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Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 8, pp. 697 - 710
Summary Background Previous trials have shown that anti-EGFR monoclonal antibodies can improve clinical outcomes of patients with recurrent or metastatic... 
Hematology, Oncology and Palliative Medicine | SURVIVAL | P16 | ONCOLOGY | COLORECTAL-CANCER | OROPHARYNGEAL CANCER | HUMAN-PAPILLOMAVIRUS | P16(INK4A) | SUBSET | III TRIAL | COOPERATIVE-ONCOLOGY-GROUP | PLUS FLUOROURACIL | Immunohistochemistry | South America | Head and Neck Neoplasms - virology | Prospective Studies | Carcinoma, Squamous Cell - virology | Humans | Middle Aged | Neoplasm Recurrence, Local - virology | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | North America | Cisplatin - administration & dosage | Neoplasm Recurrence, Local - pathology | Head and Neck Neoplasms - chemistry | Neoplasm Metastasis | Carcinoma, Squamous Cell - mortality | Cyclin-Dependent Kinase Inhibitor p16 - analysis | Fluorouracil - administration & dosage | Time Factors | Female | Retrospective Studies | Biomarkers, Tumor - analysis | Europe | Head and Neck Neoplasms - drug therapy | Kaplan-Meier Estimate | Proportional Hazards Models | Carcinoma, Squamous Cell - chemistry | Treatment Outcome | Papillomaviridae - isolation & purification | Neoplasm Recurrence, Local - chemistry | Head and Neck Neoplasms - pathology | Disease-Free Survival | Carcinoma, Squamous Cell - drug therapy | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Asia | Biopsy | Carcinoma, Squamous Cell - secondary | Aged | Head and Neck Neoplasms - mortality | Care and treatment | Relapse | Carcinoma | Monoclonal antibodies | Product development | Metastasis | Cisplatin | Cancer | Diseases | Index Medicus
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 04/2016, Volume 34, Issue 12, pp. 1300 - 1308
Purpose We conducted a retrospective evaluation of the IMCL-9815 study to examine the association of human papillomavirus (HPV) and p16 protein expression... 
SURVIVAL | PANITUMUMAB | THERAPY | ONCOLOGY | RECURRENT | CHEMORADIOTHERAPY | RISK | CANCER | CHEMOTHERAPY | Immunohistochemistry | Oropharyngeal Neoplasms - therapy | Predictive Value of Tests | Chemoradiotherapy - adverse effects | Head and Neck Neoplasms - virology | Carcinoma, Squamous Cell - pathology | Carcinoma, Squamous Cell - virology | Humans | Middle Aged | Oropharyngeal Neoplasms - mortality | Male | Antineoplastic Agents - therapeutic use | Oropharyngeal Neoplasms - pathology | Cetuximab - therapeutic use | Papillomaviridae - genetics | Cetuximab - adverse effects | Clinical Trials, Phase III as Topic | Head and Neck Neoplasms - chemistry | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - mortality | Cyclin-Dependent Kinase Inhibitor p16 - analysis | Time Factors | Antineoplastic Agents - adverse effects | Female | Retrospective Studies | Biomarkers, Tumor - analysis | Head and Neck Neoplasms - therapy | Kaplan-Meier Estimate | Proportional Hazards Models | Carcinoma, Squamous Cell - therapy | Carcinoma, Squamous Cell - chemistry | Treatment Outcome | Oropharyngeal Neoplasms - virology | Papillomaviridae - isolation & purification | Head and Neck Neoplasms - pathology | Randomized Controlled Trials as Topic | Disease-Free Survival | Oropharyngeal Neoplasms - chemistry | Aged | Human Papillomavirus DNA Tests | Head and Neck Neoplasms - mortality | DNA, Viral - genetics | Index Medicus | Hnc16 | ORIGINAL REPORTS | Hnc6
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 01/2018, Volume 110, Issue 1, pp. 109 - 120
Background: Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as... 
CELL LUNG-CANCER | PHASE-II TRIAL | OXIDATIVE STRESS | ONCOLOGY | NAB-PACLITAXEL | ACTIVATION PROTEIN | DEPENDENT INVASION | PANCREATIC-CANCER | MONOCLONAL-ANTIBODY | DIFFERENTIATION | STROMAL CELLS | Lung Neoplasms - drug therapy | Up-Regulation | Pyrazoles - therapeutic use | Reactive Oxygen Species - metabolism | Cell Count | Humans | Middle Aged | Male | Oropharyngeal Neoplasms - pathology | Head and Neck Neoplasms - chemistry | RNA Interference | Cancer-Associated Fibroblasts - chemistry | Aged, 80 and over | NADPH Oxidases - genetics | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Lung Neoplasms - chemistry | NADPH Oxidases - antagonists & inhibitors | Head and Neck Neoplasms - drug therapy | Carcinoma, Squamous Cell - chemistry | Survival Rate | Adenocarcinoma - drug therapy | Disease Progression | Phenotype | Carcinoma, Squamous Cell - drug therapy | Head and Neck Neoplasms - genetics | Mice | Neoplasm Transplantation | Carcinoma, Non-Small-Cell Lung - chemistry | Carcinoma, Squamous Cell - genetics | Colorectal Neoplasms - chemistry | Cell Transdifferentiation - genetics | Myofibroblasts - chemistry | Actins - analysis | Cell Transdifferentiation - drug effects | Adult | Female | Adenocarcinoma - genetics | Cancer-Associated Fibroblasts - physiology | Pyridines - therapeutic use | Lung Neoplasms - genetics | Myofibroblasts - pathology | Carcinoma, Non-Small-Cell Lung - genetics | NADPH Oxidases - analysis | Mouth Neoplasms - chemistry | NADPH Oxidase 4 | Cancer-Associated Fibroblasts - pathology | Animals | Esophageal Neoplasms - genetics | Mouth Neoplasms - pathology | Oropharyngeal Neoplasms - chemistry | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Colorectal Neoplasms - pathology | Esophageal Neoplasms - drug therapy | Index Medicus
Journal Article
The American Journal of Surgical Pathology, ISSN 0147-5185, 05/2017, Volume 41, Issue 5, pp. 607 - 615
Dysregulated expression of oncogenic types of E6 and E7 is necessary for human papillomavirus (HPV)-driven carcinogenesis. An HPV E6/E7 mRNA in situ... 
High-grade squamous intraepithelial lesion | Low-grade squamous intraepithelial lesion | Human papillomavirus | RNA | Cervical intraepithelial neoplasia | CIN | Cervical carcinoma | Oropharyngeal carcinoma | In situ hybridization | HPV | SURGERY | DIAGNOSIS | low-grade squamous intraepithelial lesion | ASCUS-LSIL TRIAGE | cervical carcinoma | INTRAEPITHELIAL LESIONS | HUMAN-PAPILLOMAVIRUS | PATHOLOGY | oropharyngeal carcinoma | cervical intraepithelial neoplasia | HIGH-RISK HPV | CERVIX | P16 | human papillomavirus | SQUAMOUS-CELL CARCINOMA | GRADE | high-grade squamous intraepithelial lesion | EXPRESSION | in situ hybridization | Immunohistochemistry | Predictive Value of Tests | Cervical Intraepithelial Neoplasia - pathology | Head and Neck Neoplasms - virology | Humans | Anus Neoplasms - virology | Uterine Cervical Neoplasms - pathology | Papillomavirus E7 Proteins - genetics | Papillomavirus Infections - pathology | Head and Neck Neoplasms - chemistry | Vulvar Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p16 - analysis | In Situ Hybridization | Neoplasm Grading | RNA, Viral - genetics | Polymerase Chain Reaction | Anus Neoplasms - chemistry | Female | Oncogene Proteins, Viral - genetics | Papillomavirus Infections - virology | Reproducibility of Results | Biomarkers, Tumor - analysis | RNA, Messenger - genetics | Cervical Intraepithelial Neoplasia - chemistry | Vulvar Neoplasms - virology | Anus Neoplasms - pathology | Uterine Cervical Neoplasms - genetics | Cervical Intraepithelial Neoplasia - virology | Head and Neck Neoplasms - pathology | Papillomavirus Infections - genetics | Vulvar Neoplasms - genetics | Anus Neoplasms - genetics | Uterine Cervical Neoplasms - virology | Head and Neck Neoplasms - genetics | Biomarkers, Tumor - genetics | Cervical Intraepithelial Neoplasia - genetics | Human Papillomavirus DNA Tests | Uterine Cervical Neoplasms - chemistry | Observer Variation | Vulvar Neoplasms - chemistry | Index Medicus
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2017, Volume 35, Issue 14, pp. 1542 - 1549
Journal Article
British Journal of Cancer, ISSN 0007-0920, 02/2018, Volume 118, Issue 3, pp. 428 - 434
Background: Periodontal pathogens have been linked to oral and gastrointestinal (orodigestive) carcinogenesis. However, the exact mechanisms remain unknown.... 
chymotrypsin-like proteinase | Treponema denticola | periodontopathogen | COLLAGENASE-2 MMP-8 | PORPHYROMONAS-GINGIVALIS | PANCREATIC-CANCER | TISSUE INHIBITORS | PERIODONTAL-DISEASE | METALLOPROTEINASES | ONCOLOGY | gastrointestinal cancer | ALPHA-1-ANTITRYPSIN | EXPRESSION | oral cancer | HUMAN NEUTROPHIL | PROGRESSION | Digestive System Neoplasms - metabolism | Pancreatic Neoplasms - chemistry | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Treponema denticola - enzymology | Mouth Neoplasms - metabolism | Stomach Neoplasms - pathology | Tonsillar Neoplasms - chemistry | Complement C1q - metabolism | Colonic Neoplasms - metabolism | Head and Neck Neoplasms - metabolism | Esophageal Neoplasms - pathology | Tonsillar Neoplasms - metabolism | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Head and Neck Neoplasms - chemistry | Matrix Metalloproteinase 9 - metabolism | Adenocarcinoma - metabolism | Matrix Metalloproteinase 8 - metabolism | Esophageal Neoplasms - metabolism | Digestive System Neoplasms - pathology | Colonic Neoplasms - chemistry | Stomach Neoplasms - chemistry | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Tonsillar Neoplasms - pathology | Pancreatic Neoplasms - pathology | Carcinoma, Squamous Cell - chemistry | Mouth Neoplasms - chemistry | Head and Neck Neoplasms - pathology | Cell Transformation, Neoplastic - immunology | Digestive System Neoplasms - chemistry | alpha 1-Antichymotrypsin - metabolism | Colonic Neoplasms - pathology | Chymases - analysis | Mouth Neoplasms - pathology | Immunohistochemistry | Proteinase | Virulence | Tissue inhibitor of metalloproteinase 2 | Tissues | Tissue inhibitor of metalloproteinase 1 | Carcinogenesis | Proteins | Carcinogens | Pancreatic carcinoma | Bacteria | Colon | Pancreas | Gastric cancer | Squamous cell carcinoma | Tonsil | Immunomodulation | Teeth | Proteinase inhibitors | Esophagus | Complement component C1q | Chymotrypsin | Periodontitis | Neutrophil collagenase | Tumors | Index Medicus | Molecular Diagnostics
Journal Article
The American Journal of Surgical Pathology, ISSN 0147-5185, 09/2015, Volume 39, Issue 9, pp. 1267 - 1274
Ewing sarcoma family tumors (EFTs) of the head and neck are rare and may be difficult to diagnose, as they display significant histologic overlap with other... 
Primitive neuroectodermal tumor | EWSR1 | Complex epithelial differentiation | Ewing sarcoma family tumor | Adamantinoma-like Ewing sarcoma | FLI1 | SYNOVIAL SARCOMA | SURGERY | complex epithelial differentiation | FUSION GENE | UPPER AERODIGESTIVE TRACT | PATHOLOGY | SOFT-TISSUE | CHILDREN | THYMUS-LIKE DIFFERENTIATION | ROUND-CELL TUMOR | CYTOKERATIN IMMUNOREACTIVITY | NUT MIDLINE CARCINOMA | SPINDLE EPITHELIAL TUMOR | adamantinoma-like Ewing sarcoma | primitive neuroectodermal tumor | Immunohistochemistry | Predictive Value of Tests | Humans | Middle Aged | Male | Bone Neoplasms - pathology | Antigens, CD - analysis | Young Adult | Head and Neck Neoplasms - chemistry | Myoepithelioma - chemistry | Bone Neoplasms - genetics | Cell Differentiation | Neuroectodermal Tumors, Primitive, Peripheral - diagnosis | Child | Neuroectodermal Tumors, Primitive, Peripheral - chemistry | Proto-Oncogene Protein c-fli-1 - genetics | In Situ Hybridization, Fluorescence | Sarcoma, Ewing - diagnosis | Head and Neck Neoplasms - pathology | Gene Rearrangement | Adolescent | Adamantinoma - genetics | Cell Adhesion Molecules - analysis | Head and Neck Neoplasms - genetics | Biomarkers, Tumor - genetics | Neuroectodermal Tumors, Primitive, Peripheral - genetics | Neuroectodermal Tumors, Primitive, Peripheral - pathology | RNA-Binding Proteins - genetics | Adamantinoma - pathology | Tissue Array Analysis | Sarcoma, Ewing - pathology | Myoepithelioma - pathology | Keratins - analysis | Bone Neoplasms - chemistry | Adult | Female | Calmodulin-Binding Proteins - genetics | Myoepithelioma - diagnosis | Diagnosis, Differential | Sarcoma, Ewing - chemistry | Bone Neoplasms - diagnosis | Biomarkers, Tumor - analysis | Adamantinoma - chemistry | Myoepithelioma - genetics | 12E7 Antigen | Biopsy | Adamantinoma - diagnosis | Head and Neck Neoplasms - diagnosis | Sarcoma, Ewing - genetics | RNA-Binding Protein EWS | Index Medicus
Journal Article
Journal Article
American Journal of Surgical Pathology, ISSN 0147-5185, 12/2012, Volume 36, Issue 12, pp. 1874 - 1882
Journal Article
The American Journal of Surgical Pathology, ISSN 0147-5185, 09/2017, Volume 41, Issue 12, pp. 1690 - 1701
Human papillomavirus (HPV)–related multiphenotypic sinonasal carcinoma (HMSC), originally known as HPV-related carcinoma with adenoid cystic carcinoma-like... 
SURGERY | HEAD | multiphenotypic sinonasal carcinoma | IN-SITU HYBRIDIZATION | PATHOLOGY | adenoid cystic carcinoma | SUBSET | RISK HUMAN-PAPILLOMAVIRUS | TRACT | carcinoma with adenoid cystic-like features | human papillomavirus | MYB | SQUAMOUS-CELL CARCINOMAS | MYBL1 | squamous cell carcinoma | Immunohistochemistry | Paranasal Sinus Neoplasms - genetics | Cell Proliferation | Head and Neck Neoplasms - virology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Carcinoma, Squamous Cell - virology | Humans | Middle Aged | Carcinoma, Adenoid Cystic - chemistry | Male | Carcinoma, Adenoid Cystic - virology | Paranasal Sinus Neoplasms - virology | Paranasal Sinus Neoplasms - chemistry | Papillomaviridae - genetics | Necrosis | Papillomavirus Infections - pathology | Head and Neck Neoplasms - chemistry | Squamous Cell Carcinoma of Head and Neck | Neoplasm Grading | RNA, Viral - genetics | Polymerase Chain Reaction | Aged, 80 and over | Adult | Female | Papillomavirus Infections - virology | Carcinoma, Adenoid Cystic - pathology | Biomarkers, Tumor - analysis | Carcinoma, Squamous Cell - chemistry | In Situ Hybridization, Fluorescence | Papillomaviridae - isolation & purification | Head and Neck Neoplasms - pathology | Papillomaviridae - pathogenicity | Mitotic Index | Paranasal Sinus Neoplasms - pathology | Phenotype | Carcinoma, Adenoid Cystic - genetics | Head and Neck Neoplasms - genetics | Aged | Biomarkers, Tumor - genetics | Neoplasm Staging | Index Medicus | Human papillomavirus
Journal Article
Annals of Oncology, ISSN 0923-7534, 06/2015, Volume 26, Issue 6, pp. 1216 - 1223