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1. Full Text Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma
by Graab, Ulrike and Hahn, Heidi and Fulda, Simone
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 11, pp. 8722 - 8735
Hedgehog | PI3K | Rhabdomyosarcoma | Apoptosis | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Apoptosis - drug effects | Furans - pharmacology | Humans | Zinc Finger Protein Gli2 | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Caspases - metabolism | Nuclear Proteins - biosynthesis | Amino Acid Chloromethyl Ketones - pharmacology | Apoptosis Regulatory Proteins - genetics | Rhabdomyosarcoma, Alveolar - pathology | TOR Serine-Threonine Kinases - physiology | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Rhabdomyosarcoma, Embryonal - pathology | Apoptosis Regulatory Proteins - biosynthesis | Kruppel-Like Transcription Factors - biosynthesis | Neoplasm Proteins - biosynthesis | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Proto-Oncogene Proteins c-akt - physiology | Hedgehog Proteins - antagonists & inhibitors | Pyrimidines - pharmacology | Chick Embryo | Drug Synergism | Animals | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Screening Assays, Antitumor | Index Medicus
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2. Full Text Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma
by Buonamici, Silvia and Williams, Juliet and Morrissey, Michael and Wang, Anlai and Guo, Ribo and Vattay, Anthony and Hsiao, Kathy and Yuan, Jing and Green, John and Ospina, Beatriz and Yu, Qunyan and Ostrom, Lance and Fordjour, Paul and Anderson, Dustin L and Monahan, John E and Kelleher, Joseph F and Peukert, Stefan and Pan, Shifeng and Wu, Xu and Maira, Sauveur-Michel and García-Echeverría, Carlos and Briggs, Kimberly J and Watkins, D. Neil and Yao, Yung-Mae and Lengauer, Christoph and Warmuth, Markus and Sellers, William R and Dorsch, Marion
Science translational medicine, ISSN 1946-6234, 09/2010, Volume 2, Issue 51, pp. 51ra70 - 51ra70
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Receptors, G-Protein-Coupled - metabolism | Zinc Finger Protein Gli2 | Hedgehog Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Aminopyridines - therapeutic use | Kruppel-Like Transcription Factors - metabolism | Medulloblastoma - pathology | Smoothened Receptor | Medulloblastoma - genetics | Morpholines - therapeutic use | Tumor Suppressor Protein p53 - metabolism | Morpholines - pharmacology | Mutation - genetics | Gene Amplification - drug effects | Up-Regulation - drug effects | Animals | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Aminopyridines - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Medulloblastoma - drug therapy | Insulin-Like Growth Factor I - metabolism | Medulloblastoma - enzymology | Drug Resistance, Neoplasm - drug effects | Index Medicus
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3. Full Text Hedgehog fights back: Mechanisms of acquired resistance against smoothened antagonists
by Metcalfe, Ciara and De Sauvage, Frederic J
Cancer research (Chicago, Ill.), ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5057 - 5061
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Tumors | Medulloblastoma - secondary | Anilides - therapeutic use | Skin Neoplasms - drug therapy | Carcinoma, Basal Cell - genetics | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Hedgehog Proteins - physiology | Mutation, Missense | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Biphenyl Compounds - therapeutic use | Smoothened Receptor | Antineoplastic Agents - pharmacology | Receptors, Cell Surface - physiology | Patched Receptors | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Pyridines - therapeutic use | Medulloblastoma - metabolism | Carcinoma, Basal Cell - metabolism | Mice, Knockout | Skin Neoplasms - metabolism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Mice, Nude | Skin Neoplasms - genetics | Anilides - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Carcinoma, Basal Cell - drug therapy | Mice | Pyridines - pharmacology | Receptors, G-Protein-Coupled - genetics | Basal Cell Nevus Syndrome - genetics | Medulloblastoma - drug therapy | Receptors, Cell Surface - genetics | Index Medicus
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4. Full Text Pathways involved in Drosophila and human cancer development: the Notch, Hedgehog, Wingless, Runt, and Trithorax pathway
by Geissler, Klaus and Zach, Otto
Annals of hematology, ISSN 0939-5555, 5/2012, Volume 91, Issue 5, pp. 645 - 669
Wnt/ß-Catenin | Hedgehog | Medicine & Public Health | Hematology | Notch | Oncology | MLL | Runt | Wnt/β-Catenin | Life Sciences & Biomedicine | Science & Technology | Neoplasms - metabolism | Wnt1 Protein - antagonists & inhibitors | Wnt1 Protein - genetics | Myeloid-Lymphoid Leukemia Protein - metabolism | Prognosis | Receptors, Notch - metabolism | Humans | Hedgehog Proteins - metabolism | Receptors, Notch - genetics | Antineoplastic Agents - therapeutic use | Wnt1 Protein - metabolism | Drosophila Proteins - metabolism | Molecular Targeted Therapy | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Receptors, Notch - antagonists & inhibitors | Hedgehog Proteins - genetics | Neoplasms - genetics | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Drosophila Proteins - antagonists & inhibitors | Disease Models, Animal | Drosophila - genetics | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Histone-Lysine N-Methyltransferase | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Hedgehog Proteins - antagonists & inhibitors | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Neoplasms - drug therapy | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Myeloid-Lymphoid Leukemia Protein - genetics | Nuclear Proteins - antagonists & inhibitors | Mice | Drosophila - metabolism | Drosophila Proteins - genetics | Myeloid-Lymphoid Leukemia Protein - antagonists & inhibitors | Magneto-electric machines | Fruit-flies | Developmental biology | Analysis | Drosophila | Oncology, Experimental | Research | Machinery | Cancer | Index Medicus
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5. Full Text Pancreatic cancer: From state-of-the-art treatments to promising novel therapies
by Garrido-Laguna, Ignacio and Hidalgo, Manuel
Nature reviews. Clinical oncology, ISSN 1759-4774, 06/2015, Volume 12, Issue 6, pp. 319 - 334
Life Sciences & Biomedicine | Oncology | Science & Technology | Cytotoxins - therapeutic use | Immunotherapy - methods | Neoplastic Stem Cells - drug effects | Humans | Recombinant Fusion Proteins - therapeutic use | ras Proteins - antagonists & inhibitors | Antibodies, Monoclonal - therapeutic use | Treatment Outcome | Carcinoma, Pancreatic Ductal - therapy | Clinical Trials as Topic | Hedgehog Proteins - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Hyaluronoglucosaminidase - pharmacology | Janus Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Cancer Vaccines - therapeutic use | Neoplasm Metastasis | Molecular Targeted Therapy - trends | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoadjuvant Therapy - methods | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Molecular Targeted Therapy - methods | Pancreatic Neoplasms - therapy | Care and treatment | Research | Pancreatic cancer | Oncology, Experimental | Cancer | Index Medicus
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6. Discovery of Hedgehog antagonists for cancer therapy
by Khatra, Harleen and Bose, Chandra and Sinha, Surajit
Current medicinal chemistry, ISSN 0929-8673, 06/2017, Volume 24, Issue 19, pp. 2033 - 2058
Smoothened | Inhibitors | Small molecule | Anticancer | GLI | Hedgehog pathway | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Neoplasms - metabolism | Small Molecule Libraries - pharmacology | Humans | Small Molecule Libraries - therapeutic use | Hedgehog Proteins - metabolism | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Hedgehog Proteins - antagonists & inhibitors | Antineoplastic Agents - chemistry | Drug Discovery | Neoplasms - drug therapy | Small Molecule Libraries - chemistry | Animals | Signal Transduction - drug effects | Antineoplastic Agents - pharmacology | Medical research | Histone deacetylase | Regulatory agencies | Target recognition | Clinical trials | Antagonists | Drug resistance | Kinases | Embryonic growth stage | Signal transduction | Signaling | Embryogenesis | Tubulin | Hedgehog protein | Cancer
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7. Full Text Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists
by Kim, James and Aftab, Blake T and Tang, Jean Y and Kim, Daniel and Lee, Alex H and Rezaee, Melika and Kim, Jynho and Chen, Baozhi and King, Emily M and Borodovsky, Alexandra and Riggins, Gregory J and Epstein, Ervin H and Beachy, Philip A and Rudin, Charles M
Cancer cell, ISSN 1535-6108, 01/2013, Volume 23, Issue 1, pp. 23 - 34
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Anilides - therapeutic use | Hedgehog Proteins - metabolism | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Hedgehog Proteins - physiology | Itraconazole - pharmacology | Arsenicals - therapeutic use | Medulloblastoma - pathology | Smoothened Receptor | Antineoplastic Agents - pharmacology | Pyridines - therapeutic use | Oxides - therapeutic use | Arsenicals - pharmacology | Carcinoma, Basal Cell - pathology | Medulloblastoma - metabolism | Carcinoma, Basal Cell - metabolism | Itraconazole - therapeutic use | Oxides - pharmacology | Animals | Signal Transduction - drug effects | Anilides - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Carcinoma, Basal Cell - drug therapy | Mice | Pyridines - pharmacology | Medulloblastoma - drug therapy | Arsenic | Itraconazole | Index Medicus
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