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American Journal of Clinical Pathology, ISSN 0002-9173, 01/2010, Volume 134, Issue 6, pp. 886 - 893
It is estimated that 35% of total hip arthroplasties (THAs) involve a second-generation metal-on-metal (MOM) prosthesis. A novel complication has appeared in a... 
Haptens
Journal Article
BIOCONJUGATE CHEMISTRY, ISSN 1043-1802, 06/2015, Volume 26, Issue 6, pp. 1041 - 1053
Vaccines against drugs of abuse have induced antibodies in animals that blocked the biological effects of the drug by sequestering the drug in the blood and... 
SUBSTANCE-ABUSE | GLYCOCONJUGATE VACCINES | PROTEIN | TOXIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | RATS | CHEMISTRY, ORGANIC | CHEMISTRY, MULTIDISCIPLINARY | ADDICTION | IMMUNOGENICITY | MORPHINE/HEROIN VACCINE | DERIVATIVES | 6-MONOACETYLMORPHINE | Haptens - administration & dosage | Adjuvants, Immunologic - administration & dosage | Adjuvants, Immunologic - pharmacology | Lipid A - analogs & derivatives | Bacterial Proteins - chemistry | Analgesics, Opioid - pharmacology | Crystallography, X-Ray | Heroin Dependence - prevention & control | Haptens - immunology | Drug Carriers - chemistry | Haptens - chemistry | Vaccines, Conjugate - immunology | Lipid A - immunology | Tetanus Toxoid - chemistry | Vaccines, Conjugate - pharmacology | Immunoglobulin G - immunology | Vaccines, Conjugate - chemistry | Female | Analgesics, Opioid - immunology | Heroin - pharmacology | Immunization | Lipid A - administration & dosage | Models, Molecular | Antibody Affinity | Heroin - immunology | Vaccines, Conjugate - administration & dosage | Animals | Heroin Dependence - immunology | Mice, Inbred BALB C | Haptens - pharmacology | heroin vaccine | MALDI-TOF MS | hapten density | antibody titer | protein carrier | drugs of abuse vaccines | Heroin hapten | CRM197 | antibody affinity | nociception assay | tetanus toxoid | bioconjugate vaccine
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2017, Volume 198, Issue 11, pp. 4217 - 4227
Covalent modification of protein by drugs may disrupt self-tolerance, leading to lymphocyte activation. Until now, determination of the threshold required for... 
RESPONSES | RECOGNITION | REACTIVE METABOLITES | PENICILLIN-G | PEPTIDE REPERTOIRE | CYSTIC-FIBROSIS | ALBUMIN | IMMUNOLOGY | ALLERGIC INDIVIDUALS | AMOXICILLIN | INDUCED LIVER-INJURY | beta-Lactams - metabolism | Haptens - administration & dosage | Humans | Piperacillin - immunology | Male | Piperacillin - metabolism | CD4-Positive T-Lymphocytes - physiology | Haptens - immunology | CD4-Positive T-Lymphocytes - immunology | Epitopes - immunology | Piperacillin - administration & dosage | Young Adult | Haptens - chemistry | Serum Albumin - immunology | beta-Lactams - immunology | Haptens - metabolism | Mass Spectrometry | Adult | Female | Serum Albumin - chemistry | Lymphocyte Activation | Immune Tolerance | Anti-Bacterial Agents - immunology | Drug Hypersensitivity - immunology | Antigens - immunology | Anti-Bacterial Agents - pharmacology | Epitopes - chemistry | Anti-Bacterial Agents - administration & dosage | beta-Lactams - administration & dosage | Drugs | Amides | Activation | Lymphocytes T | Immunosuppressive agents | Homing | Spectrometry | Receptors | Cell activation | Lymphocytes | Drug tolerance | Piperacillin | Human serum albumin | Incubation | β-Lactam antibiotics | Immunoregulation | Hypersensitivity | Serum albumin | Epitopes | Patients | Immunological tolerance | CD4 antigen | Antibiotics | Lysine | Skin | Cell migration
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e76557
Journal Article
Journal Article