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1. Full Text Using longitudinal profiles to characterize women's symptoms through midlife: Results from a large prospective study
by Mishra, Gita D and Dobson, Annette J
Menopause, ISSN 1072-3714, 05/2012, Volume 19, Issue 5, pp. 549 - 555
Objective: The aims of this study were to identify groups of symptoms experienced by women during midlife and to determine the main profiles or trajectories... 
Vasomotor symptoms | Health symptoms | Age at menopause | Latent class analysis | Longitudinal profiles | HOT FLUSHES | HEALTH | DURATION | MENOPAUSAL TRANSITION | OBSTETRICS & GYNECOLOGY | Prospective Studies | Sweating | Urinary Incontinence - physiopathology | Heartburn - physiopathology | Humans | Menopause | Middle Aged | Factor Analysis, Statistical | Headache - physiopathology | Hemorrhoids - physiopathology | Chest Pain - physiopathology | Hot Flashes - physiopathology | Hypersensitivity - physiopathology | Fatigue - physiopathology | Female | Respiratory Tract Diseases - physiopathology | Surveys and Questionnaires | Vaginitis - physiopathology | Longitudinal Studies | Vaginal Discharge - physiopathology
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2. Full Text The Role of Esophageal Hypersensitivity in Functional Esophageal Disorders
by Farmer, Adam D and Ruffle, James K and Aziz, Qasim
Journal of Clinical Gastroenterology, ISSN 0192-0790, 02/2017, Volume 51, Issue 2, pp. 91 - 99
The Rome IV diagnostic criteria delineates 5 functional esophageal disorders which include functional chest pain, functional heartburn, reflux... 
Sensitization | Pain | Esophagus | pain | CENTRAL SENSITIZATION | VISCERAL PAIN HYPERSENSITIVITY | SYMPTOMS | IDENTIFICATION | RESPONSES | GASTROESOPHAGEAL-REFLUX | ACID SENSITIVITY | NONCARDIAC CHEST-PAIN | HYPERALGESIA | SENSATION | sensitization | GASTROENTEROLOGY & HEPATOLOGY | esophagus | Heartburn - physiopathology | Gastroesophageal Reflux - physiopathology | Humans | Hyperalgesia - complications | Gastroesophageal Reflux - etiology | Hypersensitivity - complications | Hyperalgesia - physiopathology | Esophageal Diseases - etiology | Esophageal Motility Disorders - etiology | Esophagus - physiopathology | Chest Pain - physiopathology | Chest Pain - etiology | Hypersensitivity - physiopathology | Heartburn - etiology | Esophageal Diseases - physiopathology | Esophageal Motility Disorders - physiopathology | Deglutition Disorders - etiology | Deglutition Disorders - physiopathology
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3. Full Text Clinical and upper gastrointestinal motility features in systemic sclerosis and related disorders
by Weston, Shiobhan and Thumshirn, Miriam and Wiste, Julie and Camilleri, Michael
American Journal of Gastroenterology, ISSN 0002-9270, 07/1998, Volume 93, Issue 7, pp. 1085 - 1089
Objective: The aim of this study was to characterize the clinical and motility findings in 62 patients with systemic sclerosis or related disorders referred... 
SCLERODERMA | MANOMETRY | GASTROENTEROLOGY & HEPATOLOGY | MANIFESTATIONS | Duodenal Diseases - pathology | Heartburn - physiopathology | Esophagogastric Junction - physiopathology | Diarrhea - physiopathology | Humans | Middle Aged | Scleroderma, Systemic - pathology | Gastrointestinal Motility - physiology | Male | Mixed Connective Tissue Disease - pathology | Nausea - physiopathology | Polymyositis - physiopathology | Esophageal Stenosis - pathology | Eating - physiology | Mixed Connective Tissue Disease - physiopathology | Esophagus - physiopathology | Barrett Esophagus - pathology | Scleroderma, Systemic - physiopathology | Adult | Duodenum - physiopathology | Female | Retrospective Studies | Deglutition Disorders - physiopathology | Fasting - physiology | Gastroesophageal Reflux - pathology | Esophagogastric Junction - pathology | Constipation - physiopathology | Pyloric Antrum - pathology | Fecal Incontinence - physiopathology | Pyloric Antrum - physiopathology | Esophagus - pathology | Diverticulum - pathology | Duodenum - pathology | Peristalsis - physiology | Adolescent | Gastric Emptying - physiology | Aged | Vomiting - physiopathology
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4. Full Text Clinical and manometric characteristics of patients with Parkinson's disease and esophageal symptoms
by Su, A and Gandhy, R and Barlow, C and Triadafilopoulos, G
Diseases of the Esophagus, ISSN 1120-8694, 04/2017, Volume 30, Issue 4, pp. 1 - 6
SUMMARY Dysphagia is a common problem in patients with Parkinson's disease (PD); its etiology is multifactorial and its management is challenging. In this... 
benign esophageal diseases | Parkinson's disease | RESOLUTION IMPEDANCE MANOMETRY | ABNORMALITIES | CHEST-PAIN | dysphagia | DISORDERS | TOPOGRAPHY | esophagogastric junction | esophageal motility | GASTROENTEROLOGY & HEPATOLOGY | PERISTALSIS | MOTILITY | Prospective Studies | Heartburn - physiopathology | Esophagogastric Junction - physiopathology | Humans | Middle Aged | Male | Esophagus - physiopathology | Chest Pain - physiopathology | Chest Pain - etiology | Heartburn - etiology | Aged, 80 and over | Deglutition Disorders - etiology | Female | Retrospective Studies | Deglutition Disorders - physiopathology | Laryngopharyngeal Reflux - physiopathology | Parkinson Disease - complications | Parkinson Disease - physiopathology | Laryngopharyngeal Reflux - etiology | Algorithms | Weight Loss | Peristalsis - physiology | Aged | Disease Management | Manometry - methods
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5. Full Text New insights into the pathophysiology of achalasia and implications for future treatment
by Janette Furuzawa-Carballeda Samuel Torres-Landa Miguel ángel Valdovinos Enrique Coss-Adame Luis A Martín del Campo Gonzalo Torres-Villalobos
世界胃肠病学杂志：英文版, ISSN 1007-9327, 2016, Volume 22, Issue 35, pp. 7892 - 7907
Idiopathic achalasia is an archetype esophageal motor disorder, causing significant impairment of eating ability and reducing quality of life. The... 
Achalasia | Autoimmune disease | Treatment | Pathophysiology | IDIOPATHIC ACHALASIA | ESOPHAGEAL MOTILITY DISORDERS | ANTINEURONAL ANTIBODIES | INTERSTITIAL-CELLS | INTRASPHINCTERIC BOTULINUM TOXIN | HIGH-RESOLUTION MANOMETRY | AUTOIMMUNE-DISEASES | DOR FUNDOPLICATION | PERORAL ENDOSCOPIC MYOTOMY | MYENTERIC PLEXUS | GASTROENTEROLOGY & HEPATOLOGY | Manometry | Heartburn - physiopathology | Autoantibodies - blood | Humans | Inflammation | Esophageal Achalasia - physiopathology | Myenteric Plexus - physiopathology | Esophageal Sphincter, Lower - physiopathology | Adrenal Insufficiency | Peristalsis - physiology | Esophageal Motility Disorders - physiopathology | Quality of Life | Esophageal Achalasia - therapy | Autoimmune Diseases - metabolism | Deglutition Disorders - physiopathology | Esophageal Achalasia - diagnosis | Review
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6. Full Text Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease
by Savarino, E and Pohl, D and Zentilin, P and Dulbecco, P and Sammito, G and Sconfienza, L and Vigneri, S and Camerini, G and Tutuian, R and Savarino, V
Gut, ISSN 0017-5749, 09/2009, Volume 58, Issue 9, pp. 1185 - 1191
Introduction:Functional dyspepsia and non-erosive reflux disease (NERD) are prevalent gastrointestinal conditions with accumulating evidence regarding an... 
GASTROESOPHAGEAL-REFLUX | DOUBLE-BLIND | OMEPRAZOLE | DISORDERS | SYMPTOMS | MECHANISMS | ESOPHAGEAL ACID EXPOSURE | PREVALENCE | GASTROENTEROLOGY & HEPATOLOGY | ASSOCIATION | EPIDEMIOLOGY | Body Mass Index | Stomach - physiopathology | Diagnosis, Differential | Heartburn - physiopathology | Esophageal pH Monitoring | Dyspepsia - physiopathology | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Male | Electric Impedance | Esophagoscopy | Young Adult | Esophagus - physiopathology | Analysis of Variance | Adolescent | Sex Factors | Adult | Female | Aged | Gastroesophageal reflux | Complications and side effects | Research | Dyspepsia | Heartburn | Distribution | Studies | Motility | Acids | Disease | Rodents | Questionnaires | Alcohol | Family medical history | Endoscopy | Epidemiology | Catheters | Oesophagus | 1506
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7. Full Text Functional Esophageal Disorders
by Galmiche, Jean Paul and Clouse, Ray E and Bálint, András and Cook, Ian J and Kahrilas, Peter J and Paterson, William G and Smout, Andre J.P.M
Gastroenterology, ISSN 0016-5085, 2006, Volume 130, Issue 5, pp. 1459 - 1465
Functional esophageal disorders represent processes accompanied by typical esophageal symptoms (heartburn, chest pain, dysphagia, globus) that are not... 
ACID REFLUX | ANTIDEPRESSANTS | GASTROESOPHAGEAL-REFLUX DISEASE | NONCARDIAC CHEST-PAIN | OMEPRAZOLE | SYMPTOMS | PREVALENCE | NONOBSTRUCTIVE DYSPHAGIA | GLOBUS PHARYNGEUS | GASTROENTEROLOGY & HEPATOLOGY | PROTON-PUMP INHIBITORS | Heartburn - physiopathology | Heartburn - psychology | Humans | Heartburn - therapy | Deglutition Disorders - therapy | Chest Pain - prevention & control | Chest Pain - physiopathology | Animals | Esophageal Diseases - physiopathology | Esophageal Diseases - psychology | Esophageal Diseases - therapy | Deglutition Disorders - psychology | Chest Pain - therapy | Deglutition Disorders - physiopathology | Esophageal Diseases - diagnosis | Gastroesophageal reflux | Strategic planning (Business) | Management techniques | Care and treatment | Pain | Management
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8. Full Text Most children with eosinophilic esophagitis have a favorable outcome as young adults
by Bohm, M and Jacobs, J. W and Gupta, A and Gupta, S and Wo, J. M
Diseases of the Esophagus, ISSN 1120-8694, 01/2017, Volume 30, Issue 1, pp. 1 - 6
SUMMARY The disease progression of eosinophilic esophagitis (EoE) from childhood into adulthood is unclear. To determine the clinical outcome of patients who... 
Acid reflux | Dysphagia | Eosinophilic oesophagitis | Eosinophilic esophagitis | Eosinophils | UNITED-STATES | SIMILARITIES | eosinophilic esophagitis | dysphagia | eosinophils | acid reflux | eosinophilic oesophagitis | NATURAL-HISTORY | GASTROENTEROLOGY & HEPATOLOGY | Ambulatory Care - utilization | Follow-Up Studies | Heartburn - physiopathology | Humans | Male | Nausea - physiopathology | Adrenal Cortex Hormones - therapeutic use | Health Services - utilization | Eosinophilic Esophagitis - physiopathology | Young Adult | Eosinophilic Esophagitis - complications | Heartburn - etiology | Adult | Deglutition Disorders - etiology | Female | Registries | Emergency Service, Hospital - utilization | Odds Ratio | Deglutition Disorders - physiopathology | Abdominal Pain - etiology | Abdominal Pain - physiopathology | Proton Pump Inhibitors - therapeutic use | Disease Progression | Nausea - etiology | Adolescent | Vomiting - etiology | Eosinophilic Esophagitis - drug therapy | Food Hypersensitivity | Vomiting - physiopathology
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9. Full Text In vivo evaluation of acid-induced changes in oesophageal mucosa integrity and sensitivity in non-erosive reflux disease
by Woodland, Philip and Al-Zinaty, Mohannad and Yazaki, Etsuro and Sifrim, Daniel
Gut, ISSN 0017-5749, 09/2013, Volume 62, Issue 9, pp. 1256 - 1261
Objective Patients with non-erosive reflux disease (NERD) have impaired oesophageal mucosal integrity (dilated intercellular spaces). Oesophageal mucosal... 
erosive oesophagitis | DETERMINANTS | Gastro-oesophageal reflux disease | oesophageal reflux | acid-related diseases | DILATED INTERCELLULAR SPACES | PATHOGENESIS | oesophageal mucosa | oesophageal impedance | endoscopic ultrasonography | EPITHELIUM | mucosal barrier | IMPEDANCE | anti-reflux therapy | FUNCTIONAL HEARTBURN | EXPOSURE | gastrointestinal motility | neurogastroenterology | dysphagia | adenocarcinoma | CLASSIFICATION | oesophageal physiology | PERCEPTION | Barrett's oesophagus | GASTROENTEROLOGY & HEPATOLOGY | Severity of Illness Index | Gastroesophageal Reflux - diagnosis | Heartburn - physiopathology | Esophageal pH Monitoring | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Heartburn - diagnosis | Male | Symptom Assessment - methods | Electric Impedance | Extracellular Space | Recovery of Function | Esophagus - physiopathology | Esophagus - pathology | Gastroesophageal Reflux - complications | Mucous Membrane - physiopathology | Time Factors | Heartburn - etiology | Female | Acids - pharmacology | Hydrogen-Ion Concentration | Gastroesophageal reflux | Studies | Genotype & phenotype | Acids | Microscopy | Biopsy | Rodents | Permeability | Endoscopy | Mucous membrane
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10. Full Text Pathophysiology of Gastroesophageal Reflux Disease
by Menezes, Mariano A and Herbella, Fernando A. M
World Journal of Surgery, ISSN 0364-2313, 07/2017, Volume 41, Issue 7, pp. 1666 - 1671
Gastroesophageal reflux disease pathophysiology is multifactorial and linked to a misbalance between the aggressiveness of the refluxate into the esophagus or... 
SURGERY | POSITION | GERD | ACID-INDUCED HEARTBURN | ARTICLE | DISTAL | LOWER ESOPHAGEAL SPHINCTER | SEVERITY | Hernia, Hiatal - physiopathology | Esophageal Sphincter, Lower - physiopathology | Esophagogastric Junction - physiopathology | Gastroesophageal Reflux - physiopathology | Humans | Gastroesophageal Reflux - etiology | Pressure | Hernia | Gastroesophageal reflux | Respiratory tract diseases | Valves | Obesity | Aggressive behavior | Esophageal sphincter | Lung diseases | Organs | Thorax | Sphincter | Esophagus | Diseases | Hernias | Disruption | Diaphragm | Saliva | Failure
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11. Full Text Determinants of the Association between Non-Cardiac Chest Pain and Reflux
by Herregods, Thomas V. K and Bredenoord, Albert J and Oors, Jacobus M and Bogte, Auke and Smout, Ané J. P. M
American journal of gastroenterology, ISSN 0002-9270, 2017, Volume 112, Issue 11, pp. 1671 - 1677
Gastroesophageal reflux is considered to be the most common gastrointestinal cause of non-cardiac chest pain (NCCP). It remains unclear why some reflux... 
GASTROESOPHAGEAL-REFLUX | ACID | ABNORMAL SENSORY PERCEPTION | SENSITIZATION | DISEASE | DISTENSION | HEALTH-CARE SEEKING | ESOPHAGEAL DISORDERS | GASTROENTEROLOGY & HEPATOLOGY | EPIDEMIOLOGY | Gastroesophageal Reflux - metabolism | Heartburn - physiopathology | Esophageal pH Monitoring | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Male | Electric Impedance | Chest Pain - physiopathology | Gastroesophageal Reflux - complications | Chest Pain - etiology | Time Factors | Heartburn - etiology | Deglutition Disorders - etiology | Female | Deglutition Disorders - physiopathology | Hydrogen-Ion Concentration | Gastroesophageal reflux | Electrocardiography | Pain
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12. Full Text Functional Heartburn Overlaps with Irritable Bowel Syndrome More Often than GERD
by De Bortoli, Nicola and Frazzoni, Leonardo and Savarino, Edoardo V and Frazzoni, Marzio and Martinucci, Irene and Jania, Aleksandra and Tolone, Salvatore and Scagliarini, Michele and Bellini, Massimo and Marabotto, Elisa and Furnari, Manuele and Bodini, Giorgia and Russo, Salvatore and Bertani, Lorenzo and Natali, Veronica and Fuccio, Lorenzo and Savarino, Vincenzo and Blandizzi, Corrado and Marchi, Santino
American Journal of Gastroenterology, ISSN 0002-9270, 12/2016, Volume 111, Issue 12, pp. 1711 - 1717
OBJECTIVES: We aimed to evaluate the prevalence of irritable bowel syndrome (IBS) in patients with typical reflux symptoms as distinguished into... 
DEPRESSION | GENERAL-POPULATION | GASTROESOPHAGEAL-REFLUX DISEASE | ANXIETY | IMPEDANCE | VALIDATION | SYMPTOMS | QUALITY-OF-LIFE | PREVALENCE | GASTROINTESTINAL DISORDERS | GASTROENTEROLOGY & HEPATOLOGY | Multivariate Analysis | Prevalence | Heartburn - physiopathology | Esophageal pH Monitoring | Gastroesophageal Reflux - physiopathology | Humans | Leukocyte L1 Antigen Complex - metabolism | Middle Aged | Male | Gastroesophageal Reflux - epidemiology | Esophagoscopy | Esophageal Diseases - epidemiology | Colonoscopy | Anxiety - epidemiology | Adult | Female | Surveys and Questionnaires | Irritable Bowel Syndrome - epidemiology | Heartburn - epidemiology | Irritable Bowel Syndrome - metabolism | Depression - epidemiology | Risk Factors | Logistic Models | Irritable Bowel Syndrome - physiopathology | Feces - chemistry | Esophageal Diseases - physiopathology
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13. Full Text Symptom overlap between postprandial distress and epigastric pain syndromes of the Rome III dyspepsia classification
by Vakil, Nimish and Halling, Katarina and Ohlsson, Lis and Wernersson, Börje
American Journal of Gastroenterology, ISSN 0002-9270, 05/2013, Volume 108, Issue 5, pp. 767 - 774
OBJECTIVES: The Rome III criteria for functional dyspepsia recognize two distinct subgroups: postprandial distress syndrome (PDS) and epigastric pain syndrome... 
FUNCTIONAL GASTRODUODENAL DISORDERS | ACID REFLUX | TRIALS | GASTROESOPHAGEAL-REFLUX DISEASE | VALIDATION | ITOPRIDE | PREVALENCE | QUESTIONNAIRE | GASTROENTEROLOGY & HEPATOLOGY | ASSOCIATION | Predictive Value of Tests | Dyspepsia - diagnosis | Abdominal Pain - etiology | Gastroesophageal Reflux - diagnosis | Heartburn - physiopathology | Dyspepsia - complications | Dyspepsia - physiopathology | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Abdominal Pain - physiopathology | Capsule Endoscopy | Endoscopy, Gastrointestinal | Esophagus - metabolism | Male | Syndrome | Heartburn - complications | Gastroesophageal Reflux - complications | Postprandial Period | Adult | Female | Aged | Dyspepsia - classification | Hydrogen-Ion Concentration
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14. Full Text Functional dyspepsia - Symptoms, definitions and validity of the Rome III criteria
by Tack, Jan and Talley, Nicholas J
Nature Reviews Gastroenterology and Hepatology, ISSN 1759-5045, 03/2013, Volume 10, Issue 3, pp. 134 - 141
Dyspepsia refers to a heterogeneous group of symptoms that are localized in the epigastric region. Typical dyspeptic symptoms include postprandial fullness,... 
PREDOMINANT SYMPTOM | DISCRIMINANT VALUE | POSTPRANDIAL DISTRESS SYNDROME | NONULCER DYSPEPSIA | THERAPEUTIC-EFFICACY | QUALITY-OF-LIFE | PATHOPHYSIOLOGICAL MECHANISMS | GASTROENTEROLOGY & HEPATOLOGY | DUODENAL EOSINOPHILIA | HELICOBACTER-PYLORI | IRRITABLE-BOWEL-SYNDROME | Diagnosis, Differential | Dyspepsia - diagnosis | Reproducibility of Results | Heartburn - physiopathology | Dyspepsia - physiopathology | Humans | Inflammatory Bowel Diseases - diagnosis | Heartburn - diagnosis | Inflammatory Bowel Diseases - physiopathology | Disease Management | Dyspepsia - classification | Care and treatment | Usage | Dyspepsia | Diagnosis | Research | Epidemiology | Health aspects | Risk factors | Quality of life
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15. Full Text Reduced optimism and a heightened neural response to everyday worries are specific to generalized anxiety disorder, and not seen in social anxiety
by Blair, K.S and Blair, K.S and Otero, M and Otero, M and Teng, C and Teng, C and Geraci, M and Geraci, M and Ernst, M and Ernst, M and Blair, R.J.R and Blair, R.J.R and Pine, D.S and Pine, D.S and Grillon, C and Grillon, C
Psychological Medicine, ISSN 0033-2917, 03/2017, Volume 47, Issue 10, pp. 1 - 1815
Background. Generalized anxiety disorder (GAD) and social anxiety disorder (SAD) are co-morbid and associated with similar neural disruptions during emotion... 
worry | Functional magnetic resonance imaging | medial prefrontal cortex | generalized anxiety disorder | social anxiety disorder | ACTIVATION | VALUE REPRESENTATION | PSYCHIATRY | BIAS | PSYCHOLOGY, CLINICAL | DORSAL ANTERIOR CINGULATE | PSYCHOLOGY | FUTURE LIFE EVENTS | VENTROMEDIAL PREFRONTAL CORTEX | IMPLICIT REGULATION | UNREALISTIC OPTIMISM | PHOBIA | BRAIN | Phobia, Social - psychology | Humans | Prefrontal Cortex - physiopathology | Anxiety - psychology | Anxiety - physiopathology | Male | Anxiety Disorders - psychology | Caudate Nucleus - physiopathology | Young Adult | Magnetic Resonance Imaging | Optimism - psychology | Caudate Nucleus - diagnostic imaging | Adult | Female | Phobia, Social - physiopathology | Anxiety Disorders - physiopathology | Prefrontal Cortex - diagnostic imaging | Myocardial infarction | Brain | Pediatrics | Nuclear magnetic resonance--NMR | Intelligence | Anxiety disorders | Generalized anxiety disorders | Bias | Optimism | Emotional regulation | Intelligence tests | Positive life events | Anxiety | Biological markers | Heartburn | Cortex (prefrontal) | Panic attacks | Cortex | Glutamate decarboxylase | Patients | Studies | Anxieties | Dysfunction | Social anxiety | Biomarkers | Psychiatry | Worry | fMRI | optimism
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