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hec1 (77) 77
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humans (49) 49
cell biology (37) 37
nuclear proteins - metabolism (35) 35
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architecture (9) 9
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protein structure, tertiary (6) 6
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xenograft model antitumor assays (6) 6
antineoplastic agents - pharmacology (5) 5
aurora kinase b (5) 5
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1. Full Text A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors
by Malvezzi, Francesca and Litos, Gabriele and Schleiffer, Alexander and Heuck, Alexander and Mechtler, Karl and Clausen, Tim and Westermann, Stefan
The EMBO Journal, ISSN 0261-4189, 02/2013, Volume 32, Issue 3, pp. 409 - 423
The Ndc80 complex is the key microtubule‐binding element of the kinetochore. In contrast to the well‐characterized interaction of Ndc80‐Nuf2 heads with... 
kinetochore | centromere | Ndc80/Hec1 | chromosome segregation | histone‐fold | Histonefold | Kinetochore | Centromere | Chromosome segregation | DOMAIN | histone-fold | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | REFINEMENT | FORMS | ALIGNMENT | MOLECULAR ARCHITECTURE | MICROTUBULE ATTACHMENT | YEAST KINETOCHORE | PROTEINS | CENP-A | Ndc80/Hecl | Phosphorylation | Mutagenesis, Site-Directed | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Computational Biology | Crystallization | Models, Molecular | Nuclear Proteins - metabolism | Saccharomyces cerevisiae Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Microtubules - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Cell Cycle Proteins - genetics | Calorimetry | Protein Conformation | Nuclear Proteins - genetics | Microscopy, Fluorescence | Proteins | Genetics | Mutation | Molecular biology | Chromosomes | Cell cycle | Hec1 | Ndc80
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2. Full Text Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C
by Ji, Zhejian and Gao, Haishan and Yu, Hongtao
Science, ISSN 0036-8075, 06/2015, Volume 348, Issue 6240, pp. 1260 - 1264
The spindle checkpoint of the cell division cycle senses kinetochores that are not attached to microtubules and prevents precocious onset of anaphase, which... 
LOCALIZATION | RECRUITMENT | PROTEIN | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | SPINDLE ASSEMBLY CHECKPOINT | HEC1 | KINASE MPS1 | BUB1 | AURORA-B | REVEALS | Proteins | Cell division | Microbiology | Molecular biology | Kinases | Binding | Attachment | Spindles | Chromosomes | Recruitment
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3. Full Text MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formation
by Tang, Ngang Heok and Toda, Takashi
BioEssays, ISSN 0265-9247, 03/2015, Volume 37, Issue 3, pp. 248 - 256
Summary Mis‐regulation (e.g. overproduction) of the human Ndc80/Hec1 outer kinetochore protein has been associated with aneuploidy and tumourigenesis, but the... 
Kinesin‐8 | overexpression | loop | cancer | TACC | Ndc80/Hec1 | ch‐TOG | Loop | Overexpression | Ch-TOG | Kinesin-8 | Cancer | FISSION YEAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLUS END-TRACKING | AURORA B KINASE | BIPOLAR SPINDLE FORMATION | IN-VIVO | BIOLOGY | ch-TOG | HUMAN SOMATIC-CELLS | COILED-COIL | KINETOCHORE-MICROTUBULE ATTACHMENT | MITOTIC SPINDLES | SCHIZOSACCHAROMYCES-POMBE | Neoplasms - metabolism | Gene Expression | Animals | Microtubule-Associated Proteins - metabolism | Humans | Nuclear Proteins - metabolism | Protein Interaction Domains and Motifs | Molecular Targeted Therapy | Nuclear Proteins - chemistry | Carcinogenesis - metabolism | Neoplasms - drug therapy | Protein Interaction Maps | Kinetochores | Causes of | Aneuploidy | Genetic aspects | Research | Protein-protein interactions | Proteins | Insights & s | Hec1 | Ndc80
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4. Full Text The Ndc80 kinetochore complex forms oligomeric arrays along microtubules
by Alushin, Gregory M and Ramey, Vincent H and Pasqualato, Sebastiano and Ball, David A and Grigorieff, Nikolaus and Musacchio, Andrea and Nogales, Eva
Nature, ISSN 0028-0836, 10/2010, Volume 467, Issue 7317, pp. 805 - 810
The Ndc80 complex is a key site of regulated kinetochore-microtubule attachment (a process required for cell division), but the molecular mechanism underlying... 
CHROMOSOME BI-ORIENTATION | VISUALIZATION | ATTACHMENT SITE | STRUCTURAL BASIS | SPINDLE POLE | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | RESOLUTION | ELECTRON-MICROSCOPY | HEC1 | OUTER KINETOCHORE | Mitosis | Humans | Nuclear Proteins - ultrastructure | Models, Molecular | Nuclear Proteins - metabolism | Tubulin - ultrastructure | Nuclear Proteins - chemistry | Cryoelectron Microscopy | Kinetochores - ultrastructure | Microtubules - metabolism | Tubulin - metabolism | Models, Biological | Microtubules - ultrastructure | Microtubules - chemistry | Protein Conformation | Tubulin - chemistry | Binding Sites | Kinetochores - chemistry | Software | Microscopy | Crystal structure | Symmetry
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5. Full Text The Ndc80 Kinetochore Complex Forms Load-Bearing Attachments to Dynamic Microtubule Tips via Biased Diffusion
by Powers, Andrew F and Franck, Andrew D and Gestaut, Daniel R and Cooper, Jeremy and Gracyzk, Beth and Wei, Ronnie R and Wordeman, Linda and Davis, Trisha N and Asbury, Charles L
Cell, ISSN 0092-8674, 2009, Volume 136, Issue 5, pp. 865 - 875
Kinetochores couple chromosomes to the assembling and disassembling tips of microtubules, a dynamic behavior that is fundamental to mitosis in all eukaryotes... 
CELLBIO | CELLCYCLE | MITOSIS | BUDDING YEAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPOLYMERIZATION | MOVEMENT | ARCHITECTURE | HEC1 | CHECKPOINT | DAM1 COMPLEX | DRIVEN | CHROMOSOME MOTION | CELL BIOLOGY | Saccharomyces cerevisiae - cytology | Saccharomyces cerevisiae - metabolism | Nuclear Proteins - metabolism | Microtubules - metabolism | Kinetochores - metabolism | Saccharomyces cerevisiae Proteins - metabolism
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6. Full Text Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner
by Kuhn, J and Dumont, S
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 11/2019, Volume 218, Issue 11, pp. 3583 - 3596
The spindle assembly checkpoint (SAC) prevents anaphase until all kinetochores attach to the spindle. Each mammalian kinetochore binds many microtubules, but... 
MITOSIS | RECRUITMENT | COMPLEX | MPS1 | PHOSPHORYLATION | CHROMOSOME CONGRESSION | DYNAMICS | SPINDLE ASSEMBLY CHECKPOINT | HEC1 | POLE | CELL BIOLOGY | Binding | Change detection | Kinetochores | Microtubules | Information processing | Occupancy | Laser ablation | Mammals | Ablation | Anaphase
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7. Full Text Dynamic acetylation of the kinetochore-associated protein HEC1 ensures accurate microtubule– kinetochore attachment
by Zhao, Gangyin and Cheng, Yubao and Gui, Ping and Cui, Meiying and Liu, Wei and Wang, Wenwen and Wang, Xueying and Ali, Mahboob and Dou, Zhen and Niu, Liwen and Liu, Haiyan and Anderson, Leonard and Ruan, Ke and Hong, Jingjun and Yao, Xuebiao
Journal of Biological Chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 2, pp. 576 - 592
Faithful chromosome segregation during mitosis is critical for maintaining genome integrity in cell progeny and relies on accurate and robust... 
ACTIVATION | spindle assembly | PHOSPHORYLATION | MPS1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | HEC1 | mitosis | IDENTIFICATION | chromosomal segregation | microtubule | protein acylation | NUF2 | TIP60 | kinetochore | ARCHITECTURE | SKA COMPLEX | NDC80 complex | BINDING | mitotic spindle | AURORA-B | Index Medicus
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8. Full Text Temporal changes in Hec1 phosphorylation control kinetochore - Microtubule attachment stability during mitosis
by DeLuca, Keith F and Lens, Susanne M. A and DeLuca, Jennifer G
Journal of Cell Science, ISSN 0021-9533, 02/2011, Volume 124, Issue 4, pp. 622 - 634
Precise control of the attachment strength between kinetochores and spindle microtubules is essential to preserve genomic stability. Aurora B kinase has been... 
Hec1 | Kinetochore | Microtubule | Aurora B | NDC80 | CHROMOSOME BI-ORIENTATION | NDC80 COMPLEX | REGULATES MCAK | KINASE | SPINDLE ASSEMBLY CHECKPOINT | SEGREGATION | SMALL-MOLECULE INHIBITOR | CELL BIOLOGY | MITOTIC SPINDLE | UNATTACHED KINETOCHORES | AURORA-B | Phosphorylation | Kinetochores - metabolism | Mitosis | Humans | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Aurora Kinases | Aurora Kinase B | Microtubules - metabolism | Microtubules - genetics | Protein Binding | Microtubules - chemistry | HeLa Cells | Protein Stability | Nuclear Proteins - genetics | Kinetochores - chemistry | Protein-Serine-Threonine Kinases - metabolism
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9. Full Text Electrostatic forces drive poleward chromosome motions at kinetochores
by John Gagliardi, L and Shain, Daniel H
Cell Division, ISSN 1747-1028, 10/2016, Volume 11, Issue 1, p. 14
Background: Recent experiments regarding Ndc80/Hec1 in force generation at kinetochores for chromosome motions have prompted speculation about possible models... 
Chromosome | Motility | Ndc80/Hec1 | Mitosis | Electrostatics | COMPLEX | SPINDLE MICROTUBULES | MECHANISM | BEHAVIOR | INTRACELLULAR PH | CELL BIOLOGY | IN-VITRO | CALCIUM | MICROTUBULE ATTACHMENT | GENERATION
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10. Full Text Accurate phosphoregulation of kinetochore-microtubule affinity requires unconstrained molecular interactions
by Zaytsev, Anatoly V and Sundin, Lynsie J.R and DeLuca, Keith F and Grishchuk, Ekaterina L and DeLuca, Jennifer G
Journal of Cell Biology, ISSN 0021-9525, 2014, Volume 206, Issue 1, pp. 45 - 59
Accurate chromosome segregation relies on dynamic interactions between microtubules (MTs) and the NDC80 complex, a major kinetochore MT-binding component.... 
MITOSIS | OUTER PLATE | COMPLEX | PTK1 CELLS | MITOTIC SPINDLE | MECHANISMS | HEC1 | MODEL | POINT | ATTACHMENT SITES | CELL BIOLOGY | Chromosome Segregation | Phosphorylation | Kinetochores - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Potoroidae | Models, Molecular | Nuclear Proteins - metabolism | Chromosomes, Human - metabolism | Microtubules - metabolism | Animals | Metaphase | Protein Binding | Protein Processing, Post-Translational | HeLa Cells | Binding Sites | Chromosomes | Analysis | Cells
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11. Full Text Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore-microtubule attachments during mitosis
by Amin, Mohammed A and McKenney, Richard J and Varma, Dileep
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 16, pp. 5755 - 5765
Chromosome alignment and segregation during mitosis require kinetochore-microtubule (kMT) attachments that are mediated by the molecular motor dynein and the... 
CYTOPLASMIC DYNEIN | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONGRESSION | MITOTIC SPINDLE | CENP-E | CHROMOSOME ALIGNMENT | SPINDLE ASSEMBLY CHECKPOINT | HEC1 | MECHANISMS | POLEWARD | Rod | chromosomes | Hec1 | mitosis | Cell Biology | microtubule | dynein | kinetochore | alignment | segregation | checkpoint control | mitotic spindle | Ndc80
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12. Full Text Hec1 Tail Phosphorylation Differentially Regulates Mammalian Kinetochore Coupling to Polymerizing and Depolymerizing Microtubules
by Long, Alexandra F and Udy, Dylan B and Dumont, Sophie
Current Biology, ISSN 0960-9822, 06/2017, Volume 27, Issue 11, pp. 1692 - 1699.e3
The kinetochore links chromosomes to dynamic spindle microtubules and drives both chromosome congression and segregation. To do so, the kinetochore must hold... 
microtubule | kinetochore | Hec1 | mechanics | force generation | mitosis | spindle | kinetochore-microtubule interface | friction | Ndc80 | NDC80 COMPLEX | ANAPHASE | ATTACHMENT | FORCE GENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CENTROMERE STRETCH | MITOTIC SPINDLE | DYNAMICS | TENSION | CHROMOSOME SEGREGATION | DIRECTIONAL INSTABILITY | CELL BIOLOGY | Chromosomes | Cells | Polymerization | Mitosis
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13. Full Text Structural organization of the kinetochore–microtubule interface
by DeLuca, Jennifer G and Musacchio, Andrea
Current Opinion in Cell Biology, ISSN 0955-0674, 2011, Volume 24, Issue 1, pp. 48 - 56
Successful mitosis depends on the stable, yet regulated attachment of chromosomes to spindle microtubules. The kinetochore, a large macromolecular structure... 
Internal Medicine | NDC80 COMPLEX | ATTACHMENT SITE | CELL-DIVISION | MOLECULAR ARCHITECTURE | PROTEIN ARCHITECTURE | SPINDLE ASSEMBLY CHECKPOINT | YEAST KINETOCHORE | CHROMOSOME SEGREGATION | CENP-A | OUTER KINETOCHORE | CELL BIOLOGY | Microtubules - metabolism | Animals | Spindle Apparatus - metabolism | Kinetochores - metabolism | Mitosis | Spindle Apparatus - chemistry | Humans | Chromosomes - metabolism | Microtubules - chemistry | Chromosomes - chemistry | Kinetochores - chemistry | Chromosomes | microtubule | KMN network | centromere | chromosome segregation | cell cycle | Mis12 | kinetochore | cell division | Hec1 | Ndc80
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