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1. Full Text Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer
by Brechbiel, Jillian and Miller-Moslin, Karen and Adjei, Alex A
Cancer Treatment Reviews, ISSN 0305-7372, 2014, Volume 40, Issue 6, pp. 750 - 759
Abstract The hedgehog (Hh) pathway is aberrantly activated in a number of tumors. In medulloblastoma, basal cell carcinoma, and rhabdomyosarcoma, mutations in... 
Hematology, Oncology and Palliative Medicine | Hedgehog | Smoothened | Combination chemotherapy | Targeted therapy | Novel antitumor agents | Cell signaling | STEM-CELLS | ACTIVATED PROTEIN-KINASE | SELF-RENEWAL | CHRONIC MYELOID-LEUKEMIA | EPITHELIAL-MESENCHYMAL TRANSITION | GLI TRANSCRIPTION FACTORS | ONCOLOGY | BASAL-CELL CARCINOMA | PROSTATE-CANCER | TARGETING HEDGEHOG | SONIC-HEDGEHOG | Hedgehog Proteins - drug effects | Neoplasms - metabolism | TOR Serine-Threonine Kinases - metabolism | Receptors, Notch - metabolism | Humans | Hedgehog Proteins - metabolism | Receptor, Epidermal Growth Factor - drug effects | Phosphatidylinositol 3-Kinases - metabolism | raf Kinases - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Receptor, Epidermal Growth Factor - metabolism | Phosphatidylinositol 3-Kinases - drug effects | Proto-Oncogene Proteins c-akt - metabolism | TOR Serine-Threonine Kinases - drug effects | Janus Kinase 2 - antagonists & inhibitors | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins p21(ras) - metabolism | Receptors, Notch - drug effects | Fusion Proteins, bcr-abl - drug effects | Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - drug effects | Animals | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | raf Kinases - drug effects | Fusion Proteins, bcr-abl - metabolism | Proto-Oncogene Proteins c-akt - drug effects | Receptor Cross-Talk - drug effects | Care and treatment | Health aspects | Leukemia | Analysis | Cancer
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2. Full Text Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
by Kim, Jynho and Kim, James and Tang, Jean Y and Gong, Ruoyu and Lee, John J and Clemons, Karl V and Chong, Curtis R and Chang, Kris S and Fereshteh, Mark and Gardner, Dale and Reya, Tannishtha and Liu, Jun O and Epstein, Ervin H and Stevens, David A and Beachy, Philip A
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 4, pp. 388 - 399
In a screen of drugs previously tested in humans we identified itraconazole, a systemic antifungal, as a potent antagonist of the Hedgehog (Hh) signaling... 
CHEMBIO | CELLCYCLE | SIGNAL-TRANSDUCTION | STEM-CELLS | CANDIDA-ALBICANS | ONCOLOGY | BASAL-CELL CARCINOMA | PROSTATE-CANCER | MOUSE MODEL | HIGH-DOSE ITRACONAZOLE | LOW-DENSITY-LIPOPROTEIN | DRUG DEVELOPMENT COSTS | PRIMARY CILIUM | Antifungal Agents - pharmacology | Hedgehog Proteins - drug effects | Hedgehog Proteins - chemistry | Humans | Lipoproteins, LDL - physiology | Models, Molecular | Antineoplastic Agents - therapeutic use | Hedgehog Proteins - physiology | Hedgehog Proteins - antagonists & inhibitors | Cell Division - drug effects | Itraconazole - pharmacology | Antifungal Agents - therapeutic use | Itraconazole - therapeutic use | Animals | Signal Transduction - drug effects | Carcinoma, Basal Cell - drug therapy | Mice | Kinetics | Cyclodextrins - pharmacology | Animal models
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3. Full Text Tumor Architecture and Notch Signaling Modulate Drug Response in Basal Cell Carcinoma
by Eberl, Markus and Mangelberger, Doris and Swanson, Jacob B and Verhaegen, Monique E and Harms, Paul W and Frohm, Marcus L and Dlugosz, Andrzej A and Wong, Sunny Y
Cancer Cell, ISSN 1535-6108, 02/2018, Volume 33, Issue 2, pp. 229 - 243.e4
Hedgehog (Hh) pathway inhibitors such as vismodegib are highly effective for treating basal cell carcinoma (BCC); however, residual tumor cells frequently... 
skin cancer | basal cell carcinoma | vismodegib | Hedgehog | Notch | HEDGEHOG PATHWAY | STEM-CELLS | VISMODEGIB | ONCOLOGY | HAIR FOLLICLE | ACQUIRED-RESISTANCE | GENOMIC ANALYSIS | SKIN | SOMATIC MUTATIONS | HUMAN HOMOLOG | SMOOTHENED MUTATIONS | CELL BIOLOGY | Hedgehog Proteins - drug effects | Skin Neoplasms - pathology | Skin Neoplasms - drug therapy | Signal Transduction - drug effects | Apoptosis - drug effects | Receptors, Notch - metabolism | Humans | Carcinoma, Basal Cell - drug therapy | Hedgehog Proteins - metabolism | Antineoplastic Agents - pharmacology | Carcinoma, Basal Cell - pathology | Receptors, Notch - drug effects | Basal cell carcinoma | Architecture | Developmental biology | Skin | Drug resistance | Drug therapy | Gene expression
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4. Full Text Icariin Reduces Cartilage Degeneration in a Mouse Model of Osteoarthritis and is Associated with the Changes in Expression of Indian Hedgehog and Parathyroid Hormone-Related Protein
by Luo, Yuan and Zhang, Yiwen and Huang, Yuanliang
Medical science monitor : international medical journal of experimental and clinical research, ISSN 1643-3750, 09/2018, Volume 24, pp. 6695 - 6706
Background: The aim of this study was to determine the role of icariin, a Chinese traditional herbal medicine extracted from Epimedium, in osteoarthritis (OA),... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROLIFERATION | ARTHRITIS | HISTOPATHOLOGY | CULTURE | Hedgehog Proteins | HYPERTROPHY | BONE-FORMATION | Chondrocytes | BIOLOGY | Osteoarthritis, Knee | DIFFERENTIATION | STROMAL CELLS | Hedgehog Proteins - drug effects | Anterior Cruciate Ligament - drug effects | Mice, Inbred C57BL | Hedgehog Proteins - metabolism | Cartilage - drug effects | Osteoarthritis - drug therapy | Collagen Type II - metabolism | Cartilage, Articular - pathology | Chondrocytes - drug effects | Parathyroid Hormone-Related Protein - drug effects | Animals | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Flavonoids - pharmacology | Mice | Osteoarthritis, Knee - metabolism | Disease Models, Animal
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5. Full Text Alcohol Reduces Arterial Remodeling by Inhibiting Sonic Hedgehog‐Stimulated Stem Cell Antigen‐1 Positive Progenitor Stem Cell Expansion
by Fitzpatrick, Emma and Han, Xu and Liu, Weimin and Corcoran, Eoin and Burtenshaw, Denise and Morrow, David and Helt, Jay‐Christian and Cahill, Paul A and Redmond, Eileen M
Alcoholism: Clinical and Experimental Research, ISSN 0145-6008, 12/2017, Volume 41, Issue 12, pp. 2051 - 2065
Background Cell and molecular mechanisms mediating the cardiovascular effects of alcohol are not fully understood. Our aim was to determine the effect of... 
Stem Cells | Alcohol | Hedgehog | Stem Cell Antigen‐1 | Atherosclerosis | Progenitor Cells | MODERATE | POPULATION | CONTRIBUTE | ISCHEMIC-HEART-DISEASE | PROLIFERATION | SUBSTANCE ABUSE | Stem Cell Antigen-1 | IN-VITRO | ADVENTITIA | SMOOTH-MUSCLE-CELLS | EXPRESSION | CONSUMPTION | Carotid Arteries - drug effects | Hedgehog Proteins - drug effects | Stem Cells - immunology | Gene Expression - drug effects | Cell Proliferation - physiology | Membrane Proteins - immunology | Mice, Transgenic | Hedgehog Proteins - physiology | Animals | Patched-1 Receptor - biosynthesis | Antigens, Ly - immunology | Carotid Arteries - physiopathology | Cell Differentiation - drug effects | Veratrum Alkaloids - pharmacology | Stem Cells - physiology | Vascular Remodeling - physiology | Cell Proliferation - drug effects | Mice | Vascular Remodeling - drug effects | Zinc Finger Protein Gli2 - biosynthesis | Antigens | Analysis | Stem cells | Fluorescence | Genetic engineering | Gene expression | Differentiation (biology) | Transgenic | Stem cell transplantation | Smooth muscle | Remodeling | Alcohols | Allografts | Ataxin | Rodents | Inhibition | Carotid artery | Expansion | Injury analysis | Thickening | Ethanol | Muscles | Blood vessels | Patched protein | Polymerase chain reaction | Signaling | Molecular modelling | Hedgehog protein | Green fluorescent protein | Cells (biology)
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6. Full Text Control of inflammation by stromal Hedgehog pathway activation restrains colitis
by John J. Lee and Michael E. Rothenberg and E. Scott Seeley and Bryan Zimdahl and Sally Kawano and Wan-Jin Lu and Kunyoo Shin and Tomoyo Sakata-Kato and James K. Chen and Maximilian Diehn and Michael F. Clarke and Philip A. Beachy
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2016, Volume 113, Issue 47, pp. E7545 - E7553
Inflammation disrupts tissue architecture and function, thereby contributing to the pathogenesis of diverse diseases; the signals that promote or restrict... 
Inflammatory bowel disease | Hedgehog signaling | Colon cancer | Colitis | Interleukin-10 | STEM-CELLS | colitis | colon cancer | ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | INTERLEUKIN-10 RECEPTOR | MOUSE | PROLIFERATION | interleukin-10 | FOXP3 | inflammatory bowel disease | BOWEL-DISEASE | REGULATORY T-CELLS | MICE | CANCER PROGRESSION | Hedgehog Proteins - drug effects | Small Molecule Libraries - pharmacology | T-Lymphocytes, Regulatory - metabolism | Small Molecule Libraries - administration & dosage | Zinc Finger Protein GLI1 - genetics | Humans | Dextran Sulfate - adverse effects | Hedgehog Proteins - metabolism | Disease Progression | Animals | Signal Transduction - drug effects | Forkhead Transcription Factors - metabolism | Colitis - chemically induced | Colitis - metabolism | Interleukin-10 - metabolism | Colitis - drug therapy | Mice | Mutation | CD4 Antigens - metabolism | Disease Models, Animal | Biological Sciences | PNAS Plus
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7. Full Text Medulloblastoma: signalling a change in treatment
by Gilbertson, Richard J
Lancet Oncology, ISSN 1470-2045, 2004, Volume 5, Issue 4, pp. 209 - 218
Medulloblastoma is the most common malignant brain tumour that occurs during childhood. Multimodality treatment regimens have substantially improved survival... 
ADJUVANT CHEMOTHERAPY | PRIMITIVE NEUROECTODERMAL TUMORS | METASTATIC-DISEASE | ONCOLOGY | SONIC HEDGEHOG | SPORADIC MEDULLOBLASTOMAS | CENTRAL-NERVOUS-SYSTEM | CHILDRENS CANCER GROUP | BETA-CATENIN | BASAL-CELL CARCINOMAS | HUMAN HOMOLOG | Proto-Oncogene Proteins - pharmacology | Cerebellar Neoplasms - drug therapy | Proto-Oncogene Proteins - drug effects | Prognosis | Signal Transduction | Humans | Risk Factors | Zebrafish Proteins | Wnt Proteins | Proto-Oncogene Proteins - biosynthesis | Hedgehog Proteins | Medulloblastoma - pathology | Trans-Activators - biosynthesis | Trans-Activators - pharmacology | Cerebellar Neoplasms - pathology | Medulloblastoma - drug therapy | Receptor, Epidermal Growth Factor - physiology | Care and treatment | Medulloblastoma | Brain tumors | Cancer
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8. Full Text Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor
by Ma, Haikuo and Chen, Qin and Chen, Shuaishuai and Zhu, Fang and Zheng, Long Tai and Zheng, Jiyue and Li, Jiajun and Zhang, Hongjian and Zhang, Xiaohu and Xing, Haimei and Luo, Lusong and He, Sudan
European Journal of Medicinal Chemistry, ISSN 0223-5234, 04/2018, Volume 149, pp. 110 - 121
Embryonic stem cell pathways such as hedgehog and Wnt pathways are central to the tumorigenic properties of cancer stem cells (CSC). Since CSCs are... 
Smoothened | Wnt signaling pathway | Porcupine | Stem cell | Cancer therapy | Hedgehog signaling pathway | Antagonist | DESIGN | CHEMISTRY, MEDICINAL | RECEPTOR | IDENTIFICATION | SMOOTHENED ANTAGONISTS | CANCER-THERAPY | CLINICAL-IMPLICATIONS | OPTIMIZATION | BINDING | FUSED 3-RING SYSTEM | PORCUPINE INHIBITORS | Acyltransferases - antagonists & inhibitors | Hedgehog Proteins - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Hedgehog Proteins - metabolism | Structure-Activity Relationship | Animals | Wnt Signaling Pathway - drug effects | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Drug Design | Antineoplastic Agents - pharmacology | Mice | Smoothened Receptor - antagonists & inhibitors | Index Medicus
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9. Full Text Role of Shh and TGF in cyclosporine‐enhanced expression of collagen and α‐SMA by gingival fibroblast
by Chung, Yi and Fu, Earl and Chin, Yu‐Tang and Tu, Hsiao‐Pei and Chiu, Hsien‐Chung and Shen, E‐Chin and Chiang, Cheng‐Yang
Journal of Clinical Periodontology, ISSN 0303-6979, 01/2015, Volume 42, Issue 1, pp. 29 - 36
Objective Cyclosporine‐A (CsA)‐induced gingival overgrowth may arise from an alteration in stoma matrix homeostasis. Sonic hedgehog (Shh) plays a key role... 
collagen | Sonic hedgehog | gingival fibroblasts | transforming growth factor‐beta | cyclosporine‐A | transforming growth factor-beta | cyclosporine-A | TRANSCRIPTION FACTORS | CELLS | MYOFIBROBLAST | PROLIFERATION | EPITHELIAL-MESENCHYMAL TRANSITION | RENAL FIBROSIS | GROWTH-FACTOR-BETA | IN-VITRO | DENTISTRY, ORAL SURGERY & MEDICINE | TRANSFORMING GROWTH-FACTOR-BETA-1 | NEPHROTOXICITY | Hedgehog Proteins - drug effects | Cell Line | Cyclosporine - pharmacology | Extracellular Matrix - drug effects | Humans | Transforming Growth Factor beta - physiology | Actins - drug effects | Hedgehog Proteins - physiology | Hedgehog Proteins - antagonists & inhibitors | Transforming Growth Factor beta - drug effects | Gingiva - drug effects | Signal Transduction - drug effects | Time Factors | Fibroblasts - drug effects | Gingiva - cytology | Veratrum Alkaloids - pharmacology | Collagen Type I - drug effects | Transforming Growth Factor beta - antagonists & inhibitors | Cell Culture Techniques | Homeostasis - drug effects | Immunosuppressive Agents - pharmacology | Receptor Cross-Talk - drug effects
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10. Full Text Sonic hedgehog signalling regulates the self‐renewal and proliferation of skin‐derived precursor cells in mice
by Park, Sangkyu and Kim, Hyewon and Kim, Kichul and Roh, Sangho
Cell Proliferation, ISSN 0960-7722, 12/2018, Volume 51, Issue 6, pp. e12500 - n/a
Objectives The sonic hedgehog (Shh) signalling pathway has an important role in the maintenance of various stem cells and organogenesis during development.... 
IN-VITRO | STEM-CELLS | ACTIVATION | SMO | PATHWAY | GROWTH | DIFFERENTIATION | TUMORIGENICITY | CELL BIOLOGY | Hedgehog Proteins - drug effects | Skin - cytology | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Purines - pharmacology | Hedgehog Proteins - metabolism | Morpholines - pharmacology | Epithelial-Mesenchymal Transition - drug effects | Veratrum Alkaloids - metabolism | Animals | Neoplastic Stem Cells - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Female | Cell Proliferation - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Developmental biology | Skin | Stem cells | Cell proliferation | Phenotypes | Mesenchyme | Stem cell transplantation | Gene expression | Organogenesis | Signal transduction | Signaling | Precursors | Hedgehog protein | Immunofluorescence | Recombinant | Apoptosis
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11. Full Text Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells
by Vinardell, Tatiana and Rolfe, Rebecca A and Buckley, Conor T and Meyer, Eric G and Ahearne, Mark and Murphy, Paula and Kelly, Daniel J
European Cells and Materials, ISSN 1473-2262, 2012, Volume 23, pp. 121 - 134
Hydrostatic pressure (HP) is a key component of the in vivo joint environment and has been shown to enhance chondrogenesis of stem cells. The objective of this... 
Cartilage | Transforming growth factor (TGF)-β3 | Synovial membrane | Hydrostatic pressure | Chondrocytes | Infrapatellar fat pad | Stem cells | stem cells | MATERIALS SCIENCE, BIOMATERIALS | chondrocytes | transforming growth factor (TGF)-beta 3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | cartilage | infrapatellar fat pad | synovial membrane | Hedgehog Proteins - drug effects | Chondrogenesis - drug effects | Hedgehog Proteins - metabolism | Stem Cells - cytology | Patellofemoral Joint - metabolism | Stem Cells - metabolism | Chondrocytes - drug effects | Collagen Type X - metabolism | Swine | Cartilage - cytology | Chondrocytes - metabolism | Transforming Growth Factor beta3 - administration & dosage | Collagen Type X - drug effects | SOX9 Transcription Factor - metabolism | Glycosaminoglycans - metabolism | Cells, Cultured | SOX9 Transcription Factor - drug effects | Patellofemoral Joint - cytology | Cartilage - metabolism | Hydrostatic Pressure | Synovial Membrane - metabolism | Phenotype | Animals | Cell Differentiation - drug effects | Stem Cells - drug effects | Synovial Membrane - cytology | transforming growth factor (TGF)-β3
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12. Full Text Hedgehog signalling in colorectal tumour cells: Induction of apoptosis with cyclopamine treatment
by Qualtrough, David and Buda, Andrea and Gaffield, William and Williams, Ann C and Paraskeva, Christos
International Journal of Cancer, ISSN 0020-7136, 07/2004, Volume 110, Issue 6, pp. 831 - 837
Hedgehog (Hh) signalling controls many aspects of development. It also regulates cell growth and differentiation in adult tissues and is activated in a number... 
hedgehog | cyclopamine | colon cancer | Hedgehog | Colon cancer | Cyclopamine | TRANSDUCTION | INTESTINE | CANCER | INHIBITION | REGIONALIZATION | ONCOLOGY | PATHWAY | ADENOMA | DIFFERENTIATION | MUTATIONS | SONIC-HEDGEHOG | Proto-Oncogene Proteins - drug effects | Carcinoma | Apoptosis - drug effects | Humans | Proto-Oncogene Proteins - genetics | Wnt Proteins | Adenoma | DNA Primers | Reverse Transcriptase Polymerase Chain Reaction | Intestinal Mucosa - drug effects | Trans-Activators - physiology | Hedgehog Proteins | Signal Transduction - drug effects | Colonic Neoplasms - pathology | Proto-Oncogene Proteins - physiology | Trans-Activators - genetics | Veratrum Alkaloids - pharmacology | Cell Line, Tumor | Signal Transduction - physiology | Rectal Neoplasms - pathology | Intestinal Mucosa - pathology
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