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1. Full Text Bone Morphogenetic Protein Antagonist Gremlin 1 Is Widely Expressed by Cancer-Associated Stromal Cells and Can Promote Tumor Cell Proliferation
by Julie B. Sneddon and Hanson H. Zhen and Kelli Montgomery and Matt van de Rijn and Aaron D. Tward and Robert West and Hayes Gladstone and Howard Y. Chang and Greg S. Morganroth and Anthony E. Oro and Patrick O. Brown
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2006, Volume 103, Issue 40, pp. 14842 - 14847
Although tissue microenvironments play critical roles in epithelial development and tumorigenesis, the factors mediating these effects are poorly understood.... 
Basal cell carcinoma | RNA | Epithelial cells | Stromal cells | Stem cells | Basal cell neoplasms | Fibroblasts | Tumor stem cells | Tumors | Cancer | MULTIDISCIPLINARY SCIENCES | NICHE | BETA-CATENIN | HEDGEHOG | tissue microenvironment | EPITHELIAL-CELLS | IN-VIVO | STEM-CELL | cancer biology | JUVENILE POLYPOSIS | tumor stroma | DIFFERENTIATION | stem cell regulation | CARCINOMA | HAIR-FOLLICLE | Bone Morphogenetic Proteins - antagonists & inhibitors | Skin - cytology | Bone Morphogenetic Protein 4 | Cell Proliferation | Carcinoma, Basal Cell - genetics | Bone Morphogenetic Protein 2 | Stromal Cells - pathology | Humans | RNA, Messenger - genetics | Cells, Cultured | Gene Expression Regulation, Neoplastic | Intercellular Signaling Peptides and Proteins - genetics | Carcinoma, Basal Cell - pathology | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Models, Biological | Transforming Growth Factor beta - antagonists & inhibitors | Cell Differentiation | Epithelial Cells - cytology | Transforming Growth Factor beta - metabolism | Cell proliferation | Analysis | Homeostasis | Bone morphogenetic proteins | Genetic aspects | Research | Apoptosis | Proteins | Tissue | Bones | Oncology | Gene expression | Antagonist drugs | Index Medicus | Biological Sciences
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2. Full Text Domain-specific Modification of Heparan Sulfate by Qsulf1 Modulates the Binding of the Bone Morphogenetic Protein Antagonist Noggin
by Beth L. Viviano and Stephenie Paine-Saunders and Nijole Gasiunas and John Gallagher and Scott Saunders
Journal of Biological Chemistry, ISSN 0021-9258, 02/2004, Volume 279, Issue 7, pp. 5604 - 5611
We have reported previously that Noggin is a heparin-binding protein and associates with the cell surface through heparan sulfate proteoglycans, where it... 
PROTEOGLYCANS | OLIGOSACCHARIDES | SONIC HEDGEHOG | BIOCHEMISTRY & MOLECULAR BIOLOGY | XENOPUS EMBRYOS | SURFACE | CONTROLS CELLULAR-RESPONSES | MITOGENIC ACTIVITY | WNT | STRUCTURAL FEATURES | SPEMANN ORGANIZER | Bone Morphogenetic Proteins - antagonists & inhibitors | Temperature | Wnt Proteins | Disaccharides - chemistry | Bone Morphogenetic Proteins - metabolism | Transfection | Time Factors | Sulfatases - chemistry | Cell Membrane - metabolism | CHO Cells | Carrier Proteins | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Proteins - physiology | Cricetinae | Bone Morphogenetic Protein 4 | Signal Transduction | Zebrafish Proteins | Nitrous Acid - pharmacology | Blotting, Western | Precipitin Tests | Animals | Heparitin Sulfate - chemistry | Bone Morphogenetic Proteins - chemistry | Proteins - chemistry | Monosaccharides - chemistry | Heparin - chemistry | Microscopy, Fluorescence | Index Medicus
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3. Full Text Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
by Robert L. Yauch and Gerrit J. P. Dijkgraaf and Bruno Alicke and Thomas Januario and Christina P. Ahn and Thomas Holcomb and Kanan Pujara and Jeremy Stinson and Christopher A. Callahan and Tracy Tang and J. Fernando Bazan and Zhengyan Kan and Somasekar Seshagiri and Christine L. Hann and Stephen E. Gould and Jennifer A. Low and Charles M. Rudin and Frederic J. de Sauvage
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5952, pp. 572 - 574
The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, including medulloblastoma, an aggressive brain tumor. GDC-0449, a... 
Receptors | Relapse | Basal cell carcinoma | Medulloblastoma | Amino acids | Biopsies | Reports | Genetic mutation | Tumors | Resistance mechanisms | Cancer | PROTEIN-COUPLED RECEPTORS | CYCLOPAMINE | CANCER | MULTIDISCIPLINARY SCIENCES | Anilides - therapeutic use | Receptors, G-Protein-Coupled - metabolism | Humans | Brain Neoplasms - pathology | Hedgehog Proteins - metabolism | Molecular Sequence Data | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Mutation, Missense | Antineoplastic Agents - metabolism | Neoplasm Metastasis | Hedgehog Proteins - genetics | Medulloblastoma - pathology | Smoothened Receptor | Veratrum Alkaloids - pharmacology | Antineoplastic Agents - pharmacology | Patched Receptors | Medulloblastoma - genetics | Mutant Proteins - antagonists & inhibitors | Pyridines - therapeutic use | Amino Acid Sequence | Signal Transduction | Anilides - metabolism | Brain Neoplasms - genetics | Receptors, Cell Surface - metabolism | Mutant Proteins - metabolism | Hedgehog Proteins - antagonists & inhibitors | Brain Neoplasms - drug therapy | Cinnamates - pharmacology | Animals | Pyridines - metabolism | Mutant Proteins - chemistry | Anilides - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Mice | Pyridines - pharmacology | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Receptors, G-Protein-Coupled - chemistry | Amino Acid Substitution | Receptors, Cell Surface - genetics | Gene mutations | Development and progression | Genetic aspects | Diagnosis | Drug resistance | Identification and classification | Signal transduction | Genotype & phenotype | Inhibitor drugs | Cellular biology | Brain cancer | Mutation | Index Medicus
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4. Full Text Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: Molecular mechanisms
by Singh, Brahma N and Fu, Junsheng and Srivastava, Rakesh K and Shankar, Sharmila
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, pp. e27306 - e27306
Background: Recent evidence from in vitro and in vivo studies has demonstrated that aberrant reactivation of the Sonic Hedgehog (SHH) signaling pathway... 
COLON-CANCER | SURVIVAL | ACTIVATION | THERAPY | GLI TRANSCRIPTION FACTORS | GENOMIC ANALYSES | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | SELF-RENEWAL | MEDULLOBLASTOMA | Cell Survival - drug effects | Signal Transduction | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Pancreatic Neoplasms - pathology | Receptors, G-Protein-Coupled | Hedgehog Proteins - antagonists & inhibitors | Transcription Factors - drug effects | Pancreatic Neoplasms - drug therapy | Smoothened Receptor | Anilides - pharmacology | Cell Line, Tumor | Pyridines - pharmacology | Chemotherapy | Pancreatic cancer | Genes | Stem cells | Development and progression | DNA binding proteins | Genetic transcription | Health aspects | Mediation | Cancer | Cell proliferation | Drugs | Transcription factors | Bcl-2 protein | Laboratories | Brain cancer | Activation | Metastasis | Caspase-3 | Cancer therapies | Signal transduction | Toxicology | Transcription activation | Cell cycle | Deoxyribonucleic acid--DNA | Cell survival | Poly(ADP-ribose) polymerase | Caspase | Breast cancer | Tumor cell lines | Gene expression | Medicine | Signaling | Molecular modelling | Hedgehog protein | Medical prognosis | Cell lines | Ligands | In vivo methods and tests | Mutation | Aberration | In vitro methods and tests | Viability | Prostate | Apoptosis | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
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5. Full Text Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma
by Graab, Ulrike and Hahn, Heidi and Fulda, Simone
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 11, pp. 8722 - 8735
We previously reported that aberrant HH pathway activation confers a poor prognosis in rhabdomyosarcoma (RMS). Searching for new treatment strategies we... 
Hedgehog | PI3K | Rhabdomyosarcoma | Apoptosis | Apoptosis - drug effects | Furans - pharmacology | Humans | Zinc Finger Protein Gli2 | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Caspases - metabolism | Nuclear Proteins - biosynthesis | Amino Acid Chloromethyl Ketones - pharmacology | Apoptosis Regulatory Proteins - genetics | Rhabdomyosarcoma, Alveolar - pathology | TOR Serine-Threonine Kinases - physiology | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Rhabdomyosarcoma, Embryonal - pathology | Apoptosis Regulatory Proteins - biosynthesis | Kruppel-Like Transcription Factors - biosynthesis | Neoplasm Proteins - biosynthesis | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Proto-Oncogene Proteins c-akt - physiology | Hedgehog Proteins - antagonists & inhibitors | Pyrimidines - pharmacology | Chick Embryo | Drug Synergism | Animals | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Screening Assays, Antitumor | Index Medicus
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6. Full Text Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways
by Sharov, Andrey A and Mardaryev, Andrei N and Sharova, Tatyana Y and Grachtchouk, Marina and Atoyan, Ruzanna and Byers, H. Randolph and Seykora, John T and Overbeek, Paul and Dlugosz, Andrzej and Botchkarev, Vladimir A
American Journal of Pathology, The, ISSN 0002-9440, 2009, Volume 175, Issue 3, pp. 1303 - 1314
Bone morphogenetic proteins (BMPs) play pivotal roles in the regulation of skin development. To study the role of BMPs in skin tumorigenesis, BMP antagonist... 
Pathology | FOLLICLE STEM-CELLS | CROSS-TALK | TGF-BETA | TOOTH DEVELOPMENT | HAIR FOLLICLE | SONIC HEDGEHOG | MOUSE EPIDERMIS | SELF-RENEWAL | PATHOLOGY | BETA-CATENIN | BASAL-CELL CARCINOMAS | Bone Morphogenetic Proteins - antagonists & inhibitors | Skin - metabolism | Humans | Middle Aged | Hedgehog Proteins - metabolism | Male | Wnt Proteins - metabolism | Hair Follicle - pathology | Bone Morphogenetic Proteins - metabolism | Adult | Female | Skin - pathology | Skin Neoplasms - pathology | Carrier Proteins - biosynthesis | Mice, Transgenic | Signal Transduction - genetics | Skin Neoplasms - metabolism | Carrier Proteins - genetics | Keratinocytes - pathology | Animals | Cell Transformation, Neoplastic | Keratinocytes - metabolism | Hair Follicle - metabolism | Aged | Mice | Skin Neoplasms - etiology | Index Medicus | Abridged Index Medicus | Regular
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7. Full Text Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass
by Morvan, Frederic and Boulukos, Kim and Clément‐Lacroix, Philippe and Roman, Sergio Roman and Suc‐Royer, Isabelle and Vayssière, Béatrice and Ammann, Patrick and Martin, Patrick and Pinho, Sonia and Pognonec, Philippe and Mollat, Patrick and Niehrs, Christof and Baron, Roland and Rawadi, Georges
Journal of Bone and Mineral Research, ISSN 0884-0431, 06/2006, Volume 21, Issue 6, pp. 934 - 945
Wnt/β‐catenin signaling has been proven to play a central role in bone biology. Unexpectedly, the Wnt antagonist Dkk2 is required for terminal osteoblast... 
LRP5 | Dickkopf | osteoblast | Wnt | osteoporosis | Osteoblast | Osteoporosis | WNT SIGNALING PATHWAY | CELLS | OSTEOBLAST DIFFERENTIATION | BETA-CATENIN | SCLEROSTEOSIS | SOST GENE | ENDOCRINOLOGY & METABOLISM | RECEPTOR-RELATED PROTEIN-5 | MICE | VAN-BUCHEM-DISEASE | Bone Morphogenetic Proteins - antagonists & inhibitors | Adipogenesis - drug effects | Bone Density - genetics | Adipogenesis - physiology | Hedgehog Proteins | Intercellular Signaling Peptides and Proteins - metabolism | Gene Deletion | Transforming Growth Factor beta - antagonists & inhibitors | Osteogenesis - genetics | Recombinant Proteins - metabolism | Bone Morphogenetic Protein 2 | Down-Regulation | Osteoblasts - drug effects | Intercellular Signaling Peptides and Proteins - genetics | Rats | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Animals | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Skull - cytology | Alleles | Mice | Trans-Activators - antagonists & inhibitors | Osteoblasts - metabolism | Index Medicus
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8. Full Text Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma
by Bar, Eli E and Chaudhry, Aneeka and Lin, Alex and Fan, Xing and Schreck, Karisa and Matsui, William and Piccirillo, Sara and Vescovi, Angelo L and DiMeco, Francesco and Olivi, Alessandro and Eberhart, Charles G
STEM CELLS, ISSN 1066-5099, 10/2007, Volume 25, Issue 10, pp. 2524 - 2533
Brain tumors can arise following deregulation of signaling pathways normally activated during brain development and may derive from neural stem cells. Given... 
Glioma | Hedgehog | Stem cell | BONE-MARROW | IDENTIFICATION | BRAIN-TUMORS | CELL BIOLOGY | hedgehog | stem cell | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ALDEHYDE DEHYDROGENASE-ACTIVITY | IN-VIVO | GROWTH | glioma | GLI PROTEINS | HEMATOLOGY | EXPRESSION | MEDULLOBLASTOMA | SONIC-HEDGEHOG | Gamma Rays | Neoplasm Transplantation | Neoplastic Stem Cells - cytology | Neoplastic Stem Cells - drug effects | Humans | Neoplasm Proteins - physiology | Neoplasm Proteins - antagonists & inhibitors | Cell Line, Tumor - drug effects | Hedgehog Proteins - physiology | RNA, Messenger - biosynthesis | Hedgehog Proteins - genetics | Veratrum Alkaloids - pharmacology | Signal Transduction - radiation effects | Neoplasm Proteins - genetics | Neoplastic Stem Cells - radiation effects | Transcription Factors - physiology | Neoplasm Proteins - biosynthesis | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Transcription Factors - biosynthesis | Hedgehog Proteins - antagonists & inhibitors | Transcription Factors - genetics | Ethanol - pharmacology | Animals | Signal Transduction - drug effects | Mice, Nude | Glioblastoma - pathology | Signal Transduction - physiology | Hedgehog Proteins - biosynthesis | Mice | Zinc Finger Protein GLI1 | Index Medicus
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9. Full Text Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
by Beauchamp, Elspeth M and Ringer, Lymor and Bulut, Gülay and Sajwan, Kamal P and Hall, Michael D and Lee, Yi-Chien and Peaceman, Daniel and Özdemirli, Metin and Rodriguez, Olga and Macdonald, Tobey J and Albanese, Chris and Toretsky, Jeffrey A and Üren, Aykut
Journal of Clinical Investigation, ISSN 0021-9738, 01/2011, Volume 121, Issue 1, pp. 148 - 160
The Hedgehog (Hh) pathway is activated in some human cancers, including medulloblastoma The glioma-associated oncogene homolog (GLI) transcription factors are... 
INTRAFLAGELLAR TRANSPORT PROTEINS | MEDICINE, RESEARCH & EXPERIMENTAL | KAPPA-B ACTIVATION | EWINGS-SARCOMA FAMILY | INDUCED APOPTOSIS | SONIC HEDGEHOG | EWS-FLI1 ONCOPROTEIN | REPRESSOR FUNCTIONS | HUMAN HOMOLOG | ACUTE PROMYELOCYTIC LEUKEMIA | PRIMARY CILIA | Neoplasm Transplantation | Oncogene Proteins - genetics | Gene Expression - drug effects | Humans | Sarcoma, Ewing - pathology | Transplantation, Heterologous | DNA Primers - genetics | Recombinant Fusion Proteins - metabolism | Base Sequence | Medulloblastoma - pathology | Smoothened Receptor | Trans-Activators - genetics | Antineoplastic Agents - pharmacology | Sarcoma, Ewing - metabolism | Arsenicals - pharmacology | Oncogene Proteins - metabolism | Mice, Transgenic | Medulloblastoma - metabolism | Hedgehog Proteins - antagonists & inhibitors | Mice, SCID | Hep G2 Cells | Oncogene Proteins - antagonists & inhibitors | Sarcoma, Ewing - drug therapy | Oxides - pharmacology | Animals | Signal Transduction - drug effects | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Trans-Activators - metabolism | Mice | Receptors, G-Protein-Coupled - genetics | Zinc Finger Protein GLI1 | Trans-Activators - antagonists & inhibitors | Medulloblastoma - drug therapy | Physiological aspects | Genetic aspects | Research | Growth | Oncogenes | Cancer cells | Index Medicus | Abridged Index Medicus
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10. Full Text Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)
by Tremblay, Martin R and Lescarbeau, André and Grogan, Michael J and Tan, Eddy and Lin, Grace and Austad, Brian C and Yu, Lin-Chen and Behnke, Mark L and Nair, Somarajan J and Hagel, Margit and White, Kerry and Conley, James and Manna, Joseph D and Alvarez-Diez, Teresa M and Hoyt, Jennifer and Woodward, Caroline N and Sydor, Jens R and Pink, Melissa and MacDougall, John and Campbell, Matthew J and Cushing, Jill and Ferguson, Jeanne and Curtis, Michael S and McGovern, Karen and Read, Margaret A and Palombella, Vito J and Adams, Julian and Castro, Alfredo C
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2009, Volume 52, Issue 14, pp. 4400 - 4418
Recent evidence suggests that blocking aberrant hedgehog pathway signaling may be a promising therapeutic strategy for the treatment of several types of... 
CELL LUNG-CANCER | TERATOGENIC COMPOUNDS | CHEMISTRY, MEDICINAL | INHIBITION | SMALL-MOLECULE | SIGNALING PATHWAY | PANCREATIC-CANCER | PROSTATE-CANCER | IN-VIVO | CYCLOPAMINE | VERATRUM CALIFORNICUM DURAND | Veratrum Alkaloids - administration & dosage | Cell Line | Microsomes - metabolism | Administration, Oral | Stereoisomerism | Veratrum Alkaloids - pharmacokinetics | Humans | Hedgehog Proteins - metabolism | Antineoplastic Agents - administration & dosage | Hedgehog Proteins - antagonists & inhibitors | Antineoplastic Agents - chemistry | Drug Discovery | Veratrum Alkaloids - chemistry | Microsomes - drug effects | Animals | Signal Transduction - drug effects | Medulloblastoma - pathology | Veratrum Alkaloids - pharmacology | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Liver - cytology | Medulloblastoma - drug therapy | Index Medicus
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11. Full Text A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to smoothened antagonists
by Chenna, Venugopal and Hu, Chaoxin and Pramanik, Dipankar and Aftab, Blake T and Karikari, Collins and Campbell, Nathaniel R and Hong, Seung-Mo and Zhao, Ming and Rudek, Michelle A and Khan, Saeed R and Rudin, Charles M and Maitra, Anirban
Molecular Cancer Therapeutics, ISSN 1535-7163, 01/2012, Volume 11, Issue 1, pp. 165 - 173
Aberrant activation of the hedgehog (Hh) signaling pathway is one of the most prevalent abnormalities in human cancer. Tumors with cell autonomous Hh... 
THERAPY | GENE | ONCOLOGY | PATHWAY | IDENTIFICATION | MEDULLOBLASTOMA | REQUIREMENT | Cell Proliferation | Pancreatic Neoplasms - metabolism | Nanoparticles - chemistry | Humans | Hedgehog Proteins - metabolism | Deoxycytidine - pharmacology | Male | Tumor Suppressor Protein p53 - genetics | Medulloblastoma - pathology | Smoothened Receptor | Patched Receptors | Signal Transduction | Transcription Factors - antagonists & inhibitors | Medulloblastoma - metabolism | Hedgehog Proteins - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Mice | Receptors, G-Protein-Coupled - genetics | Zinc Finger Protein GLI1 | Deoxycytidine - analogs & derivatives | Patched-1 Receptor | Receptors, Cell Surface - genetics | Index Medicus | Hedgehog | polymeric nanoparticle | smoothened | NanoHHI | HPI-1 | Gli1 | HhAntag
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12. Full Text Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis
by Christoph Anacker and Annamaria Cattaneo and Ksenia Musaelyan and Patricia A. Zunszain and Mark Horowitz and Raffaella Molteni and Alessia Luoni and Francesca Calabrese and Katherine Tansey and Massimo Gennarelli and Sandrine Thuret and Jack Price and Rudolf Uher and Marco A. Riva and Carmine M. Pariante
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 21, pp. 8708 - 8713
Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular mechanisms mediating these effects are poorly understood. Here we... 
Phosphorylation | Messenger RNA | Glucocorticoids | Antidepressants | Genetic variation | Rodents | Neurogenesis | Progenitor cells | Hippocampus | Depressive disorders | Neuroplasticity | Hypothalamus-pituitary-adrenal axis | Stem cells | PROGENITOR CELLS | hypothalamus-pituitary-adrenal axis | stem cells | BEHAVIOR | MULTIDISCIPLINARY SCIENCES | antidepressants | CELL-PROLIFERATION | MODEL | RECEPTOR ANTAGONIST | RESPONSES | DENTATE GYRUS | MODULATION | neuroplasticity | AXIS | Receptors, Glucocorticoid - antagonists & inhibitors | Depression - pathology | Humans | Middle Aged | Stress, Physiological | Hedgehog Proteins - metabolism | Hydrocortisone - metabolism | Male | Receptors, Glucocorticoid - metabolism | RNA, Messenger - metabolism | Immediate-Early Proteins - metabolism | Cell Nucleus - metabolism | Cell Nucleus - pathology | Glucocorticoids - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Adult | Female | Hippocampus - enzymology | Protein-Serine-Threonine Kinases - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Rats | Hippocampus - pathology | Rats, Sprague-Dawley | Depression - enzymology | Nerve Tissue Proteins - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Signal Transduction - drug effects | Active Transport, Cell Nucleus - drug effects | Benzoates - pharmacology | Mifepristone - pharmacology | Cell Line, Transformed | Immediate-Early Proteins - antagonists & inhibitors | Physiological aspects | Corticosteroids | Hippocampus (Brain) | Phosphotransferases | Depression, Mental | Brain | Molecules | Hormones | Mental depression | Gene expression | Stress | Index Medicus | Biological Sciences | hypothalamus–pituitary–adrenal axis
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