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Molecular cell, ISSN 1097-2765, 2009, Volume 36, Issue 1, pp. 39 - 50
In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-interaction domain such as MATH recruits substrates for ubiquitination... 
PROTEINS | ACTIVATION | PROTEIN | NRF2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCF | ADAPTER | DEGRADATION | KEAP1 | DIMERIZATION | BTB DOMAIN | HEDGEHOG | CELL BIOLOGY | Transcription Factors - chemistry | Humans | Crystallography, X-Ray | Drosophila Proteins - metabolism | Mutation - physiology | Protein Multimerization - physiology | Protein Structure, Quaternary - physiology | Ubiquitination - physiology | Peptide Fragments - genetics | Repressor Proteins - metabolism | Amino Acid Sequence | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Repressor Proteins - genetics | Recombinant Fusion Proteins - chemistry | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligases - chemistry | DNA-Binding Proteins - chemistry | Cullin Proteins - chemistry | Peptide Fragments - chemistry | Phosphoprotein Phosphatases - genetics | Consensus Sequence - physiology | Recombinant Fusion Proteins - genetics | Histones - metabolism | Ubiquitin-Protein Ligases - genetics | Drosophila melanogaster | Phosphoprotein Phosphatases - chemistry | Protein Binding - physiology | Adaptor Proteins, Signal Transducing - chemistry | Histones - chemistry | Protein Interaction Domains and Motifs - physiology | Phosphoprotein Phosphatases - metabolism | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Cullin Proteins - metabolism | Nuclear Proteins - genetics | Peptide Fragments - metabolism | Repressor Proteins - chemistry | Nuclear Proteins - metabolism | Drosophila Proteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cullin Proteins - genetics | Transcription Factors - metabolism | Animals | Histones - genetics | Adaptor Proteins, Signal Transducing - genetics | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin | Chromatin | Phosphatases | Ligases | CHROMATIN | BASIC BIOLOGICAL SCIENCES | SUBSTRATES | FLEXIBILITY | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | LIGASES | DIMERS | PHOSPHATASES
Journal Article
Nature cell biology, ISSN 1476-4679, 2009, Volume 11, Issue 6, pp. 739 - 746
...). Here we show that, in the absence of its ligand, Ptc interacts with the adaptor protein DRAL... 
PROTEIN | INHIBITION | GENE | MECHANISM | SONIC HEDGEHOG | NEURONAL DEATH | PRODUCT INDUCES APOPTOSIS | KAPPA-B | CASPASE ACTIVATION | CELL-DEATH | CELL BIOLOGY | RNA, Small Interfering - genetics | Caspase 9 - metabolism | Homeodomain Proteins - metabolism | Humans | Hedgehog Proteins - metabolism | Neoplasm Proteins - metabolism | CARD Signaling Adaptor Proteins - genetics | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Hedgehog Proteins - genetics | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | Patched Receptors | Neoplasm Proteins - genetics | Cell Line | Receptors, Cell Surface - metabolism | Transcription Factors - genetics | Chick Embryo | Homeodomain Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Two-Hybrid System Techniques | Animals | Adaptor Proteins, Signal Transducing - genetics | LIM-Homeodomain Proteins | Signal Transduction - physiology | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Causes of | Physiological aspects | Cell receptors | Research | Proteases | Apoptosis | Caspase 9 | Signal Transduction | Multiprotein Complexes | Receptors, Cell Surface | Cellular Biology | Hedgehog Proteins | Life Sciences | Muscle Proteins | Adaptor Proteins, Signal Transducing | Apoptosis Regulatory Proteins | Homeodomain Proteins | Neoplasm Proteins | CARD Signaling Adaptor Proteins | RNA, Small Interfering | Transcription Factors | Development Biology | physiology | genetics | metabolism
Journal Article
Neuron, ISSN 0896-6273, 03/2012, Volume 73, Issue 6, pp. 1116 - 1126
...., 1995; Roelink et al., 1995; Xu et al., 2005; Xu et al., 2010 ). The secreted protein Sonic Hedgehog (Shh) is expressed in the notochord and floor plate... 
SYNAPTIC SPECIFICITY | ADULT BRAIN | SIGNALING PATHWAY | IN-VIVO | BOC | GROWTH | MECHANISMS | AXON-GUIDANCE | MEMBRANE-PROTEINS | NEUROSCIENCES | CEREBRAL-CORTEX | Silver Staining - methods | RNA, Small Interfering - genetics | Furans - metabolism | Electric Stimulation | gamma-Aminobutyric Acid - metabolism | Channelrhodopsins | Hedgehog Proteins - metabolism | Dendritic Spines - metabolism | Functional Laterality - genetics | Nerve Net - cytology | Synaptophysin - genetics | Neurons - ultrastructure | Neurons - metabolism | Repressor Proteins - metabolism | Gene Expression Regulation, Developmental - physiology | Synaptophysin - metabolism | Animals, Newborn | Fluorobenzenes - metabolism | Tumor Suppressor Proteins - metabolism | Matrix Attachment Region Binding Proteins - metabolism | Dendritic Spines - physiology | Mice, Transgenic | Synapses - ultrastructure | Electroporation - methods | Mutation - genetics | Corpus Callosum - cytology | Patch-Clamp Techniques | Immunoglobulin G - genetics | Cerebral Cortex - growth & development | Luminescent Proteins - genetics | Corpus Callosum - growth & development | Mice | Immunoglobulin G - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Membrane Potentials - genetics | Age Factors | Gene Expression Regulation, Developmental - genetics | Phosphopyruvate Hydratase - metabolism | Cerebral Cortex - cytology | DNA-Binding Proteins - metabolism | Synapses - metabolism | Hedgehog Proteins - genetics | Pyramidal Tracts - physiology | Stilbamidines - metabolism | Receptors, Cell Surface - metabolism | Nuclear Proteins - metabolism | Transcription Factors - metabolism | Animals | Nerve Net - metabolism | In Vitro Techniques | Luminescent Proteins - metabolism | Stem cell research | Neurosciences | Nervous system diseases | Neurons | Stem cells | Collateralized debt obligations | Physiological aspects | Cells | Proteins | Transcription factors | Software | Sucrose | Synaptogenesis | Circuits | Hedgehog protein | Neural networks | Pyramidal cells | Cortex | Synapses
Journal Article
Nature cell biology, ISSN 1476-4679, 2010, Volume 12, Issue 3, pp. 299 - 305
For most types of cancers, the cell at the origin of tumour initiation is still unknown. Here, we used mouse genetics to identify cells at the origin of basal... 
POPULATION | STEM-CELLS | SONIC HEDGEHOG | EPIDERMIS | HAIR FOLLICLE BULGE | KERATINOCYTES | CANCER | EXPRESSION | HUMAN HOMOLOG | MOUSE SKIN | CELL BIOLOGY | Epithelial Cells - metabolism | Cadherins - metabolism | Receptors, G-Protein-Coupled - metabolism | Skin - metabolism | Cell Count | Ear, External - pathology | Integrin beta4 - metabolism | Tail - pathology | Hair Follicle - pathology | Hedgehog Proteins - genetics | Neoplastic Stem Cells - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Neoplastic Stem Cells - pathology | Cell Differentiation | Patched Receptors | Skin - pathology | Keratin-10 - metabolism | Epidermis - metabolism | Epidermis - pathology | RNA, Untranslated | Bacterial Proteins - genetics | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Genes, Reporter - genetics | Mice, Transgenic | Carcinoma, Basal Cell - pathology | Mice, Inbred Strains | Clone Cells - metabolism | Keratin-14 - genetics | Carcinoma, Basal Cell - metabolism | Keratin-15 - metabolism | Keratin-19 - genetics | Proteins - genetics | Cell Lineage | Animals | Clone Cells - pathology | Proteins - metabolism | Models, Biological | Hair Follicle - metabolism | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | Receptors, G-Protein-Coupled - genetics | Integrases - genetics | Keratin-15 - genetics | Luminescent Proteins - metabolism | Basal cell carcinoma | Stem cells | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors
Journal Article
Annual review of cell and developmental biology, ISSN 1081-0706, 11/2011, Volume 27, Issue 1, pp. 513 - 537
Journal Article
7.