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1. Full Text The [beta]3 subunit of the nicotinic acetylcholine receptor is required for nicotine withdrawal-induced affective but not physical signs or nicotine reward in mice
by Jackson, Asti B and Toma, Wisam and Contreras, Katherine M and Alkhlaif, Yasmin and Damaj, M. Imad
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 08/2019, Volume 183, p. 1
Nicotinic acetylcholine receptors (nAChRs) are the primary target for nicotine, the addictive component in tobacco products. These pentameric receptors are... 
Evaluation | Smoking cessation products | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Nicotine | Smoking
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2. Full Text Randomized Trial of Reduced-Nicotine Standards for Cigarettes
by Donny, Eric C and Denlinger, Rachel L and Tidey, Jennifer W and Koopmeiners, Joseph S and Benowitz, Neal L and Vandrey, Ryan G and al’Absi, Mustafa and Carmella, Steven G and Cinciripini, Paul M and Dermody, Sarah S and Drobes, David J and Hecht, Stephen S and Jensen, Joni and Lane, Tonya and Le, Chap T and McClernon, F. Joseph and Montoya, Ivan D and Murphy, Sharon E and Robinson, Jason D and Stitzer, Maxine L and Strasser, Andrew A and Tindle, Hilary and Hatsukami, Dorothy K
The New England Journal of Medicine, ISSN 0028-4793, 10/2015, Volume 373, Issue 14, pp. 1340 - 1349
The Food and Drug Administration has the authority to reduce the nicotine content of cigarettes. In this randomized trial, participants assigned to... 
BIOMARKERS | MEDICINE, GENERAL & INTERNAL | METABOLISM | REDUCTION | COTININE | COMPENSATORY SMOKING | WITHDRAWAL | EXPOSURE | DEPENDENCE | Nicotine - administration & dosage | Biomarkers - urine | Nicotine - standards | Double-Blind Method | United States | Humans | Linear Models | Tobacco Products - analysis | Inhalation Exposure - analysis | Tars - analysis | Substance Withdrawal Syndrome | Creatinine - urine | Tars - standards | Nicotine - adverse effects | Tobacco - chemistry | Tobacco Use Disorder - prevention & control | Tobacco Products - standards | United States Food and Drug Administration | Usage | Smokers | Laws, regulations and rules | Clinical trials | Cigarettes | Health aspects | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Nicotine | Smoking | Drug abuse | Tobacco | Regulation | Drug dependence | Smoke | Carbon monoxide | Index Medicus | Abridged Index Medicus
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3. Full Text Nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by H.sub.2O.sub.2 and entailing Glyoxalase 1-dependent MG-H1 accumulation leading to TG2-mediated NF-kB desensitization: Implication for smokers-related osteoporosis
by Marinucci, Lorella and Balloni, Stefania and Fettucciari, Katia and Bodo, Maria and Talesa, Vincenzo N and Antognelli, Cinzia
Free Radical Biology and Medicine, ISSN 0891-5849, 03/2018, Volume 117, p. 6
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.freeradbiomed.2018.01.017 
Enzymes | Osteoporosis | Smokers | Biological products | Hydrogen peroxide | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Smoking | Nicotine | Apoptosis
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4. Full Text A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors
by de Leon, Jose and Diaz, Francisco J
Schizophrenia Research, ISSN 0920-9964, 2005, Volume 76, Issue 2, pp. 135 - 157
A meta-analysis of worldwide studies, found by a 10-year literature follow-up and/or by searching PubMed, was performed. Forty-two studies across 20 nations... 
Schizophrenia | Logistic regression | Tobacco | Nicotine | Smoking | PSYCHIATRIC-PATIENTS | ETHNIC-DIFFERENCES | nicotine | SUBSTANCE-ABUSE | PSYCHIATRY | 1ST-EPISODE PATIENTS | schizophrenia | NICOTINE DEPENDENCE | REPETITIVE BEHAVIORS | CIGARETTE-SMOKING | MOOD DISORDERS | smoking | FAGERSTROM TOLERANCE QUESTIONNAIRE | tobacco | MENTAL-ILLNESS | logistic regression | Comorbidity | Smoking - epidemiology | Humans | Tobacco Use Disorder - epidemiology | Tobacco Use Disorder - prevention & control | Female | Male | Schizophrenia - epidemiology | Smoking Cessation - methods | Smoking Prevention | Tobacco industry | Analysis | Research | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Mentally ill | Risk factors | Index Medicus
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5. Full Text Is Big Tobacco Still Trying to Deceive the Public? This Is No Time to Rest on Our Laurels
by McCaffree, Donald Robert and Desai, Neeraj R
Chest, ISSN 0012-3692, 05/2018, Volume 153, Issue 5, pp. 1085 - 1086
RESPIRATORY SYSTEM | CRITICAL CARE MEDICINE | Health aspects | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Risk factors | Drug use | Smoking | Nicotine | Tobacco habit
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6. Full Text Environmental health hazards of e-cigarettes and their components: Oxidants and copper in e-cigarette aerosols
by Lerner, Chad A and Sundar, Isaac K and Watson, Richard M and Elder, Alison and Jones, Ryan and Done, Douglas and Kurtzman, Rachel and Ossip, Deborah J and Robinson, Risa and McIntosh, Scott and Rahman, Irfan
Environmental Pollution, ISSN 0269-7491, 03/2015, Volume 198, pp. 100 - 107
To narrow the gap in our understanding of potential oxidative properties associated with Electronic Nicotine Delivery Systems (ENDS) i.e. e-cigarettes, we... 
ENDS | Oxidants | Copper | Electronic cigarettes | EPR | ROS | OXIDATION | MAINSTREAM | 2',7'-DICHLOROFLUORESCIN | TAR | BUTTS | TOXICITY | ENVIRONMENTAL SCIENCES | HYDROGEN-PEROXIDE | SMOKE | RADICALS | EXTRACTS | Particle Size | Tobacco | Copper - analysis | Environmental Health | Risk Assessment | Electronic Nicotine Delivery Systems | Aerosols | Smoke - analysis | Hazardous Substances | Nicotine | Environmental health | Fluorescein | Health aspects | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Smoking | Index Medicus | ELECTRONIC PRODUCTS | Cascades | Delivery systems | Oxidizing agents | Electronics | PARTICLE SIZE AND SHAPE | Smoke | Cigarettes | copper | oxidants | electronic cigarettes
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7. Full Text Formation of carcinogens indoors by surface-mediated reactions of nicotine with nitrous acid, leading to potential thirdhand smoke hazards
by Mohamad Sleiman and Lara A. Gundel and James F. Pankow and Peyton Jacob and Brett C. Singer and Hugo Destaillats and Barbara J. Finlayson-Pitts
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2010, Volume 107, Issue 15, pp. 6576 - 6581
This study shows that residual nicotine from tobacco smoke sorbed to indoor surfaces reacts with ambient nitrous acid (HONO) to form carcinogenic... 
Secondhand smoke | Chemical hazards | Carcinogens | Tobacco smoking | ATMOSPHERIC CHEMISTRY SPECIAL FEATURE | Mass spectroscopy | Desorption | Cigarette smoking | Cigarettes | Automobiles | Vehicles | MULTIDISCIPLINARY SCIENCES | DIOXIDE | ENVIRONMENTAL TOBACCO-SMOKE | indoor environment | CANCER | nitrosamine | NO2 | exposure | NITROSAMINES | nitrogen oxides | GAS-PHASE | OZONE | heterogeneous chemistry | Nitrous Acid - chemistry | Humans | Nitrogen Oxides - chemistry | Chromatography, Gas - methods | Gases | Cellulose - chemistry | Tobacco | Adsorption | Surface Properties | Nicotine - chemistry | Carcinogens - chemistry | Tobacco Smoke Pollution | Kinetics | Chemistry - methods | Tandem Mass Spectrometry - methods | Cocarcinogens | Physiological aspects | Genetic aspects | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Nicotine | Smoking | Sorption | Hazardous substances | Lung cancer | Health hazards | Index Medicus | Physical Sciences
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8. Full Text Early Smoking Onset and Risk for Subsequent Nicotine Dependence: A Monozygotic Co-Twin Control Study
by Kendler, Kenneth S and Myers, John and Damaj, M. Imad and Chen, Xianging
American Journal of Psychiatry, ISSN 0002-953X, 04/2013, Volume 170, Issue 4, pp. 408 - 413
ObjectiveEarly onset of regular smoking is associated with an elevated risk for later nicotine dependence. Whether or not this association is causal is unknown... 
YOUNG-ADULTS | POPULATION-BASED TWIN | INITIATION | PSYCHIATRY | SUBSTANCE-USE DISORDERS | TOBACCO USE | RATS | CHILDHOOD SEXUAL-ABUSE | MAJOR DEPRESSION | ADOLESCENT | AGE | Humans | Risk Factors | Male | Sex Characteristics | Twins, Monozygotic - psychology | Behavior, Addictive - epidemiology | Smoking - epidemiology | Substance-Related Disorders - epidemiology | Age of Onset | Tobacco Use Disorder - epidemiology | Adult | Female | Virginia | Psychological aspects | Addiction | Health aspects | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Risk factors | Age | Nicotine | Smoking | Tobacco habit | Addictions | Twins | Health behavior | Index Medicus | Abridged Index Medicus
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9. Full Text Oral nicotine aggravates endothelial dysfunction and vascular inflammation in diet-induced obese rats: Role of macrophage TNF[alpha]
by Liu, Chang and Zhou, Ming-Sheng and Li, Yao and Wang, Aimei and Chadipiralla, Kiranmai and Tian, Runxia and Raij, Leopoldo
PLoS ONE, ISSN 1932-6203, 12/2017, Volume 12, Issue 12, p. e0188439
Oxidases | Obesity | Drinking water | Inflammation | Cigarettes | Macrophages | Endothelium | Diet | Tumor necrosis factor | Nitric oxide | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Smoking | Nicotine
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10. Full Text Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures
by Schweitzer, Kelly S and Chen, Steven X and Law, Sarah and Van Demark, Mary and Poirier, Christophe and Justice, Matthew J and Hubbard, Walter C and Kim, Elena S and Lai, Xianyin and Wang, Mu and Kranz, William D and Carroll, Clinton J and Ray, Bruce D and Bittman, Robert and Goodpaster, John and Petrache, Irina
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 07/2015, Volume 309, Issue 2, pp. L175 - L187
The increased use of inhaled nicotine via e-cigarettes has unknown risks to lung health. Having previously shown that cigarette smoke (CS) extract disrupts the... 
Cell proliferation | Tobacco | Inflammation | Permeability | Sphingosine-1-phosphate | PHYSIOLOGY | cell proliferation | permeability | KINASE | LUNG INJURY | RECEPTOR | CELL APOPTOSIS | SPHINGOSINE 1-PHOSPHATE | inflammation | RESPIRATORY SYSTEM | FTY720 | GENE-EXPRESSION | BARRIER ENHANCEMENT | tobacco | sphingosine-1-phosphate | DYSFUNCTION | SPECTROMETRY | Lysophospholipids - metabolism | Gas Chromatography-Mass Spectrometry | Humans | Pneumonia - pathology | Capillary Permeability - drug effects | Endothelium, Vascular - drug effects | Immunoblotting | Nicotine - adverse effects | Pneumonia - chemically induced | Female | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Sphingosine - metabolism | Phosphorylation - drug effects | Ceramides - metabolism | Mice, Inbred C57BL | Cells, Cultured | Electronic Nicotine Delivery Systems - adverse effects | Rats | Electric Impedance | Nicotinic Agonists - adverse effects | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Endothelium, Vascular - pathology | Cell Proliferation - drug effects | Mice | Oxidative Stress - drug effects | Pneumonia - metabolism | Medical research | Electronic cigarettes | Physiological aspects | Medicine, Experimental | Research | Health aspects | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Smoking | Nicotine | Endothelium | Phosphates | Myosin | Sphingosine | Ceramides | Plant lipids | Oxidative stress | Cellular biology | Physiology | Index Medicus
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11. Full Text Nicotine exposure during gestation and lactation affects cell proliferation and lung volume during lung development in mice
by Blaskovic, S and Zanetti, F and Donati, Y and Lameille, S and Cremona, TP and Ruchonnet-Metrailler, I and Schittny, J and Barazzone-Argiroffo, C
CHEST, ISSN 0012-3692, 05/2017, Volume 151, Issue 5, pp. 107A - 107A
RESPIRATORY SYSTEM | CRITICAL CARE MEDICINE | Research | Gene expression | Epidemiology | Health aspects | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Nicotine | Smoking
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12. Full Text Global surveillance of oral tobacco products: total nicotine, unionised nicotine and tobacco-specific N-nitrosamines
by Stanfill, Stephen B and Connolly, Gregory N and Zhang, Liqin and Jia, Lily T and Henningfield, Jack E and Richter, Patricia and Lawler, Tameka S and Ayo-Yusuf, Olalekan A and Ashley, David L and Watson, Clifford H
Tobacco Control, ISSN 0964-4563, 05/2011, Volume 20, Issue 3, pp. e2 - 10
ObjectiveOral tobacco products contain nicotine and carcinogenic tobacco-specific N-nitrosamines (TSNAs) that can be absorbed through the oral mucosa. The aim... 
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | SMOKERS | SUDAN | MOIST SNUFF | SMOKELESS TOBACCO | CARCINOGEN | USERS | Global Health | Humans | Nitrosamines - analysis | Spectroscopy, Fourier Transform Infrared | Carcinogens - analysis | Tobacco, Smokeless - chemistry | Hydrogen-Ion Concentration | Nicotine - analysis | Composition | Usage | Research | Nitrosoamines | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Smokeless tobacco | Nicotine | Index Medicus
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13. Full Text Comparative study of the effects of cigarette smoke and electronic cigarettes on human gingival fibroblast proliferation, migration and apoptosis
by Alanazi, Humidah and Park, Hyun Jin and Chakir, Jamila and Semlali, Abdelhabib and Rouabhia, Mahmoud
Food and Chemical Toxicology, ISSN 0278-6915, 08/2018, Volume 118, pp. 390 - 398
In an effort to reduce smoking-related diseases, alternative products such as e-cigarettes have been proposed. However, despite their growing popularity, the... 
Wound healing | Migration | E-cigarette | Gingival fibroblasts | Cell | Nicotine | Apoptosis | FOOD SCIENCE & TECHNOLOGY | VIABILITY | ALDEHYDES | TOBACCO | THERAPY | MESSAGES | TOXICOLOGY | CYTOTOXICITY | LIQUIDS | Electronic cigarettes | College teachers | Comparative analysis | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Smoking | Index Medicus
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14. Full Text U.S. Adults’ Attitudes Toward Lowering Nicotine Levels in Cigarettes
by Ali, Fatma Romeh M and Al-Shawaf, Maeh and Wang, Teresa W and King, Brian A
American Journal of Preventive Medicine, ISSN 0749-3797, 09/2019, Volume 57, Issue 3, pp. 403 - 407
This study assessed U.S. adults’ attitudes toward lowering the nicotine levels in cigarettes to make them less addictive. Data from the 2018 SummerStyles a... 
SUPPORT | MEDICINE, GENERAL & INTERNAL | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | SMOKING | ADDICTION | Tobacco industry | Analysis | Chronic diseases | Adults | Public opinion | Cigarettes | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Nicotine | Smoking | Sociodemographic aspects | Addictive | Computer based | Attitudes | Ethnicity | Tobacco | Race | Internet
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15. Full Text Nicotine delivery to users from cigarettes and from different types of e-cigarettes
by Hajek, Peter and Przulj, Dunja and Phillips, Anna and Anderson, Rebecca and McRobbie, Hayden
Psychopharmacology, ISSN 0033-3158, 3/2017, Volume 234, Issue 5, pp. 773 - 779
Delivering nicotine in the way smokers seek is likely to be the key factor in e-cigarette (EC) success in replacing cigarettes. We examined to what degree... 
Vaping | Neurosciences | Biomedicine | Nicotine delivery | E-cigarettes | Pharmacology/Toxicology | Psychiatry | Smoking | TRIAL | PUBLIC-HEALTH | PSYCHIATRY | PHARMACOLOGY & PHARMACY | SMOKE | WITHDRAWAL | NEUROSCIENCES | Nicotine - administration & dosage | Smoking - blood | Area Under Curve | Humans | Middle Aged | Nicotinic Agonists - blood | Male | Nicotine - blood | Cross-Over Studies | Young Adult | Nicotinic Agonists - administration & dosage | Tobacco Products | Electronic Nicotine Delivery Systems | Adult | Female | Physiological aspects | Evaluation | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Electronic cigarettes | Nicotine | Pharmacology | Index Medicus | Original Investigation
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