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Molecular Neurobiology, ISSN 0893-7648, 7/2018, Volume 55, Issue 7, pp. 5847 - 5867
In addition to the classical hormonal (tissue-to-tissue) renin-angiotensin system (RAS), there are a paracrine (cell-to-cell) and an intracrine... 
Neurology | Neuroprotection | Neurosciences | Biomedicine | Neurobiology | Aging | Nuclear receptors | Renin-angiotensin system | Parkinson’s disease | Cell Biology | Dopaminergic | SYSTEM | NADPH OXIDASE | OXIDATIVE STRESS | Parkinson's disease | TYPE-2 RECEPTOR | NEUROSCIENCES | DOPAMINE NEURONS | II TYPE-1 | EXPRESSION | BRAIN | MAS | PARKINSONS-DISEASE | Microglia - metabolism | Mesencephalon - cytology | Reactive Oxygen Species - metabolism | Oxidative Stress | Receptors, G-Protein-Coupled - metabolism | Male | Substantia Nigra - metabolism | Case-Control Studies | Cell Nucleus - metabolism | Dopaminergic Neurons - metabolism | Gene Deletion | Peptidyl-Dipeptidase A - metabolism | Angiotensin II | Proto-Oncogene Proteins - metabolism | Peptide Fragments - metabolism | Paracrine Communication | Signal Transduction | Reactive Nitrogen Species - metabolism | Cells, Cultured | Rodentia | Mitochondria - metabolism | Angiotensin I - metabolism | Haplorhini | Animals | Receptor, Angiotensin, Type 2 - metabolism | Models, Biological | Receptor, Angiotensin, Type 1 - metabolism | Aging - metabolism | Astrocytes - metabolism | Medical research | Nervous system diseases | Neurons | Cell death | Angiotensin | Medicine, Experimental | Superoxide | Neurophysiology | Brain | Neurodegenerative diseases | Substantia nigra | Paracrine signalling | Glial cells | Neuronal-glial interactions | Mitochondria | Renin | Neurodegeneration | Rodents | Intracellular | Pluripotency | Movement disorders | Dopamine receptors
Journal Article
Cell Metabolism, ISSN 1550-4131, 12/2013, Volume 18, Issue 6, pp. 831 - 843
Journal Article
Journal of Pharmacokinetics and Pharmacodynamics, ISSN 1567-567X, 2/2012, Volume 39, Issue 1, pp. 67 - 86
The objectives of the following investigation were (1) development of a physiologically based pharmacokinetic (PBPK) model capable of characterizing the plasma... 
Biochemistry, general | Biomedical Engineering | Biomedicine | Physiologically based pharmacokinetic | Pharmacy | Tissue disposition | FcRn | Veterinary Medicine | Interspecies scaling | Monoclonal antibody | Pharmacology/Toxicology | PHARMACOKINETIC MODEL | SERUM HALF-LIVES | IGG ANTIBODIES | NEONATAL FC-RECEPTOR | EPITHELIAL-CELLS | I-RELATED RECEPTOR | DRUG DEVELOPMENT | PHARMACOLOGY & PHARMACY | RETROSPECTIVE ANALYSIS | IMMUNOGLOBULIN-G | DOSE ESTIMATION | Neoplasms - metabolism | Tissue Distribution - physiology | Area Under Curve | Humans | Receptors, Fc - metabolism | Immunoglobulins, Intravenous - administration & dosage | Male | Blood - metabolism | Endosomes - metabolism | Antibodies, Monoclonal - blood | Histocompatibility Antigens Class I - metabolism | Immunoglobulins, Intravenous - metabolism | Extracellular Space - metabolism | Antibodies, Monoclonal, Humanized - pharmacokinetics | Lymph - metabolism | Antibodies, Monoclonal, Humanized - blood | Antibodies, Monoclonal - immunology | Drug Evaluation, Preclinical - methods | Tissue Distribution - drug effects | Antigens, Neoplasm - immunology | Antibodies, Monoclonal - pharmacokinetics | Rats | Histocompatibility Antigens Class I - genetics | Immunoglobulins, Intravenous - pharmacology | Haplorhini | Mice, Knockout | Xenograft Model Antitumor Assays | Algorithms | Animals | Pinocytosis - physiology | Models, Biological | Neoplasms - immunology | Receptors, Fc - genetics | Mice | Antibodies, Monoclonal - metabolism | Adalimumab | Animal Structures - metabolism | Physiological aspects | Monoclonal antibodies | Immunoglobulins | Immunity | Tumors | Endothelium
Journal Article
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 3/2008, Volume 61, Issue 3, pp. 365 - 376
Journal Article
Movement Disorders, ISSN 0885-3185, 03/2008, Volume 23, Issue 4, pp. 474 - 483
Dopaminergic neurons of the substantia nigra are particularly vulnerable to oxidative and inflammatory attack. Such processes may play a crucial role in the... 
inflammation | astrocytes | MPTP | α‐synuclein | microglia | oxidative stress | oligodendroglia | Oxidative stress | Astrocytes | Oligodendroglia | Inflammation | α-synuclein | Microglia | ACTIVATED PROTEIN-KINASE | MICROGLIAL ACTIVATION | NITRIC-OXIDE SYNTHASE | alpha-synuclein | SYNERGISTIC DOPAMINERGIC NEUROTOXICITY | RAT MESENCEPHALIC CULTURES | SUBSTANTIA-NIGRA | CLINICAL NEUROLOGY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | IN-VIVO | ROTENONE-INDUCED DEGENERATION | Immunohistochemistry | Inflammation - chemically induced | Inflammation - pathology | Microglia - metabolism | Neurons - pathology | Substantia Nigra - pathology | Humans | Oxidative Stress - physiology | Astrocytes - pathology | Substantia Nigra - immunology | Male | Substantia Nigra - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Microglia - immunology | Astrocytes - immunology | Microglia - pathology | Female | Neurons - metabolism | Parkinson Disease - metabolism | Dopamine - metabolism | Parkinson Disease - pathology | Intercellular Adhesion Molecule-1 - immunology | Parkinson Disease - immunology | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - adverse effects | Neurotoxins - adverse effects | Neurons - immunology | Haplorhini | Brain - drug effects | Animals | HLA-DR Antigens - immunology | alpha-Synuclein - metabolism | Astrocytes - metabolism
Journal Article
Journal Article