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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2006, Volume 103, Issue 40, pp. 14842 - 14847
Although tissue microenvironments play critical roles in epithelial development and tumorigenesis, the factors mediating these effects are poorly understood.... 
Basal cell carcinoma | RNA | Epithelial cells | Stromal cells | Stem cells | Basal cell neoplasms | Fibroblasts | Tumor stem cells | Tumors | Cancer | MULTIDISCIPLINARY SCIENCES | NICHE | BETA-CATENIN | HEDGEHOG | tissue microenvironment | EPITHELIAL-CELLS | IN-VIVO | STEM-CELL | cancer biology | JUVENILE POLYPOSIS | tumor stroma | DIFFERENTIATION | stem cell regulation | CARCINOMA | HAIR-FOLLICLE | Bone Morphogenetic Proteins - antagonists & inhibitors | Skin - cytology | Bone Morphogenetic Protein 4 | Cell Proliferation | Carcinoma, Basal Cell - genetics | Bone Morphogenetic Protein 2 | Stromal Cells - pathology | Humans | RNA, Messenger - genetics | Cells, Cultured | Gene Expression Regulation, Neoplastic | Intercellular Signaling Peptides and Proteins - genetics | Carcinoma, Basal Cell - pathology | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Models, Biological | Transforming Growth Factor beta - antagonists & inhibitors | Cell Differentiation | Epithelial Cells - cytology | Transforming Growth Factor beta - metabolism | Cell proliferation | Analysis | Homeostasis | Bone morphogenetic proteins | Genetic aspects | Research | Apoptosis | Proteins | Tissue | Bones | Oncology | Gene expression | Antagonist drugs | Index Medicus | Biological Sciences
Journal Article
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5952, pp. 572 - 574
The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, including medulloblastoma, an aggressive brain tumor. GDC-0449, a... 
Receptors | Relapse | Basal cell carcinoma | Medulloblastoma | Amino acids | Biopsies | Reports | Genetic mutation | Tumors | Resistance mechanisms | Cancer | PROTEIN-COUPLED RECEPTORS | CYCLOPAMINE | CANCER | MULTIDISCIPLINARY SCIENCES | Anilides - therapeutic use | Receptors, G-Protein-Coupled - metabolism | Humans | Brain Neoplasms - pathology | Hedgehog Proteins - metabolism | Molecular Sequence Data | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Mutation, Missense | Antineoplastic Agents - metabolism | Neoplasm Metastasis | Hedgehog Proteins - genetics | Medulloblastoma - pathology | Smoothened Receptor | Veratrum Alkaloids - pharmacology | Antineoplastic Agents - pharmacology | Patched Receptors | Medulloblastoma - genetics | Mutant Proteins - antagonists & inhibitors | Pyridines - therapeutic use | Amino Acid Sequence | Signal Transduction | Anilides - metabolism | Brain Neoplasms - genetics | Receptors, Cell Surface - metabolism | Mutant Proteins - metabolism | Hedgehog Proteins - antagonists & inhibitors | Brain Neoplasms - drug therapy | Cinnamates - pharmacology | Animals | Pyridines - metabolism | Mutant Proteins - chemistry | Anilides - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Mice | Pyridines - pharmacology | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Receptors, G-Protein-Coupled - chemistry | Amino Acid Substitution | Receptors, Cell Surface - genetics | Gene mutations | Development and progression | Genetic aspects | Diagnosis | Drug resistance | Identification and classification | Signal transduction | Genotype & phenotype | Inhibitor drugs | Cellular biology | Brain cancer | Mutation | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, pp. e27306 - e27306
Background: Recent evidence from in vitro and in vivo studies has demonstrated that aberrant reactivation of the Sonic Hedgehog (SHH) signaling pathway... 
COLON-CANCER | SURVIVAL | ACTIVATION | THERAPY | GLI TRANSCRIPTION FACTORS | GENOMIC ANALYSES | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | SELF-RENEWAL | MEDULLOBLASTOMA | Cell Survival - drug effects | Signal Transduction | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Pancreatic Neoplasms - pathology | Receptors, G-Protein-Coupled | Hedgehog Proteins - antagonists & inhibitors | Transcription Factors - drug effects | Pancreatic Neoplasms - drug therapy | Smoothened Receptor | Anilides - pharmacology | Cell Line, Tumor | Pyridines - pharmacology | Chemotherapy | Pancreatic cancer | Genes | Stem cells | Development and progression | DNA binding proteins | Genetic transcription | Health aspects | Mediation | Cancer | Cell proliferation | Drugs | Transcription factors | Bcl-2 protein | Laboratories | Brain cancer | Activation | Metastasis | Caspase-3 | Cancer therapies | Signal transduction | Toxicology | Transcription activation | Cell cycle | Deoxyribonucleic acid--DNA | Cell survival | Poly(ADP-ribose) polymerase | Caspase | Breast cancer | Tumor cell lines | Gene expression | Medicine | Signaling | Molecular modelling | Hedgehog protein | Medical prognosis | Cell lines | Ligands | In vivo methods and tests | Mutation | Aberration | In vitro methods and tests | Viability | Prostate | Apoptosis | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 11, pp. 8722 - 8735
We previously reported that aberrant HH pathway activation confers a poor prognosis in rhabdomyosarcoma (RMS). Searching for new treatment strategies we... 
Hedgehog | PI3K | Rhabdomyosarcoma | Apoptosis | Apoptosis - drug effects | Furans - pharmacology | Humans | Zinc Finger Protein Gli2 | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Caspases - metabolism | Nuclear Proteins - biosynthesis | Amino Acid Chloromethyl Ketones - pharmacology | Apoptosis Regulatory Proteins - genetics | Rhabdomyosarcoma, Alveolar - pathology | TOR Serine-Threonine Kinases - physiology | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Rhabdomyosarcoma, Embryonal - pathology | Apoptosis Regulatory Proteins - biosynthesis | Kruppel-Like Transcription Factors - biosynthesis | Neoplasm Proteins - biosynthesis | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Proto-Oncogene Proteins c-akt - physiology | Hedgehog Proteins - antagonists & inhibitors | Pyrimidines - pharmacology | Chick Embryo | Drug Synergism | Animals | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 06/2006, Volume 21, Issue 6, pp. 934 - 945
Journal Article
STEM CELLS, ISSN 1066-5099, 10/2007, Volume 25, Issue 10, pp. 2524 - 2533
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2011, Volume 121, Issue 1, pp. 148 - 160
The Hedgehog (Hh) pathway is activated in some human cancers, including medulloblastoma The glioma-associated oncogene homolog (GLI) transcription factors are... 
INTRAFLAGELLAR TRANSPORT PROTEINS | MEDICINE, RESEARCH & EXPERIMENTAL | KAPPA-B ACTIVATION | EWINGS-SARCOMA FAMILY | INDUCED APOPTOSIS | SONIC HEDGEHOG | EWS-FLI1 ONCOPROTEIN | REPRESSOR FUNCTIONS | HUMAN HOMOLOG | ACUTE PROMYELOCYTIC LEUKEMIA | PRIMARY CILIA | Neoplasm Transplantation | Oncogene Proteins - genetics | Gene Expression - drug effects | Humans | Sarcoma, Ewing - pathology | Transplantation, Heterologous | DNA Primers - genetics | Recombinant Fusion Proteins - metabolism | Base Sequence | Medulloblastoma - pathology | Smoothened Receptor | Trans-Activators - genetics | Antineoplastic Agents - pharmacology | Sarcoma, Ewing - metabolism | Arsenicals - pharmacology | Oncogene Proteins - metabolism | Mice, Transgenic | Medulloblastoma - metabolism | Hedgehog Proteins - antagonists & inhibitors | Mice, SCID | Hep G2 Cells | Oncogene Proteins - antagonists & inhibitors | Sarcoma, Ewing - drug therapy | Oxides - pharmacology | Animals | Signal Transduction - drug effects | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Trans-Activators - metabolism | Mice | Receptors, G-Protein-Coupled - genetics | Zinc Finger Protein GLI1 | Trans-Activators - antagonists & inhibitors | Medulloblastoma - drug therapy | Physiological aspects | Genetic aspects | Research | Growth | Oncogenes | Cancer cells | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2009, Volume 52, Issue 14, pp. 4400 - 4418
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 21, pp. 8708 - 8713
Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular mechanisms mediating these effects are poorly understood. Here we... 
Phosphorylation | Messenger RNA | Glucocorticoids | Antidepressants | Genetic variation | Rodents | Neurogenesis | Progenitor cells | Hippocampus | Depressive disorders | Neuroplasticity | Hypothalamus-pituitary-adrenal axis | Stem cells | PROGENITOR CELLS | hypothalamus-pituitary-adrenal axis | stem cells | BEHAVIOR | MULTIDISCIPLINARY SCIENCES | antidepressants | CELL-PROLIFERATION | MODEL | RECEPTOR ANTAGONIST | RESPONSES | DENTATE GYRUS | MODULATION | neuroplasticity | AXIS | Receptors, Glucocorticoid - antagonists & inhibitors | Depression - pathology | Humans | Middle Aged | Stress, Physiological | Hedgehog Proteins - metabolism | Hydrocortisone - metabolism | Male | Receptors, Glucocorticoid - metabolism | RNA, Messenger - metabolism | Immediate-Early Proteins - metabolism | Cell Nucleus - metabolism | Cell Nucleus - pathology | Glucocorticoids - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Adult | Female | Hippocampus - enzymology | Protein-Serine-Threonine Kinases - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Rats | Hippocampus - pathology | Rats, Sprague-Dawley | Depression - enzymology | Nerve Tissue Proteins - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Signal Transduction - drug effects | Active Transport, Cell Nucleus - drug effects | Benzoates - pharmacology | Mifepristone - pharmacology | Cell Line, Transformed | Immediate-Early Proteins - antagonists & inhibitors | Physiological aspects | Corticosteroids | Hippocampus (Brain) | Phosphotransferases | Depression, Mental | Brain | Molecules | Hormones | Mental depression | Gene expression | Stress | Index Medicus | Biological Sciences | hypothalamus–pituitary–adrenal axis
Journal Article