATUM | SINGLE CELLS | BASAL GANGLIA | SENSORIMOTOR STRIATUM | NEUROSCIENCES | SUPERIOR COLLICULUS | RESPONSES | IN-VIVO | SOUND-LOCALIZATION | INTERNEURONS | Halothane - pharmacology | Cats | Wakefulness - drug effects | Action Potentials - physiology | Visual Pathways - physiology | Animals | Visual Pathways - drug effects | Photic Stimulation - methods | Caudate Nucleus - physiology | Neurons - physiology | Wakefulness - physiology | Behavior, Animal - drug effects | Caudate Nucleus - drug effects | Neurons - drug effects | Action Potentials - drug effects | Neurons | Analysis | Halothane | Anesthesia | Halides
Neurology | caudate nucleus | halothane anesthetized cats | visual stimulation | behaving cats | neuron classification | MEDIALIS-SUPRAGENICULATE NUCLEUS | RAT NEOSTRIATUM | SINGLE CELLS | BASAL GANGLIA | SENSORIMOTOR STRIATUM | NEUROSCIENCES | SUPERIOR COLLICULUS | RESPONSES | IN-VIVO | SOUND-LOCALIZATION | INTERNEURONS | Halothane - pharmacology | Cats | Wakefulness - drug effects | Action Potentials - physiology | Visual Pathways - physiology | Animals | Visual Pathways - drug effects | Photic Stimulation - methods | Caudate Nucleus - physiology | Neurons - physiology | Wakefulness - physiology | Behavior, Animal - drug effects | Caudate Nucleus - drug effects | Neurons - drug effects | Action Potentials - drug effects | Neurons | Analysis | Halothane | Anesthesia | Halides
Journal Article
Journal of Clinical and Diagnostic Research, ISSN 2249-782X, 05/2018, Volume 12, Issue 5, pp. UD01 - UD02
Journal Article
Anesthesiology, ISSN 0003-3022, 12/1997, Volume 87, Issue 6, pp. 1298 - 1300
Background: In the authors' clinical experience, preschool children are more likely to show delirium after sevoflurane than are older children. Methods:...
Delirium | Pediatrics | Complications | Sevoflurane halothane | Anesthetics, volatile | Age | PEDIATRIC AMBULATORY PATIENTS | age, pediatrics | ANESTHESIOLOGY | anesthetics, volatile, sevoflurane, halothane | INDUCTION | complications, delirium | HALOTHANE | DESFLURANE | K BA ANESTHESIOLOGY | CHILDREN | Ethers - adverse effects | Age Factors | Humans | Child, Preschool | Methyl Ethers | Male | Anesthetics, Inhalation - adverse effects | Incidence | Sevoflurane | Halothane - adverse effects | Anesthesia Recovery Period | Child | Anesthesia, Inhalation | Delirium - chemically induced
Delirium | Pediatrics | Complications | Sevoflurane halothane | Anesthetics, volatile | Age | PEDIATRIC AMBULATORY PATIENTS | age, pediatrics | ANESTHESIOLOGY | anesthetics, volatile, sevoflurane, halothane | INDUCTION | complications, delirium | HALOTHANE | DESFLURANE | K BA ANESTHESIOLOGY | CHILDREN | Ethers - adverse effects | Age Factors | Humans | Child, Preschool | Methyl Ethers | Male | Anesthetics, Inhalation - adverse effects | Incidence | Sevoflurane | Halothane - adverse effects | Anesthesia Recovery Period | Child | Anesthesia, Inhalation | Delirium - chemically induced
Journal Article
EUROPEAN JOURNAL OF ANAESTHESIOLOGY, ISSN 0265-0215, 07/2015, Volume 32, Issue 7, pp. 507 - 508
Journal Article
British Journal of Anaesthesia, ISSN 0007-0912, 07/2011, Volume 107, Issue 1, pp. 48 - 56
Over the past 50 yr, many drugs have been implicated as triggers of malignant hyperthermia (MH), a potentially fatal pharmacogenetic disorder of skeletal...
RYR1 | methylene blue | serotonin | inhalation anaesthetics, desflurane, halothane, isoflurane, sevoflurane | ondansetron | calcium, excitation-coupled calcium entry, store-operated calcium entry | dihydropyridine receptor | ryanodine receptor | malignant hyperthermia | neuromuscular blocking drugs, succinylcholine | CAFFEINE | SARCOPLASMIC-RETICULUM | SEVOFLURANE | SKELETAL-MUSCLE | IN-VITRO | CLINICAL PRESENTATION | INHALATION ANESTHETICS | INDUCED CA2+ RELEASE | ANESTHESIOLOGY | MG2+ DEPENDENCE | HALOTHANE | Dose-Response Relationship, Drug | Animals | Malignant Hyperthermia - etiology | Humans | Neuromuscular Depolarizing Agents - adverse effects | Succinylcholine - adverse effects | Malignant Hyperthermia - prevention & control | Anesthetics, Inhalation - adverse effects | Neuromuscular Nondepolarizing Agents - therapeutic use
RYR1 | methylene blue | serotonin | inhalation anaesthetics, desflurane, halothane, isoflurane, sevoflurane | ondansetron | calcium, excitation-coupled calcium entry, store-operated calcium entry | dihydropyridine receptor | ryanodine receptor | malignant hyperthermia | neuromuscular blocking drugs, succinylcholine | CAFFEINE | SARCOPLASMIC-RETICULUM | SEVOFLURANE | SKELETAL-MUSCLE | IN-VITRO | CLINICAL PRESENTATION | INHALATION ANESTHETICS | INDUCED CA2+ RELEASE | ANESTHESIOLOGY | MG2+ DEPENDENCE | HALOTHANE | Dose-Response Relationship, Drug | Animals | Malignant Hyperthermia - etiology | Humans | Neuromuscular Depolarizing Agents - adverse effects | Succinylcholine - adverse effects | Malignant Hyperthermia - prevention & control | Anesthetics, Inhalation - adverse effects | Neuromuscular Nondepolarizing Agents - therapeutic use
Journal Article
Annales francaises d'anesthesie et de reanimation, ISSN 0750-7658, 04/2005, Volume 24, Issue 4, p. 383
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 11/2010, Volume 132, Issue 46, pp. 16442 - 16449
Bacterial Gloeobacter violaceus pentameric ligand-gated ion channel (GLIC) is activated to cation permeation upon lowering the solution pH. Its function can be...
TRANSPORT | GATING MECHANISM | LOOP | PORE | NICOTINIC ACETYLCHOLINE-RECEPTOR | GLYCINE RECEPTOR | GRAMICIDIN | SIMULATIONS | K+ CHANNEL | BINDING | CHEMISTRY, MULTIDISCIPLINARY | Halothane - pharmacology | Protons | Anesthetics, Inhalation - chemistry | Anesthetics, Inhalation - pharmacology | Ion Channels - metabolism | Models, Molecular | Halothane - chemistry | Ions - metabolism | Ion Channels - chemistry | Molecular Dynamics Simulation | Ion Channel Gating - drug effects | Halocarbons | Usage | Molecular dynamics | Research | Brownian motion | Sodium | Analysis | Cyanobacteria | Physiological aspects | Genetic aspects | Ion channels | Chemical properties | Electric properties | ion permeation | anesthetic halothane modulation mechanism | Brownian dynamics | molecular dynamics | GLIC
TRANSPORT | GATING MECHANISM | LOOP | PORE | NICOTINIC ACETYLCHOLINE-RECEPTOR | GLYCINE RECEPTOR | GRAMICIDIN | SIMULATIONS | K+ CHANNEL | BINDING | CHEMISTRY, MULTIDISCIPLINARY | Halothane - pharmacology | Protons | Anesthetics, Inhalation - chemistry | Anesthetics, Inhalation - pharmacology | Ion Channels - metabolism | Models, Molecular | Halothane - chemistry | Ions - metabolism | Ion Channels - chemistry | Molecular Dynamics Simulation | Ion Channel Gating - drug effects | Halocarbons | Usage | Molecular dynamics | Research | Brownian motion | Sodium | Analysis | Cyanobacteria | Physiological aspects | Genetic aspects | Ion channels | Chemical properties | Electric properties | ion permeation | anesthetic halothane modulation mechanism | Brownian dynamics | molecular dynamics | GLIC
Journal Article
1985, FDI technical report, Volume no. 21, 173-174. --
Book
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e37251
The cytoskeleton is essential to cell morphology, cargo trafficking, and cell division. As the neuronal cytoskeleton is extremely complex, it is no wonder that...
MOLECULAR-DYNAMICS | COGNITIVE DECLINE | ALPHA-BETA-TUBULIN | SEVOFLURANE ANESTHESIA | MULTIDISCIPLINARY SCIENCES | HALOTHANE BINDING | CENTRAL-NERVOUS-SYSTEM | KINASE-C | HIPPOCAMPAL-NEURONS | RAT-BRAIN PROTEINS | INHALED ANESTHETICS | Neurodegenerative Diseases - pathology | Models, Chemical | Humans | Anesthesia, General - adverse effects | Neurodegenerative Diseases - metabolism | Anesthetics | Microtubules - metabolism | Tubulin - metabolism | Halothane - metabolism | Microtubules - drug effects | Computer Simulation | Volatilization | Cytoskeleton - metabolism | Protein Conformation | Cytoskeleton - drug effects | Complications and side effects | Nervous system diseases | Analysis | Force and energy | Halothane | Molecular dynamics | Anesthesia | Tubulins | Alzheimer's disease | Phosphorylation | Laboratories | Computational neuroscience | Trafficking | Cytology | Disorders | Cognitive ability | Homology | Crystallography | Cell morphology | Genetic algorithms | Proteins | Tubulin | Isotypes | Neurodegeneration | Microtubule-associated proteins | Spectrum analysis | Docking | Labeling | Stability | Neurodegenerative diseases | Computer simulation | Cell division | Mathematical morphology | Disease control | Free energy | Physics | Side effects | Tau protein | Computer applications | Cytoskeleton | Ligands | Binding sites | Surface geometry
MOLECULAR-DYNAMICS | COGNITIVE DECLINE | ALPHA-BETA-TUBULIN | SEVOFLURANE ANESTHESIA | MULTIDISCIPLINARY SCIENCES | HALOTHANE BINDING | CENTRAL-NERVOUS-SYSTEM | KINASE-C | HIPPOCAMPAL-NEURONS | RAT-BRAIN PROTEINS | INHALED ANESTHETICS | Neurodegenerative Diseases - pathology | Models, Chemical | Humans | Anesthesia, General - adverse effects | Neurodegenerative Diseases - metabolism | Anesthetics | Microtubules - metabolism | Tubulin - metabolism | Halothane - metabolism | Microtubules - drug effects | Computer Simulation | Volatilization | Cytoskeleton - metabolism | Protein Conformation | Cytoskeleton - drug effects | Complications and side effects | Nervous system diseases | Analysis | Force and energy | Halothane | Molecular dynamics | Anesthesia | Tubulins | Alzheimer's disease | Phosphorylation | Laboratories | Computational neuroscience | Trafficking | Cytology | Disorders | Cognitive ability | Homology | Crystallography | Cell morphology | Genetic algorithms | Proteins | Tubulin | Isotypes | Neurodegeneration | Microtubule-associated proteins | Spectrum analysis | Docking | Labeling | Stability | Neurodegenerative diseases | Computer simulation | Cell division | Mathematical morphology | Disease control | Free energy | Physics | Side effects | Tau protein | Computer applications | Cytoskeleton | Ligands | Binding sites | Surface geometry
Journal Article
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