Nature, ISSN 0028-0836, 05/2011, Volume 473, Issue 7347, pp. 326 - 335
Heart failure plagues industrialized nations, killing more people than any other disease. It usually results from a deficiency of specialized cardiac muscle...
SMOOTH-MUSCLE | THERAPY | PLOIDY LEVEL | DNA-CONTENT | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | CARDIAC MYOCYTES | FUNCTIONAL CARDIOMYOCYTES | DIFFERENTIATION | FIBROBLASTS | TRANSPLANTATION | Heart Failure - surgery | Myocytes, Cardiac - cytology | Heart - growth & development | Heart - physiology | Humans | Heart Failure - genetics | Heart Failure - pathology | Regeneration - physiology | Regenerative Medicine - methods | Cellular Reprogramming | Stem Cell Transplantation | Heart Failure - therapy | Myocytes, Cardiac - pathology | Animals | Regeneration - genetics | Heart failure | Care and treatment | Usage | Tissue engineering | Heart cells | Physiological aspects | Research | Proteins | Medical research | Rodents | Stem cells
SMOOTH-MUSCLE | THERAPY | PLOIDY LEVEL | DNA-CONTENT | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | CARDIAC MYOCYTES | FUNCTIONAL CARDIOMYOCYTES | DIFFERENTIATION | FIBROBLASTS | TRANSPLANTATION | Heart Failure - surgery | Myocytes, Cardiac - cytology | Heart - growth & development | Heart - physiology | Humans | Heart Failure - genetics | Heart Failure - pathology | Regeneration - physiology | Regenerative Medicine - methods | Cellular Reprogramming | Stem Cell Transplantation | Heart Failure - therapy | Myocytes, Cardiac - pathology | Animals | Regeneration - genetics | Heart failure | Care and treatment | Usage | Tissue engineering | Heart cells | Physiological aspects | Research | Proteins | Medical research | Rodents | Stem cells
Journal Article
Circulation, ISSN 0009-7322, 08/2017, Volume 136, Issue 7, pp. 680 - 686
SIGNALING PATHWAYS | CARDIAC & CARDIOVASCULAR SYSTEMS | ISCHEMIC CARDIOMYOPATHY | MYOCARDIAL-INFARCTION | ADULT-MOUSE HEARTS | RANDOMIZED PHASE-1 TRIAL | GENERATE CARDIOMYOCYTES | PERIPHERAL VASCULAR DISEASE | DNA-SYNTHESIS | MAMMALIAN HEART REGENERATION | MESENCHYMAL STEM-CELLS | CARDIAC REPAIR | Cell Proliferation | Heart Diseases - physiopathology | Stem Cell Transplantation - standards | Humans | Treatment Outcome | Cardiology - standards | Regenerative Medicine - methods | Consensus | Recovery of Function | Myocytes, Cardiac - pathology | Myocytes, Cardiac - transplantation | Regeneration | Stem Cell Transplantation - methods | Animals | Regenerative Medicine - standards | Heart Diseases - pathology | Heart Diseases - surgery | Cardiology - methods | Stem Cell Transplantation - adverse effects
Journal Article
Nature, ISSN 0028-0836, 05/2008, Volume 453, Issue 7193, pp. 314 - 321
The repair of wounds is one of the most complex biological processes that occur during human life. After an injury, multiple biological pathways immediately...
GROWTH-FACTOR-BETA | MULTIPOTENT STEM-CELLS | MARROW-DERIVED CELLS | HAIR-FOLLICLES | EPITHELIAL REPAIR | INFLAMMATORY CELLS | MULTIDISCIPLINARY SCIENCES | TISSUE-REPAIR | TRANSCRIPTIONAL CONTROL | LIMB-REGENERATION | KERATINOCYTE MIGRATION | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Fibrosis - physiopathology | Humans | Stem Cells - cytology | Wound Healing - physiology | Regeneration - physiology | Stem Cells - metabolism | Regenerative Medicine - trends | Evaluation | Care and treatment | Wound healing | Physiological aspects | Forecasts and trends | Regeneration (Biology) | Wounds and injuries | Proteins | Heart failure | Heart attacks | Prenatal development | Skin | Organisms | Gene expression | Cells | Injuries | Immune system
GROWTH-FACTOR-BETA | MULTIPOTENT STEM-CELLS | MARROW-DERIVED CELLS | HAIR-FOLLICLES | EPITHELIAL REPAIR | INFLAMMATORY CELLS | MULTIDISCIPLINARY SCIENCES | TISSUE-REPAIR | TRANSCRIPTIONAL CONTROL | LIMB-REGENERATION | KERATINOCYTE MIGRATION | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Fibrosis - physiopathology | Humans | Stem Cells - cytology | Wound Healing - physiology | Regeneration - physiology | Stem Cells - metabolism | Regenerative Medicine - trends | Evaluation | Care and treatment | Wound healing | Physiological aspects | Forecasts and trends | Regeneration (Biology) | Wounds and injuries | Proteins | Heart failure | Heart attacks | Prenatal development | Skin | Organisms | Gene expression | Cells | Injuries | Immune system
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 05/2006, Volume 47, Issue 9, pp. 1769 - 1776
Cardiac Regeneration Piero Anversa, Annarosa Leri, Jan Kajstura Heart homeostasis is regulated by a stem cell compartment characterized by multipotent cardiac...
MYOCARDIUM | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCYTE PROLIFERATION | MULTIPOTENT | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | HEART-FAILURE | MUSCLE | CARDIOMYOCYTES | DIFFERENTIATION | EXPRESSION | Regeneration | Animals | Bone Marrow Cells - cytology | Heart Diseases - therapy | Myocytes, Cardiac - physiology | Heart - physiology | Humans | Bone Marrow Cells - physiology | Cell Transplantation | Cell Differentiation | Multipotent Stem Cells - physiology | Myocardium - cytology | Heart failure | Fluorescence | Stem cells | Heart | Transcription factors | Rodents | Muscular system | Deoxyribonucleic acid--DNA | Apoptosis
MYOCARDIUM | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCYTE PROLIFERATION | MULTIPOTENT | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | HEART-FAILURE | MUSCLE | CARDIOMYOCYTES | DIFFERENTIATION | EXPRESSION | Regeneration | Animals | Bone Marrow Cells - cytology | Heart Diseases - therapy | Myocytes, Cardiac - physiology | Heart - physiology | Humans | Bone Marrow Cells - physiology | Cell Transplantation | Cell Differentiation | Multipotent Stem Cells - physiology | Myocardium - cytology | Heart failure | Fluorescence | Stem cells | Heart | Transcription factors | Rodents | Muscular system | Deoxyribonucleic acid--DNA | Apoptosis
Journal Article
Developmental Cell, ISSN 1534-5807, 02/2016, Volume 36, Issue 4, pp. 362 - 374
Adult humans fail to regenerate their hearts following injury, and this failure to regenerate myocardium is a leading cause of heart failure and death...
VERTEBRATE REGENERATION | STEM-CELLS | MYOCARDIAL-INFARCTION | CARDIOMYOCYTE PROLIFERATION | IN-VIVO | HIPPO PATHWAY | GENE-EXPRESSION | DEVELOPMENTAL BIOLOGY | ZEBRAFISH HEART REGENERATION | NEONATAL MOUSE HEART | ADULT MAMMALIAN HEART | CELL BIOLOGY | Animals | Myocytes, Cardiac - cytology | Heart - growth & development | Humans | Cell Proliferation - physiology | Mammals | Regeneration - physiology | Myocardium - cytology
VERTEBRATE REGENERATION | STEM-CELLS | MYOCARDIAL-INFARCTION | CARDIOMYOCYTE PROLIFERATION | IN-VIVO | HIPPO PATHWAY | GENE-EXPRESSION | DEVELOPMENTAL BIOLOGY | ZEBRAFISH HEART REGENERATION | NEONATAL MOUSE HEART | ADULT MAMMALIAN HEART | CELL BIOLOGY | Animals | Myocytes, Cardiac - cytology | Heart - growth & development | Humans | Cell Proliferation - physiology | Mammals | Regeneration - physiology | Myocardium - cytology
Journal Article
Transplantation, ISSN 0041-1337, 08/2010, Volume 90, Issue 4, pp. 364 - 372
Background. We hypothesized that autologous skeletal cell (SC) sheets regenerate the infract myocardium in porcine heart as a preclinical trial. Methods and...
Heart failure | Myocardial infarction | Tissue | Transplantation | Cells | SURVIVAL | SURGERY | CARDIOMYOPLASTY | CARDIOMYOCYTE SHEETS | DIASTOLIC FUNCTION | HEART-FAILURE | IMMUNOLOGY | BIOENGINEERED CARDIAC GRAFTS | MYOBLAST SHEETS | REPAIR | GROWTH | CORONARY-ARTERY-DISEASE | Heart - physiopathology | Myocardial Contraction | Myocardial Infarction - surgery | Anesthesia - methods | Tissue Engineering - methods | Diastole | Muscle, Skeletal - transplantation | Tissue Engineering - trends | Myocardial Infarction - diagnostic imaging | Muscle, Skeletal - physiology | Regeneration - physiology | Stroke Volume | Animals | Myoblasts, Skeletal - transplantation | Swine | Guided Tissue Regeneration - methods | Myocardial Infarction - pathology | Systole - physiology | Ultrasonography | Myocardial Infarction - physiopathology | Anesthesia - veterinary
Heart failure | Myocardial infarction | Tissue | Transplantation | Cells | SURVIVAL | SURGERY | CARDIOMYOPLASTY | CARDIOMYOCYTE SHEETS | DIASTOLIC FUNCTION | HEART-FAILURE | IMMUNOLOGY | BIOENGINEERED CARDIAC GRAFTS | MYOBLAST SHEETS | REPAIR | GROWTH | CORONARY-ARTERY-DISEASE | Heart - physiopathology | Myocardial Contraction | Myocardial Infarction - surgery | Anesthesia - methods | Tissue Engineering - methods | Diastole | Muscle, Skeletal - transplantation | Tissue Engineering - trends | Myocardial Infarction - diagnostic imaging | Muscle, Skeletal - physiology | Regeneration - physiology | Stroke Volume | Animals | Myoblasts, Skeletal - transplantation | Swine | Guided Tissue Regeneration - methods | Myocardial Infarction - pathology | Systole - physiology | Ultrasonography | Myocardial Infarction - physiopathology | Anesthesia - veterinary
Journal Article
2013, ISBN 1466578394, viii, 366
"This book presents the current status and a future perspective of cardiac regeneration using pluripotent stem cells. To achieve cardiac regeneration using iPS...
Stem Cell Transplantation | Heart | Regeneration | Pluripotent Stem Cells | methods | Stem cells | transplantation | Myocardium | physiology
Stem Cell Transplantation | Heart | Regeneration | Pluripotent Stem Cells | methods | Stem cells | transplantation | Myocardium | physiology
Book
Circulation Research, ISSN 0009-7330, 01/2017, Volume 120, Issue 2, pp. 400 - 406
The adult human heart is unable to regenerate after various forms of injury, suggesting that this organ lacks a biologically meaningful endogenous stem cell...
consensus | stem cells | myocardium | myocytes cardiac | regeneration | myocytes, cardiac | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIOMYOCYTE DNA-SYNTHESIS | MYOCARDIAL-INFARCTION | ADULT-MOUSE HEARTS | CRE KNOCK-INS | C-KIT LOCUS | MAMMALIAN HEART | GENETIC LINEAGE | C-KIT(+) CELLS | HEMATOPOIETIC STEM-CELLS | PERIPHERAL VASCULAR DISEASE | NEURAL CREST | HEMATOLOGY | Heart Diseases - diagnosis | Myocytes, Cardiac - transplantation | Stem Cell Transplantation - methods | Animals | Heart Diseases - physiopathology | Heart Diseases - therapy | Myocytes, Cardiac - physiology | Humans | Stem Cells - physiology | Stem Cell Transplantation - trends | Regeneration - physiology | Cell Differentiation - physiology | proliferation | c-Kit | Cardiac
consensus | stem cells | myocardium | myocytes cardiac | regeneration | myocytes, cardiac | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIOMYOCYTE DNA-SYNTHESIS | MYOCARDIAL-INFARCTION | ADULT-MOUSE HEARTS | CRE KNOCK-INS | C-KIT LOCUS | MAMMALIAN HEART | GENETIC LINEAGE | C-KIT(+) CELLS | HEMATOPOIETIC STEM-CELLS | PERIPHERAL VASCULAR DISEASE | NEURAL CREST | HEMATOLOGY | Heart Diseases - diagnosis | Myocytes, Cardiac - transplantation | Stem Cell Transplantation - methods | Animals | Heart Diseases - physiopathology | Heart Diseases - therapy | Myocytes, Cardiac - physiology | Humans | Stem Cells - physiology | Stem Cell Transplantation - trends | Regeneration - physiology | Cell Differentiation - physiology | proliferation | c-Kit | Cardiac
Journal Article
Circulation Research, ISSN 0009-7330, 03/2017, Volume 120, Issue 6, pp. 941 - 959
Palliative surgery for congenital heart disease has allowed patients with previously lethal heart malformations to survive and, in most cases, to thrive....
Cardiac development | cardiac regeneration | cardiomyocyte maturation | signaling pathways | transcriptional regulation | PROGENITOR CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | FUNCTIONAL MATURATION | ORGAN SIZE CONTROL | HIPPO PATHWAY | CELL-DERIVED CARDIOMYOCYTES | ZEBRAFISH HEART REGENERATION | ADULT MAMMALIAN HEART | PLURIPOTENT STEM-CELLS | EARLY MOUSE EMBRYO | WNT/BETA-CATENIN | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | cardiac development | Regeneration | Animals | Myocytes, Cardiac - cytology | Signal Transduction | Heart Diseases - therapy | Myocytes, Cardiac - physiology | Heart - embryology | Heart - physiology | Humans | Myocytes, Cardiac - metabolism | Regenerative Medicine - methods
Cardiac development | cardiac regeneration | cardiomyocyte maturation | signaling pathways | transcriptional regulation | PROGENITOR CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | FUNCTIONAL MATURATION | ORGAN SIZE CONTROL | HIPPO PATHWAY | CELL-DERIVED CARDIOMYOCYTES | ZEBRAFISH HEART REGENERATION | ADULT MAMMALIAN HEART | PLURIPOTENT STEM-CELLS | EARLY MOUSE EMBRYO | WNT/BETA-CATENIN | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | cardiac development | Regeneration | Animals | Myocytes, Cardiac - cytology | Signal Transduction | Heart Diseases - therapy | Myocytes, Cardiac - physiology | Heart - embryology | Heart - physiology | Humans | Myocytes, Cardiac - metabolism | Regenerative Medicine - methods
Journal Article