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Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 11, pp. 8722 - 8735
Hedgehog | PI3K | Rhabdomyosarcoma | Apoptosis | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Apoptosis - drug effects | Furans - pharmacology | Humans | Zinc Finger Protein Gli2 | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Caspases - metabolism | Nuclear Proteins - biosynthesis | Amino Acid Chloromethyl Ketones - pharmacology | Apoptosis Regulatory Proteins - genetics | Rhabdomyosarcoma, Alveolar - pathology | TOR Serine-Threonine Kinases - physiology | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Rhabdomyosarcoma, Embryonal - pathology | Apoptosis Regulatory Proteins - biosynthesis | Kruppel-Like Transcription Factors - biosynthesis | Neoplasm Proteins - biosynthesis | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Proto-Oncogene Proteins c-akt - physiology | Hedgehog Proteins - antagonists & inhibitors | Pyrimidines - pharmacology | Chick Embryo | Drug Synergism | Animals | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
Science translational medicine, ISSN 1946-6234, 09/2010, Volume 2, Issue 51, pp. 51ra70 - 51ra70
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Receptors, G-Protein-Coupled - metabolism | Zinc Finger Protein Gli2 | Hedgehog Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Aminopyridines - therapeutic use | Kruppel-Like Transcription Factors - metabolism | Medulloblastoma - pathology | Smoothened Receptor | Medulloblastoma - genetics | Morpholines - therapeutic use | Tumor Suppressor Protein p53 - metabolism | Morpholines - pharmacology | Mutation - genetics | Gene Amplification - drug effects | Up-Regulation - drug effects | Animals | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Aminopyridines - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Medulloblastoma - drug therapy | Insulin-Like Growth Factor I - metabolism | Medulloblastoma - enzymology | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5057 - 5061
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Tumors | Medulloblastoma - secondary | Anilides - therapeutic use | Skin Neoplasms - drug therapy | Carcinoma, Basal Cell - genetics | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Hedgehog Proteins - physiology | Mutation, Missense | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Biphenyl Compounds - therapeutic use | Smoothened Receptor | Antineoplastic Agents - pharmacology | Receptors, Cell Surface - physiology | Patched Receptors | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Pyridines - therapeutic use | Medulloblastoma - metabolism | Carcinoma, Basal Cell - metabolism | Mice, Knockout | Skin Neoplasms - metabolism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Mice, Nude | Skin Neoplasms - genetics | Anilides - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Carcinoma, Basal Cell - drug therapy | Mice | Pyridines - pharmacology | Receptors, G-Protein-Coupled - genetics | Basal Cell Nevus Syndrome - genetics | Medulloblastoma - drug therapy | Receptors, Cell Surface - genetics | Index Medicus
Journal Article
Annals of hematology, ISSN 0939-5555, 5/2012, Volume 91, Issue 5, pp. 645 - 669
Wnt/ß-Catenin | Hedgehog | Medicine & Public Health | Hematology | Notch | Oncology | MLL | Runt | Wnt/β-Catenin | Life Sciences & Biomedicine | Science & Technology | Neoplasms - metabolism | Wnt1 Protein - antagonists & inhibitors | Wnt1 Protein - genetics | Myeloid-Lymphoid Leukemia Protein - metabolism | Prognosis | Receptors, Notch - metabolism | Humans | Hedgehog Proteins - metabolism | Receptors, Notch - genetics | Antineoplastic Agents - therapeutic use | Wnt1 Protein - metabolism | Drosophila Proteins - metabolism | Molecular Targeted Therapy | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Receptors, Notch - antagonists & inhibitors | Hedgehog Proteins - genetics | Neoplasms - genetics | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Drosophila Proteins - antagonists & inhibitors | Disease Models, Animal | Drosophila - genetics | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Histone-Lysine N-Methyltransferase | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Hedgehog Proteins - antagonists & inhibitors | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Neoplasms - drug therapy | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Myeloid-Lymphoid Leukemia Protein - genetics | Nuclear Proteins - antagonists & inhibitors | Mice | Drosophila - metabolism | Drosophila Proteins - genetics | Myeloid-Lymphoid Leukemia Protein - antagonists & inhibitors | Magneto-electric machines | Fruit-flies | Developmental biology | Analysis | Drosophila | Oncology, Experimental | Research | Machinery | Cancer | Index Medicus
Journal Article
Nature reviews. Clinical oncology, ISSN 1759-4774, 06/2015, Volume 12, Issue 6, pp. 319 - 334
Life Sciences & Biomedicine | Oncology | Science & Technology | Cytotoxins - therapeutic use | Immunotherapy - methods | Neoplastic Stem Cells - drug effects | Humans | Recombinant Fusion Proteins - therapeutic use | ras Proteins - antagonists & inhibitors | Antibodies, Monoclonal - therapeutic use | Treatment Outcome | Carcinoma, Pancreatic Ductal - therapy | Clinical Trials as Topic | Hedgehog Proteins - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Hyaluronoglucosaminidase - pharmacology | Janus Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Cancer Vaccines - therapeutic use | Neoplasm Metastasis | Molecular Targeted Therapy - trends | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoadjuvant Therapy - methods | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Molecular Targeted Therapy - methods | Pancreatic Neoplasms - therapy | Care and treatment | Research | Pancreatic cancer | Oncology, Experimental | Cancer | Index Medicus
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 06/2017, Volume 24, Issue 19, pp. 2033 - 2058
Smoothened | Inhibitors | Small molecule | Anticancer | GLI | Hedgehog pathway | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Neoplasms - metabolism | Small Molecule Libraries - pharmacology | Humans | Small Molecule Libraries - therapeutic use | Hedgehog Proteins - metabolism | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Hedgehog Proteins - antagonists & inhibitors | Antineoplastic Agents - chemistry | Drug Discovery | Neoplasms - drug therapy | Small Molecule Libraries - chemistry | Animals | Signal Transduction - drug effects | Antineoplastic Agents - pharmacology | Medical research | Histone deacetylase | Regulatory agencies | Target recognition | Clinical trials | Antagonists | Drug resistance | Kinases | Embryonic growth stage | Signal transduction | Signaling | Embryogenesis | Tubulin | Hedgehog protein | Cancer
Journal Article
Cancer cell, ISSN 1535-6108, 01/2013, Volume 23, Issue 1, pp. 23 - 34
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Anilides - therapeutic use | Hedgehog Proteins - metabolism | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Hedgehog Proteins - physiology | Itraconazole - pharmacology | Arsenicals - therapeutic use | Medulloblastoma - pathology | Smoothened Receptor | Antineoplastic Agents - pharmacology | Pyridines - therapeutic use | Oxides - therapeutic use | Arsenicals - pharmacology | Carcinoma, Basal Cell - pathology | Medulloblastoma - metabolism | Carcinoma, Basal Cell - metabolism | Itraconazole - therapeutic use | Oxides - pharmacology | Animals | Signal Transduction - drug effects | Anilides - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Carcinoma, Basal Cell - drug therapy | Mice | Pyridines - pharmacology | Medulloblastoma - drug therapy | Arsenic | Itraconazole | Index Medicus
Journal Article